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Vaccination: Malaria Vaccine
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Total 1513 results found since Jan 2013.
The mRNA Vaccine Technology Era and the Future Control of Parasitic Infections
This article considers the characteristics that are required to develop a potent antiparasite vaccine and provides a conceptual foundation to promote the development of parasite mRNA-based vaccines. We review the recent advances and challenges encountered in developing antiparasite vaccines and evaluate the potential of developing mRNA vaccines against parasites, including those causing diseases such as malaria and schistosomiasis, against which vaccines are currently suboptimal or not yet available.PMID:36625671 | DOI:10.1128/cmr.00241-21
Source: Clinical Microbiology Reviews - January 10, 2023 Category: Microbiology Authors: Hong You Malcolm K Jones Catherine A Gordon Alexa E Arganda Pengfei Cai Harry Al-Wassiti Colin W Pouton Donald P McManus Source Type: research
Human IL-10-producing Th1 cells exhibit a molecular signature distinct from Tr1 cells in malaria
J Clin Invest. 2023 Jan 3;133(1):e153733. doi: 10.1172/JCI153733.ABSTRACTControl of intracellular parasites responsible for malaria requires host IFN-γ+T-bet+CD4+ T cells (Th1 cells) with IL-10 produced by Th1 cells to mitigate the pathology induced by this inflammatory response. However, these IL-10-producing Th1 (induced type I regulatory [Tr1]) cells can also promote parasite persistence or impair immunity to reinfection or vaccination. Here, we identified molecular and phenotypic signatures that distinguished IL-10-Th1 cells from IL-10+Tr1 cells in Plasmodium falciparum-infected people who participated in controlled h...
Source: Cancer Control - January 3, 2023 Category: Cancer & Oncology Authors: Chelsea L Edwards Susanna S Ng Fabian de Labastida Rivera Dillon Corvino Jessica A Engel Marcela Montes de Oca Luzia Bukali Teija Cm Frame Patrick T Bunn Shashi Bhushan Chauhan Siddharth Sankar Singh Yulin Wang Jinrui Na Fiona H Amante Jessica R Loughland Source Type: research
Engineering of a plant-produced virus-like particle to improve the display of the Plasmodium falciparum Pfs25 antigen and transmission-blocking activity of the vaccine candidate
This study demonstrates an improved version of the virus-like particle antigen display molecule by eliminating known protease sites from the prior A85 variant. This re-engineered molecule, termed B29, displays three times the number of Pfs25 antigens per virus-like particle compared to the original Pfs25 virus-like particle. An improved purification scheme was also developed, resulting in a substantially higher yield and improved purity. The molecule was evaluated in a mouse model and found to induce improved transmission-blocking activity at lower doses and longer durations than the original molecule.PMID:36585278 | DOI:1...
Source: Vaccine - December 30, 2022 Category: Allergy & Immunology Authors: Stephen Tottey Yoko Shoji R Mark Jones Konstantin Musiychuk Jessica A Chichester Kazutoyo Miura Luwen Zhou Shwu-Maan Lee Jordan Plieskatt Yimin Wu Carole A Long Stephen J Streatfield Vidadi Yusibov Source Type: research
Detection of positive selection acting on protein surfaces at the whole-genome scale in the human malaria parasite Plasmodium falciparum
This study test hypothesizes that proteins subject to sequence evolution structural constraints play a crucial role and that these constraints hinder the modification of such proteins in this process. These hypotheses were tested using Plasmodium falciparum model and evaluated protein structures predicted for the entire proteome by the AlphaFold method. Based on dN/dS test results and P. falciparum and P. reichenowi comparisons, the presented approach identified proteins subject to purifying selection acting on the whole sequence and buried residues (dN < dS) and positive selection on nonburied residues. Of the 26 prote...
Source: Infection, Genetics and Evolution - December 26, 2022 Category: Genetics & Stem Cells Authors: Szymon Kaczanowski Source Type: research
Isolation, Purification, and Characterization of Homogenous Novel Bioactive Protein from < em > Datura stramonium < /em > Stem Exhibited Larvicidal Activity against < em > Anopheles stephensi < /em >
J Trop Med. 2022 Dec 5;2022:1637896. doi: 10.1155/2022/1637896. eCollection 2022.ABSTRACTThe insecticidal resistance of mosquitoes necessitates the development of a natural, safe, and plant-based method for vector control. Unfortunately, there are no effective vaccines or particular medications available to combat malaria; therefore, mosquitoes must be targeted directly. Previous studies have shown the health benefits of Datura stramonium, but its bioactive peptides or proteins are less explored. This is the first study on D. stramonium stem protein used for mosquito larval protein. The present study aimed to identify the ...
Source: Journal of Tropical Medicine - December 15, 2022 Category: Tropical Medicine Authors: Manisha Kirar S P Singh Neelam Sehrawat Source Type: research
Response to "The Importance of Exercising Caution When Comparing Results from Malaria Vaccines Administered on the EPI Schedule and on a Seasonal Schedule"
Am J Trop Med Hyg. 2022 Nov 21:tpmd220544b. doi: 10.4269/ajtmh.22-0544b. Online ahead of print.NO ABSTRACTPMID:36410330 | DOI:10.4269/ajtmh.22-0544b
Source: The American Journal of Tropical Medicine and Hygiene - November 21, 2022 Category: Tropical Medicine Authors: Philip J Rosenthal Source Type: research
The Importance of Exercising Caution When Comparing Results from Malaria Vaccines Administered on the EPI Schedule and on a Seasonal Schedule
Am J Trop Med Hyg. 2022 Nov 21:tpmd220544a. doi: 10.4269/ajtmh.22-0544a. Online ahead of print.NO ABSTRACTPMID:36410329 | DOI:10.4269/ajtmh.22-0544a
Source: The American Journal of Tropical Medicine and Hygiene - November 21, 2022 Category: Tropical Medicine Authors: Ashley Birkett R Scott Miller Lorraine A Soisson Source Type: research
