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Drug: Morphine

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Total 98 results found since Jan 2013.

The Risk of Ischemic Cardio- and Cerebrovascular Events Associated with Oxycodone –Naloxone and Other Extended-Release High-Potency Opioids: A Nested Case–Control Study
ConclusionsOur study does not indicate an association between oxycodone –naloxone and ischemic cardio- or cerebrovascular events. However, our findings do suggest that every change in ER HPO therapy should be conducted with caution.
Source: Drug Safety - February 12, 2017 Category: Drugs & Pharmacology Source Type: research

Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor
Cannabidiol (CBD), the major non-psychotomimetic compound present in the Cannabis sativa plant, exhibits therapeutic potential for various human diseases, including chronic neurodegenerative diseases, such as Alz...
Source: Molecular Brain - September 17, 2018 Category: Neuroscience Authors: Mar ía Rodríguez-Muñoz, Yara Onetti, Elsa Cortés-Montero, Javier Garzón and Pilar Sánchez-Blázquez Tags: Research Source Type: research

Morphine and Ticagrelor Interaction in Primary Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction: ATLANTIC-Morphine
ConclusionsMorphine-treatment was associated with increased GP IIb/IIIa inhibitor use, less pre-PCI TIMI 3 flow, and more bleeding. Judicious morphine use is advised with non-opioid analgesics preferred for non-severe acute pain.Trial Registrationclinicaltrials.gov identifier: NCT01347580.
Source: American Journal of Cardiovascular Drugs - October 23, 2018 Category: Cardiology Source Type: research

Effect of morphine use on oral P2Y12 platelet inhibitors in acute myocardial infarction: Meta-analysis
ConclusionCo-administration of morphine with P2Y12 inhibitors possibly decreases their efficacy in platelet inhibition. However, this did not translate into higher adverse outcomes due to low event rates, inadequate for analysis. A large randomized study is needed to evaluate the narcotic-P2Y12 interaction.
Source: Indian Heart Journal - March 20, 2019 Category: Cardiology Source Type: research

Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTP β/ζ Axis: Relevance in Therapeutic Development
Conclusion The expression of the components of the PTN-MK-RPTPβ/ζ axis in immune cells and in inflammatory diseases suggests important roles for this axis in inflammation. Pleiotrophin has been recently identified as a limiting factor of metainflammation, a chronic pathological state that contributes to neuroinflammation and neurodegeneration. Pleiotrophin also seems to potentiate acute neuroinflammation independently of the inflammatory stimulus while MK seems to play different -even opposite- roles in acute neuroinflammation depending on the stimulus. Which are the functions of MK and PTN in chronic neuroi...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Challenge to the Intestinal Mucosa During Sepsis
Conclusion The impact of sepsis on the gut is manifold, e.g., sepsis mediated alteration of the gut-blood barrier and increase in the intestinal permeability, which may correlate with the phenomena of bacterial translocation and lymphatic activation (“toxic-lymph”). Systemic consequences of sepsis are widespread and concern to the coagulative system, the microbiome as well as enzymes, such as pancreatic proteases, MMPs and IAPs. Nevertheless, the therapeutic approaches for modulating the mucosal immune system are still rarely effective in daily routine. Recent published studies showing that treatment with ...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

Effect of morphine use on oral P2Y12 platelet inhibitors in acute myocardial infarction: Meta-analysis.
CONCLUSION: Co-administration of morphine with P2Y12 inhibitors possibly decreases their efficacy in platelet inhibition. However, this did not translate into higher adverse outcomes because of low event rates, inadequate for analysis. A large randomized study is needed to evaluate the narcotic-P2Y12 interaction. PMID: 31280824 [PubMed - in process]
Source: Indian Heart J - February 28, 2019 Category: Cardiology Authors: Vaidya GN, Khan A, Ghafghazi S Tags: Indian Heart J Source Type: research

Lysophosphatidic Acid Receptor Signaling Underlying Chronic Pain and Neuroprotective Mechanisms through Prothymosin α.
Abstract For my Ph.D. research topic, I isolated endogenous morphine-like analgesic dipeptide, kyotorphin, which mediates Met-enkephalin release, and discovered kyotorphin synthetase, a putative receptor and antagonist. Furthermore, I succeeded in purifying μ-opioid receptor and functional reconstitution with purified G proteins. After receiving my full professor position at Nagasaki University in 1996, I worked on two topics of research, molecular mechanisms of chronic pain through lysophosphatidic acid (LPA) and identification and characterization of neuroprotective protein, prothymosin α. In a series of studi...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - November 8, 2019 Category: Drugs & Pharmacology Authors: Ueda H Tags: Yakugaku Zasshi Source Type: research

Complex regional pain syndrome: A case report and review of the literature
Conclusion: A multidisciplinary approach is needed for effective management of CRPS, and refractory disease may respond to intrathecal baclofen with morphine.
Source: Annals of African Medicine - March 12, 2020 Category: African Health Authors: Nura H Alkali Abdulrahman M Al-Tahan Mohammad Al-Majed Husam Al-Tahan Source Type: research

Daily intermittent fasting in mice enhances morphine-induced antinociception while mitigating reward, tolerance, and constipation
The opioid epidemic has plagued the United States with high levels of abuse and poor quality of life for chronic pain patients requiring continuous use of opioids. New drug discovery efforts have been implemented to mitigate this epidemic; however, new medications are still limited by low efficacy and/or high side effect and abuse potential. Intermittent fasting (IF) has recently been shown to improve a variety of pathological states, including stroke and neuroinflammation. Numerous animal and human studies have shown the benefits of IF in these disease states, but not in pain and opioid treatment. We thus subjected male a...
Source: Pain - September 24, 2020 Category: Anesthesiology Tags: Research Paper Source Type: research

Observation of hemodynamic parameters using a non-invasive cardiac output monitor system to identify predictive indicators for post-spinal anesthesia hypotension in parturients undergoing cesarean section.
In conclusion, the baseline CI obtained via the bioreactance-based NICOM™ system may serve as a predictor of post-spinal anesthesia hypotension in parturients regardless of patient position. PMID: 33093906 [PubMed]
Source: Experimental and Therapeutic Medicine - October 24, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Morphine overinfusion of intrathecal drug administration system under magnetic resonance evaluation for the diagnosis of stroke: a case report
In this study, we presented a case of morp...
Source: BMC Neurology - April 5, 2021 Category: Neurology Authors: Seoyeon Kim and Min Kyoung Kang Tags: Case report Source Type: research

FMD and SCAD: Sex-Biased Arterial Diseases With Clinical and Genetic Pleiotropy
Circ Res. 2021 Jun 11;128(12):1958-1972. doi: 10.1161/CIRCRESAHA.121.318300. Epub 2021 Jun 10.ABSTRACTMultifocal fibromuscular dysplasia (FMD) and spontaneous coronary artery dissection are both sex-biased diseases disproportionately affecting women over men in a 9:1 ratio. Traditionally known in the context of renovascular hypertension, recent advances in knowledge about FMD have demonstrated that FMD is a systemic arteriopathy presenting as arterial stenosis, aneurysm, and dissection in virtually any arterial bed. FMD is also characterized by major cardiovascular presentations including hypertension, stroke, and myocardi...
Source: Circulation Research - June 10, 2021 Category: Cardiology Authors: Esther S H Kim Jacqueline Saw Daniella Kadian-Dodov Malissa Wood Santhi K Ganesh Source Type: research

Compound Developed at UArizona Health Sciences Provides Innovative Pain Relief
Digital media& downloads Compound Developed at UArizona Health Sciences Provides Innovative Pain Relief Researchers targeted a common sodium ion channel to reverse pain and saw positive results that could lead to a nonaddictive solution to treat pain. Today University of Arizona Health Sciencespain-relief-web.jpgHealthBIO5College of Medicine - TucsonExpertsResearch Media contact(s)Stacy Pigott University of Arizona Health Sciencesspigott@arizona.edu520-539-4152Researchers at the  University of Arizona Health Sciences are closer to developing a safe and effective non-opioid pain reliever after a study showed that...
Source: The University of Arizona: Health - November 15, 2021 Category: Universities & Medical Training Authors: mittank Source Type: research

Opioid-Use, COVID-19 Infection, and Their Neurological Implications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an imminent threat to human health and public safety. ACE2 and transmembrane serine protease 2 proteins on host cells provide the viral entry point to SARS-CoV-2. Although SARS-CoV-2 mainly infects the respiratory system, there have been reports of viral neurotropism and central nervous system injury as indicated by plasma biomarkers, including neurofilament light chain protein and glial fibrillary acidic protein. Even with a small proportion of infections leading to neurological manifestation, the overall number remains high. Common neurological manifestation...
Source: Frontiers in Neurology - May 23, 2022 Category: Neurology Source Type: research