Compound Developed at UArizona Health Sciences Provides Innovative Pain Relief

Digital media&downloads Compound Developed at UArizona Health Sciences Provides Innovative Pain Relief Researchers targeted a common sodium ion channel to reverse pain and saw positive results that could lead to a nonaddictive solution to treat pain. Today University of Arizona Health Sciencespain-relief-web.jpgHealthBIO5College of Medicine - TucsonExpertsResearch Media contact(s)Stacy Pigott University of Arizona Health Sciencesspigott@arizona.edu520-539-4152Researchers at the  University of Arizona Health Sciences are closer to developing a safe and effective non-opioid pain reliever after a study showed that a new compound they created reduces the sensation of pain by regulating a biological channel linked to pain.Most people experience pain at some point in their lives, and the National Institutes of Health estimates 100 million people in the U.S. suffer from chronic pain. Approximately 21-29% of patients prescribed opioids for chronic pain misuse them, and 8-12% of people using an opioid for chronic pain develop an opioid-use disorder, according to the National Institute on Drug Abuse. In 2019, nearly 50,000 people in the U.S. died from opioid-involved overdoses.Khanna_Raj-web.jpg Rajesh Khanna Kris Hanning/University of Arizona Health Sciences" Drug discovery for chronic pain is at the forefront of this research, and it's being amplified by the intersection of the COVID-19 pandemic and the opioid epidemic, " said  Rajesh Khanna, associate...
Source: The University of Arizona: Health - Category: Universities & Medical Training Authors: Source Type: research

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Purpose: To report the long-term outcomes after phototherapeutic keratectomy (PTK) for the treatment of bullous keratopathy. Methods: This is a retrospective medical record review of all patients with symptomatic bullous keratopathy who underwent PTK between June 2005 and March 2019 at the Royal Victorian Eye and Ear Hospital who were followed up for at least 12 months after the procedure. Medical records were used to extract demographic data, etiology of bullous keratopathy, complication rates, and subsequent procedures after PTK. The main outcomes recorded were pain and recurrence of bullae, which were assesse...
Source: Cornea - Category: Opthalmology Tags: Clinical Science Source Type: research
Purpose: The purpose of this article was to study the clinical, optical, and morphological correlates of visual function in patients with Fuchs endothelial corneal dystrophy (FECD). Methods: The case records were analyzed for patients diagnosed with FECD between September 2019 and March 2020. The best-corrected visual acuity (BCVA) was recorded as decimal visual acuity and converted to the logarithm of the minimum angle of resolution units. Contrast sensitivity was measured with the Pelli–Robson contrast sensitivity test. Corneal alterations, including central corneal thickness, depression of the posterior...
Source: Cornea - Category: Opthalmology Tags: Clinical Science Source Type: research
Conclusions: Using the new 6-mm cylindrical light guide for IPL treatment in patients with MGD induced less pain during treatment and had similar treatment effects to the conventional 8 × 15-mm light guide. The new 6-mm cylindrical light guide can be useful when treating patients with dark or hyperpigmented skin and for pediatric patients with low compliance.
Source: Cornea - Category: Opthalmology Tags: Clinical Science Source Type: research
Conclusions: In this study, postoperative SARS-CoV-2 infection was similar for individuals undergoing corneal transplantation or cataract surgery. Further research is required to evaluate the transmission of SARS-CoV-2 through corneal tissue.
Source: Cornea - Category: Opthalmology Tags: Clinical Science Source Type: research
Conclusions: The overall prevalence of SARS-CoV-2 was 1% (2% for conjunctival and 0% for corneal samples, P value = 0.5) in the donors who were found suitable for cornea recovery and transplantation. The findings of exceptionally low positive rates in our samples validate the criticality of history-based donor screening and do not support the necessity of postmortem PCR testing as a criterion for procurement and subsequent use for corneal transplantation.
Source: Cornea - Category: Opthalmology Tags: Basic Investigation Source Type: research
Conclusions: The novel SARS-CoV-2 vaccine upregulates the immune system to produce an adaptive immune response. The SARS-CoV-2 vaccine may potentially be associated with increased risk of rejection in those with ocular surface transplants.
Source: Cornea - Category: Opthalmology Tags: Case Report Source Type: research
Abstract: As the understanding of COVID-19 infection becomes better, it is being recognized as a complex multisystem pathology rather than just affecting the lungs. Several ocular findings have been documented by researchers in individuals infected with COVID-19, and ocular symptoms may even be the first presenting feature of COVID-19 infection in 2.26% individuals. Several countries have started vaccination with inactivated or live vaccines to combat this pandemic, and varied side effects have been reported after vaccination. Few cases of herpes zoster have previously been reported in elderly patients with comorbiditi...
Source: Cornea - Category: Opthalmology Tags: Case Report Source Type: research
Conclusions: To the best of our knowledge, this case of full-thickness graft rejection after the Moderna SARS-CoV-2 mRNA vaccination is the first to be reported worldwide. The temporal relationship between vaccination and subsequent rejection is highly suggestive of causation due to the short interval (3 days) between vaccination and rejection and the lack of other inciting factors in an otherwise healthy graft. Patients with corneal transplants who plan to take the COVID-19 vaccinations should be counseled on symptoms and closely monitored, and an individualized plan should be made in discussion with the ophthalmologist.
Source: Cornea - Category: Opthalmology Tags: Case Report Source Type: research
No abstract available
Source: Cornea - Category: Opthalmology Tags: Letters to the Editor Source Type: research
No abstract available
Source: Cornea - Category: Opthalmology Tags: Letters to the Editor Source Type: research
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