Effect of morphine use on oral P2Y12 platelet inhibitors in acute myocardial infarction: Meta-analysis

ConclusionCo-administration of morphine with P2Y12 inhibitors possibly decreases their efficacy in platelet inhibition. However, this did not translate into higher adverse outcomes due to low event rates, inadequate for analysis. A large randomized study is needed to evaluate the narcotic-P2Y12 interaction.
Source: Indian Heart Journal - Category: Cardiology Source Type: research