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Total 114 results found since Jan 2013.

Salt not as damaging to health as previously thought, says study
New research reignites a row with scientists who want to reduce salt intake to near zeroSalt may not be as damaging to health as is usually claimed, according to a controversial new study which suggests campaigns to persuade people to cut down may only be worthwhile in countries with very high sodium consumption, such as China.The World Health Organization recommends cutting sodium intake to no more than 2g a day – the equivalent of 5g of salt – because of the link to increased blood pressure, which is in turn implicated in stroke.Continue reading...
Source: Guardian Unlimited Science - August 9, 2018 Category: Science Authors: Sarah Boseley Health editor Tags: Science Health Diets and dieting Medical research Nutrition Food & wellbeing Heart attack Source Type: news

Too Much Sleep Linked To Greater Risk Of Disease & Death, Study Finds
(CNN) — The recommended amount of sleep for adults is six to eight hours a night. Sleeping more than those hours is associated with an increased risk of death and cardiovascular diseases, says a global study published Wednesday in the European Heart Journal. Looking at data from 21 countries, across seven regions, the research team found that people sleeping more than the recommended upper limit of eight hours increased their risk of major cardiovascular events, like stroke or heart failure, as well as death by up to 41%. But a possible reason for this could be that people have underlying conditions causing them to s...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - December 5, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Local TV Sleep Source Type: news

6-Bromoindirubin-3 ′-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver
In this study, we aimed to investigate the anti-aging effect, and molecular mechanism, of the novel anti-aging drug 6BIO on naturally aged mouse liver. Rapamycin, a well-known promising anti-aging drug that delays aging through mTOR-dependent autophagy (Zhou and Ye, 2018), was used as the positive control in the study. To our knowledge, this is the first study to demonstrate the effects of 6BIO treatment in models of natural aging. Our results indicated that 6BIO ameliorates the decline of liver function with age, including lipid metabolism disorder, and attenuates hepatocyte senescence in aged mice, as revealed by altera...
Source: Frontiers in Pharmacology - April 9, 2019 Category: Drugs & Pharmacology Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer ’s Disease Through Activation of BDNF-TrkB Signaling Pathway
Conclusion The data in this manuscript demonstrates that apelin-13 upregulates BDNF against STZ-induced congnitive impairment by suppressing glial cell activity and inflammatory factors release. This suggests apelin signaling may be a new target in the treatment of AD. Ethics Statement All experimental protocols were carried out according to the National Institutes of Health Guide for the Care and Use of Laboratory Animals approved by the Central South University at XiangYa Animal Care and Use Committee. Author Contributions XqQ and LH conceived the study and contributed to its experimental design. HqL carried out the...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research

Osteoporosis and Sarcopenia Increase Frailty Syndrome in the Elderly
Conclusions World population is aging and the increase in life expectancy is often unhealthy. In particular, musculoskeletal aging, which leads to sarcopenia and osteoporosis, has several causes such as changes in body composition, inflammation, and hormonal imbalance. Sarcopenia, osteoporosis, and more frequently, sarcopenic obesity are commonly associated with aging and frequently closely linked each other, often leading to the development of a frailty syndrome. Frailty syndrome favors an increased risk of loss function in daily activities, for cardiovascular diseases, cancers, falls, and mortality. As the number of eld...
Source: Frontiers in Endocrinology - April 23, 2019 Category: Endocrinology Source Type: research

Atrial Transcriptional Profiles of Molecular Targets Mediating Electrophysiological Function in Aging and Pgc-1 β Deficient Murine Hearts
Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis. Introduction Atrial arrhythmias constitute a major public health pro...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

The dietary transition and its association with cardiometabolic mortality among Chinese adults, 1982–2012: a cross-sectional population-based study
Publication date: Available online 10 May 2019Source: The Lancet Diabetes & EndocrinologyAuthor(s): Yuna He, Yanping Li, Xiaoguang Yang, Elena C Hemler, Yuehui Fang, Liyun Zhao, Jian Zhang, Zhenyu Yang, Zhu Wang, Li He, Jing Sun, Dong D Wang, Jingzhong Wang, Jianhua Piao, Xiaofeng Liang, Gangqiang Ding, Frank B HuSummaryBackgroundFew studies have used nationally representative data to describe dietary trends and the related cardiometabolic mortality burden in China. Thus, we aimed to characterise the trends in disease-related dietary factors as well as their associated disease burden among Chinese adults from 1982 to 2012....
Source: The Lancet Diabetes and Endocrinology - May 12, 2019 Category: Endocrinology Source Type: research

People in China have more salt in their diet than anyone else in world
People in China consume 10 grams of salt each day on average – the most of any country and twice the level recommended to avoid risks including stroke
Source: New Scientist - Health - July 11, 2019 Category: Consumer Health News Source Type: research

Many take anticoagulants and OTC supplements, which poses risk
FINDINGSNearly 98% percent of people prescribed direct-acting oral anticoagulants such as apixaban also used  over-the-counter products. Of those, 33% took at least one such product that, in combination with the anticoagulants, could cause dangerous internal bleeding. People taking these medications largely lacked knowledge of some potentially serious interactions.BACKGROUNDDirect-acting oral anticoagulants are the drug of choice for stroke prevention in patients with atrial fibrillation, which occurs most frequently in older patients. Apixaban is one of the most frequently prescribed. However, most people prescribed apix...
Source: UCLA Newsroom: Health Sciences - October 31, 2019 Category: Universities & Medical Training Source Type: news

Associations of choline-related nutrients with cardiometabolic and all-cause mortality: results from 3 prospective cohort studies of blacks, whites, and Chinese.
CONCLUSIONS: High choline intake was associated with increased cardiometabolic mortality in racially diverse populations. PMID: 31915809 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - January 7, 2020 Category: Nutrition Authors: Yang JJ, Lipworth LP, Shu XO, Blot WJ, Xiang YB, Steinwandel MD, Li H, Gao YT, Zheng W, Yu D Tags: Am J Clin Nutr Source Type: research

Greater macrovascular and microvascular morbidity from type 2 diabetes in Northern compared with Southern China: a cross ‐sectional study
ConclusionsMore macrovascular and microvascular complications were found in Northern compared to Southern patients, and the largest difference also appeared in the younger age groups under 55, which may be meaningful to a screening and treatment strategy according to geographic differences.
Source: Journal of Diabetes Investigation - March 31, 2020 Category: Endocrinology Authors: Li Wang, Ying Xing, Xinwen Yu, Jie Ming, Xiangyang Liu, Xiaomiao Li, Jianfang Fu, Jie Zhou, Bin Gao, Dayi Hu, Changyu Pan, Linong Ji, Qiuhe Ji Tags: ORIGINAL ARTICLE Source Type: research

Associations of choline-related nutrients with cardiometabolic and all-cause mortality: results from 3 prospective cohort studies of blacks, whites, and Chinese
ConclusionsHigh choline intake was associated with increased cardiometabolic mortality in racially diverse populations.
Source: American Journal of Clinical Nutrition - January 8, 2020 Category: Nutrition Source Type: research

Association of cardiovascular diseases with milk intake among general Chinese adults.
CONCLUSIONS: Daily milk intake was associated with lower risk of CVD incidence and mortality in a linear inverse relationship. The findings provide new evidence for dietary recommendations in CVD prevention among Chinese adults and people with similar dietary pattern in other countries. PMID: 32304403 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - April 14, 2020 Category: General Medicine Authors: Wang XY, Liu FC, Yang XL, Li JX, Cao J, Lu XF, Huang JF, Li Y, Chen JC, Zhao LC, Shen C, Hu DS, Zhao YX, Yu L, Liu XQ, Wu XP, Gu DF Tags: Chin Med J (Engl) Source Type: research

Greater macrovascular and microvascular morbidity from type  2 diabetes in northern compared with southern China: A cross‐sectional study
ConclusionsMore macrovascular and microvascular complications were found in northern compared with southern patients, and the largest difference also appeared in the younger age groups<55  years, which might be meaningful to a screening and treatment strategy according to geographic differences.
Source: Journal of Diabetes Investigation - May 3, 2020 Category: Endocrinology Authors: Li Wang, Ying Xing, Xinwen Yu, Jie Ming, Xiangyang Liu, Xiaomiao Li, Jianfang Fu, Jie Zhou, Bin Gao, Dayi Hu, Changyu Pan, Linong Ji, Qiuhe Ji Tags: Original Article Source Type: research