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Infectious Disease: Parasitic Diseases

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Total 613 results found since Jan 2013.

Expanding Research Capacity in Sub-Saharan Africa Through Informatics, Bioinformatics, and Data Science Training Programs in Mali
Conclusion Bioinformatics and data science training programs in developing countries necessitate incremental and collaborative strategies for their feasible and sustainable development. The progress described here covered decades of collaborative efforts centered on training and research on computationally intensive topics. These efforts laid the groundwork and platforms conducive for hosting a bioinformatics and data science training program in Mali. Training programs are perhaps best facilitated through Africa’s university systems as they are perhaps best positioned to maintain core resources during lapses in sho...
Source: Frontiers in Genetics - April 11, 2019 Category: Genetics & Stem Cells Source Type: research

From “Serum Sickness” to “Xenosialitis”: Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc
Conclusions and Perspectives In this review, we have discussed important milestones from the early description of “Serum-sickness” as being due to antibodies directed against Neu5Gc epitopes all the way to the present-day therapeutic implications of these antibodies in cancer therapy. Some of these milestones have been represented in a concise timeline (Figure 6). While the “Xenosialitis” hypothesis is well-supported in the human-like mouse models, it has yet to be conclusively proven in humans. It remains to be seen if “Xenosialitis” plays a role in other uniquely-human dis...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

A Novel Human Microbe-Disease Association Prediction Method Based on the Bidirectional Weighted Network
Conclusion Human microbiome is normal flora for humans, which has been proved to be of symbiotic relationship with humans and harmless to humans. If the microbes that breed in the human body become “unhealthy,” it will definitely affect the host's physical condition. People are continuing to explore the pathologic relationship between microorganisms and the human body through high-throughput sequencing technologies and analysis systems. However, it is a pity that their pathogenesis cannot be fully understood as yet. Considering that relying only on conventional experimental methods is time-consumin...
Source: Frontiers in Microbiology - April 8, 2019 Category: Microbiology Source Type: research

Innate Lymphoid Cells in Helminth Infections —Obligatory or Accessory?
Conclusion ILC2s are clearly an inherent feature of the immune response to helminth infection, and in all probability their evolution has been driven by the threat of parasites. While in experimental model systems they are not always found to be essential, they are often center stage, particularly in the early phases of infection of each helminth system so far analyzed. They also form an important conceptual and mechanistic link with the allergic response that will allow us to understand in more detail the genesis and control of allergic disorders. In this respect, a much fuller analysis of ILC biology and function in the...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

What Are Some Mast Cell Disorders?
Discussion Mast cells (MCs) were first discovered by Paul Ehrlich in 1878. Previously in 1869, Nettleship and Tay described a toddler with chronic urticaria and a brown skin lesion which is believed to be the first reported case of mastocytosis. Urticaria pigmentosa was a term first used by Sangster in 1878, and in 1936 the term mastocytosis was used. “Mast cells first evolved 500 million years ago in Ascidians (sea squirts), providing host innate immunity against bacteria and parasites….MCs gained additional functions regulating inflammation, wound healing, coagulation, adaptive immunity and acute allergic res...
Source: PediatricEducation.org - February 21, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Human Ascariasis Increases the Allergic Response and Allergic Symptoms
Abstract Ascariasis is still very prevalent; one billion people are infected all around the world. In rural areas, severe ascariasis impairs the immune responses to natural infections and vaccination programs. However, in urbanized areas, improved hygiene conditions and periodic anthelmintic treatments have led to light forms of ascariasis, where parasite-induced immunosuppressive effects are surpassed by the immunostimulating effects of the infection. During the last years, the clinical impact of this type of ascariasis on allergic diseases, especially asthma, has been well documented, and it is currently accepte...
Source: Current Tropical Medicine Reports - September 30, 2015 Category: Tropical Medicine Source Type: research

Parasitic infections and allergies
Abstract: The hygiene hypothesis has been proposed to explain temporal trends of increasing allergy prevalence in high-income countries and in urbanizing populations in low-income countries (LICs). Improvements in hygiene and reductions in exposures to childhood infectious diseases are considered to cause increased allergy through a failure to educate appropriately the developing immune system leading to inadequate regulation of allergic inflammation. Parasite infections are extremely common in poor populations in LICs and a high prevalence of parasites, particularly helminth parasites, has been put forward to explain the ...
Source: International Journal of Infectious Diseases - March 29, 2016 Category: Infectious Diseases Authors: P. Cooper Tags: Type: Invited Presentation Source Type: research

Eosinophilic colitis in children.
CONCLUSIONS: The higher concentration of total IgE in less than half of the patients with eosinophilic colitis indicates the need for improving allergy diagnosis also in terms of IgE-independent allergy. The presence of higher levels of antibodies of ASCA and ANCA in some of the patients with isolated eosinophilic colitis indicates the need for further observation for the occurrence of inflammatory bowel disease. PMID: 28261032 [PubMed - in process]
Source: Advances in Dermatology and Allergology - March 8, 2017 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Humoral Immunity in Arsenic-Exposed Children in Rural Bangladesh: Total Immunoglobulins and Vaccine-Specific Antibodies
Conclusions: Arsenic exposure increased tIgG and tIgE in plasma, and tended to decrease mumps-specific IgG in children at 9 years of age. https://doi.org/10.1289/EHP318 Received: 09 April 2016 Revised: 09 October 2016 Accepted: 24 October 2016 Published: 14 June 2017 Address correspondence to R. Raqib, Immunobiology, Nutrition and Toxicology Laboratory, Infectious Diseases Division, icddr,b, 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka-1212, Bangladesh. Telephone: 880-2-9827068. E-mail: rubhana@icddrb.org Supplemental Material is available online (https://doi.org/10.1289/EHP318). The authors declare they have n...
Source: EHP Research - June 15, 2017 Category: Environmental Health Authors: Karla Gonzalez Tags: Research Source Type: research

A Bidirectional Label Propagation Based Computational Model for Potential Microbe-Disease Association Prediction
Discussion There are numerous microbial communities inhabited in the human body, which is critical to human health. The relationship between human microbiome and diseases received much attention from both medical and bioinformatics community recently. However, traditional methods to detect their association is costly and labor-intensive. Thus, we proposed here a new computational model called NBLPIHMDA to infer potential microbe-disease associations. NBLPIHMDA first combined known microbe-disease associations in HMDAD and the Gaussian interaction profile kernel similarity to construct disease similarity network and microb...
Source: Frontiers in Microbiology - April 8, 2019 Category: Microbiology Source Type: research

Cellular Immune Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
This study was carried out in accordance with the recommendations of The London School of Hygiene & Tropical Medicine (LSHTM) Research Ethics Committee (Ref. 6123) and the National Research Ethics Service (NRES) London-Bloomsbury Research Ethics Committee (REC ref. 11/10/1760, IRAS ID: 77765), with written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the LSHTM Research Ethics Committee and the NRES London-Bloomsbury Research Ethics Committee. Author Contributions JC, HD, LN, EL, and ER devised the study ...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research

Urticaria and silent parasitism by Ascaridoidea: Component-resolved diagnosis reinforces the significance of this association
The objectives of this study were to analyse a possible relationship between parasitism by Ascarididae (Toxocara canis andAnisakis simplex) and the clinical expression of urticaria and to identify possible parasitic molecular markers for improving the diagnosis of unknown urticaria aetiology. The prevalence ofToxocara andAnisakis infestations was evaluated by measuring the levels of specific IgG (sIgG) and IgE (sIgE) antibodies against crude extracts and isolated components from whole larvae ofAnisakis simplex (Ani s 1, Ani s 3 and Ani s 7) andToxocara canis (TES-120, TES-70, TES-32 and TES-26) using immunologic and molecu...
Source: PLoS Neglected Tropical Diseases - April 2, 2020 Category: Tropical Medicine Authors: Marta Vi ñas Source Type: research

Clinical signs and diagnosis of feline atopic syndrome: detailed guidelines for a correct diagnosis.
CONCLUSIONS AND CLINICAL IMPORTANCE: In a similar way to atopic dermatitis in dogs, FASS is a clinical diagnosis based on the presence of compatible clinical signs and exclusion of other diseases with similar clinical features. Elimination or exclusion of fleas/flea allergy, other parasites, infections and food allergy is mandatory before reaching a diagnosis of FASS. PMID: 33470017 [PubMed - in process]
Source: Veterinary Dermatology - January 21, 2021 Category: Veterinary Research Authors: Santoro D, Pucheu-Haston CM, Prost C, Mueller RS, Jackson H Tags: Vet Dermatol Source Type: research

Ticks Carry More Diseases Than Just Lyme. Here ’ s What You Need to Know
Chris Rose lost ten years of his health—not to mention his gallbladder—to a single tick bite. The tick bit in 2010 and Rose, now a 50-year-old network engineer in Chapel Hill, N.C., thought little of it at the time. “It was one of those lone star ticks,” he says, “and I just picked it off me. It wasn’t a big deal.” Before long, however, Rose began developing crushing chest pains, abdominal discomfort, diarrhea, and other symptoms. Doctors screened him for heart disease, irritable bowel syndrome, and gallstones, and even removed his gallbladder to see if that might ease the intesti...
Source: TIME: Health - April 5, 2023 Category: Consumer Health News Authors: Jeffrey Kluger Tags: Uncategorized Disease healthscienceclimate Source Type: news

Bacterial infection in mosquitoes renders them immune to malaria parasites
(NIH/National Institute of Allergy and Infectious Diseases) Scientists funded by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, have established an inheritable bacterial infection in malaria-transmitting Anopheles mosquitoes that renders them immune to malaria parasites. Specifically, the scientists infected the mosquitoes with Wolbachia, a bacterium common among insects that previously has been shown to prevent malaria-inducing Plasmodium parasites from developing in Anopheles mosquitoes.
Source: EurekAlert! - Infectious and Emerging Diseases - May 9, 2013 Category: Infectious Diseases Source Type: news