Humoral Immunity in Arsenic-Exposed Children in Rural Bangladesh: Total Immunoglobulins and Vaccine-Specific Antibodies

Author Affiliations open 1Infectious Diseases Division, icddr,b (International Centre for Diarrhoeal Disease Research, Bangladesh), Dhaka, Bangladesh 2Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden 3Maternal and Child Health Division, icddr,b, Dhaka, Bangladesh 4Department of Clinical Trial and Clinical Epidemiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan PDF Version (995 KB) Abstract About This Article Supplemental Material Background: Early-life arsenic exposure has been associated with reduced cell-mediated immunity, but little is known about its effects on humoral immunity. Objective: We evaluated whether prenatal and childhood arsenic exposure was associated with humoral immune function in school-aged children. Methods: Children born in a prospective mother–child cohort in rural Bangladesh were immunized with measles, mumps, and rubella (MMR) vaccines at 9 years of age (n=525). Arsenic exposure was assessed in urine (U-As), from mothers during pregnancy and their children at 4.5 and 9 years of age. Total IgG (tIgG), tIgE, tIgA, and MMR-specific IgG concentrations were measured in plasma using immunoassays. Results: Arsenic exposure was positively associated with child tIgG and tIgE, but not tIgA. The association with tIgG was mainly apparent in boys (p for interaction=0.055), in whom each doubling of maternal U-As was related to an increase in tIgG by 28 mg/dL. The associations of U-As at 9 years with...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research

Related Links:

Source: BMJ Comments - Category: General Medicine Source Type: forums
DNA changes in a common type of breast cancer cell may be linked to hormone therapy resistance, according to a study published inNature Communications.Science Daily
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
BPA exposure may activate an immune system response linked to asthma that is passed down through generations, according to a study published in the journal ofProteome Research.Science Daily
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
We have vacancies for the Editor-in-Chief positions on the Editorial Boards of Endocrine Connections and Endocrine-Related Cancer.Endocrine Connections is jointly owned by the Society for Endocrinology and the European Society of Endocrinology. It is an open access journal offering authors the highest possible visibility for their work and stimulating cross-discipline collaboration. Read the full job description.Endocrine-Related Cancer is the official flagship journal of the Society for Endocrinology and is endorsed by the European Society of Endocrinology, Endocrine Society of Australia...
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
In 2019, 84% of Americans think vaccinating children is important, down from 94% in 2001; 10% still believe vaccines can cause autism, according to a new Gallup survey.Medscape Medical News
Source: Medscape Infectious Diseases Headlines - Category: Infectious Diseases Tags: Infectious Diseases News Source Type: news
Conclusion The current level of awareness for clinical trials of cancer patients in our hospital was relatively low, even in patients who had atte nded clinical trials before. It’s necessary to improve patients’ awareness of clinical trial by promoting harmony relationship between patients and doctors, as well as by enhancing related propagation. Strengthening the adequacy and efficacy of informed consent in clinical trials also needs to b e achieved in the future. DOI: 10.3779/j.issn.1009-3419.2020.01.02
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
Conclusion T4 stage patients had worse survival in N2 group. To get a more precisely stratification, skip metastasis and number of involved lymph node stations should be considered in future N stage classification. 
 DOI: 10.3779/j.issn.1009-3419.2020.01.03
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
Conclusion The expression of TRIM59 is closely related to the prognosis of NSCLC patients, and it is an independent risk factor for NSCLC patients. DOI: 10.3779/j.issn.1009-3419.2020.01.04
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
This study mainly explores the relationship between the ASPM expression of lung adenocarcinoma and the development and prognosis of lung cancer. The aim of this study was to investigate the relationship between the expression of abnormal spindle-like microcephaly-associated protein (ASPM) in lung adenocarcinoma and the development and prognosis in lung cancer. Methods A total of 90 cases of lung adenocarcinoma tissue specimens and 90 cases of benign pulmonary lesions were collected, the expression of ASPM was detected by immunohistochemical technique, and the expression of ASPM in 12 pairs of tissues was detected by real-t...
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
Conclusion It was safety to discontinued oral antiplatelet agents before operation, with no MACE and death in perioperative period. 
 DOI: 10.3779/j.issn.1009-3419.2020.01.06
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research
More News: Allergy | Allergy & Immunology | Asthma | Autoimmune Disease | Bangladesh Health | Biology | Boys | Cancer | Cancer & Oncology | Cancer in Adolescents | Cancer Vaccines | Chemistry | Child Development | Childhood Cancer | Children | Cholera | Clinical Trials | Diphtheria | Disability | Education | Environmental Health | Epidemiology | Folic Acid | Food Allergy | Gastroenterology | Girls | Grants | Hepatitis | Hepatitis B | Hepatitis Vaccine | Infectious Diseases | International Medicine & Public Health | Laboratory Medicine | Legislation | Measles | Measles Vaccine | Medical Ethics | Men | Miscarriage | Mumps | Mumps Vaccine | Niacin | Niaspan | Nutrition | Oral Cancer | Parasitic Diseases | Parasitology | Pediatrics | Polio | Polio Vaccine | Pregnancy | Respiratory Medicine | Rheumatology | Rubella | Rubella Vaccine | Rural Health | Science | Skin | Statistics | Students | Study | Tetanus | Tetanus Diptheria Pertussis Vaccine Tdap,Dtap,Dpt | Tetanus Vaccine | Toxicology | Training | Tuberculosis | Universities & Medical Training | Vaccines | Vitamins | WHO | Whooping Cough (Pertussis) Vaccine | Women