Innate Lymphoid Cells in Helminth Infections —Obligatory or Accessory?

This study also revealed adenosine as a novel danger-associated molecular pattern (DAMP), responsible for initiating helminth-induced type-2 responses, through activation of ILC2s. Additional receptors reported to be highly expressed by ILC2s and required for their expansion and function include the tumor necrosis factor (TNF)-receptor superfamily member DR3 (TNFRSF25) and the IL-9R. In the absence of TL1A ligation to DR3, there is significantly reduced ILC2 expansion, type-2 cytokine production and N. brasiliensis expulsion (74), whereas IL-9R signaling was required for ILC2 accumulation, expulsion of N. brasiliensis and resolution of tissue damage in the lung (75). IL-4- and IL-13-dependent expression of the acidic mammalian chitinase (AMCase) was also found to promote ILC2 expansion in the lung and expulsion of both N. brasiliensis and H. polygyrus from the gut (76). Recently, the capacity of ILC2s to migrate between mucosal sites has become recognized with the experimental demonstration of a S1P-dependent pathway leading ILCs from the gut to the lung (30). MLN and lung iILC2s express S1P receptors and FTY720 inhibition of this pathway blocked the accumulation of intestinal iILC2s in the lung. When administered to Rag1−/− mice, FTY720 induced a significant increase in mortality to N. brasiliensis infection, which in turn can be prevented by an intravenous adoptive transfer of iILC2s prior to FTY720 administration (31). The role of chemokines in ILC2 migration...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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Publication date: Available online 15 July 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Lisa M. Bartnikas, Michelle F. Huffaker, William J. Sheehan, Watcharoot Kanchongkittiphon, Carter R. Petty, Robert Leibowitz, Michael C. Young, Wanda Phipatanakul
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 15 July 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Emad I. Wafa, Sean M. Geary, Kathleen A. Ross, Jonathan T. Goodman, Balaji Narasimhan, Aliasger K. SalemAbstractThe primary objective of this study was to enhance the antitumor efficacy of a model cancer vaccine through co-delivery of pentaerythritol lipid A (PELA), an immunological adjuvant, and a model tumor antigen, ovalbumin (OVA), separately loaded into polyanhydride particles (PA). In vitro experiments showed that encapsulation of PELA into PA (PA-PELA) significantly enhanced its stimulatory capacity on...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
A new study finds that patients with autoimmune disease treated with anti- tumor necrosis factor alpha have an increased risk of developing inflammatory bowel disease.Medscape Medical News
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Rheumatology News Source Type: news
ConclusionsThe result showed that sampling region, fish status, fish species and sampling month were the main factors influencing infection rate. Regulations or guidelines are urgent in China for the control of Anisakis spp. infection in marine fish.
Source: Food Control - Category: Food Science Source Type: research
Publication date: Available online 15 July 2019Source: Preventive Veterinary MedicineAuthor(s): Alessia Libera Gazzonis, Sergio Aurelio Zanzani, Luca Villa, Maria Teresa ManfrediAbstractThe zoonotic protozoa Toxoplasma gondii is one of the major abortive pathogens in small ruminants. Nevertheless, data on T. gondii infection in goats during lactation and on the presence of T. gondii in goat milk are lacking. A longitudinal study was planned in a T. gondii naturally infected dairy goat farm with the aim of (i) evaluating the variation of anti-T. gondii antibodies in blood and milk during the lactation; (ii) identifying the ...
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
Publication date: Available online 13 July 2019Source: Biosensors and BioelectronicsAuthor(s): Chunzhu Bao, Dawei Fan, Xin Liu, Xueying Wang, Dan Wu, Hongmin Ma, Lihua Hu, Huan Wang, Xu Sun, Qin WeiAbstractA signal-off type photoelectrochemical (PEC) immunosensor based on Ru (bpy)32+ and Bi2S3 co-sensitized ZnTiO3/TiO2 polyhedra as matrix and SiO2/PDA-Au as the label of second antibody was proposed for the ultrasensitive detection of procalcitonin (PCT). The hollow ZnTiO3/TiO2 polyhedra called zinc titanium composite hollow structures (ZTCHS) was prepared by hydrothermal method to enhance the utilization of visible light c...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
UPMC began its transplant program in 1981 and has, since then, performed 20,000.
Source: Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
[WHO] Brazzaville, 15 July 2019 - The World Health Organization (WHO) is scaling up operations in Burkina Faso in response to a growing humanitarian crisis, which has seen over 200,000 displaced. WHO is mobilizing experts to strengthen interventions, including preventative and responsive vaccination campaigns and strategies for provision of health services, as well as increasing supplies of medicines and medical equipment.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
J. Mater. Chem. A, 2019, Advance Article DOI: 10.1039/C9TA04185K, CommunicationPing Li, Zhengsong Fang, You Zhang, Chunshao Mo, Xuanhe Hu, Junhua Jian, Shuangyin Wang, Dingshan Yu A specially designed poly(aniline-co-azure C) (PANAC) copolymer cathode harnesses intelligent proton-self-buffering capability and fast electron/ion transport in a highly bendable, quasi-solid-state Zn –PANAC battery. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - J. Mater. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Agency blames war, inequality and complacency for 20 million children missing immunisationA dangerous stagnation in vaccination rates is putting children at risk of preventable diseases around the world, the UN children ’s agency has warned, blaming conflict, inequality and complacency.One in 10 children, totalling 20 million globally, missed out on basic immunisation against the life-threatening infections of measles, diphtheria and tetanus last year, says Unicef.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Global health Vaccines and immunisation United Nations MMR Polio Global development Society World news Source Type: news
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