A Novel Human Microbe-Disease Association Prediction Method Based on the Bidirectional Weighted Network

Conclusion Human microbiome is normal flora for humans, which has been proved to be of symbiotic relationship with humans and harmless to humans. If the microbes that breed in the human body become “unhealthy,” it will definitely affect the host's physical condition. People are continuing to explore the pathologic relationship between microorganisms and the human body through high-throughput sequencing technologies and analysis systems. However, it is a pity that their pathogenesis cannot be fully understood as yet. Considering that relying only on conventional experimental methods is time-consuming and laborious, in this article, we proposed a novel prediction model called BWNMHMDA to accelerate the process of inferring potential microbe-disease associations, in which, the core idea is to construct a weighted bidirectional microbe-disease association network and then convert it into a matrix for correlation probability calculation. While constructing the prediction model BWNMHMDA, we first downloaded known microbe-disease associations from the HDMDA database, and then, based on these downloaded associations, we constructed a heterogeneous network through adopting the Gaussian interaction profile kernel similarity to calculate the weights of nodes in the heterogeneous network. Moreover, based on the heterogeneous network, we further constructed a weighted bidirectional network by standardizing the weights of edges in the heterogeneous network and introduc...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

Related Links:

Publication date: 15 February 2021Source: Journal of Hazardous Materials, Volume 404, Part BAuthor(s): Yanhua Liu, Yang Li, Shanshan Dong, Lu Han, Ruixin Guo, Yourong Fu, Shenghu Zhang, Jianqiu Chen
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
Publication date: 15 February 2021Source: Journal of Hazardous Materials, Volume 404, Part AAuthor(s): Zhongyi Zhang, Wen-Xiong Wang, Nengjian Zheng, Yansheng Cao, Hongwei Xiao, Renguo Zhu, Hui Guan, Huayun Xiao
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
Authors: Musio F Abstract INTRODUCTION: Anemia has and will continue to be a central theme in medicine particularly as clinicians are treating a burgeoning population of complex multi-organ system processes. As a result of multiple randomized controlled trials (RCTs), meta-analyses, and societal recommendations overly restrictive paradigms and under-administration of erythropoiesis stimulating agents (ESAs) have likely been followed by clinicians among all specialties. AREAS COVERED: A review of anemia in the context of chronic kidney disease, hematologic malignancies and cancer is presented with focus on the e...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
Authors: Zhang W, Xu JZ, Lu XH, Li H, Wang D, Wang JG Abstract PURPOSE: We hypothesise that dietary sodium intake interacts with serum uric acid to influence blood pressure (BP) in children and adolescents. In the present study, we investigated ambulatory BP in relation to hyperuricaemia, dietary sodium intake and their interaction in children and adolescents with hypertension. MATERIALS AND METHODS:  A total of 616 study participants were 10-24 years old and had primary hypertension diagnosed after admission in a specialised inpatient ward. Ambulatory BP monitoring was performed during hospitalisat...
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
Conclusion: These findings suggest that consumption of peanuts high in oleic acid (D7) may have the potential to delay primary fatty liver symptoms. PMID: 33033472 [PubMed]
Source: Food and Nutrition Research - Category: Nutrition Authors: Tags: Food Nutr Res Source Type: research
Publication date: Available online 10 October 2020Source: Journal of Genetics and GenomicsAuthor(s): Chengqi Wang, Justin Gibbons, Swamy R. Adapa, Jenna Oberstaller, Xiangyun Liao, Min Zhang, John H. Adams, Rays H.Y. Jiang
Source: Journal of Genetics and Genomics - Category: Genetics & Stem Cells Source Type: research
Publication date: January 2021Source: Urology Case Reports, Volume 34Author(s): Nina Al-Saadi, Safa Al-Musawi, Yousuf Khan, Daben Dawam
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: Available online 10 October 2020Source: European UrologyAuthor(s): Stanley Weng, Renzo G. DiNatale, Andrew Silagy, Roy Mano, Kyrollis Attalla, Mahyar Kashani, Kate Weiss, Nicole E. Benfante, Andrew G. Winer, Jonathan A. Coleman, Victor E. Reuter, Paul Russo, Ed Reznik, Satish K. Tickoo, A. Ari Hakimi
Source: European Urology - Category: Urology & Nephrology Source Type: research
CONCLUSIONS: Xyloglucan/gelose plus ORS was effective and safe in treating acute diarrhea in children. PMID: 33028102 [PubMed - as supplied by publisher]
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
Publication date: Available online 10 October 2020Source: Respiratory Medicine Case ReportsAuthor(s): Vipul Patel, Tilottama Majumdar, Isha Samreen, Harpreet Grewal, Thomas Kaleekal
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
More News: Academia | Allergy | Allergy & Immunology | Asthma | Bacteroides Infection | Biotechnology | Cancer | Cancer & Oncology | Carbohydrates | Carcinoma | Child Development | Childhood Cancer | Children | China Health | Chronic Obstructive Pulmonary | Clostridium Difficile | Colon Cancer | Colorectal Cancer | Computers | Cough | Databases & Libraries | Diabetes | Diabetes Type 1 | Diabetes Type 2 | Diets | Disability | Eating Disorders & Weight Management | Endocrinology | Environmental Health | Epithelial Cancer | Forensic Medicine | Fusobacterium | Gastric (Stomach) Cancer | Gastric Bypass | Gastroenteritis | Gastroenterology | Genetics | Haemophilia | Hemophilia | High Fat | Infectious Diseases | Internet | Kidney Stones | Laboratory Medicine | Learning | Men | Microbiology | Nutrition | Obesity | Oral Cancer | Oropharyngeal Cancer | Parasitic Diseases | Parasitology | Perinatology & Neonatology | Primary Care | Probiotics | Reproduction Medicine | Respiratory Medicine | Science | Smokers | Staphylococcus Aureus | Study | Training | Universities & Medical Training | Urology & Nephrology | USA Health | Women | Workshops