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Two cases of eosinophilic gastrointestinal disorder due to newly appearing food allergies after cord blood transplantation
Transpl Immunol. 2023 Jan 2;77:101781. doi: 10.1016/j.trim.2022.101781. Online ahead of print.ABSTRACTEosinophilic gastrointestinal disorders (EGIDs) are infrequent complications after allogeneic hematopoietic cell transplantation (allo-HCT). Furthermore, it is well-known that allergic diseases are transferable after allo-HCT from allergic donors to non-allergic recipients. However, the type of graft-versus host disease (GVHD) prophylaxis that leads to allergic disease transfer is unclear. Furthermore, no study has reported a case of acquired food allergy resulting in EGID that was detected based on the clinical course and...
Source: Transplant Immunology - January 5, 2023 Category: Transplant Surgery Authors: Naonori Harada Yosuke Makuuchi Masatomo Kuno Teruhito Takakuwa Hiroshi Okamura Mitsutaka Nishimoto Yasuhiro Nakashima Hideo Koh Miho Sakaida Sayaka Tanaka Yuko Kuwae Akira Higashimori Fumino Tanaka Masahiko Ohsawa Yasuhiro Fujiwara Masayuki Hino Hirohisa Source Type: research

Chronic Granulomatous Disease: a Comprehensive Review
AbstractChronic granulomatous disease (CGD) is a primary immunodeficiency of phagocyte function due to defective NADPH oxidase (phox). Compared with the common types ofCYBB/gp91phox,NCF1/p47phox, andCYBA/p22phox deficiency,NCF4/p40phox deficiency is a mild and atypical form of CGD without invasive bacterial or fungal infections. It can be diagnosed using serum-opsonizedE.coli as a stimulus in dihydrorhodamine (DHR) assay. Patients withCYBC1/Eros deficiency, a new and rare form of CGD, present as loss of respiratory burst and gp91phox expression in phagocytes. Neutrophils from patients with CGD are deficient in neutrophil e...
Source: Clinical Reviews in Allergy and Immunology - June 9, 2020 Category: Allergy & Immunology Source Type: research

Evaluation of hypersensitivity reactions to cancer chemotherapeutic agents in pediatric patients.
CONCLUSION: Among all chemotherapeutic agents reviewed in our study which caused HSRs, asparaginase was the most co. PMID: 31981613 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - January 21, 2020 Category: Allergy & Immunology Authors: Yagmur IT, Guzelkucuk Z, Yarali N, Ozyoruk D, Toyran M, Civelek E, Ozbek NY, Misirlioglu ED Tags: Ann Allergy Asthma Immunol Source Type: research

Human Gut-Associated Natural Killer Cells in Health and Disease
Alessandro Poggi1*, Roberto Benelli2, Roberta Venè1, Delfina Costa1, Nicoletta Ferrari1, Francesca Tosetti1 and Maria Raffaella Zocchi3 1Molecular Oncology and Angiogenesis Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 2Immunology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 3Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy It is well established that natural killer (NK) cells are involved in both innate and adaptive immunity. Indeed, they can recognize molecules induced at the cell surface by stress signals...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

Core Gut Bacteria Analysis of Healthy Mice
Conclusion In conclusion, our results exhibited a relatively complete picture of core gut bacteria in healthy mice that they were mainly composed of carbohydrate- and amino acids-metabolizing bacteria and immunomodulatory bacteria, as well as their ecological relationships of symbiosis or functional redundancy. It was worth noting that the core bacteria resident in healthy gut was of fundamental importance for not only the healthy physiological characteristics, but also the chronic metabolic disease phenotypes. Our study focused on the gut microbiota of healthy host, and would be an important complement to the case–...
Source: Frontiers in Microbiology - April 23, 2019 Category: Microbiology Source Type: research

From “Serum Sickness” to “Xenosialitis”: Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc
Conclusions and Perspectives In this review, we have discussed important milestones from the early description of “Serum-sickness” as being due to antibodies directed against Neu5Gc epitopes all the way to the present-day therapeutic implications of these antibodies in cancer therapy. Some of these milestones have been represented in a concise timeline (Figure 6). While the “Xenosialitis” hypothesis is well-supported in the human-like mouse models, it has yet to be conclusively proven in humans. It remains to be seen if “Xenosialitis” plays a role in other uniquely-human dis...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

Editorial: Shaping of Human Immune System and Metabolic Processes by Viruses and Microorganisms
Conclusions In conclusion, articles in this Research Topic made a very significant contribution to our understanding of the role played by environmental factors, dysbiotic conditions, and infections in triggering diseases. Since this is a rapidly expanding area of research, many other factors contributing to the onset of these diseases are not covered here. We are confident, however, that further studies will expand the list as well as bring a better understanding of mechanisms involved in the onset of autoimmune and autoinflammatory diseases. Author Contributions All authors listed have made a substantial, direct and i...
Source: Frontiers in Microbiology - April 16, 2019 Category: Microbiology Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Lactobacillus plantarum KLDS1.0318 Ameliorates Impaired Intestinal Immunity and Metabolic Disorders in Cyclophosphamide-Treated Mice
Conclusion In conclusion, the present study showed that the oral administration of L. plantarum KLDS1.0318 normalized the parameters altered by CTX-induced toxicities, strengthening intestinal health by regulating the Th1/Th2 balance, ameliorating the intestinal morphology and improving profiles of intestinal microbiota and metabolism. Therefore, our findings suggested that the administration of L. plantarum KLDS1.0318 could be of significant advantage in reducing intestinal immunity impairment caused by cyclophosphamide. Ethics Statement This study was carried out according to the Animal Care Review Committee, Northeas...
Source: Frontiers in Microbiology - April 11, 2019 Category: Microbiology Source Type: research

Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation
Conclusions As the intestinal mucosa surface constitutes the major surface of the body which is in direct contact with the outer environment, intestinal immune homeostasis must be accurately regulated. The interplay between commensal microbiota, intestinal stromal cells, and the mucosal immune system components should guarantee the intestinal homeostasis to avoid a sustained inflammation that could induce tissue damage. However, several factors can lead to inflammation through homeostasis breakdown. Figure 1 summarizes the main points that have been reviewed here. We have described what it is known so far about the role o...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

The Pivotal Role of Regulatory T Cells in the Regulation of Innate Immune Cells
This study was provided by the Canadian Institutes of Health Research and the Manitoba Health Research Council. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. References 1. Sprent J, Kishimoto H. The thymus and central tolerance. Philos Trans R Soc Lond B Biol Sci. (2001) 356:609–16. doi: 10.1098/rstb.2001.0846 PubMed Abstract | CrossRef Full Text | Google Scholar 2. Sakaguchi S, Wing K, Miyara M. Regulatory T cells - a brief history and perspective...
Source: Frontiers in Immunology - April 8, 2019 Category: Allergy & Immunology Source Type: research

Pegaspargase Allergic Reactions Are Related to Anti-Pegaspargase Antibodies and to Intensity of Intrathecal Therapy
Conclusions: Serum anti-PEG-ASP has good specificity and sensitivity for clinical allergic reactions to PEG-ASP treatment. Patients who received fewer IT injections during induction had a higher risk of allergy to PEG-ASP, possibly due to increased immunosuppression from multiple ITs. Anti-PEG, commonly observed pre-treatment, is likely the major mediator of PEG-ASP reactions and may be predictive of future reactions.Figure 1.DisclosuresInaba: Shire: Research Funding. Relling: Shire Pharmaceuticals: Research Funding.
Source: Blood - November 21, 2018 Category: Hematology Authors: Liu, Y., Smith, C. A., Yang, W., Thompson, L., Dash, A., Counts, J., Chung, M., Molinelli, A. R., Pei, D., Kornegay, N. M., Springer, E. A., Panetta, J. C., Crews, K. R., Swanson, H., Cheng, C., Karol, S. E., Evans, W. E., Inaba, H., Pui, C.-H., Jeha, S., Tags: 614. Acute Lymphoblastic Leukemia: Therapy, excluding Transplantation: Poster II Source Type: research

Effect of Host Genetic Background on Development of Autoimmunity in Transplanted and Vertically Transmitted Human Microbiota Mouse Models
Transplanted human microbiota (Humicrobiota) dominated by Bacteroidetes and Firmicutes enhanced Type 2 autoantibody responses following Campylobacter jejuni 260.94 infection in C57BL/6 mice. We hypothesized that similar Type 2 responses occur in NOD mice given this Humicrobiota.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Linda S. Mansfield, Alexander D. Ethridge, Phillip T. Brooks, Kelsey A. Brakel, Julia A. Bell Source Type: research

Transplanted Human Microbiota and Enteric Pathogen Challenge Enhanced Susceptibility to Allergen-Mediated Asthma in a Murine Model
We hypothesized that particular microbiotas enhance risk for allergic diseases. Our goal was to provide proof-of-concept that C57BL/6 mice transplanted with young adult human microbiota (Humice) that enhances Th2 immunity had higher responses to house dust mite allergen (HDM) than C57BL/6 mice with mouse microbiota (Momice) and that colonization with Campylobacter jejuni 260.94 would further amplify Th2 responses.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Susan L. Ewart, Julia A. Bell, Daniel J. Claiborne, Alexander T. Zanetti, Lindsey Lund, Syed H. Arshad, Linda S. Mansfield Source Type: research

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