Lactobacillus plantarum KLDS1.0318 Ameliorates Impaired Intestinal Immunity and Metabolic Disorders in Cyclophosphamide-Treated Mice

Conclusion
In conclusion, the present study showed that the oral administration of L. plantarum KLDS1.0318 normalized the parameters altered by CTX-induced toxicities, strengthening intestinal health by regulating the Th1/Th2 balance, ameliorating the intestinal morphology and improving profiles of intestinal microbiota and metabolism. Therefore, our findings suggested that the administration of L. plantarum KLDS1.0318 could be of significant advantage in reducing intestinal immunity impairment caused by cyclophosphamide.
Ethics Statement
This study was carried out according to the Animal Care Review Committee, Northeast Agricultural University.
Author Contributions
CL supervised the whole experiments. YM contributed to paper writing. YM, JW, ZW, and GZ performed the practical work and completed the experiments. LL and GH provided help during the experiments. CL provided place, lab facilities, and funding for the present work.
Funding
This work was financially supported by the National Key Research and Development Program of China (No. 2017YFD0400303), the National Natural Science Foundation of China (Grant No. 31671874), the National Key Research and Development Project (2018YFD0502404), the Natural Science Foundation of Heilongjiang Province of China (Grant No. C2018022), and the Academic Backbone Plan of Northeast Agricultural University (Grant No. 17XG15).
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any com...

Source: Frontiers in Microbiology - April 11, 2019 Category: Microbiology Source Type: research