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Drug: Dexamethasone

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Total 367 results found since Jan 2013.

Geniposide Alleviates Glucocorticoid-Induced Inhibition of Osteogenic Differentiation in MC3T3-E1 Cells by ERK Pathway
Conclusion In summary, we demonstrated that geniposide alleviated GC-induced osteogenic suppression in MC3T3-E1 cells. The effects of geniposide were at least partially associated with activating ERK signaling pathway via GLP-1 receptor. Geniposide might be a potential therapeutic agent for protection against GC-induced osteoporosis. Author Contributions BX, DX, CZ, and LW participated in research design. BX, JW, YL, XW, and ZZ conducted the experiments. BX, DX, and LW contributed new reagents or analytic tools and wrote or contributed to the writing of the manuscript. BX, JW, CZ, and DX performed the data analysis. Fu...
Source: Frontiers in Pharmacology - April 17, 2019 Category: Drugs & Pharmacology Source Type: research

Efficacy of Dexamethasone Versus Fluticasone Nasal Sprays in Postoperative Patients With Chronic Rhinosinusitis With Nasal Polyps.
CONCLUSION: There is no significant increased benefit in using a higher dose nasal steroid spray compared to the standard dose nasal steroid spray after ESS. PMID: 30987428 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - April 15, 2019 Category: ENT & OMF Authors: Seiberling KA, Kidd SC, Kim GH, Church CA Tags: Am J Rhinol Allergy Source Type: research

Dietary Vitamin D3 Deficiency Increases Resistance to Leishmania (Leishmania) amazonensis Infection in Mice
Conclusion Altogether, our results indicate that dietary VitD deficiency is able to decrease lesion growth and provide an increase in Th1 response in C57BL/6 and BALB/c mice upon L. (L.) amazonensis infection, although it does not decrease parasite burden in either of the murine models used. Thus, VitD may contribute to host susceptibility to murine tegumentary leishmaniasis. Further studies on the influence of immunonutrition in the leishmaniases are needed to better understand the immunobiology of these diseases. Author Contributions HdMG conceived and designed the experiments. GO-S, DB, MM, JEP, JCP, TR, AdF-M, and L...
Source: Frontiers in cellular and infection microbiology - April 9, 2019 Category: Microbiology Source Type: research

Inhibition of Airway Contraction and Inflammation by Pomalidomide in a Male Wistar Rat Model of Ovalbumin-induced Asthma.
In conclusion, we found that pomalidomide ameliorated the symptoms, histopathological changes and inflammatory markers induced by ovalbumin in asthmatic rats and these effects might be related to its anti-inflammatory properties. PMID: 31066257 [PubMed - in process]
Source: Iranian Journal of Allergy, Asthma and Immunology - March 31, 2019 Category: Allergy & Immunology Authors: Ghaderi M, Oryan S, Yousofvand N, Eidi A Tags: Iran J Allergy Asthma Immunol Source Type: research

Dexamethasone Promotes Keratinocyte Proliferation by Triggering Keratinocyte Growth Factor in Mast Cells
Conclusion: Taken together, our results show that a stressful environment may disturb skin barrier homeostasis through mast cell-derived KGF expression.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - March 31, 2019 Category: Allergy & Immunology Source Type: research

Successful management of type IV hypersensitivity reactions to human insulin analogue with injecting mixtures of biphasic insulin aspart and dexamethasone
Publication date: Available online 28 January 2019Source: Journal of the Formosan Medical AssociationAuthor(s): Wei-Lun Wen, Kun-Bow Tsai, Yi-Huei Lin, Shang-Jyh Hwang, Pi-Jung Hsiao, Shyi-Jang Shin, Wei-Wen HungAlthough hypersensitivity reaction to insulin was supposed to be less-frequent with current insulin analogue, case reports with different types of allergic reactions to insulin analogue were still reported. The most common form is type I hypersensitivity reaction with IgE-mediated. Besides, type III (IgG and IgM-mediated) and type IV (T-cell mediated delayed reaction) hypersensitivity reactions were also reported. ...
Source: Journal of the Formosan Medical Association - January 29, 2019 Category: General Medicine Source Type: research

Successful management of type IV hypersensitivity reactions to human insulin analogue with injecting mixtures of biphasic insulin aspart and dexamethasone.
Abstract Although hypersensitivity reaction to insulin was supposed to be less-frequent with current insulin analogue, case reports with different types of allergic reactions to insulin analogue were still reported. The most common form is type I hypersensitivity reaction with IgE-mediated. Besides, type III (IgG and IgM-mediated) and type IV (T-cell mediated delayed reaction) hypersensitivity reactions were also reported. Here we presented a long-standing type 2 diabetes with insulin requirements with hypersensitivity reactions to insulin actrapid, insulin aspart, insulin glargine, insulin detemir, and biphasic i...
Source: J Formos Med Assoc - January 28, 2019 Category: General Medicine Authors: Wen WL, Tsai KB, Lin YH, Hwang SJ, Hsiao PJ, Shin SJ, Hung WW Tags: J Formos Med Assoc Source Type: research

Nrf2 Suppresses Allergic Lung Inflammation by Attenuating the Type 2 Innate Lymphoid Cell Response.
Abstract The Keap1-Nrf2 system plays a pivotal role in the oxidative stress response by inducing a number of cytoprotective genes. Under stress, damaged epithelial cells release cytokines that activate type 2 innate lymphoid cells (ILC2s), which mediate the allergic immune response. In this article, we investigated the role of the Keap1-Nrf2 pathway in ILC2 homeostasis and allergic inflammation using Nrf2 knockout mice. ILC2s from Nrf2-deficient mice showed a transient, upregulated IL-33 response and underwent hyperproliferation in response to a combined stimulation of IL-33 with IL-2, IL-7, or TSLP. This enhanced...
Source: Journal of Immunology - January 23, 2019 Category: Allergy & Immunology Authors: Nagashima R, Kosai H, Masuo M, Izumiyama K, Noshikawaji T, Morimoto M, Kumaki S, Miyazaki Y, Motohashi H, Yamamoto M, Tanaka N Tags: J Immunol Source Type: research

Allergy inhibitory receptor ‐1 inhibits autoantibody production via upregulation of apoptotic debris clearance by macrophages
ConclusionAllergin ‐1 might play an inhibitory role in autoantibody production via upregulation of macrophage phagocytosis.
Source: International Journal of Rheumatic Diseases - December 16, 2018 Category: Rheumatology Authors: Akira Iizuka, Seiji Segawa, Yuya Kondo, Shunta Kaneko, Masahiro Yokosawa, Kotona Furuyama, Haruka Miki, Satoko Tahara ‐Hanaoka, Akira Shibuya, Hiroto Tsuboi, Daisuke Goto, Isao Matsumoto, Shiro Shibayama, Takayuki Sumida Tags: ORIGINAL ARTICLE Source Type: research

Safety profile of a novel peptide, PIN201104, with potential to act as a disease modifying, broad spectrum treatment for asthma
Conclusion: From these studies, 104 does not show potential to induce significant safety concerns going into clinical development.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Watson, J., Federici-Canova, D., Cooper, N., Burgess, C. Tags: Allergy and immunology Source Type: research

Traffic ‐related air pollution induces non‐allergic eosinophilic airway inflammation and cough hypersensitivity in guinea pigs
Conclusions& Clinical RelevanceTRAP exposures induced cough hypersensitivity and non ‐allergic eosinophilic inflammation of airways in guinea pigs. This study highlights the potential mechanisms of eosinophilia‐related chronic cough that can be induced by traffic‐related air pollution.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - November 11, 2018 Category: Allergy & Immunology Authors: Zhangfu Fang, Chuqin Huang, Junfeng(Jim) Zhang, Jiaxing Xie, Shouhui Dai, Erjia Ge, Juan Xiang, Hongmei Yao, Rongquan Huang, Xinhui Bi, Boguang Wang, Nanshan Zhong, Kefang Lai Tags: Original Article ‐Experimental Models of Allergic Disease Source Type: research

Standardized Citrus unshiu peel extract ameliorates dexamethasone-induced neurotoxicity and depressive-like behaviors in mice
AbstractDriedCitrus unshiu peel, also known as Chinpi, have been commonly used as a traditional medicine to improve for allergy, inflammation and hepatopathy. Many previously studies have reported that citrus flavonoids show neuroprotective activities. However, the antidepressant-related effects ofC. unshiu peels have not been well characterized. Here, the antidepressant-like effects of standardizedC. unshiu peel extract (SCP) were evaluated in in vivo and in vitro depression models induced by dexamethasone (DEX), a synthetic glucocorticoid. Male ICR mice (9-week-old) were injected the DEX (40  mg/kg) and were orally give...
Source: Metabolic Brain Disease - November 10, 2018 Category: Neurology Source Type: research

Notch Signaling Promotes Development of Allergic Rhinitis by Suppressing Foxp3 Expression and Treg Cell Differentiation
Conclusion: Notch signaling downregulates Foxp3 expression and inhibits the differentiation of Treg cells to promote the development of AR. Blocking Notch signaling may be a potential treatment for AR.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - November 2, 2018 Category: Allergy & Immunology Source Type: research

Effects of Viola tricolor Flower Hydroethanolic Extract on Lung Inflammation in a Mouse Model of Chronic Asthma.
Abstract Asthma is a chronic inflammatory disease of the lungs driven by T cell activation. Viola tricolor L. as a traditional medical herb could suppress activated T lymphocytes and has been used empirically for asthma remedy. In the present study, we investigated the anti-inflammatory effect of Viola tricolor and its underlying mechanism on asthma characteristics induced by ovalbumin (OVA) in mice. BALB/c mice were randomly divided into six groups: normal control, Ovalbumin (OVA) control, OVA mice treated with Viola tricolor (50, 100 and 200 mg/kg) and dexamethasone (3 mg/kg). All mice except normal controls wer...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 14, 2018 Category: Allergy & Immunology Authors: Harati E, Bahrami M, Razavi A, Kamalinejad M, Mohammadian M, Rastegar T, Sadeghipour HR Tags: Iran J Allergy Asthma Immunol Source Type: research

Differential Hrd1 Expression and B-Cell Accumulation in Eosinophilic and Non-eosinophilic Chronic Rhinosinusitis With Nasal Polyps.
CONCLUSIONS: Differential Hrd1 expression and B-cell accumulation between the ECRS and non-ECRS subsets suggests that they can exhibit distinct pathogenic mechanisms and play important roles in NP. PMID: 30306751 [PubMed]
Source: Allergy, Asthma and Immunology Research - October 13, 2018 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research