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Total 16 results found since Jan 2013.

The reason and mechanism of propylene glycol alginate sodium sulfate (PSS) mediated allergic side effect
Int J Biol Macromol. 2023 Apr 27:124638. doi: 10.1016/j.ijbiomac.2023.124638. Online ahead of print.ABSTRACTPropylene glycol alginate sodium sulfate (PSS) is a heparinoid polysaccharide drug used in clinic for >30 years in China. But its allergy events happened from time to time and should not be ignored. Here, ammonium salt in PSS (PSS-NH4+), PSS fractions with high Mw (PSS-H-Mw) and low mannuronic acid (M) to guluronic acid (G) ratio (PSS-L-M/G) were found to induce allergic response by the structure-activity and impurity-activity relationships in vitro. Furthermore, we confirmed the reason and elucidated the mechanis...
Source: International Journal of Biological Macromolecules - April 29, 2023 Category: Biochemistry Authors: Yi-Ting Xue Shuang Li Xin-Yang Jiang Meng Xin Hai-Hua Li Guang-Li Yu Xiao-Xi He Chun-Xia Li Source Type: research

Science ’s 2022 Breakthrough of the Year: A telescope’s golden eye sees the universe anew
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Source: ScienceNOW - December 15, 2022 Category: Science Source Type: news

Does phenotypic expression of bitter taste receptor T2R38 show association with COVID ‐19 severity?
ConclusionOur results show objective data that taste disturbance, specifically global loss of taste, appears to correlate with the clinical course specific to each individual, because 100% of the patients requiring inpatient admission were classified as nontasters.
Source: International Forum of Allergy and Rhinology - November 5, 2020 Category: Allergy & Immunology Authors: Henry P. Barham, Mohamed A. Taha, Christian A. Hall Tags: RESEARCH NOTE Source Type: research

TRPV1 Channel Contributes to the Behavioral Hypersensitivity in a Rat Model of Complex Regional Pain Syndrome Type 1
This study was carried out in accordance with National Institutes of Health guide for the care and use of Laboratory animals (NIH Publications No. 8023, revised 1978) and approved by the Animal Ethics Committee of Zhejiang Chinese Medical University. Author Contributions QH performed the western blot, immunostaining, and behavioral test. QW performed the patch clamp experiments. CW supervised the patch clamp experiments. QH and BoyuL performed the behavioral test. YT, XS, and JF analyzed the data and reviewed the manuscript. BoyiL designed, supervised the study, and wrote the manuscript. Funding This project was suppor...
Source: Frontiers in Pharmacology - April 25, 2019 Category: Drugs & Pharmacology Source Type: research

Core Gut Bacteria Analysis of Healthy Mice
Conclusion In conclusion, our results exhibited a relatively complete picture of core gut bacteria in healthy mice that they were mainly composed of carbohydrate- and amino acids-metabolizing bacteria and immunomodulatory bacteria, as well as their ecological relationships of symbiosis or functional redundancy. It was worth noting that the core bacteria resident in healthy gut was of fundamental importance for not only the healthy physiological characteristics, but also the chronic metabolic disease phenotypes. Our study focused on the gut microbiota of healthy host, and would be an important complement to the case–...
Source: Frontiers in Microbiology - April 23, 2019 Category: Microbiology Source Type: research

The Differentiation in vitro of Human Tonsil B Cells With the Phenotypic and Functional Characteristics of T-bet+ Atypical Memory B Cells in Malaria
This study was conducted in the rural village of Kalifabougou, Mali where intense P. falciparum transmission occurs from June to December each year. Isolation of Tonsil B Cells Tonsils were mechanically disrupted in complete RPMI (RPMI 1640 with L-glutamine supplemented with 10% heat-inactivated FBS, 1 mM sodium pyruvate, 1% MEM nonessential amino acids, 50 μM 2-mercaptoethanol, 100 U/ml penicillin, 100 μg/ml streptomycin, and 25 mM HEPES, pH 7.2–7.5 [all from GIBCO, Invitrogen]) and passed through a 70-μm cell strainer to make a single cell suspension. B cells were then negatively selecte...
Source: Frontiers in Immunology - April 23, 2019 Category: Allergy & Immunology Source Type: research

Dysbiosis of the Gut Microbiome in Lung Cancer
In conclusion, compared to previous analyses of the relationship between LC and the lung microbiome, this is the first study of LC in connection with the gut microbiome (Hosgood et al., 2014; Kosikowska et al., 2016). Our findings support the hypothesis of LC-specific microbiota. We suggest that the reduced levels of Actinobacteria sp. and Bifidobacterium sp. and elevated levels of Enterococcus sp. are associated with LC. At the same time, we have further revealed that the damage of the normal function of the gut microbiome is associated with the progression of LC. the progress of LC. We hope that the results herein can pr...
Source: Frontiers in cellular and infection microbiology - April 17, 2019 Category: Microbiology Source Type: research

ST18 Enhances PV-IgG-Induced Loss of Keratinocyte Cohesion in Parallel to Increased ERK Activation
Discussions Autoantibodies targeting Dsg1 and Dsg3 are pathogenic and cause blister formation by inducing structural desmosomal changes in the skin of PV patients (42). However, the mechanisms underlying disease development and the factors enhancing its manifestation have not yet been fully elucidated. Secondary factors promoting severity of the disease include non-Dsg antibodies (43) as well as genetic alterations such as recently reported ST18 SNPs (29–31) and may also entail keratinocyte-derived cytokine release. Here, we investigate the effect of ST18 overexpression and cytokine secretion on PV-IgG mediated l...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Lactobacillus plantarum KLDS1.0318 Ameliorates Impaired Intestinal Immunity and Metabolic Disorders in Cyclophosphamide-Treated Mice
Conclusion In conclusion, the present study showed that the oral administration of L. plantarum KLDS1.0318 normalized the parameters altered by CTX-induced toxicities, strengthening intestinal health by regulating the Th1/Th2 balance, ameliorating the intestinal morphology and improving profiles of intestinal microbiota and metabolism. Therefore, our findings suggested that the administration of L. plantarum KLDS1.0318 could be of significant advantage in reducing intestinal immunity impairment caused by cyclophosphamide. Ethics Statement This study was carried out according to the Animal Care Review Committee, Northeas...
Source: Frontiers in Microbiology - April 11, 2019 Category: Microbiology Source Type: research

ALCAM Mediates DC Migration Through Afferent Lymphatics and Promotes Allospecific Immune Reactions
In conclusion, our findings identify ALCAM as a novel therapeutic target for preventing corneal allograft rejection in high-risk patient populations. Moreover, given the documented contribution of ALCAM to (lymph)angiogenesis, DC migration, and T cell activation, ALCAM blockade might represent a therapeutic strategy for treating other immune-mediated inflammatory conditions, such as solid organ transplant rejection, allergy or autoimmune diseases. Experimental Procedures Cloning, Expression, and Purification of I/F8-Fc and KSF-Fc For cloning of I/F8-Fc and KSF-Fc the respective scFv sequence was amplified from previousl...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation
Conclusions As the intestinal mucosa surface constitutes the major surface of the body which is in direct contact with the outer environment, intestinal immune homeostasis must be accurately regulated. The interplay between commensal microbiota, intestinal stromal cells, and the mucosal immune system components should guarantee the intestinal homeostasis to avoid a sustained inflammation that could induce tissue damage. However, several factors can lead to inflammation through homeostasis breakdown. Figure 1 summarizes the main points that have been reviewed here. We have described what it is known so far about the role o...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Effects of Orally Ingested Arsenic on Respiratory Epithelial Permeability to Bacteria and Small Molecules in Mice
Conclusions: Peroral arsenic has little effect on local airway immune responses to bacteria but compromises respiratory epithelial barrier integrity, increasing systemic translocation of inhaled pathogens and small molecules. https://doi.org/10.1289/EHP1878 Received: 09 March 2017 Revised: 14 August 2017 Accepted: 16 August 2017 Published: 28 September 2017 Address correspondence to M.B. Fessler, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr., P.O. Box 12233, Maildrop D2-01, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-3701. Email: fesslerm@niehs.nih.gov *Current address: UN...
Source: EHP Research - September 28, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Maternal Exposure of BALB/c Mice to Indoor NO2 and Allergic Asthma Syndrome in Offspring at Adulthood with Evaluation of DNA Methylation Associated Th2 Polarization
Conclusions: Maternal exposure to indoor environmental NO2 causes allergic asthma-related consequences in offspring absent any subsequent lung provocation and potentiates the symptoms of allergic asthma in adult offspring following postnatal allergic sensitization and challenge; this response is associated with the Th2-based immune response and DNA methylation of the IL4 gene. https://doi.org/10.1289/EHP685 Received: 19 June 2016 Revised: 07 June 2017 Accepted: 19 June 2017 Published: 13 September 2017 Address correspondence to N. Sang, College of Environment and Resource, Shanxi University, Taiyuan, Shanxi 030006, P...
Source: EHP Research - September 13, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research