Dysbiosis of the Gut Microbiome in Lung Cancer

In this study, the gut microbiota of 30 LC patients and 30 healthy controls were examined via next-generation sequencing of 16S rRNA and analyzed for diversity and biomarkers. We found that there was no decrease in significant microbial diversity (alpha diversity) in LC patients compared to controls (P observed = 0.1422), while the composition (beta diversity) differed significantly between patients and controls (phylum [stress = 0.153], class [stress = 0.16], order [stress = 0.146], family [stress = 0.153]). Controls had a higher abundance of the bacterial phylum Actinobacteria and genus Bifidobacterium, while patients with LC showed elevated levels of Enterococcus. These bacteria were found as possible biomarkers for LC. A decline of normal function of the gut microbiome in LC patients was also observed. These results provide the basic guidance for a systematic, multilayered assessment of the role of the gut microbiome in LC, which has a promising potential for early prevention and targeted intervention. Introduction Lung cancer (LC) is one of the deadliest malignancies, which has growing morbidity and mortality worldwide. It poses an enormous threat to the human health (Torre et al., 2015). Research on LC genetics and biology has opened opportunities for novel therapeutic strategies against the disease (Allison, 2015; Chowdhury et al., 2018; Hendriks and Besse, 2018; Herbst et al., 2018; Lissanu Deribe et al., 2018; Wei et al., 2018), but the knowledge about the etio...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research

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Authors: Stange EF, Schroeder BO Abstract Introduction: Inflammatory bowel diseases (IBD) are on the rise worldwide. This review covers the current concepts of the etiology of Crohn´s disease and ulcerative colitis by focusing on an unbalanced interaction between the intestinal microbiota and the mucosal barrier. Understanding these issues is of paramount importance for the development of targeted therapies aiming at the disease cause. Area covered: Gut microbiota alterations and a dysfunctional intestinal mucosa are associated with IBD. Here we focus on specific defense structures of the mucosal barrier, nam...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
ConclusionsMore than half (51%) of women who underwent genetic counseling and received an uninformative negative genetic test result had a significantly elevated risk for the development of breast cancer. It is, therefore, imperative that women do not conclude that a negative genetic test result represents a lack of risk.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Publication date: Available online 11 October 2019Source: The American Journal of SurgeryAuthor(s): Dhruv J. Patel, Waseem Lutfi, Patrick Sweigert, Emanuel Eguia, Gerard Abood, Lawrence Knab, Paul C. Kuo, Marshall S. BakerAbstractBackgroundPrior studies of adjuvant systemic therapy in pancreatic acinar cell carcinoma have been underpowered.MethodsWe queried the National Cancer Data Base to identify patients presenting with resectable (clinical stage I and II) acinar cell carcinoma between 2004 and 2015. Multivariable Cox Regression was used to evaluate the association between overall survival and systemic therapy.Results29...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
ConclusionsAdjuvant therapy is associated with improved OS for patients with gastric GISTs>10cm but provides no benefit in OS for those with GISTs 2-10cm.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
https://marginalrevolution.com/marginalrevolution/2019/05/physician-and-nurse-incomes-have-increased-tremendously.html New Findings Confirm Predictions on Physician Shortage The United States will see a shortage of up to nearly 122,000 physicians by 2032 as demand for physicians continues to grow faster than supply, according to new www.aamc.org The Demand for Physicians is Increasing and That’s Not All G...
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pre-Medical - MD Source Type: forums
Publication date: Available online 12 October 2019Source: Journal of Advanced ResearchAuthor(s): Yanguang Cong, Sijin Yang, Xiancai RaoAbstractThe infection caused by methicillin-resistant Staphylococcus aureus (MRSA) is a global threat to public health. Vancomycin remains one of the first-line drugs for the treatment of MRSA infections. However, S. aureus isolates with complete resistance to vancomycin have emerged in recent years. Vancomycin-resistant S. aureus (VRSA) is mediated by a vanA gene cluster, which is transferred from vancomycin-resistant enterococcus. Since the first VRSA isolate was recovered from Michigan, ...
Source: Journal of Advanced Research - Category: Research Source Type: research
ConclusionsMen with BRCA-related cancer risks lack understanding about their risks and how to manage them. Increased attention should be paid to the development of interventions tailored specifically to men. Further, interventions focusing on strategically developing proactive family communication behaviors would also be beneficial to men and their families.
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Publication date: Available online 12 October 2019Source: Journal of Research in PersonalityAuthor(s): Rodica Ioana Damian, Olivia E. Atherton, Katherine M. Lawson, Richard W. RobinsAbstractThe present research examined: (a) the co-development of chores and effortful control, and (b) the prospective impact of effortful control development (i.e., initial levels and the trajectory of effortful control from late childhood through adolescence) on work outcomes in young adulthood. We used data from a longitudinal study of 674 Mexican-origin youth assessed at ages 10, 12, 14, 16, and 19. We found no evidence of co-developmental ...
Source: Journal of Research in Personality - Category: Psychiatry & Psychology Source Type: research
This study suggests that higher doses of RK may cause adverse effects in health compromised conditions. Under these conditions, prolonged use of RK, especially in high doses, may pose a health hazard. PMID: 31603036 [PubMed - as supplied by publisher]
Source: Journal of Dietary Supplements - Category: Nutrition Tags: J Diet Suppl Source Type: research
ConclusionsT-CPT correlated well with microscopic scores. F-CPT and PUCAI appear to be better predictors of unfavorable outcome in patients with UC.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
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