Dysbiosis of the Gut Microbiome in Lung Cancer

In conclusion, compared to previous analyses of the relationship between LC and the lung microbiome, this is the first study of LC in connection with the gut microbiome (Hosgood et al., 2014; Kosikowska et al., 2016). Our findings support the hypothesis of LC-specific microbiota. We suggest that the reduced levels of Actinobacteria sp. and Bifidobacterium sp. and elevated levels of Enterococcus sp. are associated with LC. At the same time, we have further revealed that the damage of the normal function of the gut microbiome is associated with the progression of LC. the progress of LC. We hope that the results herein can provide some guidance for using gut microbes as biomarkers to assess the progression of lung cancer, or lead to interventional targets to control the development of the disease. Ethics Statement Fecal samples were collected in this research without any medical expense or suffering by the subjects, and the results were used for scientific research purposes. We declare that none of the authors have any conflicts of interest or financial ties to disclose. This study was carried out in accordance with the recommendations of Ethical Guidelines for Biomedical Research, Harbin Medical University Ethics Review Committee (an affiliated department of Harbin Medical University). The protocol was approved by the Harbin Medical University Ethics Review Committee. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The subjects�...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research