Effects of Orally Ingested Arsenic on Respiratory Epithelial Permeability to Bacteria and Small Molecules in Mice

Conclusions: Peroral arsenic has little effect on local airway immune responses to bacteria but compromises respiratory epithelial barrier integrity, increasing systemic translocation of inhaled pathogens and small molecules. https://doi.org/10.1289/EHP1878 Received: 09 March 2017 Revised: 14 August 2017 Accepted: 16 August 2017 Published: 28 September 2017 Address correspondence to M.B. Fessler, National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr., P.O. Box 12233, Maildrop D2-01, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-3701. Email: fesslerm@niehs.nih.gov *Current address: UNC School of Medicine, Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, CB7035, Genetic Medicine Building, Chapel Hill, North Carolina 27599. †Current address: East Carolina Diabetes and Obesity Institute, Dept. of Physiology, East Carolina University, ECHI 4101C, Greenville, North Carolina 27834. The authors declare they have no actual or potential competing financial interests. Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet ...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research

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Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
AbstractBackgroundUntil now, there is no clear conclusion on the relationship between the surgical margin status after radical prostatectomy (RP) and prostate cancer-specific mortality (PCSM). Therefore, we conducted this systematic review and meta-analysis based on all eligible case –control studies.MethodsA systematic and comprehensive literature search was performed based on PUBMED and EMBASE to identify all of the potentially relevant publications which were published before September 2019. Hazard ratio (HR) for PCSM was independently extracted by two reviewers from all eligible studies. Pooled HR estimates with ...
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
ConclusionThe findings declare that inhibition ofPVT1 could be a new target in the treatment of AML-M0 and help to approach more to treatments with fewer side effects.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
AbstractPurposeTo identify patients with metastatic urothelial cancer (mUC) unlikely to benefit from immune-checkpoint inhibitors (ICIs).Methods/PatientsWe explored the predictive and prognostic values of baseline neutrophil-to-lymphocyte ratio (NLR), with cut-offs  ≥ 3 and ≥ 5, and of a urothelial immune prognostic index (UIPI, based on increased NLR and LDH), on 146 patients.ResultsNLR and UIPI significantly predicted progressive disease and progression-free survival with both cut-offs (p = 0.0069,p = 0.0034,p = 0.0160,p = 0.0063;p 
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsIn conclusion, both the venous access catheter selection algorithm and the proposed recommendations aim to respond to the needs revealed in clinical practice and to become an integrable tool in electronic prescription systems to offer homogeneous criteria for action in cancer patients that require venous access, optimizing the use of available health resources with the highest safety and quality of life for the patient.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
ConclusionmiR-1976 may serve as a promising non-invasive biomarker for the diagnosis of BC in the future.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
AbstractIn this update of the consensus of the Spanish Society of Medical Oncology (Sociedad Espa ñola de Oncología Médica—SEOM) and the Spanish Society of Pathology (Sociedad Española de Anatomía Patológica—SEAP), advances in the analysis of biomarkers in advanced colorectal cancer (CRC) as well as susceptibility markers of hereditary CRC and molecular biomarkers of localized CRC are reviewed. Recently published information on the essential determination ofKRAS,NRAS andBRAF mutations and the convenience of determining the amplification of human epidermal growth factor ...
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
Publication date: October 2020Source: Trends in Anaesthesia and Critical Care, Volume 34Author(s): Massimiliano Sorbello, Robert Greif
Source: Trends in Anaesthesia and Critical Care - Category: Anesthesiology Source Type: research
Publication date: October 2020Source: Trends in Anaesthesia and Critical Care, Volume 34Author(s):
Source: Trends in Anaesthesia and Critical Care - Category: Anesthesiology Source Type: research
Publication date: Available online 21 September 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): George Makedonas, Satish K. Mehta, Richard A. Scheuring, Robert Haddon, Brian E. Crucian
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
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