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Condition: Mania

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Total 407 results found since Jan 2013.

Burst Motor Cortex Stimulation Evokes Sustained Suppression of Thalamic Stroke Pain: A Narrative Review and Single-Case Overview
AbstractChronic refractory central post-stroke pain (CPSP), one of the most disabling consequences of cerebral stroke, occurs in up to 10% of patients with CPSP. Because a considerable proportion of these patients with chronic pain remain resistant to pharmacological and behavioral therapies, adjunctive invasive and non-invasive brain stimulation therapies are needed. We performed a review of human studies applying burst and conventional motor cortex stimulation (burstMCS and cMCS, respectively) for chronic pain states, on the basis of data sources identified through searches of PubMed, MEDLINE/OVID, and SCOPUS, as well as...
Source: Pain and Therapy - December 16, 2020 Category: Anesthesiology Source Type: research

Stroke Risk Among Elderly Users of Haloperidol and Typical Antipsychotics Versus Atypical Antipsychotics: A Real-World Study From a US Health Insurance Claims Database
Antipsychotics are approved and prescribed to treat various conditions such as schizophrenia, mania, major depressive disorder, agitation, delusional disorder, psychosis, and Tourette's syndrome.1 The haloperidol prescribing information2 in the United States (US) does not warn about the risk of stroke but has a black box warning for an increased risk of death among elderly patients with dementia-related psychosis treated with antipsychotic drugs. Nonetheless, antipsychotics are used for indications such as neuropsychiatric symptoms of dementia, in the presence or absence of psychosis; such use is not approved by the Food a...
Source: The American Journal of Geriatric Psychiatry - September 26, 2020 Category: Geriatrics Authors: Daniel Fife, Clair Blacketer, R. Karl Knight, James Weaver Tags: Regular Research Article Source Type: research

Stroke Risk among Elderly Users of Haloperidol and Typical Antipsychotics vs. Atypical Antipsychotics: A Real-World Study from a US Health Insurance Claims Database
Antipsychotics are approved and prescribed to treat various conditions such as schizophrenia, mania, major depressive disorder, agitation, delusional disorder, psychosis, and Tourette's syndrome1. The haloperidol prescribing information2 in the United States (US) does not warn about the risk of stroke but has a black box warning for an increased risk of death among elderly patients with dementia-related psychosis treated with antipsychotic drugs. Nonetheless, antipsychotics are used for indications such as neuropsychiatric symptoms of dementia, in the presence or absence of psychosis; such use is not approved by the Food a...
Source: The American Journal of Geriatric Psychiatry - September 25, 2020 Category: Geriatrics Authors: Daniel Fife, Clair Blacketer, R. Karl Knight, James Weaver Source Type: research

The association between carotid atherosclerosis and treatment with lithium and antipsychotics in patients with bipolar disorder.
CONCLUSION: Lithium treatment may be associated with less progression in carotid intima-media thickness and the reduced risk for atherosclerosis in adults with bipolar disorder, including those with high cardiovascular disease risk. In addition to age and body mass index, antipsychotics may increase carotid intima-media thickness even in the low cardiovascular disease-risk patients. PMID: 32900219 [PubMed - as supplied by publisher]
Source: The Australian and New Zealand Journal of Psychiatry - September 7, 2020 Category: Psychiatry Authors: Tsai SY, Shen RS, Kuo CJ, Chen PH, Chung KH, Hsiao CY, Huang SH Tags: Aust N Z J Psychiatry Source Type: research

Association between periodontitis and bipolar disorder: A nationwide cohort study
Whether periodontitis is a risk factor for developing bipolar disorders (BD) has not been investigated. We aimed to determine whether periodontitis is associated with the subsequent development of BD and examine the risk factors for BD among patients with periodontitis. Using ambulatory and inpatient claims data from the National Health Insurance Research Database (NHIRD), we identified 12,337 patients who were aged at least 20 years and newly diagnosed with periodontitis between 2000 and 2004. The date of the first claim with a periodontitis diagnosis was set as the index date. For each patient with periodontitis, 4 subj...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Study Documents Neurological, Psychiatric Complications From COVID-19
While previous studies and case reports have found that COVID-19 patients have experienced vascular and neurological problems, a newstudy inthe Lancet Psychiatry reports that patients are also showing symptoms of psychiatric disorders, including psychosis and depression.The study was the result of a collaborative effort of specialists in the United Kingdom to document COVID-19 complications.“To our knowledge, this is the first systematic, nationwide U.K. surveillance study of the breadth of acute complications of COVID-19 in the nervous system,” wrote Aravinthan Varatharaj, M.R.C.P., of University Hospital Southampton ...
Source: Psychiatr News - June 29, 2020 Category: Psychiatry Tags: Aravinthan Varatharaj brain hemorrhage brain inflammation cognition COVID-19 depression Lancet Psychiatry pain psychiatric disorders psychosis stroke United Kingdom weakness Source Type: research

A Data-Driven Volitional EMG Extraction Algorithm During Functional Electrical Stimulation With Time Variant Parameters
Conclusions: All results showed that SICEEMDAN-LR is capable of extracting EMG during FES with time-variant parameters.
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - April 30, 2020 Category: Neuroscience Source Type: research

A stroke of bad luck: new-onset mania in elderly patient following undetected stroke, a case report
The phenomenon of developing depression after a stroke is fairly common in the literature (29%) but developing mania after a stroke is rare reportedly to be 1-2% of stroke survivors (Starkstein). One of the earliest descriptions of mania after stroke was described in 1989 of the right hemisphere (Starkstein). In 2011, a systematic review looking at 32 studies identified 49 cases describing symptoms of mania post-stroke. At initial presentation, 92% of these patients presented with elevated mood, 71% with increased rate of speech, 69% with insomnia and 63% with agitation (Santos).
Source: The American Journal of Geriatric Psychiatry - March 14, 2020 Category: Geriatrics Authors: Carolina Osorio, Stephanie Bolton, Hans von Walter, Mamdouh Hanna Tags: Poster Number: NR - 21 Source Type: research

Safety and Tolerability of Ketamine Use in Treatment-Resistant Bipolar Depression Patients with Regard to Central Nervous System Symptomatology: Literature Review and Analysis.
Abstract The current psychopharmacological treatment approaches for major depression focus on monoaminergic interventions, which are ineffective in a large proportion of patients. Globally, treatment-resistant bipolar depression (TRBD) affects up to 33% of depressive patients receiving treatment. Certain needs are still unmet and require new approaches. Many studies are in favor of treatments with ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, even in single use, whose effects emerge in minutes to hours post administration. However, little data are available on ketamine performance in TRBD patients ...
Source: Medicina (Kaunas) - February 8, 2020 Category: Universities & Medical Training Authors: Włodarczyk A, Cubała WJ Tags: Medicina (Kaunas) Source Type: research

Neuroserpin in Bipolar Disorder.
CONCLUSION: Since we detected difference between the patients and the controls, not the disease states, the dysregulation in the neuroserpin gene could be interpreted as a result of the disease itself. PMID: 32003693 [PubMed - as supplied by publisher]
Source: Current Topics in Medicinal Chemistry - January 30, 2020 Category: Chemistry Authors: Çınar RK Tags: Curr Top Med Chem Source Type: research

Lithium treatment mitigates white matter injury after intracerebral hemorrhage through brain-derived neurotrophic factor signaling in mice.
Abstract Intracerebral hemorrhage (ICH), a subtype of stroke with high morbidity and mortality, occurs mainly in the basal ganglia and causes white matter injury (WMI), resulting in severe motor dysfunction and poor prognosis in patients. The preservation of the white matter around the hematoma is crucial for motor function recovery, but there is currently no effective treatment for WMI following ICH. Lithium has been widely used for the treatment of bipolar disorder for decades. Although the protective effects of lithium on neurodegenerative diseases and cerebral trauma have been studied in recent years, whether ...
Source: Translational Research : the journal of laboratory and clinical medicine - December 26, 2019 Category: Laboratory Medicine Authors: Li M, Xia M, Chen W, Wang J, Yin Y, Guo C, Li C, Tang X, Zhao H, Tan Q, Chen Y, Jia Z, Liu X, Feng H Tags: Transl Res Source Type: research

Lithium treatment mitigates white matter injury after intracerebral hemorrhage through brain-derived neurotrophic factor signalling in mice
Intracerebral hemorrhage (ICH), a subtype of stroke with high morbidity and mortality, occurs mainly in the basal ganglia and causes white matter injury (WMI), resulting in severe motor dysfunction and poor prognosis in patients. The preservation of the white matter around the hematoma is crucial for motor function recovery, but there is currently no effective treatment for WMI following ICH. Lithium has been widely used for the treatment of bipolar disorder for decades. Although the protective effects of lithium on neurodegenerative diseases and cerebral trauma have been studied in recent years, whether it can be used to ...
Source: Translational Research - December 26, 2019 Category: Research Authors: MINGXI LI, MIN XIA, WEIXIANG CHEN, JIE WANG, YI YIN, CHAO GUO, CHENGCHENG LI, XIAOQIN TANG, HENGLI ZHAO, QIANG TAN, YUJIE CHEN, ZHENGCAI JIA, XIN LIU, HUA FENG Source Type: research

Dual-Antithrombotic Therapy With DOACs After Acute Coronary Syndrome or Percutaneous Coronary Intervention in Atrial Fibrillation: A Meta-analysis of Randomized Controlled Trials
ConclusionsIn patients with AF and recent ACS or PCI, the use of dual-antithrombotic therapy with DOACs was associated with less major bleeding and less major bleeding or clinically relevant nonmajor bleeding compared with triple therapy. The use of dual therapy also showed nonsignificantly higher composite of death and ischemic events but no difference in mortality.RésuméContexteIl est difficile de choisir un traitement antithrombotique en cas de fibrillation auriculaire (FA) chez les patients ayant subi un syndrome coronarien aigu (SCA) ou une intervention coronarienne percutanée (ICP). Nous avons comparé les résult...
Source: Canadian Journal of Cardiology - December 24, 2019 Category: Cardiology Source Type: research

Associations Between Two Single-Nucleotide Polymorphisms in NINJ2 Gene and Risk of Psychiatric Disorders
AbstractNINJ2 encodes a transmembrane protein that contributes in neurodevelopment and regeneration of neurons. Single-nucleotide polymorphisms (SNPs) within this gene have been associated with Alzheimer ’s disease, ischemic stroke, and multiple sclerosis. The rs11833579 and rs3809263 SNPs have been associated with risk of ischemic stroke in Iranian population. While theNINJ2 rs12425791 has been with risk of ischemic stroke in East Asian population, the rs11833579 has not been associated with this condition either in East Asian population or Chinese Han population. In the current project, we genotyped rs11833579 and rs38...
Source: Journal of Molecular Neuroscience - December 22, 2019 Category: Neuroscience Source Type: research

The Prevalence and Factors Associated with Antiepileptic Drug Use in US Nursing Home Residents
ConclusionsAED use was common in nursing homes, with gabapentin most commonly used (presumably for pain). That multiple comorbidities were associated with AED use underscores the need for future studies to investigate the safety and effectiveness of AED use in nursing home residents.
Source: Drugs and Aging - December 15, 2019 Category: Geriatrics Source Type: research