Safety and Tolerability of Ketamine Use in Treatment-Resistant Bipolar Depression Patients with Regard to Central Nervous System Symptomatology: Literature Review and Analysis.
Safety and Tolerability of Ketamine Use in Treatment-Resistant Bipolar Depression Patients with Regard to Central Nervous System Symptomatology: Literature Review and Analysis. Medicina (Kaunas). 2020 Feb 09;56(2): Authors: Włodarczyk A, Cubała WJ Abstract The current psychopharmacological treatment approaches for major depression focus on monoaminergic interventions, which are ineffective in a large proportion of patients. Globally, treatment-resistant bipolar depression (TRBD) affects up to 33% of depressive patients receiving treatment. Certain needs are still unmet and require new approaches. Many studies are in favor of treatments with ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, even in single use, whose effects emerge in minutes to hours post administration. However, little data are available on ketamine performance in TRBD patients with somatic comorbidities, including highly prevalent ones, i.e., cardiovascular disease (heart failure, hypertension, post-myocardial infarct, arrhythmias, etc.) diabetes, and obesity, and depression-associated comorbidities such as stroke, epilepsy, as well as in the elderly population. The literature shows that treatment with ketamine is efficacious and safe, and the majority of adverse drug reactions are mild and tend to mostly disappear within 30 min to 2 h of ketamine administration. PMID: 32050466 [PubMed - in process]
Publication date: Available online 5 April 2020Source: Urology Case ReportsAuthor(s): Arvind Krishnan, Jeffy Jacob, Trushar Patel
I was offered an out of match fellowship position and accepted it 2 days ago. Now, due to family issues It would not be ideal for me to relocate to that area. Is there a way I can withdraw my acceptance (I haven’t sign the intent letter or anything whatsoever, just email agreement) or would it be profesional suicide?
Publication date: Available online 4 April 2020Source: Aggression and Violent BehaviorAuthor(s): Scott Harcourt
Authors: Annette S, Stephan G, Mueser KT, Martin H, Elisabeth R, Ulrich G, Marketa C, Rolf E, Hans-Jürgen M, Peter F Abstract Neuropsychological functioning turns out to be a rate-limiting factor in psychiatry. However, little is known when comparing neuropsychological and psychosocial functioning in inpatients with schizophrenia or severe depression in their treatment pathways including add-on psychoeducation or the latter combined with cognitive behavioral therapy up to 2-year follow-up. To evaluate this question, we investigated these variables in two randomised controlled trials including 196 patients with...
Publication date: June 2020Source: Journal of Functional Foods, Volume 69Author(s): Ji Wang, Tong Wu, Li Fang, Chunlei Liu, Xiaoting Liu, Hongmei Li, Junhua Shi, Meihe Li, Weihong Min
In this study, we aimed to assess the possible association between affective temperaments and GH.Methods: This cross-sectional study was conducted on women with GH hospitalized in hospitals affiliated with Mashhad University of Medical Sciences, compared with healthy women admitted for normal delivery in the same centers during the study. Data were collected via Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Auto-questionnaire (TEMPS-A) and Depression Anxiety Stress Scale (DASS) 21.Results: TEMPS-A revealed that scores anxious (P
Conclusion: This study provides evidence for blood pressure management in Chinese pregnant women. PMID: 32243195 [PubMed - as supplied by publisher]
For millions of Americans, these are challenging times. For some insight into resilience from a generation that survived a depression and world war, Turner Classic Movies host Ben Mankiewicz turns to funnymen Mel Brooks and Carl Reiner. Via cyberchat, the two comedy writers, who first met in the 1950s ("Call it laugh at first sight"), talk about enduring World War II and coming out on top. Mankiewicz also talks with "Star Trek" actor and activist George Takei (who as a child was detained in a Japanese-American internment camp in the 1940s) about what Americans look for when facing an uncertain future.
Publication date: Available online 5 April 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Omid Asbaghi, Faezeh Fouladvand, Sajjad Moradi, Damoon Ashtary-Larky, Razieh Choghakhori, Amir Abbasnezhad
Publication date: Available online 4 April 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Amerta Ghosh, Ritesh Gupta, Anoop Misra