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Specialty: Drugs & Pharmacology
Condition: Heart Failure

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Total 434 results found since Jan 2013.

Residual risk reduction opportunities in patients with chronic coronary syndrome. Role of Dual Pathway Inhibition.
Abstract INTRODUCTION: In this review, the role of the rivaroxaban-plus-aspirin approach (dual pathway inhibition - DPI) in patients with chronic coronary syndrome (CCS) and to perform practical recommendations about its use was updated. AREAS COVERED: The contents of this review were proposed in an expert meeting. To identify relevant articles, a systematic search of Medline/Embase was performed (to July 2019), using the key words "rivaroxaban", "vascular dose", "COMPASS" and "coronary artery disease" in the search strategy. EXPERT OPINION: Despite current antithrombotic strategies (single/dual antiplat...
Source: Pharmacological Reviews - May 19, 2020 Category: Drugs & Pharmacology Authors: González-Juanatey JR, Almendro-Delia M, Cosín-Sales J, Bellmunt-Montoya S, Gómez-Doblas JJ, Riambau V, García-Moll X, García-Alegría J, Hernández JL, Lozano FS, Suarez Fernández C Tags: Expert Rev Clin Pharmacol Source Type: research

Risk factors for severe bleeding events during warfarin treatment: the influence of sex, age, comorbidity and co-medication
ConclusionMost of the well-established risk factors were found to be significantly associated with bleeding events in our study. We additionally found that women had a lower incidence of bleeding. Potential biases are selection effects, residual confounding and unmeasured frailty.
Source: European Journal of Clinical Pharmacology - March 27, 2020 Category: Drugs & Pharmacology Source Type: research

Vitamin D and vascular disease.
Abstract Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide. Vitamin D deficiency has been identified as a potential risk factor for a number of diseases unrelated to the classical skeletal pathophysiology, such as cancer and CVD, but the effects of vitamin D supplementation are less clear. Purpose of this narrative review is to discuss the evidence suggesting an association between vitamin D status and CVD as well as the results of supplementation studies. Vitamin D deficiency has been associated with CVD risk factors such as hypertension, dyslipidemia and diabetes mellitus as well...
Source: Current Vascular Pharmacology - March 16, 2020 Category: Drugs & Pharmacology Authors: Gouni-Berthold I, Berthold HK Tags: Curr Vasc Pharmacol Source Type: research

Management of Left Ventricular Thrombi with Direct Oral Anticoagulants: Retrospective Comparative Study with Vitamin K Antagonists
ConclusionsThis retrospective observational study found a similar efficacy between DOAC and VKA agents in patients with LV thrombi (70.6% vs. 71.5%); however, when the thrombus remains, VKAs are still the standard of care as it is possible to control INR levels (3 –4) with them.
Source: Clinical Drug Investigation - March 5, 2020 Category: Drugs & Pharmacology Source Type: research

Epigenetic-sensitive pathways in personalized therapy of major cardiovascular diseases
Publication date: Available online 24 February 2020Source: Pharmacology & TherapeuticsAuthor(s): Concetta Schiano, Giuditta Benincasa, Monica Franzese, Nunzia Della Mura, Katia Pane, Marco Salvatore, Claudio NapoliAbstractThe complex pathobiology underlying cardiovascular diseases (CVDs) has yet to be explained. Aberrant epigenetic changes may result from alterations in enzymatic activities, which are responsible for putting in and/or out the covalent groups, altering the epigenome and then modulating gene expression. The identification of novel individual epigenetic-sensitive trajectories at single cell level might provid...
Source: Pharmacology and Therapeutics - February 24, 2020 Category: Drugs & Pharmacology Source Type: research

Trends of antihypertensive agents in patients with hypertension and coronary artery disease in a tertiary hospital of China
Conclusion The compliance to guidelines is overall well for patients with hypertension and coronary artery disease, but improvements is needed for patients with type 2 diabetes. Multi-center studies with large-scale data are required to further assess the usage of antihypertensive agents in patients.
Source: International Journal of Clinical Pharmacy - February 19, 2020 Category: Drugs & Pharmacology Source Type: research

A Real-World Analysis of Patient Characteristics and Predictors of Hospitalization Among US Medicare Beneficiaries with Respiratory Syncytial Virus Infection
ConclusionHospitalized Medicare beneficiaries with RSV infections pose a significant healthcare burden as compared with non-hospitalized patients, mainly driven by higher comorbidity, higher likelihood of multiple inpatient admissions, and costly medical interventions.
Source: Advances in Therapy - February 4, 2020 Category: Drugs & Pharmacology Source Type: research

Beta-blocker therapy and risk of vascular dementia: A population-based prospective study.
Abstract There are a few studies that report cognitive impairment as a complication of treatment with beta- blockers. We aimed to evaluate the longitudinal association between use of beta-blockers, as a class, and incident risk of all-cause dementia, vascular dementia, Alzheimer's and mixed dementia in the prospective population-based Malmö Preventive Project. We included 18,063 individuals (mean age 68.2, males 63.4%) followed up for 84,506 person-years. Dementia cases were retrieved from the Swedish National Patient Register and validated by review of medical records and neuroimaging data. We performed propensi...
Source: Vascular Pharmacology - January 16, 2020 Category: Drugs & Pharmacology Authors: Holm H, Ricci F, Di Martino G, Bachus E, Nilsson ED, Ballerini P, Melander O, Hansson O, Nägga K, Magnusson M, Fedorowski A Tags: Vascul Pharmacol Source Type: research

Pharmacotherapy for the treatment of obstructive hypertrophic cardiomyopathy.
Authors: Spoladore R, Fragasso G, Pannone L, Slavich M, Margonato A Abstract Introduction: Hypertrophic cardiomyopathy (HCM) is one of the most common genetic heart diseases and represents a leading cause of sudden cardiac death as well as a prevalent cause of heart failure and stroke. HCM is characterized by a very complex pathophysiology, consisting of heterogeneous clinical manifestations and natural history. Left ventricular outflow tract (LVOT) obstruction has been considered the most knowable feature of HCM since the initial clinical descriptions of the disease.Areas covered: In this review, the authors discu...
Source: Expert Opinion on Pharmacotherapy - January 3, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

The efficacy of Chinese herbal medicines on acute coronary syndrome with renal insufficiency after percutaneous coronary intervention
ConclusionChinese herbal medicines plus western medicine standard therapy improved clinical outcomes in patients with ACS and mild-to-moderate renal insufficiency. Additionally, this study also demonstrated Chinese herbal medicines were useful in deferring decline of renal function.Graphical abstract
Source: Journal of Ethnopharmacology - November 3, 2019 Category: Drugs & Pharmacology Source Type: research

All-Cause Mortality and Cardiovascular Outcomes With Non-Vitamin K Oral Anticoagulants Versus Warfarin in Patients With Heart Failure in the Food and Drug Administration Adverse Event Reporting System
Background: Many patients with heart failure (HF) are treated with warfarin or non-vitamin K oral anticoagulants (NOACs). Randomized outcome-driven comparisons of different anticoagulant strategies in HF are lacking. Data from international, government-mandated registries may be useful in understanding the real-life use of various anticoagulants and how they are linked to outcomes. Study Question: To assess 2015 annual all-cause mortality, myocardial infarction, and stroke rates co-reported for warfarin and NOACs in subjects with and without HF in the US Food and Drug Administration Adverse Event Reporting System (FAE...
Source: American Journal of Therapeutics - November 1, 2019 Category: Drugs & Pharmacology Tags: Original Research Source Type: research

Sacubitril/Valsartan Improves Left Atrial and Left Atrial Appendage Function in Patients With Atrial Fibrillation and in Pressure Overload-Induced Mice
LCZ696 (sacubitril/valsartan) is an angiotensin receptor-neprilysin inhibitor and has shown beneficial effects in patients with heart failure. However, whether LCZ696 protects against left atrial (LA) and LA appendage (LAA) dysfunction is still unclear. The present study aimed to assess the efficacy of LCZ696 for improving the function of LA and LAA. We performed both a retrospective study comparing LCZ696 with angiotensin receptor blockers (ARBs) to assess the efficacy of LCZ696 in patients with atrial fibrillation and an animal study in a mouse model with pressure overload. LA peak systolic strain, LAA emptying flow velo...
Source: Frontiers in Pharmacology - October 28, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of ANP on Pulmonary Vein Electrophysiology, Ca2+ Homeostasis and Adrenergic Arrhythmogenesis via PKA.
In conclusion, ANP directly regulates PV electrophysiological characteristics and Ca2+ homeostasis, and attenuates isoproterenol-induced arrhythmogenesis through NPR-C/cAMP/PKA signal pathway. PMID: 31637746 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - October 21, 2019 Category: Drugs & Pharmacology Authors: Lu YY, Cheng CC, Wu HJ, Lin YK, Chen YC, Chen SA, Chen YJ Tags: Clin Exp Pharmacol Physiol Source Type: research

Efficacy and Safety of Direct Oral Anticoagulants in Patients With Atrial Fibrillation and High Thromboembolic Risk. A Systematic Review
Conclusions: The use of DOACs is a reasonable alternative to vitamin K antagonists in AF patients with CHADS2 score ≥3, advanced age, and HF. The RI constitutes a useful, additional tool to facilitate clinicians in choosing DOACs or warfarin in particular category of AF patients.
Source: Frontiers in Pharmacology - September 18, 2019 Category: Drugs & Pharmacology Source Type: research

A review of the role of statins in heart failure treatment.
Abstract Heart failure is a common medical problem in the world, which has a high prevalence in both developed and developing countries. Today, among the medications used for the heart failure treatment, there are many medications with a positive cardiac contraction effect (positive inotropic such as digital glycosides, adrenergic receptor stimulants, and phosphodiesterase inhibitors), a large number of cardiac diluents (such as Angiotensin-converting enzyme (ACE) inhibitor group), and a few other types of drugs whose final effects are still under review Statins are valuable drugs that are broadly prescribed in hy...
Source: Current Clinical Pharmacology - August 1, 2019 Category: Drugs & Pharmacology Authors: Niazi M, Galehdar N, Jamshidi M, Mohammadi R, Moayyedkazemi A Tags: Curr Clin Pharmacol Source Type: research