Epigenetic-sensitive pathways in personalized therapy of major cardiovascular diseases

Publication date: Available online 24 February 2020Source: Pharmacology &TherapeuticsAuthor(s): Concetta Schiano, Giuditta Benincasa, Monica Franzese, Nunzia Della Mura, Katia Pane, Marco Salvatore, Claudio NapoliAbstractThe complex pathobiology underlying cardiovascular diseases (CVDs) has yet to be explained. Aberrant epigenetic changes may result from alterations in enzymatic activities, which are responsible for putting in and/or out the covalent groups, altering the epigenome and then modulating gene expression. The identification of novel individual epigenetic-sensitive trajectories at single cell level might provide additional opportunities to establish predictive, diagnostic and prognostic biomarkers as well as drug targets in CVDs. To date, most of studies investigated DNA methylation mechanism and miRNA regulation as epigenetics marks. During atherogenesis, big epigenetic changes in DNA methylation and different ncRNAs, such as miR-93, miR-340, miR-433, miR-765, CHROME, were identified into endothelial cells, smooth muscle cells, and macrophages. During man development, lipid metabolism, inflammation and homocysteine homeostasis, alter vascular transcriptional mechanism of fundamental genes such as ABCA1, SREBP2, NOS, HIF1. At histone level, increased HDAC9 was associated with matrix metalloproteinase 1 (MMP1) and MMP2 expression in pro-inflammatory macrophages of human carotid plaque other than to have a positive effect on toll like receptor signaling and innat...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research

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Publication date: Available online 24 May 2020Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Maira Jaqueline da Cunha, Katia Daniele Rech, Ana Paula Salazar, Aline Souza Pagnussat
Source: Annals of Physical and Rehabilitation Medicine - Category: Rehabilitation Source Type: research
ConclusionsThe e-ASPECTS software generates robust values for e-ASPECTS and acute infarct volumes when using ST ≤ 4 mm with ST = 1 mm yielding the best performance for predicting baseline stroke severity and clinical outcome after 90 days.Key Points•Clinical utility of automatically derived ASPECTS from computed tomography scans was shown in patients with acute ischemic stroke and treatment with mechanical thrombectomy.•Thin slices (=  1 mm) had the highest clinical utility in comparison with thicker slices (2–10 mm) by having the strongest correlation...
Source: European Radiology - Category: Radiology Source Type: research
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
At any given time, more than a third of Americans are on a specific diet, with weight loss as a leading reason. Most are going to be disappointed, because even when successful, lost weight is frequently regained within a few months. While most weight-loss diets can help you lose weight, they may be unsuccessful over the long run for a number of reasons. Some people don’t follow their diets carefully and don’t lose much weight even from the start. Others may go off the diet entirely after a while, because it’s too restrictive or the foods aren’t appealing. Some may engage in less physical activity as...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Diet and Weight Loss Source Type: blogs
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
This study sought to report the driving habits and reaction times of older patients with HF in a spe...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
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Source: Biorheology - Category: Biochemistry Tags: Biorheology Source Type: research
Conditions:   Stroke;   Sleep-disordered Breathing;   Sleep Apnea Syndromes;   Sleep Apnea, Obstructive;   Sleep Apnea, Central;   Fragmentation, Sleep Intervention:   Device: Treatment according to standard care recommandation Sponsor:   University Hospital, Grenoble Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Stroke;   Activities of Daily Living Interventions:   Behavioral: Approach-Instrumental Activities of Daily Living;   Behavioral: Home rehabilitation Sponsor:   National Taipei University of Nursing and Health Sciences Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
How prevalent is statin use among terminally ill nursing home residents? Should statins be discontinued in those unlikely to benefit from continued use?Journal of the American Geriatrics Society
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news
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