Comparative pharmacokinetic study of hesperetin after oral administration in normal and hyperuricemia rats by UPLC-MS/MS.
This study aimed to develop a highly sensitive and specific method for the determination of hesperetin in normal and hyperuricemia rats, and to compare pharmacokinetic profiles of hesperetin after oral administration between normal and hyperuricemia rats. METHODS: Sprague-Dawley (SD) rats were randomly divided into one normal group (group A) and four hyperuricemia groups (group B, C, D, and E). Groups A, B, C, and D received a single dose (9-81 mg/kg) of hesperetin on Day 28, respectively, while group E received multiple doses (27 mg/kg) of hesperetin once daily for 28 days. Blood samples were collected at 10 differen...
Source: Current Clinical Pharmacology - July 2, 2020 Category: Drugs & Pharmacology Authors: Li K, Wei L, Han Z, Xiong H, Zhang F, Liu X, Zhao D, Pan Y, Han W Tags: Curr Clin Pharmacol Source Type: research

Clavulanic Acid in the Scope of Helicobacter pylori Treatment: A Literature Review and Beyond.
CONCLUSION: The presented literature suggests potential avenues for the use of CA in the management of peptic ulcer disease and H.pylori infection. PMID: 32614751 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - July 2, 2020 Category: Drugs & Pharmacology Authors: Alrabadi N, Albustami IS, Abuhayyeh HA, El-Muwalla KM, Alawneh RJ, Al-Eitan LN, Alzoubi KH, Masadeh M, Khabour OF, Haddad R Tags: Curr Clin Pharmacol Source Type: research

Vemurafenib Induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A Disproportionality Analysis in FAERS Database.
CONCLUSION: Positive signal strength was observed for vemurafenib associated DRESS. The signal strength was higher for vemurafenib in combination with cobimetinib than vemurafenib alone. Health care professionals should be cautious about encountering serious adverse events and should be reported to the regulatory authorities. PMID: 32598268 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - June 28, 2020 Category: Drugs & Pharmacology Authors: Neha R, Beulah E, Anusha B, Vasista S, Stephy C, Subeesh V Tags: Curr Clin Pharmacol Source Type: research

Berberine nanoencapsulation attenuates hallmarks of scoplomine induced Alzheimer's-like disease in rats.
CONCLUSIONS: The enhancing effect of BBR- NPs could be related to the enhancing of its bioavailability, absorption and brain drug uptake which need more investigation in future work. PMID: 32598269 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - June 28, 2020 Category: Drugs & Pharmacology Authors: Saleh SR, Abady MM, Nofal M, Yassa NW, Abdel-Latif MS, Nounou MI, Ghareeb DA, Abdel-Monaem N Tags: Curr Clin Pharmacol Source Type: research

Remifentanil with or without Propofol as Anesthesia Agents for Trans-Vaginal Ultrasonography Oocyte Retrieval (TUGOR) on Pregnancy and Anesthesia Outcomes: A Randomized Controlled Trial.
CONCLUSION: Using remifentanil alone in comparison to remifentanil & propofol in TUGOR procedure can be achieved better pregnancy outcomes without imposing the side effects of propofol; therefore, it is not recommended to use propofol as an anesthesia agent for a TUGOR procedure. PMID: 32576131 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - June 23, 2020 Category: Drugs & Pharmacology Authors: Atashkhoei S, Pouya K, Hakimi P, Zakeri R, Soltanzadeh N, Hatami-Marandi P Tags: Curr Clin Pharmacol Source Type: research

The role of Direct Oral Anticoagulant in patients with Acute Coronary Syndrome on single or dual antiplatelet regime: review of opportunities and challenges.
CONCLUSION: Cardiologists should balance the efficacy with higher risk of bleeding with more intensified DOAC therapy. Better risk characterization and timely adaptation of the regime to the patients need should be tested. Recurrent ischemic event and bleeding event risk scoring should guide individualized treatment. PMID: 32418529 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - May 17, 2020 Category: Drugs & Pharmacology Authors: Elnour AA, Komócsi A, Kupó P, El Khidir IY, Zachariah S, Gnana K, Asim S, Sadik A Tags: Curr Clin Pharmacol Source Type: research

Repurposing Available Anti-inflammatory and Immunomodulating Agents for Cardiovascular Risk Management: A Call for Submissions to Current Clinical Pharmacology.
PMID: 32407260 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - May 16, 2020 Category: Drugs & Pharmacology Authors: Mangoni AA, Erre GL Tags: Curr Clin Pharmacol Source Type: research

Survival benefits of N- Acetylcysteine in rodenticide poisoning: Retrospective Evidence from an Indian tertiary care setting.
CONCLUSION: NAC is shown to have a significant survival benefit with good safety profile among the rodenticide poisoners. Further, adequately powered prospective researches with more emphasis on dosing parameters are warranted for better quantification in different settings and for clinical implementation. PMID: 32400335 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - May 12, 2020 Category: Drugs & Pharmacology Authors: Mark K, Hyder S, Rashid M, Chandran VP, Seshadri S, Seshadri S, Nair S, Thunga G Tags: Curr Clin Pharmacol Source Type: research

In-Silico Model for Predicting CYP2D6-Mediated Drug-Drug Interactions.
CONCLUSIONS: According to our results, knowledge of the inhibition constant and therapeutic range (or its plasma levels if disponible) of the inhibitor would be sufficient to determine the intensity and clinical relevance of a CYP2D6-mediated DDI. PMID: 32379594 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - May 7, 2020 Category: Drugs & Pharmacology Authors: Lozano R, Frutos A, Martinez A Tags: Curr Clin Pharmacol Source Type: research

Upcoming Drifts In Bio-Similars.
CONCLUSION: Updates on biosimilars will support to investigate the possible impact of bio-similars on healthcare market. PMID: 32379595 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - May 7, 2020 Category: Drugs & Pharmacology Authors: Aggarwal G, Nagpal M, Sharma A, Puri V, Dhingra GA Tags: Curr Clin Pharmacol Source Type: research

Assessment of Withania somnifera root extract efficacy in patients with generalized anxiety disorder: A randomized double-blind placebo-controlled trial.
Abstract BACKGROUND: Anxiety disorders are the most universal psychiatric problems in the general population. Due to their chronic nature, these diseases are managed with a multi-drug regimen lasting for a long period of time. Medication discontinuation leads to 25% and 80% recurrence in the first month and the first year, respectively. Despite several treatment approaches, there is no specific and optimal method for patient management. Therefore, it is necessary to find some new theraputic approaches with fewer side effects. Withania somnifera is a plant with GABAergic property responsible for its anxiolytic effe...
Source: Current Clinical Pharmacology - April 13, 2020 Category: Drugs & Pharmacology Authors: Fuladi S, Emami SA, Mohammadpour AH, Karimani A, Manteghi AA, Sahebkar A Tags: Curr Clin Pharmacol Source Type: research

Warburg effects on cancer cells survival: the role of sugar starvation in cancer therapy.
CONCLUSION: As cancer cells use glucose for aerobic glycolysis as a preferred substrate for energy yielding metabolism, we discuss in this review the Warburg effect and a strategy of starving cancer from glucose to prevent cancer cell survival and induce apoptosis in various types of cancer which could be the key to future treatment. PMID: 32282309 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - April 13, 2020 Category: Drugs & Pharmacology Authors: Zam W, Ahmed I, Yousef H Tags: Curr Clin Pharmacol Source Type: research

Effect of chamomile oil on cesarean section pain in primiparous women: a randomized clinical trial.
In this study, the analgesic effect of chamomile oil was studied. PURPOSE: The current research was conducted to study the effect of chamomile oil on cesarean section pain in primiparous women. MATERIALS AND METHODS: This was a randomized double blind clinical trial wherein 128 primiparous pregnant women (who willingly selected cesarean section) took part. In the aromatherapy group, the subjects inhaled one drop of 5% chamomile oil, and in the control group the subjects inhaled one placebo drop. In both groups the subjects inhaled for 15-20 minutes at a distance of 5 cm from the nose at 4, 8, and 12 hours after s...
Source: Current Clinical Pharmacology - March 31, 2020 Category: Drugs & Pharmacology Authors: Zardosht R, Basir A, Sahebkar A, Emami SA Tags: Curr Clin Pharmacol Source Type: research

Experimental phage therapies in companion animals with historical review.
CONCLUSIONS: The effectiveness of phages therapies depends on many factors and the properties of the bacteriophages themselves, which requires comprehensive knowledge of them. PMID: 32223736 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 29, 2020 Category: Drugs & Pharmacology Authors: Pyzik E, Urban-Chmiel R, Radzki RP Tags: Curr Clin Pharmacol Source Type: research

Prebiotics and Probiotics in Inflammatory Bowel Disease (IBD): Where Are We Now And Where Are We Going?Funders.
Abstract The incidence, prevalence, and cost of care associated with diagnosis and management of inflammatory bowel disease are on the rise. The role of gut microbiota in the causation of Crohn's disease and ulcerative colitis has not been established yet. Nevertheless, several animal models and human studies point towards the association. Targeting intestinal dysbiosis for the remission induction, maintenance, and relapse prevention is an attractive treatment approach with minimal adverse effects. However, the data is still conflicting. The purpose of this article is to provide the most comprehensive and updated ...
Source: Current Clinical Pharmacology - March 11, 2020 Category: Drugs & Pharmacology Authors: Naseer M, Poola S, Ali S, Samiullah S, Tahan V Tags: Curr Clin Pharmacol Source Type: research

Effects of Adjuvant Ketamine on Induction of Anesthesia for the Cesarean Section.
CONCLUSION: Overall use of ketamine is associated with better sedation and no significant side effects with low doses of ketamine, were seen in our study. Comparative studies using other analgesics, with larger sample size are therefore recommended. PMID: 32156239 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 9, 2020 Category: Drugs & Pharmacology Authors: Moradkhani M, Beiranvand S, Nadri S, Hejri P Tags: Curr Clin Pharmacol Source Type: research

Long-acting injectable vs oral antipsychotics: Adherence, persistence and switching over three years of real-life analysis.
CONCLUSIONS: In all drugs of the present study, adherence values were better in LAI than in OA, whereas no statistically significant difference was found in persistence values. PMID: 32148198 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 9, 2020 Category: Drugs & Pharmacology Authors: Romagnoli A, Santoleri F, Costantini A Tags: Curr Clin Pharmacol Source Type: research

Effects of Probiotics on Diabetic Nephropathy: A Systematic Review.
Abstract Diabetic nephropathy is a frequent complication of diabetes mellitus as a result of functional and structural modifications in multiple kidney compartments. Probiotics have risen lately as the forthcoming therapeutic intervention but have not been systematically evaluated in diabetic nephropathy so far. The aim of this review is to systematically evaluate randomized controlled trials and experimental studies assessing the effect of probiotic supplements on diabetic nephropathy. An extensive literature search was conducted through electronic databases (Pubmed, Scopus, Cinahl and Medline) with the Medical S...
Source: Current Clinical Pharmacology - March 2, 2020 Category: Drugs & Pharmacology Authors: Vlachou E, Ntikoudi A, Govina O, Lavdaniti M, Kotsalas N, Tsartsalis A, Dimitriadis G Tags: Curr Clin Pharmacol Source Type: research

Title: Is intraoperative opioids avoidance a utopia? A matched case-control study in laparoscopic hysterectomy.
Abstract INTRODUCTION: Opioid-sparing strategies are recommended, and opioid-free anaesthesia (OFA) is proposed in the literature. But few data exist about the feasibility of OFA in the routine practice. From a larger series of 21,463 patients receiving OFA, this work investigates the postoperative pain and related outcomes in patients undergoing laparoscopic hysterectomy. PATIENTS AND METHODS: This matched retrospective study concerned 521 patients scheduled for a laparoscopic hysterectomy between 2010 and 2015 (118 receiving OFA and 403 receiving anaesthesia with opioids, AO). Primary outcome was pain in th...
Source: Current Clinical Pharmacology - March 2, 2020 Category: Drugs & Pharmacology Authors: Forget P, De Kock M, Lovqvist L, Lois F Tags: Curr Clin Pharmacol Source Type: research

Comparison of the effects of Dexamethasone and Ondansetron on the Reduction of Postoperative Nausea and Vomiting following Cesarean Section under Spinal Anesthesia.
CONCLUSION: Based on the results of this study, ondansetron had a significant effect on the alleviation of postoperative nausea and vomiting, as compared to dexamethasone in c-section surgical candidates. PMID: 32116199 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 2, 2020 Category: Drugs & Pharmacology Authors: Karimi A, Nejadi J, Shamseh M, Ronasi N, Birjandi M Tags: Curr Clin Pharmacol Source Type: research

Therapeutic Effects of Prebiotics in Constipation: A Review.
Abstract Constipation is a highly prevalent functional gastrointestinal disorder that may significantly affect the quality of life and health care costs. Treatment for constipation has been broadly reviewed by cognitive therapies, medications, and surgical interventions. Gut microbiota such as Bifidobacterium, Clostridium, Bacteroidetes, and Lactobacilli have been demonstrated in functional gastrointestinal disorders and prebiotics play a role in augmenting their presence. Prebiotics are ingredients in foods that remain undigested that may stimulate bacteria. There are variety of prebiotics however there only a ha...
Source: Current Clinical Pharmacology - February 12, 2020 Category: Drugs & Pharmacology Authors: Naseer M, Poola S, Uraz S, Tahan V Tags: Curr Clin Pharmacol Source Type: research

Determination of fundamental medication reconciliation features with an international perspective.
CONCLUSION: According to the results, inclusion of factors like establishing phases for implementation, proper education, developing academic coordination, providing suitable facilities, specialization of the services, periodical evaluations and promoting pharmacy practice in development of medication reconciliation will potentially lead to an optimized plan. PMID: 32039687 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 10, 2020 Category: Drugs & Pharmacology Authors: Tafazoli A Tags: Curr Clin Pharmacol Source Type: research

Angiotensin-Receptor Blockers (ARBs) and risk of Alzheimer ´s Disease: A meta-analysis.
This study aimed to systematically review the association between the use of Angiotensin-Receptor Blockers (ARBs)and the incidence of Alzheimer's Disease (AD). METHODS: We systematically searched studies reporting the association between ARB use and incidence of AD. RESULTS: Ten studies (1 RCT, 2 case-control studies and 7 cohort studies) met the inclusion criteria. When all observational studies (9) were analyzed, ARB use was associated with a reduced risk of incident AD (HR 0.72, 95% CI: 0.58-0.88, p
Source: Current Clinical Pharmacology - January 31, 2020 Category: Drugs & Pharmacology Authors: Oscanoa TJ, Amado J, Vidal X, Romero-Ortuno R Tags: Curr Clin Pharmacol Source Type: research

An Assessment of Patients Factors Effect on Prescriber Adherence to Ischemic Stroke Secondary Prevention Guidelines.
CONCLUSION: Adherence to stroke secondary prevention guidelines was suboptimal especially in the antihypertensive prescription component. Further assessments and evaluations are required improve guidelines adherence. PMID: 31971113 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - January 23, 2020 Category: Drugs & Pharmacology Authors: Al Qawasmeh M, Alhusban A, Alfwaress F, El-Salem K Tags: Curr Clin Pharmacol Source Type: research

Medication non-adherence in patients with osteoporosis: implications for clinical pharmacists and osteoporosis care providers.
CONCLUSION: Medication adherence for patients with osteoporosis has considered scope for improvement in Jordan. Simplifying dosage regimen in addition to taking patients' preferences when selecting the medications should be taken into account in future interventions designed to improve health outcomes for patients with osteoporosis. PMID: 31951176 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - January 15, 2020 Category: Drugs & Pharmacology Authors: Jarab A, Mukattash T, Hilan H Tags: Curr Clin Pharmacol Source Type: research

Pomegranate Juice does not Affect the Bioavailability of Cyclosporine in Healthy Thai Volunteers.
CONCLUSION: Single dose administration of pomegranate juice with cyclosporine did not significantly affect the oral bioavailability of cyclosporine. However, further work is needed to thoroughly evaluate the effect of pomegranate on narrow therapeutic drugs. PMID: 31924158 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - January 10, 2020 Category: Drugs & Pharmacology Authors: Anlamlert W, Sermsappasuk P Tags: Curr Clin Pharmacol Source Type: research

Use of Synbiotics for Ulcerative Colitis Treatment.
CONCLUSION: The mechanism of actions in synbiotics supplementation is still unclear and needs more investigation although there are a wide number of data indicating that the synergism between probiotics and prebiotics is able to modulate the inflammatory response through cytokine expression and immune cell modulation induced by probiotic bacteria, that are also able to favour the production of SCFA by prebiotics digestion. SCFA are involved in mucosal barrier stabilization, regulatory T cell induction, promotion of anti-inflammatory cytokines secretion and inhibition of inflammatory factors such as TNF-α. Other: An u...
Source: Current Clinical Pharmacology - December 26, 2019 Category: Drugs & Pharmacology Authors: Roselli M, Finamore A Tags: Curr Clin Pharmacol Source Type: research

Drug therapies for patients with IgA nephropathy: A network meta-analysis of randomized clinical trials.
CONCLUSION: We observed few interventions to perform better in the management of IgAN. The results of this study will aid in further evaluation of such drugs that may assist in saving the resources and time. However, the readers should interpret the findings with great caution as the results might change with the advent of future head-to-head clinical trials. PMID: 31870272 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - December 22, 2019 Category: Drugs & Pharmacology Authors: Sridharan K, Sivaramakrishnan G Tags: Curr Clin Pharmacol Source Type: research

Prevalence and Predictors of Self-Medication Practices in India: A Systematic Literature Review and Meta-Analysis.
Abstract BACKGROUND: Self-medication (SM) is a practice of using medications to treat the self-diagnosed symptoms without legitimate prescription by a health care professional. Alongside posing burden on to a patient, SM practices are associated with certain unfavourable health conditions such as drug-resistance, adverse effects, drug-interactions, including death. OBJECTIVE: To systematically review and quantify the prevalence of SM practices and its associated factors in India. METHODOLOGY: A comprehensive systematic search was performed using scientific databases such as PubMed and Cochrane library fo...
Source: Current Clinical Pharmacology - November 21, 2019 Category: Drugs & Pharmacology Authors: Rashid M, Chhabra M, Kashyap A, Undela K, Gudi SK Tags: Curr Clin Pharmacol Source Type: research

Effects of Probiotics and Prebiotics on Frailty and Ageing: A Narrative Review.
Abstract Globally, the population over the age of 60 is growing fast, but people age in different ways. Frailty, shown by the accumulation of age-related deficits, is a state of increased vulnerability to adverse outcomes among people of the same chronological age. Ageing results in a decline in diversity and homeostasis of microbiomes, and gut flora changes are related to health deficit accumulation and adverse health outcomes. In older people, health deficits including inappropriate intake, sarcopenia, physical inactivity, polypharmacy, and social vulnerability are factors associated with gut dysbiosis. The use ...
Source: Current Clinical Pharmacology - November 20, 2019 Category: Drugs & Pharmacology Authors: Jayanama K, Theou O Tags: Curr Clin Pharmacol Source Type: research

Systematic review on rocuronium continuous infusion for deep neuromuscular blockade.
CONCLUSION: Continuous infusion for deep NMB presents inherent advantages in terms of maintenance and stability of the muscle relaxation. For that purpose, monitoring and rocuronium administration approaches are fundamental and intrinsically connected. Additional efforts should be placed in further studies to better understand the variability and methodological parameters for an improved maintenance of deep NMB. PMID: 31750807 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - November 20, 2019 Category: Drugs & Pharmacology Authors: Couto M, Couto JG, Nunes CS, Vide S, Amorim P, Mendes JG Tags: Curr Clin Pharmacol Source Type: research

Effects of probiotics in the management of infected chronic wounds: from cell culture to human studies.
CONCLUSIONS: Although preliminary evidence supports the use of specific strains of probiotics in certain clinical settings such as infected chronic wounds, large, long-term clinical trials are still lacking, and further researches are needed . PMID: 31713496 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - November 11, 2019 Category: Drugs & Pharmacology Authors: Lorenzo B, Luca S, Antonio M, Alberto DM, Cesare F, Omar C Tags: Curr Clin Pharmacol Source Type: research

Tenofovir urine assay to monitor adherence to HIV pre-exposure prophylaxis (PrEP).
CONCLUSION: The findings of this review confirm the utility of tenofovir urine assay to monitor adherence to HIV pre-exposure prophylaxis. Further studies are underway to implement the tenofovir urine assay to monitor adherence and pre-exposure prophylaxis, nationally and internationally. PMID: 31713497 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - November 11, 2019 Category: Drugs & Pharmacology Authors: Moorthy GS, Lalley-Chareczko L, Koenig HC, Zuppa AF Tags: Curr Clin Pharmacol Source Type: research

First-in-Human study of the Safety, Tolerability, Pharmacokinetics and - Preliminary Dynamics of Neuroprotectant 2-Iminobiotin in Healthy Subjects.
CONCLUSION: Single and multiple doses of 2-IB up to 6 doses of 6 mg/kg with and without Captisol® were safe and well tolerated in healthy male subjects. 2-IB proved to be a high-clearance drug with volume of distribution slightly exceeding total body water volume, and with linear PK that appeared not be affected by presence of Captisol®. Sulfobutylether-beta-cyclodextrin (SBECD) in Captisol® had a low-clearance profile with small volume of distribution, with time independent PK. Preliminary PD characterization of repeated iv dosing of 2-IB in an acute peripheral hypoxic ischemia model in healthy subjects did no...
Source: Current Clinical Pharmacology - October 17, 2019 Category: Drugs & Pharmacology Authors: van Hoogdalem EJ, Peeters-Scholte CMPCD, Leufkens PWTJ, Hartstra J, van Lier JJ, de Leede LGJ Tags: Curr Clin Pharmacol Source Type: research

Formulation and evaluation of polyherbal cream and lotion to treat psoriasis-induced secondary infections.
Conclusion: The present study concluded that most of the formulated lotions and creams showed good antimicrobial activity and may be applied topically against scalp psoriasis. PMID: 31622222 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - October 17, 2019 Category: Drugs & Pharmacology Authors: Joshi P, Joshi S, Rajani U, Semwal RB, Semwal DK Tags: Curr Clin Pharmacol Source Type: research

Comparative effectiveness of Agmatine and Choline treatment in rats with cognitive impairment induced by AlCl3 and Forced Swim Stress.
CONCLUSION: Present study determines that agmatine treatment at the dose of (100 mg/kg/BW) attenuate memory and cognitive impairment that leads to behavioral disorders and deficits in comparison with choline supplements. PMID: 31622210 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - October 16, 2019 Category: Drugs & Pharmacology Authors: Rafi H, Ahmad F, Anis J, Khan R, Rafiq H, Farhan M Tags: Curr Clin Pharmacol Source Type: research

Severe Group A and Group B Streptococcus diseases at a Pediatric ICU: Are they still sensitive to the penicillins?
CONCLUSIONS: Severe GAS and GBS are rare but associated with high mortality and rates of mechanical ventilation and inotropic supports in PICU. The streptococci are invariably sensitive to penicillin. The high PIM2 and Sepsis scores suggest that prompt recognition of sepsis and timely judicious institution of antibiotics and intensive care support may be life-saving for these devastating infections. PMID: 31556861 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - September 26, 2019 Category: Drugs & Pharmacology Authors: Hon KL, Chow TC, Cheung TS, Lam WT, Hung LT, So KW, Ip M, Qian SY Tags: Curr Clin Pharmacol Source Type: research

Efficacy and Safety Curcuma zadoaria L. to inactivate the hydatid cyst protoscoleces.
Abstract Now, surgery is considered as the most reliable method for hydatid cyst treatment. Present protoscolicidal substances used in operating and percutaneous methods have restrictions because of the severe adverse effects for example biliary tract fibrosis, and liver necrosis. Thus, the present work aimed to evaluate the chemical composition of Curcuma zadoaria essential oil and investigate its efficacy and safety against hydatid cyst protoscoleces. Collected protoscoleces from liver fertile hydatid cysts of infected sheep were exposed to different concentrations of the essential oil (35-280 µl/mL) for 5...
Source: Current Clinical Pharmacology - September 18, 2019 Category: Drugs & Pharmacology Authors: Mahmoudvand H, Pakravanan M, Kheirandish F, Jahanbakhsh S, Sepahvand M, Niazi M, Rouientan A, Aflatoonian MR Tags: Curr Clin Pharmacol Source Type: research

Mitochondrial and oxidative impacts of short and long-term administration of HAART on HIV patients.
Abstract BACKGROUND AND OBJECTIVE: There may be possible association among use of HAART, oxidative stress and mitochondrial functions in HIV patients. We evaluated the mitochondrial and oxidative impacts of short and long-term administration of HAART on HIV patients attending the Enugu State University Teaching (ESUT) Hospital, Parklane, Enugu, Nigeria following short and long-term therapy. METHODS: 96 patients categorized into four groups of 24 individuals were recruited for the study. Group 1 comprised age-matched, apparently healthy, sero-negative individuals (the No HIV group); group 2 consisted of HIV se...
Source: Current Clinical Pharmacology - September 5, 2019 Category: Drugs & Pharmacology Authors: Ikekpeazu JE, Orji OC, Uchendu IK, Ezeanyika LUS Tags: Curr Clin Pharmacol Source Type: research

Awareness and perception of thromboembolism and thromboprophylaxis among hospitalized patients in Jordan.
CONCLUSION: The findings reveal that there is a lack of awareness about VTE and its thromboprophylaxis among the study participants. Patients with lower educational level and those with no history of previous VTE need awareness improvement about VTE and its thromboprophylaxis. Clinical Pharmacists need to focus on providing information about VTE and improving patients' perception about VTE and its thromboprophylaxis with the aim of improving the awareness about VTE, and hence improve health outcome. PMID: 31441731 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 23, 2019 Category: Drugs & Pharmacology Authors: Jarab A, Al-Azzam S, Badaineh R, Mukattash T, Bsoul R Tags: Curr Clin Pharmacol Source Type: research

The New Immunotherapy Combinations in the Treatment of Advanced Non-Small Cell Lung Cancer: Reality and Perspectives.
CONCLUSION: Nivolumab plus ipilimumab represent the most promising immunotherapy combination for the treatment of advanced NSCLC patients; safety, tolerability and efficacy of new immune modulators (in monotherapy and in immune combinations) must be further assessed in future studies. PMID: 31400270 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 9, 2019 Category: Drugs & Pharmacology Authors: Rocco D, Gravara LD, Gridelli C Tags: Curr Clin Pharmacol Source Type: research

Cadazolid vs Vancomycin for Treatment of Clostridioides difficile Infection: Systematic Review with Meta-Analysis.
CONCLUSION: Cadazolid is non-inferior to vancomycin and offers a promising alternative for the treatment of CDI. PMID: 31376824 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 2, 2019 Category: Drugs & Pharmacology Authors: Aziz M, Simcha W, Fatima R, Rajani S, Eid A, Nawras A Tags: Curr Clin Pharmacol Source Type: research

A review of the role of statins in heart failure treatment.
Abstract Heart failure is a common medical problem in the world, which has a high prevalence in both developed and developing countries. Today, among the medications used for the heart failure treatment, there are many medications with a positive cardiac contraction effect (positive inotropic such as digital glycosides, adrenergic receptor stimulants, and phosphodiesterase inhibitors), a large number of cardiac diluents (such as Angiotensin-converting enzyme (ACE) inhibitor group), and a few other types of drugs whose final effects are still under review Statins are valuable drugs that are broadly prescribed in hy...
Source: Current Clinical Pharmacology - August 2, 2019 Category: Drugs & Pharmacology Authors: Niazi M, Galehdar N, Jamshidi M, Mohammadi R, Moayyedkazemi A Tags: Curr Clin Pharmacol Source Type: research

Oral and intranasal administration of nanoparticles in the cerebral ischemia treatment; Considering the advantages and disadvantages.
CONCLUSION: Despite the limitations of oral and intranasal routes, the therapeutic potential of oral and intranasal administration of Nano-medicines is high in cerebral ischemia treatment. PMID: 31272358 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - July 4, 2019 Category: Drugs & Pharmacology Authors: Alavian F, Shams N Tags: Curr Clin Pharmacol Source Type: research

Comparison of the mean minimum dose of bolus oxytocin for proper uterine contraction during cesarean section.
CONCLUSION: Since the minimum effective dose of oxytocin in elective cesarean section was 1IU, and in those in labor progress was 1-1.5IU, less oxytocin administration represent a lesser side effect for the patients. It is recommended that patients who are candidates for cesarean section should be administered with about 1.5IU of oxytocin in the form of bolus. PMID: 31124424 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - May 23, 2019 Category: Drugs & Pharmacology Authors: Beiranvand S, Karimi A, Vahabi S, Amin-Bidokhti A Tags: Curr Clin Pharmacol Source Type: research

Melatonin modulates regulation of NOX2 and NOX4 following irradiation in the lung.
CONCLUSION: It is possible that upregulation of NOX2 and NOX4 are involved in radiation-induced targeted and non-targeted lung injury. Melatonin may reduce oxidative stress following upregulation of these enzymes in direct irradiated lung tissues but not for bystander. PMID: 31057124 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - May 2, 2019 Category: Drugs & Pharmacology Authors: Najafi M, Shirazi A, Motevaseli E, Geraily G, Amini P, Tooli LF, Shabeeb D Tags: Curr Clin Pharmacol Source Type: research

Medication Management Issues in Old Age: A Call for Submissions to Current Clinical Pharmacology.
PMID: 30968764 [PubMed - in process] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - April 12, 2019 Category: Drugs & Pharmacology Authors: Mangoni AA, Bryant K, Jarmuzewska EA Tags: Curr Clin Pharmacol Source Type: research

Science-Based Ethnic Bridging in Drug Development; Review of Recent Precedence and Suggested Steps Forward.
CONCLUSIONS: Recent precedence reflected a pragmatic, descriptive approach of racial or ethnic bridging, apparently meeting current regulatory expectations, whilst not resulting in strict guidance to prescribers. Next steps: We recommend further work on defining the objectives of bridging studies, as well as criteria for their design and data analysis. Regarding the latter we recommend investigating the value of prospectively defined tests for similarity with appropriate follow-up analysis in the case where the test has failed. PMID: 30961506 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - April 8, 2019 Category: Drugs & Pharmacology Authors: van Hoogdalem EJ, Jones JP, Constant J, Achira M Tags: Curr Clin Pharmacol Source Type: research

Concomitant use of Cotrimoxazole and Atazanavir in HIV-infected patients: A Therapeutic Drug Monitoring and Pharmacovigilance based dual approach.
CONCLUSION: This study showed a relevant concomitant use between Cotrimoxazole and ATV based on TDM and PV approaches. PMID: 30961507 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - April 5, 2019 Category: Drugs & Pharmacology Authors: Joe MB, Rolandc L, Laurentg C, Patrick LM, Sawoo O, Gastonf TL, Brunoe E, Gilles P, Philippe P Tags: Curr Clin Pharmacol Source Type: research

Surotomycin (a novel cyclic lipopeptide) vs Vancomycin for treatment of Clostridioides difficile infection: A systematic review and Meta-analysis.
Abstract BACKGROUND: Current guidelines recommend the use of vancomycin for the initial treatment of moderate to severe Clostridioides difficile infection (CDI). Surotomycin, a novel antibiotic, has been utilized for the management of CDI with variable results. METHODS: A systematic literature search was performed using the following electronic databases [Medline, embase, google scholar and Cochrane] for eligible studies. Randomized controlled trials comparing Surotomycin with Vancomycin for the CDI treatment were included. Demographic variables and outcomes (CDI resolution, CDI recurrence, B1/NAP1/027-specif...
Source: Current Clinical Pharmacology - March 28, 2019 Category: Drugs & Pharmacology Authors: Aziz M, Desai M, Fatima R, Chandrasekar VT, Eid A, Jackson M, Sharma P Tags: Curr Clin Pharmacol Source Type: research