Trends of Clinical Trials for Drug Development in Rare Diseases.
CONCLUSION: This study revealed details of the three registries and bias among rare diseases in the number of the trials. This information could contribute to drug-repositioning and a broad range of rare disease studies. PMID: 29866013 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - June 3, 2018 Category: Drugs & Pharmacology Authors: Sakate R, Fukagawa A, Takagaki Y, Okura H, Matsuyama A Tags: Curr Clin Pharmacol Source Type: research

Pharmacokinetic and Pharmacodynamic Relationship of Blinatumomab in Patients With Non-Hodgkin Lymphoma.
CONCLUSION: B-lymphocyte depletion following blinatumomab infusion was exposure-dependent. Transient cytokine elevation increased with dose; it was less pronounced at low starting dose. Tumor response was a function of exposure, suggesting utility for the PK/PD relationship in dose selection for future studies, including NHL and other malignant settings. PMID: 29773068 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - May 17, 2018 Category: Drugs & Pharmacology Authors: Hijazi Y, Klinger M, Kratzer A, Wu B, Baeuerle PA, Kufer P, Wolf A, Nagorsen D, Zhu M Tags: Curr Clin Pharmacol Source Type: research

Analysis of Toxicity Effects of Buspirone, Cetirizine and Olanzapine on Human Blood Lymphocytes: in Vitro Model.
Abstract The current study investigates the cytotoxicity mechanism of common drugs with piperazine ring such as cetirizine, olanzapine and buspirone on human lymphocytes. The viability of lymphocytes, reactive oxygen species (ROS) formation, mitochondrial membrane potential (MMP) collapse, lysosomal integrity, content of glutathione and lipid peroxidation were determined. Buspirone and cetirizine showed more toxicity than olanzapine on human lymphocytes with an IC50 value of 200 μg/ml, after 6 h of incubation. Significant ROS formation, MMP collapse, lipid peroxidation, lysosomal damage and elevation of glutath...
Source: Current Clinical Pharmacology - May 15, 2018 Category: Drugs & Pharmacology Authors: Pourahmad J, Salimi A, Razian M Tags: Curr Clin Pharmacol Source Type: research

The effect of tranexamic acid on preventing post-partum hemorrhage due to uterine atony: a triple-blind randomized clinical trial.
CONCLUSION: The results of the present study showed that administrating intravenous TXA had comparable effects with prostaglandin analogue on reducing PPH in women with uterine atony and in those undergoing C section or vaginal delivery. Therefore, TXA can be used instead of prostaglandin in managing such patients. PMID: 29732978 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - May 6, 2018 Category: Drugs & Pharmacology Authors: Zargar M, Nikbakht R, Ahmadi M Tags: Curr Clin Pharmacol Source Type: research

Targeting Brain Tumors with Nanomedicines: Overcoming Challenges of Blood Brain Barrier.
Abstract This review elucidates ongoing research, which show improved delivery of anticancer drugs alone and/ or enclosed in carriers collectively called nanomedicines to cross the Blood brain barrier (BBB) / blood-brain tumor barrier (BTB) to kill tumor cells and impact patient survival. We highlighted various advances in understanding the mechanism of BTB function that impact on anticancer therapeutics delivery. We discussed latest breakthroughs in developing pharmaceutical strategies, including nanomedicines and delivering them across BTB for brain tumor management and treatment. We highlight various studies on...
Source: Current Clinical Pharmacology - April 12, 2018 Category: Drugs & Pharmacology Authors: Ningaraj NS, Reddy PL, Khaitan D Tags: Curr Clin Pharmacol Source Type: research

Phase IV Studies: Some Insights, Clarifications, And Issues.
CONCLUSIONS: Critical remarks are raised against the pure commercial perspective in the proposal of PASS and PAES and on the design of registries which should be mainly based on the objectives and the planned analyses, as it has reported in the study protocol. Finally, a particular focus is also placed on the work of the Ethical Committees regarding the approval of the observational studies on the safety and the efficacy of the drugs in their pragmatic clinical use. PMID: 29651962 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - April 12, 2018 Category: Drugs & Pharmacology Authors: Biganzoli EM, Cesana BM Tags: Curr Clin Pharmacol Source Type: research

Lupus Nephritis: A Treatment Update.
CONCLUSION: Lupus nephritis which does not respond to initial treatment is associated with worse renal outcomes. Several therapeutic approaches are available for the induction and maintenance immunosuppression of the different classes of LN. Management of LN should be individualized for each patient based on their risk-benefit profile. PMID: 29611488 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - April 3, 2018 Category: Drugs & Pharmacology Authors: Aziz F, Chaudhary K Tags: Curr Clin Pharmacol Source Type: research

Hepatic Elimination of Drugs in Gestational Diabetes.
CONCLUSION: Considering the frequency of the disease and the effects that these pharmacokinetic changes might have on the mother and child, the need for further research seems advisable. In the meantime, cautious clinical judgment in the management of drug administration in women affected by this disease is recommended. PMID: 29577863 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 25, 2018 Category: Drugs & Pharmacology Authors: Gonzalez CD, Alvarinas J, Bolanos R, Di Girolamo G Tags: Curr Clin Pharmacol Source Type: research

Formulation of herbal fast disintegrating tablets and its ex-vivo study for anti-histaminic activity in guinea pig ileum.
CONCLUSION: On the basis of in-vitro and ex-vivo studies, it was concluded that prepared herbal fast disintegrating tablets were stable and had potent antihistaminic activity. PMID: 29521214 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 9, 2018 Category: Drugs & Pharmacology Authors: Puri D, Bhandari A, Gaur PK, Yasir M, Kumar SS, Choudhary D Tags: Curr Clin Pharmacol Source Type: research

Knowledge, attitudes, and practices of pharmacovigilance and ADRs spontaneous reporting among pediatricians and pediatric residents in Jordan.
CONCLUSION: The results of the present study reveals that pediatricians lack knowledge of PV and ADRs reporting. However, they have a good attitude towards ADRs reporting and enhancing their PV practice. This is still not reflected in their own practice. Further training and education about ADRs reporting is very important to move toward safer medications in children. PMID: 29521246 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 8, 2018 Category: Drugs & Pharmacology Authors: Mukattash TL, Alwadi MW, Abu-Farha RK, Jarab A, Alzubiedi SA, Alwedyan T Tags: Curr Clin Pharmacol Source Type: research

Determination of parameters of oxidative stress in vitro models of neurodegenerative diseases-A review.
Abstract Oxidative stress is a major mechanism underlying the development of various neurodegenerative diseases (Alzheimer, Parkinson, Huntington and amyotrophic lateral sclerosis). Excessive formation of reactive oxygen species (ROS) and nitrogen (RNSs) can overburden the ability of the enzymatic antioxidant defense mechanisms (superoxide dismutase, catalase and glutathione reductase) and non-enzymatic (uric acid, ascorbic acid, α-tocopherol and reduced glutathione) causing the development of oxidative stress and consequently impairing the neuronal system cells by means of oxidative damage to a variety of i...
Source: Current Clinical Pharmacology - February 28, 2018 Category: Drugs & Pharmacology Authors: Feitosa CM Tags: Curr Clin Pharmacol Source Type: research

More Evidence For The Therapeutic Role Of Dopamine Agonists In Upper Limb Restlessness Due To Cervical Disc Pathology?
Abstract BACKGROUND: The causal link between upper limb restlessness and cervical disc prolapsus is still unclear, and the exact role of the spinal cord in the origination of limb restlessness is not yet completely understood. METHODS: Here we have evaluated the therapeutic effect of pramipexole (0.5 mg/kg) in a 47-year old male with cervical disc prolapsus who described restlessness in his upper limb and neck. RESULTS: The patient felt significantly better, and his symptoms improved near to complete after five days after we have initiated 0.5 mg/day pramipexole treatment. Conclussion: In our present pap...
Source: Current Clinical Pharmacology - February 27, 2018 Category: Drugs & Pharmacology Authors: Yulug B, Brandmeier S, Hanoglu L Tags: Curr Clin Pharmacol Source Type: research

Minocycline in alcohol withdrawal induced anxiety and alcohol relapse in rats.
Abstract INTRODUCTION: Anxiety and negative sensations due to alcohol withdrawal are factors leading to alcohol relapse and addiction. Minocycline, an antibiotic, can decrease alcohol consumption in rats, however, its effects on alcohol withdrawal anxiety and relapse have not been studied. MATERIAL AND METHODS: Part 1: Forced alcohol drinking in gradually increasing concentration was administered till day 22 in rats. Effect of drugs on anxiety was assessed using elevated plus maze (EPM) and two chambered box apparatus, after removal of alcohol. Part 2: For relapse, an alcohol deprivation effect model was used...
Source: Current Clinical Pharmacology - February 27, 2018 Category: Drugs & Pharmacology Authors: Gajbhiye SV, Tripathi RK, Petare AU, Potey AV, Shankar A Tags: Curr Clin Pharmacol Source Type: research

An Evidence-Based Review of Off-Label Uses of Polidocanol.
CONCLUSION: Numerous successful administrations of this drug in a variety of clinical conditions lead to promising perspectives toward it. Sclerotherapy with polidocanol as a minimal-invasive method (having similar outcomes like the prevalent surgeries) may reduce the rate of complications. Furthermore, for determining the most appropriate method and dosage, randomized clinical trials are needed, confirming and providing more clear instructions for different conditions. PMID: 29473522 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 23, 2018 Category: Drugs & Pharmacology Authors: Babaei H, Enamzadeh E Tags: Curr Clin Pharmacol Source Type: research

Drug-induced QT Interval prolongation in the Intensive Care Unit.
Abstract Drug-induced QT interval prolongation is the most frequent cause of Long QT syndrome (LQTS) in the clinical practice. This electrophysiological entity, produced by an extended duration of the myocardial repolarization and reflected as a prolonged QT interval in the superficial electrocardiogram (EKG), increases the risk of polymorphic ventricular tachycardia (Torsades de Pointes) appearance and sudden death. Certain antiarrhythmic drugs such as amiodarone, sotalol, quinidine, procainamide, verapamil and diltiazem are known as drugs that, due to their mechanism of action, prolong the QT interval, demanding...
Source: Current Clinical Pharmacology - February 23, 2018 Category: Drugs & Pharmacology Authors: Etchegoyen CV, Keller GA, Mrad S, Cheng S, DiGirolamo G Tags: Curr Clin Pharmacol Source Type: research

Pharmacogenetics of Glucagon-like Peptide-1 agonists for the treatment of Type 2 Diabetes Mellitus.
CONCLUSION: Although the exact DNA sequences that cause the molecular changes leading to a variable response to GLP-1 agonists have not been yet fully identified, these findings underline the importance of an individualized approach in anti-diabetic treatment. PMID: 29473524 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 21, 2018 Category: Drugs & Pharmacology Authors: Karras S, Rapti E, Koufakis T, Kyriazou A, Goulis D, Kotsa K Tags: Curr Clin Pharmacol Source Type: research

Strategies empowering paediatric drug safety.
Conclusion Together, these methods provide a comprehensive picture of causality and risk improving the management of therapy in a paediatric setting and they should be considered as a unique tool to be integrate with post-marketing activities. PMID: 29412117 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 6, 2018 Category: Drugs & Pharmacology Authors: Gentili M, Pozzi M, Peeters G, Radice S, Carnovale C Tags: Curr Clin Pharmacol Source Type: research

Evaluation of the Antiproliferative Activity of Some Nanoparticulate Essential Oils Formulated in Microemulsion on Selected Human Carcinoma Cell Lines.
CONCLUSION: Some EOs and their microemulsions can potentially be used as natural adjuvant to cancer drugs. PMID: 29318975 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - January 10, 2018 Category: Drugs & Pharmacology Authors: Abd-Rabou A, Edris AE Tags: Curr Clin Pharmacol Source Type: research

Curcuminoids plus piperine modulate adipokines in type 2 diabetes mellitus.
Abstract OBJECTIVE: Curcumin is a naturally occurring polyphenol derived from tumeric that has been reported to have anti-inflammatory properties with effects on adipokine and ghrelin levels. Adiponectin, leptin and ghrelin modulate energy homeostasis but each have modulatory effects on inflammatory cytokines and the immune system. Therefore this analysis was performed to investigate the effect of curcumin on adiponectin, leptin and ghrelin. METHODS: A double blind randomised control trial comparing curcumin 1000mg with 10mg of piperine daily to placebo over a 12 week period. 118 patients with type 2 diabetes...
Source: Current Clinical Pharmacology - January 3, 2018 Category: Drugs & Pharmacology Authors: Sahebkar A, Panahi Y, Khalili N, Sahebi E, Namazi S, Atkin SL, Majeed M Tags: Curr Clin Pharmacol Source Type: research

Comparison of Two Naloxone Regimens in Addicted Methadone-Overdosed Patients, a Clinical Trial Study.
Abstract BACKGROUND: Methadone toxicity is one of the major causes of death in opioid dependent individuals. OBJECTIVE: We aimed to compare two different protocols for naloxone in terms of reversal of overdose and frequency of complications in opioid-dependent methadone-intoxicated patients. METHODS: One-hundred opioid-dependent patients with signs/symptoms of methadone overdose were included. The patients were consecutively assigned into Tintinalli (group 1) or Goldfrank regimen protocol (group 2) of naloxone administration. Group 1 received naloxone with the dose 0.1 mg given every 2-3 minutes while gr...
Source: Current Clinical Pharmacology - December 11, 2017 Category: Drugs & Pharmacology Authors: Khosravi N, Zamani N, Hassanian-Moghaddam H, Ostadi A, Rahimi M, Kabir A Tags: Curr Clin Pharmacol Source Type: research

Perioperative Management of Hyperlipidemia Medications.
CONCLUSION: Clinicians must be familiar with the various lipid-lowering agents because it is very likely they will encounter such medications during preoperative visits. PMID: 29119935 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - November 7, 2017 Category: Drugs & Pharmacology Authors: Renew JR Tags: Curr Clin Pharmacol Source Type: research

Pharmacology and Perioperative Considerations of Pain Medications.
CONCLUSION: Management of postoperative pain is an important concern for all perioperative health care providers. Although most pain medications should be continued in the perioperative period, it is important to preoperatively discontinue those that antagonize pain receptors to avoid significant postoperative morbidities associated with poorly managed pain. PMID: 29076431 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - October 27, 2017 Category: Drugs & Pharmacology Authors: Chadha RM, Aniskevich S, Egan BJ Tags: Curr Clin Pharmacol Source Type: research

Perioperative Management of Female Hormone Medications.
CONCLUSION: Until additional studies are performed, the risks and benefits must be weighed on an individual basis with consideration of prophylaxis when a decision is made to continue these medications in the perioperative period. Part of this decision making includes the risk of fetal harm in an unwanted pregnancy in preparation for nonobstetric surgery versus an increased risk of venous thromboembolism. PMID: 28969534 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - September 26, 2017 Category: Drugs & Pharmacology Authors: Seim LA, Irizarry-Alvarado JM Tags: Curr Clin Pharmacol Source Type: research

Pharmacologic and Perioperative Considerations for Antihypertensive Medications.
CONCLUSION: Current evidence supports the perioperative continuation of b-blockers, calcium-channel blockers, and a-2 agonists. However, diuretics should be discontinued on the day of the surgery and resumed in the postoperative period. Debates persist about the continuation of renin-angiotensin-aldosterone system inhibitors. PMID: 28925860 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - September 18, 2017 Category: Drugs & Pharmacology Authors: Pai SL, Chadha RM, Alvarado JMI, Renew JR, Aniskevich S Tags: Curr Clin Pharmacol Source Type: research

Perioperative Pulmonary Medication Management.
CONCLUSION: Patients with chronic pulmonary conditions have risk of perioperative complications. Their pulmonary treatment regimens should be maintained in the perioperative period to reduce the risk of such complications. PMID: 28925861 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - September 18, 2017 Category: Drugs & Pharmacology Authors: Renew JR, Aniskevich S Tags: Curr Clin Pharmacol Source Type: research

Perioperative Considerations of Herbal Medications.
CONCLUSION: The management of herbals and supplements is an issue for the anesthesiologist. Although it would be prudent to stop use of most substances a week or more preoperatively, the perioperative physician must be wary of the potential for withdrawal. PMID: 28914190 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - September 13, 2017 Category: Drugs & Pharmacology Authors: Chadha RM, Egan BJ Tags: Curr Clin Pharmacol Source Type: research

Pharmacologic Considerations during the Preoperative Evaluation of Neurologic Patients.
CONCLUSION: The systemic inflammation that occurs in the perioperative period is detrimental to a patient's neurologic status. It is important to recognize that the proper management of neurologic medications can limit the negative effects of these stresses on a patient. Most medications appear safe to continue until the morning of surgery. Consultation of a neurologist regarding continuation of specific medications may be necessary to ensure patient safety. PMID: 28847275 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 28, 2017 Category: Drugs & Pharmacology Authors: Mabry C Tags: Curr Clin Pharmacol Source Type: research

Perioperative Management of Beta Blockers and Other Antiarrhythmic Medications.
CONCLUSION: Continuation of antiarrhythmic medications is safe perioperatively. However, initiation of beta blockers should be patient-tailored and titrated to a target heart rate in advance of surgery. PMID: 28847276 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 28, 2017 Category: Drugs & Pharmacology Authors: Irizarry-Alvarado JM Tags: Curr Clin Pharmacol Source Type: research

Evaluating Scientific Research Knowledge and Attitude among Medical Representative in Jordan: A Cross-sectional Survey.
CONCLUSION: The majority of medical representatives had positive attitudes towards clinical trials and research communication and found that it will increase the value of their work, but still there is a gap in their frequency of detailing. Thus, local pharmaceutical companies need to invest more in research and clinical trials knowledge kind of training. Also, universities need to include research related courses and subject in their bachelors' program curriculum in order to make pharmacists equipped in terms of research knowledge, regardless of the career path they choose. PMID: 28847277 [PubMed - as supplied by pub...
Source: Current Clinical Pharmacology - August 28, 2017 Category: Drugs & Pharmacology Authors: Mukattash T, Alattar M, Farha RA, Alsous M, Jarab A, El-Hajii F, Mukattash IL Tags: Curr Clin Pharmacol Source Type: research

Pharmacology and Perioperative Considerations for Psychiatric Medications.
CONCLUSION: Psychotropic medications can be broadly divided into classes, which include antidepressants, antipsychotics, anxiolytics, mood stabilizers, and stimulants. Although most evidence suggests the continuation of these medications in the perioperative period, it is still important to determine how psychotropic medications interact with routinely used anesthetic agents and which medications should be continued and which should not on an individualized basis for each patient. PMID: 28831913 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 23, 2017 Category: Drugs & Pharmacology Authors: Sadana N, Joshi GP Tags: Curr Clin Pharmacol Source Type: research

Perioperative Management of Anticoagulants.
CONCLUSION: Perioperative healthcare providers need to balance risks and benefits of anticoagulant therapy with its interruption preoperatively. PMID: 28828987 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 21, 2017 Category: Drugs & Pharmacology Authors: Irizarry-Alvarado JM, Seim LA Tags: Curr Clin Pharmacol Source Type: research

Pharmacology and Perioperative Considerations for Diabetes Mellitus Medications.
CONCLUSION: Perioperative control of blood glucose levels is associated with less morbidity and improved surgical outcomes in patients with and without DM. Preoperatively, clinicians need to thoughtfully adjust diabetic medications on the basis of patient comorbidities, the duration of the fasting period, and the duration of surgery. Intraoperative and postoperative strategies typically use insulin to maintain blood glucose levels in the range of 80 to 180 mg/dL. PMID: 28799484 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 10, 2017 Category: Drugs & Pharmacology Authors: Aniskevich S, Renew JR, Chadha RM, Irizarry-Alvarado JM Tags: Curr Clin Pharmacol Source Type: research

Monoclonal Antibodies: A Review.
Abstract Over the last three decades, monoclonal antibodies (MAbs) have made a striking transformation from scientific tools to powerful human therapeutics. Muromonab CD3 a murine MAb, was first FDA approved therapeutic MAb for prevention of kidney transplant rejection. Since its approval in 1986, there has been decline in the further application and approvals until the late 1990s when the first chimeric Mab, Rituximab was approved for the treatment of low grade B cell lymphoma in 1997. With the approval by licensing authorities of chimeric, followed by humanized and then fully human monoclonal antibodies, rate o...
Source: Current Clinical Pharmacology - August 9, 2017 Category: Drugs & Pharmacology Authors: Singh S, Kumar N, Dwiwedi P, Charan J, Kaur R, Sidhu P, Chugh VK Tags: Curr Clin Pharmacol Source Type: research

The Role of N-acetylcysteine in Platelet Aggregation and Reperfusion Injury in Recent Years.
CONCLUSION: Due to the limited data about effectiveness of NAC in both human and animal as antiplatelet agent, more investigation is needed to evaluate NAC efficacy in platelet aggregation and reperfusion injury especially in human studies in the future. PMID: 28676007 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - July 4, 2017 Category: Drugs & Pharmacology Authors: Nikbakht M, Ahmadi F, Vaseghi G, Talasaz AH, Eshraghi A, Naderi J, Daneshmehr MA Tags: Curr Clin Pharmacol Source Type: research

Repurposing Pharmaceuticals as Neuroprotective Agents for Cerebral Malaria.
CONCLUSION: The findings of this review highlight recently licensed pharmaceuticals that may developed as future adjunctive therapies for CM. PMID: 28676008 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - July 4, 2017 Category: Drugs & Pharmacology Authors: Brooks HM, Hawkes MT Tags: Curr Clin Pharmacol Source Type: research

Aging eye microbiota in Dry Eye Syndrome in patients treated with Enterococcus faecium and Saccharomyces boulardii.
ri CG Abstract Aging seem to have a key role in the onset and progression of ocular surface diseases. Dry Eye Syndrome (DES) is a multifactorial disease of the tears and ocular surface in which symptoms may interfere with the ability to work and carry out daily functions. METHODS: This clinical trial was a pilot study to evaluate the effects of supplementation with mixture (MYA796 and Enterococcus faecium SGEf01) on the tear film. Following the run-in period subjects were randomized in two groups: group A (n.30 subjects) and group B (n.30 subjects). Group A (control) treated only with substitute tear and grou...
Source: Current Clinical Pharmacology - July 4, 2017 Category: Drugs & Pharmacology Authors: Chisari G, Chisari EM, Borzì AM, Ozyalcin E, Chisari CG Tags: Curr Clin Pharmacol Source Type: research

EDITORIAL: Spicing Up the Management of Type 2 Diabetes with Cinnamon.
PMID: 28629313 [PubMed - in process] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - June 22, 2017 Category: Drugs & Pharmacology Authors: Mangoni AA, Jarmuzewska EA Tags: Curr Clin Pharmacol Source Type: research

The anti-migraine effects of M2000 ( β-D-mannuronic acid) on a patient with rheumatoid arthritis; as a case report.
CONCLUSION: A significant improvement was seen after 12 weeks of M2000 therapy in both rheumatoid arthritis and migraine which are considered as inflammatory diseases. Therefore, it might be concluded that M2000 as a novel non-steroidal anti-inflammatory drugs (NSAIDs) with immunosuppressive property is able to treat migraine in addition to its potent efficacy on treatment of rheumatoid arthritis. PMID: 28578645 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - June 4, 2017 Category: Drugs & Pharmacology Authors: Vojdanian M, Ahmadi H, Jamshidi AR, Mahmoudi M, Gharibdoost F, Barati A, Mirshafiey A Tags: Curr Clin Pharmacol Source Type: research

Clonidine, but not Dexamethasone, Prolongs Ropivacaine-Induced Supraclavicular Brachial Plexus Nerve Block Duration.
CONCLUSION: The results demonstrated that clonidine significantly prolongs the duration of ropivacaine effects for the postoperative analgesia in patient underwent upper arm surgeries. PMID: 28578646 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - June 4, 2017 Category: Drugs & Pharmacology Authors: Nasir D, Gasanova I, Drummond S, Alexander J, Howard J, Melikman E, Hill G, Minhajuddin A, Ogunnaike B, Whitten C Tags: Curr Clin Pharmacol Source Type: research

Safety and Toxicological Considerations of Nanomedicines: The Future Directions.
Abstract Nanomedicine, an emerging nanotechnology, imparts special biological features due to their quantum size and is a promising candidate for targeted drug delivery. At present, in spite of its novel applications in medical sciences, certain existing gaps still needs to be addressed such as fate of nanoparticles and its toxicity assessment on human health. Behaviour of the entities post human body exposure and its deposition up to certain extent are some of the crucial factors to be considered for a successful treatment approach. Also, safety evaluation applicable for nanomedicine would be drastically differen...
Source: Current Clinical Pharmacology - May 9, 2017 Category: Drugs & Pharmacology Authors: Patel P, Shah J Tags: Curr Clin Pharmacol Source Type: research

Effect of crocin on antibody titers to heat-shock protein 27 in subjects with metabolic syndrome.
CONCLUSION: Findings of this study did not suggest a significant effect of crocin on serum anti-hsp27 titers in subjects with MetS, but this needs further confirmation in larger-scale trials. PMID: 28486907 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - May 9, 2017 Category: Drugs & Pharmacology Authors: Nosrati M, Nikbakht-Jam I, Eslami S, Khademi M, Foroutan-Tanha M, Hadizadeh F, Hosein Sahebkar A, Tavallaie S, Taherzadeh Z, Ghayour-Mobarhan M, A A Ferns G Tags: Curr Clin Pharmacol Source Type: research

The Journey of the Non-Vascular Relief for Migraine: From 'Triptans' To 'ditans'.
Abstract Migraine is a recurrent, disabling, complex and highly prevalent neurological disorder. The mystery behind the cause of migraine is continuously evolving, according to the scientific understanding of the disease. This growing understanding helps to identify novel therapeutic targets for the management of migraine to treat the ailing migraineurs. The role of serotonin (5HT) in migraine is recognized to be the cornerstone for the currently available therapeutic options namely ergot alkaloids and triptans. The role of mediators such as Calcitonin Gene-Related Peptide (CGRP), nitric oxide and excitatory neuro...
Source: Current Clinical Pharmacology - April 19, 2017 Category: Drugs & Pharmacology Authors: Xavier AS, Lakshmanan M, Gunaseelan V Tags: Curr Clin Pharmacol Source Type: research

Levetiracetam in compare to Sodium Valproate for prophylaxis in Chronic Migraine Headache: A Randomized Double-blind Clinical Trial.
Abstract BACKGROUND: Migraine is not curable, but preventive treatments are usually used to decrease the intensity and frequency of headache attacks. Different therapeutic options are widely studied for chronic migraine (CM), but all of them have different inefficacy. OBJECTIVE: The aim of this study was to compare the efficacy of levetiracetam versus sodium valproate in the treatment of CM. METHODS: A randomized controlled clinical trial was conducted on 62 patients with chronic migraine (30 patients in intervention group-treated with levetiracetam and 32 patients in control group- treated with sodium v...
Source: Current Clinical Pharmacology - March 28, 2017 Category: Drugs & Pharmacology Authors: Kashipazha D, Ghadikolaei HS, Siavashi M Tags: Curr Clin Pharmacol Source Type: research

Pediatric off-label and unlicensed drug use and its implications.
CONCLUSIONS: Given the prevalence of unlicensed and off-label drug use, the cooperation of various stakeholders including health professionals, pediatric population and their parents/caregivers, regulatory authorities, and the pharmaceutical industry is integral to instituting individual measures to avoid exposing children to unnecessary risks and avoid depriving them of potentially effective pharmacotherapy. Initiatives to encourage clinical trials for licensing drug use in children by providing market exclusivity and patent extension could aid in bridging the gap between approval and contemporary drug prescribing practic...
Source: Current Clinical Pharmacology - March 17, 2017 Category: Drugs & Pharmacology Authors: Gore R, Chugh PK, Tripathi CD, Lhamo Y, Gautam S Tags: Curr Clin Pharmacol Source Type: research

Dutasteride in androgenetic alopecia: An update.
CONCLUSION: Like finasteride, dutasteride is now becoming popular treatment option in AGA, due to its good response shown by various randomized control studies and meta-analysis. Also, in most of these studies dutasteride found to be better than finasteride with comparable adverse effect. Therefore, dutasteride could become a treatment of choice for AGA in near future. PMID: 28294070 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 9, 2017 Category: Drugs & Pharmacology Authors: Arif T, Dorjay K, Adil M, Sami M Tags: Curr Clin Pharmacol Source Type: research

Potential Usefulness of Clopidogrel Pharmacogenetics in Cerebral Endovascular Procedures and Carotid Artery Stenting.
CONCLUSION: Studies assessing the influence of CYP2C19 polymorphisms on high on-treatment platelet reactivity in CAS and cerebrovascular disease patients are still limited and need further validation in large multicenter studies. This review covers an important topic in the field of antiplatelet therapy for cerebral endovascular procedures and CAS. PMID: 28245774 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 26, 2017 Category: Drugs & Pharmacology Authors: Duconge J, Hernandez-Suarez DF Tags: Curr Clin Pharmacol Source Type: research

Effect of Cinnamomum cassia on the Pharmacokinetics and Pharmacodynamics of Pioglitazone.
CONCLUSION: Cinnamon enhanced the bioavailability of pioglitazone by inhibiting the CYP3A4 enzyme. Hence, cinnamon might be beneficial when used in combination with pioglitazone in diabetic patients and an adjustment of dose of pioglitazone may be necessary. PMID: 28176623 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 6, 2017 Category: Drugs & Pharmacology Authors: Mamindla S, Koganti P, Ravouru N, Koganti B Tags: Curr Clin Pharmacol Source Type: research

Interaction of antipsychotic drugs with sucrase; kinetics and structural study.
In this study, the interaction between trifluoperazine and haloperidol as antipsychotic drugs on oral drug yeast sucrase was investigated. The results showed that both drugs could reduce sucrase activity and decrease the Vmax of the enzyme by non-competitive inhibition. The IC50 and Ki values of the drugs were determined to be 0.7 and 0.068 mM and 0.45 and 0.063 mM for haloperidol and trifluoperazine, respectively. The results suggested that trifluoperazine binds to the enzyme with higher affinity than haloperidol. Fluorescence measurement was used for conformational investigations of the drugs and sucrase interaction. It ...
Source: Current Clinical Pharmacology - January 17, 2017 Category: Drugs & Pharmacology Authors: Jafari N, Dehganpour H, Ghavanini N, Mollasalehi H, Minai-Tehrani D Tags: Curr Clin Pharmacol Source Type: research

Therapeutic approaches blocking glycan synthesis as targeting strategy for malaria.
Abstract Malaria annually infected million people around the world, especially in subtropical and tropical regions in the world. Thereby, the research effort is focused on new therapeutic targets to strike malaria, as drug resistance is one of the greatest challenges in malaria eradication. Carbohydrate recognition in Plasmodium-host interactions is one area for potential targets against disease. The glycan derivatives interfere with replication and invasion of Plasmodium falciparum. Sulfated glycosaminoglycans (GAGs) are known to block merozoite and sporozoite invasion. Heparin is a GAG that has been shown blocki...
Source: Current Clinical Pharmacology - December 19, 2016 Category: Drugs & Pharmacology Authors: Gomes PS, Morrot A Tags: Curr Clin Pharmacol Source Type: research

The combination of new immunotherapy and radiotherapy: A new potential treatment for locally advanced non-small cell lung cancer.
Abstract Lung cancer is the main reason of cancer death worldwide. About 30% of non-small-cell lung cancer (NSCLC) cases are diagnosed with locally advanced disease (stage III). This is a mixed population including patients who have far more extensive and bulky disease than others. Management of these patients continue to be a challenge; frequently, patients have both local recurrence and distant metastases in this stage and the prognosis is very poor with a 5-year overall survival estimated between 3% and 7% for inoperable disease. The standard treatment for these patients is concurrent chemo-radiotherapy (CRT) i...
Source: Current Clinical Pharmacology - November 30, 2016 Category: Drugs & Pharmacology Authors: Sacco PC, Maione P, Guida C, Gridelli C Tags: Curr Clin Pharmacol Source Type: research