Comparison of efficacy of remifentanil, sufentanil and alfentanil with fentanyl when combined with propofol for general anesthesia: A systematic review and meta-analysis of randomized controlled trials.
CONCLUSION: To conclude, we found that remifentanil has a statistically significant anesthetic profile than fentanyl when combined with propofol. Scanty evidence for both alfentanil and sufentanil precludes any such confirmation. PMID: 30868958 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 13, 2019 Category: Drugs & Pharmacology Authors: Sridharan K, Sivaramakrishnan G Tags: Curr Clin Pharmacol Source Type: research

A Comprehensive Review On the Screening Models for The Pharmacological Assessment of Antiulcer Drugs.
CONCLUSION: On the basis of our study, we found some useful models for the antiulcer activity of drugs and we suggest that if we use In-vitro and In-vivo methods together, then, we get the most relevant result in our research area. PMID: 30864527 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 12, 2019 Category: Drugs & Pharmacology Authors: Mishra AP, Bajpai A, Chandra S Tags: Curr Clin Pharmacol Source Type: research

Investigation of the roles of new antiepileptic drugs' and serum BDNF levels in efficacy and safety monitoring and quality of life: a clinical research.
kkan AG Abstract OBJECTIVE: We aimed to determine the therapeutic drug monitoring (TDM) features and the relation to brain-derived neurotropic factor (BDNF) of frequently used new antiepileptic drugs (NAD) including lamotrigine (LTG), oxcarbazepine (OXC), zonisamide (ZNS) and lacosamide (LCM). Moreover, we investigated their effect on the quality of life (QoL). METHODS: Eighty epileptic patients who had been using the NAD, thirteen healthy participants were included in this cross-sectional study. The participants were randomized to groups. The QOLIE-31 test was used for the assessment of QoL. We also prepared...
Source: Current Clinical Pharmacology - March 12, 2019 Category: Drugs & Pharmacology Authors: Demir M, Akarsu EO, Dede HÖ, Bebek N, Yıldız SÖ, Baykan B, Akkan AG Tags: Curr Clin Pharmacol Source Type: research

Azithromycin-induced aphthous stomatitis: a case series.
CONCLUSION: It could be stated that aphthous stomatitis is an important adverse effect of azithromycin that can affect the patient's quality of life during therapy and in the majority of cases, it can be neglected by healthcare practitioners. PMID: 30827258 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 1, 2019 Category: Drugs & Pharmacology Authors: Moghadam ET, Tafazoli A Tags: Curr Clin Pharmacol Source Type: research

Minocycline increases in-vitro cortical neuronal cell survival after laser induced axotomy.
Abstract Antibiotic therapies targeting multiple regenerative mechanisms have the potential for neuroprotective effects, but the diversity of experimental strategies and analyses of non-standardised therapeutic trials are challenging. In this respect, there are no cases of successful clinical application of such candidate molecules when it comes to human patients. To address this problem, we tested minocycline in an in-vitro model of laser-axotomy. Here, we have shown that minocycline exerted a significant neuroprotective effect at 1 and 100μM doses. Beyond confirming the neuroprotective effect of minocycline i...
Source: Current Clinical Pharmacology - February 25, 2019 Category: Drugs & Pharmacology Authors: Yulug B, Ozansoy M, Alokten M, Ozansoy MBC, Cankaya S, Hanoglu L, Kilic U, Kilic E Tags: Curr Clin Pharmacol Source Type: research

Impact of ondansetron on withdrawal signs, fentanyl requirement and pain relief in opioid addicted patients under general anesthesia.
CONCLUSION: This study demonstrated a few evidence for beneficial treatment of ondansetron for control of withdrawal symptoms and pain in addicted patients, and more clinical studies are suggested in this regard. PMID: 30706788 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - January 31, 2019 Category: Drugs & Pharmacology Authors: Mahikhan F, Hashemian M, Dehesh T, Jafari E, Jafari M, Rahimi HR Tags: Curr Clin Pharmacol Source Type: research

Drug-Induced Peripheral Neuropathy, a Narrative Review.
Abstract Peripheral neuropathy is a painful condition deriving from many and varied etiologies. Certain medications have been implicated in the iatrogenic development of drug induced peripheral neuropathy (DIPN) and include chemotherapeutic agents, antimicrobials, cardiovascular drugs, psychotropic, anticonvulsants, among others. In many cases, DIPN develops in a dose dependent fashion following continued use of a neurotoxic agent. The development of DIPN should be suspected in patients who are receiving drug treatment and report new onset symptoms of pain, paresthesia, or weakness. In patients in whom a history o...
Source: Current Clinical Pharmacology - January 21, 2019 Category: Drugs & Pharmacology Authors: Jones MR, Urits I, Wolf J, Corrigan D, Colburn L, Peterson E, Williamson A, Viswanath O Tags: Curr Clin Pharmacol Source Type: research

Efficacy and safety of Nilutamide in patients with metastatic prostate cancer who underwent orchiectomy: A systematic review and meta-analysis.
Abstract BACKGROUND: Prostate cancer is the sixth leading cause of death, among the death caused due to cancer. By 2030, the burden is expected an increase with 1.7 million new cases and 499,000 new deaths. We aimed to evaluate the efficacy and safety of Nilutamide in metastatic prostate cancer (mPCa) patients who underwent orchiectomy. METHODS: A comprehensive search was conducted in the Medline/PubMed and Cochrane Library. References from included studies and studies from clinicaltrials.gov were explored without language and date restrictions. We included only randomized controlled trials, comparing the saf...
Source: Current Clinical Pharmacology - January 12, 2019 Category: Drugs & Pharmacology Authors: Rashid M, Shamshavali K, Chhabra M Tags: Curr Clin Pharmacol Source Type: research

The Effect of methylphenidate on Reed Scaling in Benzodiazepine Poisoning, A Prospective Trial.
CONCLUSION: Our study provided the MPH superiority over PBO in reversing CNS symptoms in loss of consciousness in acute BZD poisoned patients. Thus, this trial provides concrete evidence that improvement in consciousness levels (Reed Scale rated) among those patients receiving MPH was associated with a methylphenidate use. PMID: 30648520 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - January 12, 2019 Category: Drugs & Pharmacology Authors: Latifi-Pour M, Hassanian-Moghaddam H, Mortazavi HS, Shadnia S, Zamani N, Rahimi M Tags: Curr Clin Pharmacol Source Type: research

The possibility of therapeutic drug monitoring of the most important interactions in nursing homes.
CONCLUSION: In this pilot study, therapeutic drug monitoring was possible in the majority of the most important interactions in Norwegian nursing homes. This is option is of importance since adjust dose or monitoring were frequently recommended actions associated with these interactions. PMID: 30585548 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - December 24, 2018 Category: Drugs & Pharmacology Authors: Schjøtt P, Šutovská M, Schjøtt J Tags: Curr Clin Pharmacol Source Type: research

Metformin And Pregnancy Outcomes: Evidence Gaps And Unanswered Questions.
CONCLUSIONS: It seems to have no sense to prolong the use of metformin after a pregnancy diagnosis in women with PCOS. Patients with GDM may be treated with metformin under on judicious basis, and a careful attachment to clinical guidelines and regulations is recommended. The long-term effects of pre-natal exposure to metformin on the offspring remain uncertain. PMID: 30585549 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - December 24, 2018 Category: Drugs & Pharmacology Authors: Gonzalez CD, Alvariñas J, Bagnes MFG, Di Girolamo G Tags: Curr Clin Pharmacol Source Type: research

Protective effect of Selenium-L-methionine on radiation-induced acute pneumonitis and lung fibrosis in rat.
CONCLUSION: Selenium-L-methionine can protect lung tissues against toxic effects of ionizing radiation. It is possible that modulation of immune responses and redox interactions are involved in the radioprotective effect of this agent. PMID: 30556505 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - December 13, 2018 Category: Drugs & Pharmacology Authors: Amini P, Kolivand S, Saffar H, Rezapoor S, Motevaseli E, Najafi M, Nouruzi F, Shabeeb D, Musa AE Tags: Curr Clin Pharmacol Source Type: research

Role of muscarinic acetylcholine receptors in Breast Cancer. Design of metronomic chemotherapy.
CONCLUSION: The usage of subthreshold concentrations of muscarinic agonists combined with conventional chemotherapeutic agents could be a promising tool for breast cancer therapy. PMID: 30501602 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - December 2, 2018 Category: Drugs & Pharmacology Authors: Sales ME, Español AJ, Salem AR, Martínez PP, Sanchez Y, Sanchez F Tags: Curr Clin Pharmacol Source Type: research

Pycnogenol Protects against Pentylenetetrazole-Induced Oxidative Stress and Seizures in Mice.
Abstract BACKGROUND: Epilepsy is one of the most common and severe brain disorders in the world, characterized by recurrent spontaneous seizures due to an imbalance between cerebral excitability and inhibition. Oxidative stress is a biochemical state in which reactive oxygen species are generated and associated with various diseases including epilepsy. Pycnogenol, a polyphenol obtained from the pine tree and has antioxidant& anti-inflammatory activity. So, The aim of the study was carried out to evaluate the effect of pycnogenol on pentylenetetrazole (PTZ)-induced seizures in mice. METHOD: The mice of swi...
Source: Current Clinical Pharmacology - November 21, 2018 Category: Drugs & Pharmacology Authors: Goel R, Saxena P Tags: Curr Clin Pharmacol Source Type: research

Rabbit as an Animal Model for Pharmacokinetics Studies of Enteric Capsule Contains Recombinant Human Keratinocyte Growth Factor-Loaded Chitosan Nanoparticles.
We report on chitosan nanoparticles (CNPs) with diameter
Source: Current Clinical Pharmacology - November 19, 2018 Category: Drugs & Pharmacology Authors: Kumar PV, Maki MAA, Wei YS, Tatt LM, Elumalai M, Cheah SC, Raghavan B, Majeed ABBA Tags: Curr Clin Pharmacol Source Type: research

The Ascent of Mineralocorticoid Receptor Antagonists in Diabetic Nephropathy.
Abstract Diabetic nephropathy (DN) is defined as a decline in the renal function and an increase in the amount of albuminuria (>300 mg/day). The well-established first-line drug therapies for DN include angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARBs) and the second line drug therapies include calcium channel blockers or diuretics. The interruption of the renin-angiotensin-aldosterone system (RAAS) by ACEi and ARBs has been beneficial in reducing the progression of renal diseases; however, there is an increase in the levels of aldosterone due to the aldosterone escape phen...
Source: Current Clinical Pharmacology - November 15, 2018 Category: Drugs & Pharmacology Authors: Goenka L, Padmanaban R, George M Tags: Curr Clin Pharmacol Source Type: research

Desensitization Of 5-Ht-1a Somatodentritic Receptors In Tryptophan Treated And Co-Treated Rats Induced By Methylphenidate.
CONCLUSION: Present study suggests the potential of tryptophan to decrease the risk of behavioral sensitization induced by methylphenidate. PMID: 30417792 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - November 12, 2018 Category: Drugs & Pharmacology Authors: Farhan M, Riaz F, Wali S, Rafiq H Tags: Curr Clin Pharmacol Source Type: research

Multiple Drug Intolerance Syndrome: An Underreported Distinct Clinical Entity.
Conclusion MDIS occurs by a nonimmune mechanism which requires a prompt withdrawal of the offending drug(s), and in some cases may require drug re-challenge and desensitization. PMID: 30417793 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - November 12, 2018 Category: Drugs & Pharmacology Authors: Behera SK, Das S, Chengappa KG, Xavier AS, Selvarajan S Tags: Curr Clin Pharmacol Source Type: research

The cytotoxicity and synergistic potential of aspirin and aspirin analogues towards oesophageal and colorectal cancer.
CONCLUSION: These findings indicate the potential and limitations of aspirin and aspirin analogues as chemotherapeutic agents against OC and CRC when combined with platins. PMID: 30417794 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - November 12, 2018 Category: Drugs & Pharmacology Authors: Kilari RS, Bashir AIJ, Devitt A, Perry CJ, Safrany ST, Nicholl ID Tags: Curr Clin Pharmacol Source Type: research

The added value of liquid antipsychotics: the case of quetiapine.
CONCLUSION: The liquid form of quetiapine can facilitate pharmacotherapy of schizophrenia and it can be defined as value added medicine bringing key benefits for the patients, the caregivers but also for the health care system. PMID: 30387400 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - November 2, 2018 Category: Drugs & Pharmacology Authors: Papazisis G, Siafis S Tags: Curr Clin Pharmacol Source Type: research

A critique on computer simulation software's used in pharmacokinetics and pharmacodynamics analysis.
Abstract Computer has wide applicability in many field, and in pharmaceutical science the computer play a crucial role as a commander of all the theoretical aspects and provide a workbench to improve the overall quality system of the pharmaceutical research and development. The aim of this article is to provide computational approach in development of the many booming technology of computer software in the field of clinical pharmacokinetics. The computational technique practiced by clinical pharmacist and scientist with the applied knowledge and skills of dealing with clinical pharmacokinetics problems, which can ...
Source: Current Clinical Pharmacology - October 25, 2018 Category: Drugs & Pharmacology Authors: Dave V, Yadav RB, Yadav S, Sharma S, Sahu RK, Ajayi AF Tags: Curr Clin Pharmacol Source Type: research

Biosimilars: an approach to current worldwide regulation frameworks.
gui E Abstract Developing new biological medicaments has led to the regulations and norms regarding such drugs, in terms of marketing, prescription, use, interchangeability and switching, have become fundamental aspects guaranteeing their safety, quality and effectiveness. Biologics are of great importance in treating patients suffering rheumatic, autoimmune, inflammatory, neoplastic and other diseases. The expiry/lapse of reference biologics or originators' patents has meant that developing biosimilars needs accompanying legal requirements for their approval in countries worldwide. This paper has thus been aimed ...
Source: Current Clinical Pharmacology - October 25, 2018 Category: Drugs & Pharmacology Authors: Esteban E, Bustos RH, García JC, Jauregui E Tags: Curr Clin Pharmacol Source Type: research

Metformin as a radiation modifier; implications to normal tissue protection and tumor sensitization.
Abstract Nowadays, ionizing radiation is used for several applications in medicine, industry, agriculture, and nuclear power generation. Besides the beneficial roles of ionizing radiation, there are some concerns for accidental exposure to radioactive sources. The threat posed by its use in terrorism is of global concern. Furthermore, there are several side effects to normal organs for patients had undergone radiation treatment for cancer. Hence, modulation of radiation response in normal tissues was one of the most important aims of radiobiology. Although, so far, several agents have been investigated for protect...
Source: Current Clinical Pharmacology - October 25, 2018 Category: Drugs & Pharmacology Authors: Mortezaee K, Shabeeb D, Musa AE, Najafi M, Farhood B Tags: Curr Clin Pharmacol Source Type: research

Efficacy Of Zofenopril Alone Or In Combination With Hydrochlorothiazide In Patients With Kidney Dysfunction.
Abstract Hypertension and kidney disease often coexist, further increasing the risk of future cardiovascular events. Treatment of hypertensive adults with an angiotensin converting enzyme inhibitor in case of concomitant kidney disease may slow disease progression. The third-generation liphophilic angiotensin converting enzyme inhibitor zofenopril, administered alone or combined with a thiazide diuretic, has proved to be effective in lowering blood pressure in hypertensive patients and to reduce the risk of fatal and non-fatal events in post-acute myocardial infarction and heart failure. In almost three-hundred hy...
Source: Current Clinical Pharmacology - October 25, 2018 Category: Drugs & Pharmacology Authors: Omboni S, Borghi C Tags: Curr Clin Pharmacol Source Type: research

Anaemogenic, Obesogenic And Thermogenic Potentials Of Graded Doses Of Monosodium Glutamate Sub-Acutely Fed To Experimental Wistar Rats.
Abstract BACKGROUND: Monosodium glutamate (MSG) is one of the most commonly used food additives for the enhancement of food taste and flavour. There are several conflicting reports of toxicity or otherwise safety of the compound, which raises a growing concern regarding the safety of monosodium glutamate as food additive. OBJECTIVE: In the present study, we sought to investigate the effect of monosodium glutamate on body weight, feed consumption, body temperature and some haematological parameters. METHODOLOGY: Twenty adult Wistar rats divided into four groups of five rats each were used for the study. R...
Source: Current Clinical Pharmacology - October 2, 2018 Category: Drugs & Pharmacology Authors: Salisu N, Aliyu FS, Garba H, Garba MH Tags: Curr Clin Pharmacol Source Type: research

Preface: Vitamin D and QT Interval in Epilepsy: More than an Association?
PMID: 30175694 [PubMed - in process] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - September 5, 2018 Category: Drugs & Pharmacology Authors: Mangoni AA, Jarmuzewska EA Tags: Curr Clin Pharmacol Source Type: research

Interventions for improving bone mineral density and reducing fracture risk in osteogenesis imperfecta: A mixed treatment comparison network meta-analysis of randomized controlled clinical trials.
CONCLUSION: Oral bisphosphonates and teriparatide significantly increase BMD but are not associated with fracture risk reduction. Of the available interventions, oral bisphosphonates could perform better than others in osteogenesis imperfecta. This evidence should be considered preliminary and may change with future head-to-head clinical trials. PMID: 30160216 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 29, 2018 Category: Drugs & Pharmacology Authors: Sridharan K, Sivaramakrishnan G Tags: Curr Clin Pharmacol Source Type: research

Lipid-based siRNA Nanodelivery Systems: a Learning Process for Improving Transfer from Concepts to Clinical Applications.
CONCLUSION: Formulation design should be increasingly addressed with industrial criteria; it should be based on quality by design and on the estimation of critical attributes that affect performance, and supported by a range of characterization techniques and appropriate analytical methods. PMID: 30160217 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 29, 2018 Category: Drugs & Pharmacology Authors: Perez SE, Carlucci AM Tags: Curr Clin Pharmacol Source Type: research

Evaluation the effects of oral and topical simvastatin as adjunct therapy in the treatment of acne vulgaris.
Abstract OBJECTIVES: Acne vulgaris is a common dermatologic disorder which results in psychological consequences. Inflammation plays an important role in the formation of acne lesions. Recently, many studies demonstrated anti-inflammatory effects of statins; thus, the aim of this study was to evaluate the efficacy of oral and topical Simvastatin as adjunct treatment in acne vulgaris. MATERIAL AND METHOD: In 76 patients with moderate to very severe acne vulgaris, beside antibiotic treatment including oral azithromycin (250 mg, 3 times a week, orally) and topical benzoyl peroxide gel (5%, once daily), oral grou...
Source: Current Clinical Pharmacology - August 21, 2018 Category: Drugs & Pharmacology Authors: Ahmadvand A, Yazdanfar A, Yasrebifar F, Mohammadi Y, Mahjoub R, Mehrpooya M Tags: Curr Clin Pharmacol Source Type: research

Therapeutic Approach for Irritable Bowel Syndrome: Old and New Strategies.
CONCLUSIONS: The treatment of IBS remains focused on treating the patient's predominant, or most troublesome, symptoms. New promising treatments have recently become available for the treatment of IBS but long term studies are still needed. PMID: 30084333 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 7, 2018 Category: Drugs & Pharmacology Authors: Usai-Satta P, Bellini M, Lai M, Oppia F, Cabras F Tags: Curr Clin Pharmacol Source Type: research

A recent update on the effects of omega-3 fatty acids in Alzheimer's disease.
Abstract Dietary long chain polyunsaturated fatty acids belong to omega (ω)-3, -6 or -9 series. Both experimental and clinical studies demonstrated the beneficial effect of ω -3 fatty acids of fish oil, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) against human ailments including cardiovascular diseases and rheumatoid arthritis. They are metabolized in cyclooxygenase and lipooxygenase pathways and also by cytochrome P450 isozymes. Biological importance of DHA in the development of brain and retina are established as well. Recent studies highlighted the beneficial effect of ω-3 fatty...
Source: Current Clinical Pharmacology - August 7, 2018 Category: Drugs & Pharmacology Authors: Ajith TA Tags: Curr Clin Pharmacol Source Type: research

SGLT-2 inhibitors in type 1 diabetes mellitus: a comprehensive review of the literature.
CONCLUSION: This novel class of antidiabetics seems to be a very attractive treatment option in patients with T1DM, due to their multiple beneficial effects, but the increased risk of DKA should be taken into account. PMID: 30084335 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 7, 2018 Category: Drugs & Pharmacology Authors: Patoulias D, Imprialos K, Stavropoulos K, Athyros V, Doumas M Tags: Curr Clin Pharmacol Source Type: research

How to design and validate a questionnaire: A guide.
CONCLUSION: Since it is equally important to verify the usefulness of the designed questionnaire, the article briefly describes the process of psychometric evaluation of a questionnaire. PMID: 30084336 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 7, 2018 Category: Drugs & Pharmacology Authors: Sidhu JK, Singh S, Kathuria P Tags: Curr Clin Pharmacol Source Type: research

Differentially enhancing effects of long-term treatment with Serrazyme, Boswellia and Pine on seminal bacterial detection in patients with chronic bacterial or inflammatory prostatitis, probably related to several degrees of bacterial adherence.
CONCLUSION: The results of the present study showed that 2 months of treatment with PEM, decreasing bacterial adherence and inflammatory prostatitis, reveals a subgroup of apparent inflammation associated with infection that microbial biofilms likely mask in inflammatory prostatitis patients. PMID: 30073929 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - August 2, 2018 Category: Drugs & Pharmacology Authors: Vicari E, Malaguarnera G, Vicari BO, Salmeri M, Salemi M, Castiglione R Tags: Curr Clin Pharmacol Source Type: research

Antibody-Drug Conjugates: A Review on the Epitome of Targeted Anti-Cancer Therapy.
Abstract Cancer is one of the deadly diseases which is characterized by unchecked cell division or abnormal cell growth due to the incapability of cell cycle arrest. As the treatment for this is to kill the cancerous cells the main challenge for scientists is to direct the cell killing to cancerous cells while leaving the normal cells unharmed. Antibody-drug conjugates (ADC) are one such targeted anti-cancer therapy. It is an effective drug delivery system that utilizes the targeting action of antibody along with cell death by potent cytotoxic agent, linked up with one another by a linker molecule and thus helps t...
Source: Current Clinical Pharmacology - August 1, 2018 Category: Drugs & Pharmacology Authors: Hasan M, Alam S, Poddar SK Tags: Curr Clin Pharmacol Source Type: research

Nanovehicle-based small interfering RNA (siRNA) delivery for therapeutic purposes: a new molecular approach in the pharmacogenomics.
Abstract RNA interference (RNAi) is a process for regulating the gene expression in which small interfering RNAs (siRNAs) silence target genes. siRNA-based therapy as a new molecular treatment approach, offers therapeutic prospects for many common diseases such as cancer and cardiovascular disorders. Nevertheless, the efficacy of siRNA delivery has, so far, remained a challenging issue. This is due to their easy degradation through the circulation system and the difficulties in the intracellular delivery to specific tissues where they silence the target genes. There have been many efforts to develop suitable, safe...
Source: Current Clinical Pharmacology - July 9, 2018 Category: Drugs & Pharmacology Authors: Akhtari J, Tafazoli A, Mehrad-Majd H, Mahrooz A Tags: Curr Clin Pharmacol Source Type: research

Trends of Clinical Trials for Drug Development in Rare Diseases.
CONCLUSION: This study revealed details of the three registries and bias among rare diseases in the number of the trials. This information could contribute to drug-repositioning and a broad range of rare disease studies. PMID: 29866013 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - June 3, 2018 Category: Drugs & Pharmacology Authors: Sakate R, Fukagawa A, Takagaki Y, Okura H, Matsuyama A Tags: Curr Clin Pharmacol Source Type: research

Pharmacokinetic and Pharmacodynamic Relationship of Blinatumomab in Patients With Non-Hodgkin Lymphoma.
CONCLUSION: B-lymphocyte depletion following blinatumomab infusion was exposure-dependent. Transient cytokine elevation increased with dose; it was less pronounced at low starting dose. Tumor response was a function of exposure, suggesting utility for the PK/PD relationship in dose selection for future studies, including NHL and other malignant settings. PMID: 29773068 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - May 17, 2018 Category: Drugs & Pharmacology Authors: Hijazi Y, Klinger M, Kratzer A, Wu B, Baeuerle PA, Kufer P, Wolf A, Nagorsen D, Zhu M Tags: Curr Clin Pharmacol Source Type: research

Analysis of Toxicity Effects of Buspirone, Cetirizine and Olanzapine on Human Blood Lymphocytes: in Vitro Model.
Abstract The current study investigates the cytotoxicity mechanism of common drugs with piperazine ring such as cetirizine, olanzapine and buspirone on human lymphocytes. The viability of lymphocytes, reactive oxygen species (ROS) formation, mitochondrial membrane potential (MMP) collapse, lysosomal integrity, content of glutathione and lipid peroxidation were determined. Buspirone and cetirizine showed more toxicity than olanzapine on human lymphocytes with an IC50 value of 200 μg/ml, after 6 h of incubation. Significant ROS formation, MMP collapse, lipid peroxidation, lysosomal damage and elevation of glutath...
Source: Current Clinical Pharmacology - May 15, 2018 Category: Drugs & Pharmacology Authors: Pourahmad J, Salimi A, Razian M Tags: Curr Clin Pharmacol Source Type: research

The effect of tranexamic acid on preventing post-partum hemorrhage due to uterine atony: a triple-blind randomized clinical trial.
CONCLUSION: The results of the present study showed that administrating intravenous TXA had comparable effects with prostaglandin analogue on reducing PPH in women with uterine atony and in those undergoing C section or vaginal delivery. Therefore, TXA can be used instead of prostaglandin in managing such patients. PMID: 29732978 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - May 6, 2018 Category: Drugs & Pharmacology Authors: Zargar M, Nikbakht R, Ahmadi M Tags: Curr Clin Pharmacol Source Type: research

Targeting Brain Tumors with Nanomedicines: Overcoming Challenges of Blood Brain Barrier.
Abstract This review elucidates ongoing research, which show improved delivery of anticancer drugs alone and/ or enclosed in carriers collectively called nanomedicines to cross the Blood brain barrier (BBB) / blood-brain tumor barrier (BTB) to kill tumor cells and impact patient survival. We highlighted various advances in understanding the mechanism of BTB function that impact on anticancer therapeutics delivery. We discussed latest breakthroughs in developing pharmaceutical strategies, including nanomedicines and delivering them across BTB for brain tumor management and treatment. We highlight various studies on...
Source: Current Clinical Pharmacology - April 12, 2018 Category: Drugs & Pharmacology Authors: Ningaraj NS, Reddy PL, Khaitan D Tags: Curr Clin Pharmacol Source Type: research

Phase IV Studies: Some Insights, Clarifications, And Issues.
CONCLUSIONS: Critical remarks are raised against the pure commercial perspective in the proposal of PASS and PAES and on the design of registries which should be mainly based on the objectives and the planned analyses, as it has reported in the study protocol. Finally, a particular focus is also placed on the work of the Ethical Committees regarding the approval of the observational studies on the safety and the efficacy of the drugs in their pragmatic clinical use. PMID: 29651962 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - April 12, 2018 Category: Drugs & Pharmacology Authors: Biganzoli EM, Cesana BM Tags: Curr Clin Pharmacol Source Type: research

Lupus Nephritis: A Treatment Update.
CONCLUSION: Lupus nephritis which does not respond to initial treatment is associated with worse renal outcomes. Several therapeutic approaches are available for the induction and maintenance immunosuppression of the different classes of LN. Management of LN should be individualized for each patient based on their risk-benefit profile. PMID: 29611488 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - April 3, 2018 Category: Drugs & Pharmacology Authors: Aziz F, Chaudhary K Tags: Curr Clin Pharmacol Source Type: research

Hepatic Elimination of Drugs in Gestational Diabetes.
CONCLUSION: Considering the frequency of the disease and the effects that these pharmacokinetic changes might have on the mother and child, the need for further research seems advisable. In the meantime, cautious clinical judgment in the management of drug administration in women affected by this disease is recommended. PMID: 29577863 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 25, 2018 Category: Drugs & Pharmacology Authors: Gonzalez CD, Alvarinas J, Bolanos R, Di Girolamo G Tags: Curr Clin Pharmacol Source Type: research

Formulation of herbal fast disintegrating tablets and its ex-vivo study for anti-histaminic activity in guinea pig ileum.
CONCLUSION: On the basis of in-vitro and ex-vivo studies, it was concluded that prepared herbal fast disintegrating tablets were stable and had potent antihistaminic activity. PMID: 29521214 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 9, 2018 Category: Drugs & Pharmacology Authors: Puri D, Bhandari A, Gaur PK, Yasir M, Kumar SS, Choudhary D Tags: Curr Clin Pharmacol Source Type: research

Knowledge, attitudes, and practices of pharmacovigilance and ADRs spontaneous reporting among pediatricians and pediatric residents in Jordan.
CONCLUSION: The results of the present study reveals that pediatricians lack knowledge of PV and ADRs reporting. However, they have a good attitude towards ADRs reporting and enhancing their PV practice. This is still not reflected in their own practice. Further training and education about ADRs reporting is very important to move toward safer medications in children. PMID: 29521246 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - March 8, 2018 Category: Drugs & Pharmacology Authors: Mukattash TL, Alwadi MW, Abu-Farha RK, Jarab A, Alzubiedi SA, Alwedyan T Tags: Curr Clin Pharmacol Source Type: research

Determination of parameters of oxidative stress in vitro models of neurodegenerative diseases-A review.
Abstract Oxidative stress is a major mechanism underlying the development of various neurodegenerative diseases (Alzheimer, Parkinson, Huntington and amyotrophic lateral sclerosis). Excessive formation of reactive oxygen species (ROS) and nitrogen (RNSs) can overburden the ability of the enzymatic antioxidant defense mechanisms (superoxide dismutase, catalase and glutathione reductase) and non-enzymatic (uric acid, ascorbic acid, α-tocopherol and reduced glutathione) causing the development of oxidative stress and consequently impairing the neuronal system cells by means of oxidative damage to a variety of i...
Source: Current Clinical Pharmacology - February 28, 2018 Category: Drugs & Pharmacology Authors: Feitosa CM Tags: Curr Clin Pharmacol Source Type: research

More Evidence For The Therapeutic Role Of Dopamine Agonists In Upper Limb Restlessness Due To Cervical Disc Pathology?
Abstract BACKGROUND: The causal link between upper limb restlessness and cervical disc prolapsus is still unclear, and the exact role of the spinal cord in the origination of limb restlessness is not yet completely understood. METHODS: Here we have evaluated the therapeutic effect of pramipexole (0.5 mg/kg) in a 47-year old male with cervical disc prolapsus who described restlessness in his upper limb and neck. RESULTS: The patient felt significantly better, and his symptoms improved near to complete after five days after we have initiated 0.5 mg/day pramipexole treatment. Conclussion: In our present pap...
Source: Current Clinical Pharmacology - February 27, 2018 Category: Drugs & Pharmacology Authors: Yulug B, Brandmeier S, Hanoglu L Tags: Curr Clin Pharmacol Source Type: research

Minocycline in alcohol withdrawal induced anxiety and alcohol relapse in rats.
Abstract INTRODUCTION: Anxiety and negative sensations due to alcohol withdrawal are factors leading to alcohol relapse and addiction. Minocycline, an antibiotic, can decrease alcohol consumption in rats, however, its effects on alcohol withdrawal anxiety and relapse have not been studied. MATERIAL AND METHODS: Part 1: Forced alcohol drinking in gradually increasing concentration was administered till day 22 in rats. Effect of drugs on anxiety was assessed using elevated plus maze (EPM) and two chambered box apparatus, after removal of alcohol. Part 2: For relapse, an alcohol deprivation effect model was used...
Source: Current Clinical Pharmacology - February 27, 2018 Category: Drugs & Pharmacology Authors: Gajbhiye SV, Tripathi RK, Petare AU, Potey AV, Shankar A Tags: Curr Clin Pharmacol Source Type: research

An Evidence-Based Review of Off-Label Uses of Polidocanol.
CONCLUSION: Numerous successful administrations of this drug in a variety of clinical conditions lead to promising perspectives toward it. Sclerotherapy with polidocanol as a minimal-invasive method (having similar outcomes like the prevalent surgeries) may reduce the rate of complications. Furthermore, for determining the most appropriate method and dosage, randomized clinical trials are needed, confirming and providing more clear instructions for different conditions. PMID: 29473522 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - February 23, 2018 Category: Drugs & Pharmacology Authors: Babaei H, Enamzadeh E Tags: Curr Clin Pharmacol Source Type: research