Zoledronic acid induces ferroptosis by upregulating POR in osteosarcoma
In this study, we discovered that z oledronic acid (ZOL) dramatically increased cell death in osteosarcoma cells, and this cytotoxicity was greatly reversed by liproxstatin-1 (a ferroptosis inhibitor). ZOL also had an obvious effect on lipid peroxidation and reactive oxygen species (ROS), which suggested that ZOL most certain ly induces ferroptosis in osteosarcoma cells. In addition, we further found that ZOL increases cytochrome P450 oxidoreductase (POR) expression dose dependently in osteosarcoma cell lines. Knockdown of POR attenuated ZOL-induced cytotoxicity and attenuated the effect of ferroptosis in osteo...
Source: Medical Oncology - April 10, 2023 Category: Cancer & Oncology Source Type: research
Comparison of the Efficacy of Zoledronate Acid or Denosumab After Switching from Romosozumab in Japanese Postmenopausal Patients
AbstractWe aimed to compare the efficacy of switching from romosozumab (RMAb) to denosumab (DMAb) or zoledronic acid (Zol) with respect to changes in bone mineral density (BMD) and bone metabolism. We also aimed to determine predictors of changes in BMD among patients who received sequential therapy from RMAb. One hundred patients who received RMAb therapy were recruited for this study. A total 49 patients received bisphosphonate (BP) pre-treatment and 51 received active vitamin D3 analog pre-treatment or no treatment. Forty-two patients were switched to Zol (BP –RMAb–Zol; 20 and RMAb–Zol; 22), and 58 patients were s...
Source: Calcified Tissue International - April 10, 2023 Category: Orthopaedics Source Type: research
Cancers, Vol. 15, Pages 2211: The CDK4/6 Inhibitor Palbociclib Inhibits Estrogen-Positive and Triple Negative Breast Cancer Bone Metastasis In Vivo
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Ingunn Holen
CDK 4/6 inhibitors have demonstrated significant improved survival for patients with estrogen receptor (ER) positive breast cancer (BC). However, the ability of these promising agents to inhibit bone metastasis from either ER+ve or triple negative BC (TNBC) remains to be established. We therefore investigated the effects of the CDK 4/6 inhibitor, palbociclib, using in vivo models of breast cancer bone metastasis. In an ER+ve T47D model of spontaneous breast cancer metastasis from the mammary fat pad to bone, primary tumour growth and the number of hind limb skeletal tumours were significantly lower in...
Source: Cancers - April 8, 2023 Category: Cancer & Oncology Authors: Lubaid Saleh Penelope D. Ottewell Janet E. Brown Steve L. Wood Nichola J. Brown Caroline Wilson Catherine Park Simak Ali Ingunn Holen Tags: Article Source Type: research
Zoledronic acid affects the process of Porphyromonas gingivalis infecting oral mucosal epithelial barrier: An in-vivo and in-vitro study
This study aimed to investigate the influences of ZA on the process of Porphyromonas gingivalis (P. gingivalis) infecting the gingival epithelial barrier via in-vitro and in-vivo experiments. In the in-vitro experiments, under the condition of different concentrations of ZA (0, 1, 10, and 100 μM), P. gingivalis was used to infect human gingival epithelial cells (HGECs). The infections were detected by transmission electron microscope and confocal laser scanning microscope. Besides, the internalization assay was applied to quantify the P. gingivalis, which infected the HGECs, in the different groups. To evaluate the expres...
Source: Frontiers in cellular and infection microbiology - March 28, 2023 Category: Microbiology Source Type: research
A Bone ‐Penetrating Precise Controllable Drug Release System Enables Localized Treatment of Osteoporotic Fracture Prevention via Modulating Osteoblast‐Osteoclast Communication
In this study, a featured radial extracorporeal shock wave (rESW) responsive nano-drug delivery system (NDDS) is developed for local treatment. Based on a mechanic simulation, a sequence of hollow zoledronic acid (ZOL)-contained nanoparticles (HZNs) with controllable shell thickness that predicts various mechanical responsive properties is constructed by controlling the deposition time of ZOL and Ca2+ on liposome templates. Attributed to the controllable shell thickness, the fragmentation of HZNs and the release of ZOL and Ca2+ can be precisely controlled with the intervention of rESW. Furthermore, the distinct effect of H...
Source: Small - March 27, 2023 Category: Nanotechnology Authors: Haojun Liang,
Kui Chen,
Jing Xie,
Lei Yao,
Yunpeng Liu,
Fan Hu,
Hao Li,
Yinze Lei,
Yujiao Wang,
Linwen Lv,
Ziteng Chen,
Sen Liu,
Qiuyang Liu,
Zhijie Wang,
Jiacheng Li,
Ya ‐Nan Chang,
Juan Li,
Hui Yuan,
Gengyan Xing,
Gengmei Xing Tags: Research Article Source Type: research
The role of semaphorin 4D in the mechanism of bisphosphonate-related osteonecrosis of the jaw in rats
CONCLUSIONS: BPs can interfere with normal bone healing time by up-regulating the expression of Sema4D in tissues, leading to coupling disorder between osteoclasts and osteoblasts with inhibition of the maturation of osteoclasts, thereby inhibiting the growth of osteoblasts. Differentiation and expression of related osteogenic factors mediate the development of BRONJ.PMID:36970799 (Source: Shanghai Journal of Stomatology)
Source: Shanghai Journal of Stomatology - March 27, 2023 Category: Dentistry Authors: Qiao-Ting Pan Xiao-Long Zang Zhao-Wei Sun Meng-Qi Pan Xin-Mei Zhu Zhi-Yong Li Source Type: research
The role of semaphorin 4D in the mechanism of bisphosphonate-related osteonecrosis of the jaw in rats
CONCLUSIONS: BPs can interfere with normal bone healing time by up-regulating the expression of Sema4D in tissues, leading to coupling disorder between osteoclasts and osteoblasts with inhibition of the maturation of osteoclasts, thereby inhibiting the growth of osteoblasts. Differentiation and expression of related osteogenic factors mediate the development of BRONJ.PMID:36970799 (Source: Shanghai Journal of Stomatology)
Source: Shanghai Journal of Stomatology - March 27, 2023 Category: Dentistry Authors: Qiao-Ting Pan Xiao-Long Zang Zhao-Wei Sun Meng-Qi Pan Xin-Mei Zhu Zhi-Yong Li Source Type: research
The role of semaphorin 4D in the mechanism of bisphosphonate-related osteonecrosis of the jaw in rats
CONCLUSIONS: BPs can interfere with normal bone healing time by up-regulating the expression of Sema4D in tissues, leading to coupling disorder between osteoclasts and osteoblasts with inhibition of the maturation of osteoclasts, thereby inhibiting the growth of osteoblasts. Differentiation and expression of related osteogenic factors mediate the development of BRONJ.PMID:36970799 (Source: Shanghai Journal of Stomatology)
Source: Shanghai Journal of Stomatology - March 27, 2023 Category: Dentistry Authors: Qiao-Ting Pan Xiao-Long Zang Zhao-Wei Sun Meng-Qi Pan Xin-Mei Zhu Zhi-Yong Li Source Type: research
The role of semaphorin 4D in the mechanism of bisphosphonate-related osteonecrosis of the jaw in rats
CONCLUSIONS: BPs can interfere with normal bone healing time by up-regulating the expression of Sema4D in tissues, leading to coupling disorder between osteoclasts and osteoblasts with inhibition of the maturation of osteoclasts, thereby inhibiting the growth of osteoblasts. Differentiation and expression of related osteogenic factors mediate the development of BRONJ.PMID:36970799 (Source: Shanghai Journal of Stomatology)
Source: Shanghai Journal of Stomatology - March 27, 2023 Category: Dentistry Authors: Qiao-Ting Pan Xiao-Long Zang Zhao-Wei Sun Meng-Qi Pan Xin-Mei Zhu Zhi-Yong Li Source Type: research
The role of semaphorin 4D in the mechanism of bisphosphonate-related osteonecrosis of the jaw in rats
CONCLUSIONS: BPs can interfere with normal bone healing time by up-regulating the expression of Sema4D in tissues, leading to coupling disorder between osteoclasts and osteoblasts with inhibition of the maturation of osteoclasts, thereby inhibiting the growth of osteoblasts. Differentiation and expression of related osteogenic factors mediate the development of BRONJ.PMID:36970799 (Source: Shanghai Journal of Stomatology)
Source: Shanghai Journal of Stomatology - March 27, 2023 Category: Dentistry Authors: Qiao-Ting Pan Xiao-Long Zang Zhao-Wei Sun Meng-Qi Pan Xin-Mei Zhu Zhi-Yong Li Source Type: research
The role of semaphorin 4D in the mechanism of bisphosphonate-related osteonecrosis of the jaw in rats
CONCLUSIONS: BPs can interfere with normal bone healing time by up-regulating the expression of Sema4D in tissues, leading to coupling disorder between osteoclasts and osteoblasts with inhibition of the maturation of osteoclasts, thereby inhibiting the growth of osteoblasts. Differentiation and expression of related osteogenic factors mediate the development of BRONJ.PMID:36970799 (Source: Shanghai Journal of Stomatology)
Source: Shanghai Journal of Stomatology - March 27, 2023 Category: Dentistry Authors: Qiao-Ting Pan Xiao-Long Zang Zhao-Wei Sun Meng-Qi Pan Xin-Mei Zhu Zhi-Yong Li Source Type: research
Response to Letter to the Editor from Riahi and Gruntmanis: 'Inpatient Zoledronic Acid and Integrated Orthopedic and Fracture Liaison Services Improve Osteoporosis Treatment Rates'
J Clin Endocrinol Metab. 2023 Mar 22:dgad161. doi: 10.1210/clinem/dgad161. Online ahead of print.NO ABSTRACTPMID:36947075 | DOI:10.1210/clinem/dgad161 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 22, 2023 Category: Endocrinology Authors: WuQiang Fan Benjamin Z Leder Marcy B Bolster Source Type: research
"Letter to the Editor from Riahi and Gruntmanis: 'Inpatient Zoledronic Acid and Integrated Orthopedic and Fracture Liaison Services Improve Osteoporosis Treatment Rates'
J Clin Endocrinol Metab. 2023 Mar 22:dgad162. doi: 10.1210/clinem/dgad162. Online ahead of print.NO ABSTRACTPMID:36947069 | DOI:10.1210/clinem/dgad162 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - March 22, 2023 Category: Endocrinology Authors: Shayan Riahi Ugis Gruntmanis Source Type: research
Screening for the primary prevention of fragility fractures among adults aged 40 years and older in primary care: systematic reviews of the effects and acceptability of screening and treatment, and the accuracy of risk prediction tools
ConclusionAn offer of 2-step screening with risk assessment and BMD measurement toselected postmenopausal females with low prevalence of prior fracture probably results in a small reduction in the risk of clinical fragility fracture and hip fracture compared to no screening. These findings were most applicable to the use of clinical FRAX for risk assessment and were not replicated in theoffer-to-screen population where the rate of response to mailed screening questionnaires was low. Limited direct evidence on harms of screening were available; using study data to provide estimates, there may be a moderate degree of overdia...
Source: Systematic Reviews - March 21, 2023 Category: International Medicine & Public Health Source Type: research
