Long-term effectiveness of zoledronic acid in patients with Paget ’s disease of bone – a retrospective cohort study
ConclusionThe majority of patients with PDB experience a mild disease course, marked by monostotic involvement and a low prevalence of fractures. Zoledronic acid effectively manages PDB, providing sustained biochemical response. The necessity for multiple zoledronic acid injections remains questionable, often implemented due to osteoporosis. (Source: Endocrine)
Source: Endocrine - March 30, 2024 Category: Endocrinology Source Type: research
Laser-assisted synthesis of nano-hydroxyapatite and functionalization with bone active molecules for bone regeneration
Colloids Surf B Biointerfaces. 2024 Mar 18;237:113859. doi: 10.1016/j.colsurfb.2024.113859. Online ahead of print.ABSTRACTThe main goal of bone tissue engineering research is to replace the allogenic and autologous bone graft substitutes that can promote bone repair. Owing to excellent biocompatibility and osteoconductivity, hydroxyapatite is in extensive research and high demand for both medical and non-medical applications. Although various methods have been developed for the synthesis of hydroxyapatite, in the present study we have shown the use of nanosecond laser energy in the wet precipitation method of nano-hydroxya...
Source: Colloids and Surfaces - March 28, 2024 Category: Biotechnology Authors: Shazia Shaikh Sneha Gupta Ankita Mishra Parvaiz A Sheikh Prerna Singh Ashok Kumar Source Type: research
Laser-assisted synthesis of nano-hydroxyapatite and functionalization with bone active molecules for bone regeneration
Colloids Surf B Biointerfaces. 2024 Mar 18;237:113859. doi: 10.1016/j.colsurfb.2024.113859. Online ahead of print.ABSTRACTThe main goal of bone tissue engineering research is to replace the allogenic and autologous bone graft substitutes that can promote bone repair. Owing to excellent biocompatibility and osteoconductivity, hydroxyapatite is in extensive research and high demand for both medical and non-medical applications. Although various methods have been developed for the synthesis of hydroxyapatite, in the present study we have shown the use of nanosecond laser energy in the wet precipitation method of nano-hydroxya...
Source: Colloids and Surfaces - March 28, 2024 Category: Biotechnology Authors: Shazia Shaikh Sneha Gupta Ankita Mishra Parvaiz A Sheikh Prerna Singh Ashok Kumar Source Type: research
Zoledronic Acid Accelerates ER Stress-Mediated Inflammation by Increasing PDE4B Expression in Bisphosphonate-Related Osteonecrosis of the Jaw
Appl Biochem Biotechnol. 2024 Mar 25. doi: 10.1007/s12010-024-04859-w. Online ahead of print.ABSTRACTLong-term administration of bisphosphonates can lead to a significant side effect known as bisphosphonate-related osteonecrosis of the jaw (BRONJ). Although macrophage-mediated inflammation has been established as an important factor in BRONJ, the underlying mechanism remains elusive. In the current study, the roles of endoplasmic reticulum (ER) stress in zoledronic acid (ZOL)-induced inflammation were analyzed in macrophages, and the regulatory mechanism of ER stress activation was next investigated. An in vitro model of B...
Source: Applied Biochemistry and Biotechnology - March 25, 2024 Category: Biochemistry Authors: Qu Xz Sun Zq Liu L Ong Hs Source Type: research
Real-World Evaluation of Primary Versus Secondary Prevention of Skeletal-Related Events in Metastatic Castration-Resistant Prostate Cancer
CONCLUSION: A majority of patients with mCRPC never receive BTAs prior to first SRE, despite universal access and availability of these agents in Ontario. These results highlight an opportunity to improve outcomes by emphasizing early introduction of BTA in patients with mCRPC being started on systemic therapy.PMID:38527096 | DOI:10.1093/oncolo/oyae036 (Source: The Oncologist)
Source: The Oncologist - March 25, 2024 Category: Cancer & Oncology Authors: William J Phillips Fred Saad Jennifer Leigh Alborz Jooya Colleen Webber Scott Morgan Robert MacRae Jean-Marc Bourque Peter Tanuseputro Michael Ong Source Type: research
Zoledronic Acid Accelerates ER Stress-Mediated Inflammation by Increasing PDE4B Expression in Bisphosphonate-Related Osteonecrosis of the Jaw
Appl Biochem Biotechnol. 2024 Mar 25. doi: 10.1007/s12010-024-04859-w. Online ahead of print.ABSTRACTLong-term administration of bisphosphonates can lead to a significant side effect known as bisphosphonate-related osteonecrosis of the jaw (BRONJ). Although macrophage-mediated inflammation has been established as an important factor in BRONJ, the underlying mechanism remains elusive. In the current study, the roles of endoplasmic reticulum (ER) stress in zoledronic acid (ZOL)-induced inflammation were analyzed in macrophages, and the regulatory mechanism of ER stress activation was next investigated. An in vitro model of B...
Source: Applied Biochemistry and Biotechnology - March 25, 2024 Category: Biochemistry Authors: Qu Xz Sun Zq Liu L Ong Hs Source Type: research
Reducing Re-fractures Post Percutaneous Kyphoplasty: The Impact of Zoledronic Acid with Calcium and Vitamin D3 in Osteoporotic Patients
CONCLUSIONS: Zoledronic acid in combination with calcium carbonate and vitamin D3 effectively enhances bone health in osteoporosis patients, warranting its clinical recommendation. This regimen shows promise for improving patient outcomes in osteoporosis management.PMID:38518159 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Weiqian Wu Wenbiao Zheng Weiwei Pan Fanghu Chen Langqing Jiang Source Type: research
Reducing Re-fractures Post Percutaneous Kyphoplasty: The Impact of Zoledronic Acid with Calcium and Vitamin D3 in Osteoporotic Patients
CONCLUSIONS: Zoledronic acid in combination with calcium carbonate and vitamin D3 effectively enhances bone health in osteoporosis patients, warranting its clinical recommendation. This regimen shows promise for improving patient outcomes in osteoporosis management.PMID:38518159 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Weiqian Wu Wenbiao Zheng Weiwei Pan Fanghu Chen Langqing Jiang Source Type: research
Reducing Re-fractures Post Percutaneous Kyphoplasty: The Impact of Zoledronic Acid with Calcium and Vitamin D3 in Osteoporotic Patients
CONCLUSIONS: Zoledronic acid in combination with calcium carbonate and vitamin D3 effectively enhances bone health in osteoporosis patients, warranting its clinical recommendation. This regimen shows promise for improving patient outcomes in osteoporosis management.PMID:38518159 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Weiqian Wu Wenbiao Zheng Weiwei Pan Fanghu Chen Langqing Jiang Source Type: research
Reducing Re-fractures Post Percutaneous Kyphoplasty: The Impact of Zoledronic Acid with Calcium and Vitamin D3 in Osteoporotic Patients
CONCLUSIONS: Zoledronic acid in combination with calcium carbonate and vitamin D3 effectively enhances bone health in osteoporosis patients, warranting its clinical recommendation. This regimen shows promise for improving patient outcomes in osteoporosis management.PMID:38518159 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Weiqian Wu Wenbiao Zheng Weiwei Pan Fanghu Chen Langqing Jiang Source Type: research
Reducing Re-fractures Post Percutaneous Kyphoplasty: The Impact of Zoledronic Acid with Calcium and Vitamin D3 in Osteoporotic Patients
CONCLUSIONS: Zoledronic acid in combination with calcium carbonate and vitamin D3 effectively enhances bone health in osteoporosis patients, warranting its clinical recommendation. This regimen shows promise for improving patient outcomes in osteoporosis management.PMID:38518159 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Weiqian Wu Wenbiao Zheng Weiwei Pan Fanghu Chen Langqing Jiang Source Type: research
Randomised trial of genetic testing and targeted intervention to prevent the development and progression of Pagets disease of bone
Conclusions
Genetic testing for pathogenic SQSTM1 variants coupled with intervention with ZA is well tolerated and has favourable effects on the progression of early PDB.
Trial registration number
ISRCTN11616770. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - March 12, 2024 Category: Rheumatology Authors: Phillips, J., Subedi, D., Lewis, S. C., Keerie, C., Cronin, O., Porteous, M., Moore, D., Cetnarskyj, R., Ranganath, L., Selby, P. L., Turgut, T., Hampson, G., Chandra, R., Ho, S., Tobias, J., Young-Min, S., McKenna, M. J., Crowley, R. K., Fraser, W. D., T Tags: Open access, ARD, Miscellaneous Source Type: research
Mechanism exploration of Zoledronic acid combined with PD-1 in the treatment of hepatocellular carcinoma
Cancer Immunol Immunother. 2024 Mar 2;73(4):62. doi: 10.1007/s00262-024-03652-2.ABSTRACTHow to increase the response of immune checkpoint inhibitors (ICIs) is a challenge. In clinical, we found that Zoledronic acid (ZA) may increase the anti-tumor effect of immunotherapy for hepatocellular carcinoma (HCC). To explore the underlying mechanism, we established a mouse model of HCC by subcutaneously injecting Hepa1-6 cell line. The result showed that the tumor volume in the ZA plus anti-PD-1 monocloning antibody (anti-PD-1 mAb) treatment groups was significantly smaller than that of control group, and the onset time of tumor i...
Source: Cancer Control - March 2, 2024 Category: Cancer & Oncology Authors: Xinru Fan Zijun Yan Yunkai Lin Qing Wang Li Jiang Xiaomeng Yao Liwei Dong Lei Chen Tuan Zhao Jieqiong Zhao Heping Hu Hui Wang Source Type: research
Mechanism exploration of Zoledronic acid combined with PD-1 in the treatment of hepatocellular carcinoma
AbstractHow to increase the response of immune checkpoint inhibitors (ICIs) is a challenge. In clinical, we found that Zoledronic acid (ZA) may increase the anti-tumor effect of immunotherapy for hepatocellular carcinoma (HCC). To explore the underlying mechanism, we established a mouse model of HCC by subcutaneously injecting Hepa1-6 cell line. The result showed that the tumor volume in the ZA plus anti-PD-1 monocloning antibody (anti-PD-1 mAb) treatment groups was significantly smaller than that of control group, and the onset time of tumor inhibition was even shorter than that of the anti-PD-1 mAb group. Using flow cyto...
Source: Cancer Immunology, Immunotherapy - March 2, 2024 Category: Cancer & Oncology Source Type: research
Treatment of bone metastases from solid tumors with bone-modifying agents: a web survey of Italian oncologists investigating patterns of practice drug prescription and prevention of side effects
ConclusionItalian oncologists showed a high attitude in prescribing bisphosphonates or denosumab at the time of diagnosis of bone metastases, with a large application of preventive measures of side effects. Further studies are needed to investigate some controversial aspects, such as optimal drug treatment duration and long-term drug schedules. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - March 1, 2024 Category: Cancer & Oncology Source Type: research
