M < sub > 4 < /sub > IDP stimulates ROS elevation through inhibition of mevalonate pathway and pentose phosphate pathway to inhibit colon cancer cells
This study revealed for the first time a possible mechanism of bisphosphonate-induced increase of ROS in malignant tumor cells. This is helpful for the development of new molecular therapeutic targets and can provide new ideas for the combined therapy of bisphosphonates in tumors.PMID:37838274 | DOI:10.1016/j.bcp.2023.115856 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - October 14, 2023 Category: Drugs & Pharmacology Authors: Ying Peng Qing-Zhu Liu Dong Xu Jia-Yu Fu Li-Xia Zhang Ling Qiu Jian-Guo Lin Source Type: research
M < sub > 4 < /sub > IDP stimulates ROS elevation through inhibition of mevalonate pathway and pentose phosphate pathway to inhibit colon cancer cells
This study revealed for the first time a possible mechanism of bisphosphonate-induced increase of ROS in malignant tumor cells. This is helpful for the development of new molecular therapeutic targets and can provide new ideas for the combined therapy of bisphosphonates in tumors.PMID:37838274 | DOI:10.1016/j.bcp.2023.115856 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - October 14, 2023 Category: Drugs & Pharmacology Authors: Ying Peng Qing-Zhu Liu Dong Xu Jia-Yu Fu Li-Xia Zhang Ling Qiu Jian-Guo Lin Source Type: research
Postoperative Anti-Osteoporotic Therapy with Zoledronic Acid Improves Rotator Cuff Healing but Not Ameliorates Outcomes in Female Patients with Postmenopausal Osteoporosis: A Prospective, Single-Blinded Randomized Study
To investigate the effect of the anti-osteoporotic agent zoledronic acid (ZA) on rotator cuff healing and clinical outcomes in patients with postmenopausal osteoporosis. (Source: Arthroscopy - Journal of Arthroscopic and Related Surgery)
Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - October 10, 2023 Category: Surgery Authors: Mingjie Lei, Zhenglin Zhu, Xiaobo Hu, Dandong Wu, Wei Huang, Yong Zhang, Hong Chen Source Type: research
Postoperative Antiosteoporotic Treatment with Zoledronic Acid Improves Rotator Cuff Healing but Not Ameliorates Outcomes in Female Patients with Postmenopausal Osteoporosis: A Prospective, Single-Blinded Randomized Study
To investigate the effect of the antiosteoporotic agent zoledronic acid (ZA) on rotator cuff healing and clinical outcomes in patients with postmenopausal osteoporosis. (Source: Arthroscopy - Journal of Arthroscopic and Related Surgery)
Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - October 10, 2023 Category: Surgery Authors: Mingjie Lei, Zhenglin Zhu, Xiaobo Hu, Dandong Wu, Wei Huang, Yong Zhang, Hong Chen Source Type: research
Postoperative Antiosteoporotic Treatment with Zoledronic Acid Improves Rotator Cuff Healing but Does Not Improve Outcomes in Female Patients with Postmenopausal Osteoporosis: A Prospective, Single-Blinded, Randomized Study
To investigate the effect of the antiosteoporotic agent zoledronic acid (ZA) on rotator cuff healing and clinical outcomes in patients with postmenopausal osteoporosis. (Source: Arthroscopy - Journal of Arthroscopic and Related Surgery)
Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - October 10, 2023 Category: Surgery Authors: Mingjie Lei, Zhenglin Zhu, Xiaobo Hu, Dandong Wu, Wei Huang, Yong Zhang, Hong Chen Tags: Original Article Source Type: research
CREB1 alleviates the apoptosis and potentiates the osteogenic differentiation of zoledronic acid-treated human periodontal ligament stem cells via up-regulating VEGF
Tissue Cell. 2023 Sep 22;85:102223. doi: 10.1016/j.tice.2023.102223. Online ahead of print.ABSTRACTPeriodontitis represents a severe inflammatory illness in tooth supporting tissue. It has been supported that cAMP response element binding protein 1 (CREB1), a common transcription factor, extensively participates in osteogenic differentiation. Here, the current study was to look into the impacts of CREB1 on the process of periodontitis and its possible action mechanism. After human periodontal ligament stem cells (PDLSCs) were challenged with zoledronic acid (ZA), CREB1 expression was examined with RT-qPCR and western blott...
Source: Tissue and Cell - September 30, 2023 Category: Cytology Authors: Yao Duan Chanyuan Jin Yuwei Wu Yan Chen Minjuan Zhang Jun Qian Ting Shuai Jian Li Huimin Chen Dan Li Source Type: research
CREB1 alleviates the apoptosis and potentiates the osteogenic differentiation of zoledronic acid-treated human periodontal ligament stem cells via up-regulating VEGF
Tissue Cell. 2023 Sep 22;85:102223. doi: 10.1016/j.tice.2023.102223. Online ahead of print.ABSTRACTPeriodontitis represents a severe inflammatory illness in tooth supporting tissue. It has been supported that cAMP response element binding protein 1 (CREB1), a common transcription factor, extensively participates in osteogenic differentiation. Here, the current study was to look into the impacts of CREB1 on the process of periodontitis and its possible action mechanism. After human periodontal ligament stem cells (PDLSCs) were challenged with zoledronic acid (ZA), CREB1 expression was examined with RT-qPCR and western blott...
Source: Tissue and Cell - September 30, 2023 Category: Cytology Authors: Yao Duan Chanyuan Jin Yuwei Wu Yan Chen Minjuan Zhang Jun Qian Ting Shuai Jian Li Huimin Chen Dan Li Source Type: research
CREB1 alleviates the apoptosis and potentiates the osteogenic differentiation of zoledronic acid-treated human periodontal ligament stem cells via up-regulating VEGF
Tissue Cell. 2023 Sep 22;85:102223. doi: 10.1016/j.tice.2023.102223. Online ahead of print.ABSTRACTPeriodontitis represents a severe inflammatory illness in tooth supporting tissue. It has been supported that cAMP response element binding protein 1 (CREB1), a common transcription factor, extensively participates in osteogenic differentiation. Here, the current study was to look into the impacts of CREB1 on the process of periodontitis and its possible action mechanism. After human periodontal ligament stem cells (PDLSCs) were challenged with zoledronic acid (ZA), CREB1 expression was examined with RT-qPCR and western blott...
Source: Tissue and Cell - September 30, 2023 Category: Cytology Authors: Yao Duan Chanyuan Jin Yuwei Wu Yan Chen Minjuan Zhang Jun Qian Ting Shuai Jian Li Huimin Chen Dan Li Source Type: research
Blocking glycosphingolipid production alters autophagy in osteoclasts and improves myeloma bone disease
Autophagy. 2023 Sep 29:1-3. doi: 10.1080/15548627.2023.2208931. Online ahead of print.ABSTRACTGlycosphingolipids (GSLs) are key constituents of membrane bilayers playing a role in structural integrity, cell signalling in microdomains, endosomes and lysosomes, and cell death pathways. Conversion of ceramide into GSLs is controlled by GCS (glucosylceramide synthase) and inhibitors of this enzyme for the treatment of lipid storage disorders and specific cancers. With a diverse range of functions attributed to GSLs, the ability of the GSC inhibitor, eliglustat, to reduce myeloma bone disease was investigated. In pre-clinical m...
Source: Autophagy - September 29, 2023 Category: Cytology Authors: Houfu Leng Anna Katharina Simon Nicole J Horwood Source Type: research
Blocking glycosphingolipid production alters autophagy in osteoclasts and improves myeloma bone disease
Autophagy. 2023 Sep 29:1-3. doi: 10.1080/15548627.2023.2208931. Online ahead of print.ABSTRACTGlycosphingolipids (GSLs) are key constituents of membrane bilayers playing a role in structural integrity, cell signalling in microdomains, endosomes and lysosomes, and cell death pathways. Conversion of ceramide into GSLs is controlled by GCS (glucosylceramide synthase) and inhibitors of this enzyme for the treatment of lipid storage disorders and specific cancers. With a diverse range of functions attributed to GSLs, the ability of the GSC inhibitor, eliglustat, to reduce myeloma bone disease was investigated. In pre-clinical m...
Source: Autophagy - September 29, 2023 Category: Cytology Authors: Houfu Leng Anna Katharina Simon Nicole J Horwood Source Type: research
Optimization of the dosage regimen of zoledronic acid with a kinetic-pharmacodynamic model and exposure-response analysis
Conclusion: Overall, the kinetic-pharmacodynamic model described changes of bone mineral density in different doses of zoledronic acid in vivo. And, the model and the exposure-response analysis also showed to provide the assessment of dose-response relationship for zoledronic acid. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 27, 2023 Category: Drugs & Pharmacology Source Type: research
Drug efficacy and safety of denosumab, teriparatide, zoledronic acid, and ibandronic acid for the treatment of postmenopausal osteoporosis: a network meta-analysis of randomized controlled trials
CONCLUSIONS: Our current results suggested that when considering both safety and efficacy, denosumab or teriparatide might be a better choice for women with postmenopausal osteoporosis.PMID:37750653 | DOI:10.26355/eurrev_202309_33586 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - September 26, 2023 Category: Drugs & Pharmacology Authors: W-Y Wang L-H Chen W-J Ma R-X You Source Type: research
Drug efficacy and safety of denosumab, teriparatide, zoledronic acid, and ibandronic acid for the treatment of postmenopausal osteoporosis: a network meta-analysis of randomized controlled trials
CONCLUSIONS: Our current results suggested that when considering both safety and efficacy, denosumab or teriparatide might be a better choice for women with postmenopausal osteoporosis.PMID:37750653 | DOI:10.26355/eurrev_202309_33586 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - September 26, 2023 Category: Drugs & Pharmacology Authors: W-Y Wang L-H Chen W-J Ma R-X You Source Type: research
Drug efficacy and safety of denosumab, teriparatide, zoledronic acid, and ibandronic acid for the treatment of postmenopausal osteoporosis: a network meta-analysis of randomized controlled trials
CONCLUSIONS: Our current results suggested that when considering both safety and efficacy, denosumab or teriparatide might be a better choice for women with postmenopausal osteoporosis.PMID:37750653 | DOI:10.26355/eurrev_202309_33586 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - September 26, 2023 Category: Drugs & Pharmacology Authors: W-Y Wang L-H Chen W-J Ma R-X You Source Type: research
Drug efficacy and safety of denosumab, teriparatide, zoledronic acid, and ibandronic acid for the treatment of postmenopausal osteoporosis: a network meta-analysis of randomized controlled trials
CONCLUSIONS: Our current results suggested that when considering both safety and efficacy, denosumab or teriparatide might be a better choice for women with postmenopausal osteoporosis.PMID:37750653 | DOI:10.26355/eurrev_202309_33586 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - September 26, 2023 Category: Drugs & Pharmacology Authors: W-Y Wang L-H Chen W-J Ma R-X You Source Type: research
