Drug-related hypophosphatemia: Descriptive study and case/non-case analysis of the French national pharmacovigilance database
Therapie. 2023 Jul 27:S0040-5957(23)00108-7. doi: 10.1016/j.therap.2023.07.007. Online ahead of print.ABSTRACTPhosphorus is an essential element for all living organisms and is involved in various biological pathways. A severe hypophosphatemia can lead to serious complications (acute heart or respiratory failure, rhabdomyolysis, hemolysis…) and increases mortality in patients at risk. Various drugs are known to induce hypophosphatemia through various mechanisms. The aim of this study was to highlight the main drugs associated with hypophosphatemia and to deduce the underlying mechanisms based on a descriptive analysis an...
Source: Therapie - August 27, 2023 Category: Psychiatry & Psychology Authors: Eve-Marie Thillard Paula Sade Joelle Michot Virginie Bres Annie-Pierre Jonville-Bera Source Type: research
Drug-related hypophosphatemia: Descriptive study and case/non-case analysis of the French national pharmacovigilance database
Therapie. 2023 Jul 27:S0040-5957(23)00108-7. doi: 10.1016/j.therap.2023.07.007. Online ahead of print.ABSTRACTPhosphorus is an essential element for all living organisms and is involved in various biological pathways. A severe hypophosphatemia can lead to serious complications (acute heart or respiratory failure, rhabdomyolysis, hemolysis…) and increases mortality in patients at risk. Various drugs are known to induce hypophosphatemia through various mechanisms. The aim of this study was to highlight the main drugs associated with hypophosphatemia and to deduce the underlying mechanisms based on a descriptive analysis an...
Source: Therapie - August 27, 2023 Category: Psychiatry & Psychology Authors: Eve-Marie Thillard Paula Sade Joelle Michot Virginie Bres Annie-Pierre Jonville-Bera Source Type: research
Drug-related hypophosphatemia: Descriptive study and case/non-case analysis of the French national pharmacovigilance database
Therapie. 2023 Jul 27:S0040-5957(23)00108-7. doi: 10.1016/j.therap.2023.07.007. Online ahead of print.ABSTRACTPhosphorus is an essential element for all living organisms and is involved in various biological pathways. A severe hypophosphatemia can lead to serious complications (acute heart or respiratory failure, rhabdomyolysis, hemolysis…) and increases mortality in patients at risk. Various drugs are known to induce hypophosphatemia through various mechanisms. The aim of this study was to highlight the main drugs associated with hypophosphatemia and to deduce the underlying mechanisms based on a descriptive analysis an...
Source: Therapie - August 27, 2023 Category: Psychiatry & Psychology Authors: Eve-Marie Thillard Paula Sade Joelle Michot Virginie Bres Annie-Pierre Jonville-Bera Source Type: research
Drug-related hypophosphatemia: Descriptive study and case/non-case analysis of the French national pharmacovigilance database
Therapie. 2023 Jul 27:S0040-5957(23)00108-7. doi: 10.1016/j.therap.2023.07.007. Online ahead of print.ABSTRACTPhosphorus is an essential element for all living organisms and is involved in various biological pathways. A severe hypophosphatemia can lead to serious complications (acute heart or respiratory failure, rhabdomyolysis, hemolysis…) and increases mortality in patients at risk. Various drugs are known to induce hypophosphatemia through various mechanisms. The aim of this study was to highlight the main drugs associated with hypophosphatemia and to deduce the underlying mechanisms based on a descriptive analysis an...
Source: Therapie - August 27, 2023 Category: Psychiatry & Psychology Authors: Eve-Marie Thillard Paula Sade Joelle Michot Virginie Bres Annie-Pierre Jonville-Bera Source Type: research
Drug-related hypophosphatemia: Descriptive study and case/non-case analysis of the French national pharmacovigilance database
Therapie. 2023 Jul 27:S0040-5957(23)00108-7. doi: 10.1016/j.therap.2023.07.007. Online ahead of print.ABSTRACTPhosphorus is an essential element for all living organisms and is involved in various biological pathways. A severe hypophosphatemia can lead to serious complications (acute heart or respiratory failure, rhabdomyolysis, hemolysis…) and increases mortality in patients at risk. Various drugs are known to induce hypophosphatemia through various mechanisms. The aim of this study was to highlight the main drugs associated with hypophosphatemia and to deduce the underlying mechanisms based on a descriptive analysis an...
Source: Therapie - August 27, 2023 Category: Psychiatry & Psychology Authors: Eve-Marie Thillard Paula Sade Joelle Michot Virginie Bres Annie-Pierre Jonville-Bera Source Type: research
Drug-related hypophosphatemia: Descriptive study and case/non-case analysis of the French national pharmacovigilance database
Therapie. 2023 Jul 27:S0040-5957(23)00108-7. doi: 10.1016/j.therap.2023.07.007. Online ahead of print.ABSTRACTPhosphorus is an essential element for all living organisms and is involved in various biological pathways. A severe hypophosphatemia can lead to serious complications (acute heart or respiratory failure, rhabdomyolysis, hemolysis…) and increases mortality in patients at risk. Various drugs are known to induce hypophosphatemia through various mechanisms. The aim of this study was to highlight the main drugs associated with hypophosphatemia and to deduce the underlying mechanisms based on a descriptive analysis an...
Source: Therapie - August 27, 2023 Category: Psychiatry & Psychology Authors: Eve-Marie Thillard Paula Sade Joelle Michot Virginie Bres Annie-Pierre Jonville-Bera Source Type: research
Zoledronic acid modulates cytokine expression and mitigates bone loss during the development of induced apical periodontitis in a mice model
This study aimed to assess the impact of zoledronic acid on the progression of induced apical periodontitis and expression of cytokines IL-1 β, IL-10, IL-6 and TNF-α, in a mice model. (Source: Journal of Endodontics)
Source: Journal of Endodontics - August 24, 2023 Category: Dentistry Authors: Caroline Andrade Maia, Hebertt Gonzaga dos Santos Chaves, Francine Benetti, ustavo Batista de Menezes, Ma ísa Mota Antunes, Karem Paula Pinto, Emmanuel João Nogueira Leal da Silva, Antônio Paulino Ribeiro Sobrinho, Warley Luciano Fonseca Tavares Tags: Basic Research-Biology Source Type: research
Cancers, Vol. 15, Pages 4115: Zoledronic Acid Prevents Bone Resorption Caused by the Combination of Radium-223, Abiraterone Acetate, and Prednisone in an Intratibial Prostate Cancer Mouse Model
In conclusion, radium-223/abiraterone/prednisone combination increased bone resorption, which may have been one of the mechanisms leading to an increased fracture risk in patients with mCRPC. (Source: Cancers)
Source: Cancers - August 15, 2023 Category: Cancer & Oncology Authors: Mari I. Suominen Matias Knuuttila Birgitta Sj öholm Timothy Wilson Esa Alhoniemi Dominik Mumberg Sanna-Maria K äkönen Arne Scholz Tags: Article Source Type: research
Oral fibroblasts rescue osteogenic differentiation of mesenchymal stem cells after exposure to Zoledronic acid in a paracrine effect
Conclusion: Oral fibroblasts secrete proteins that enable osteogenic differentiation of MSCs in the presence of Zoledronic Acid. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - August 11, 2023 Category: Drugs & Pharmacology Source Type: research
Increased apoptosis of gingival epithelium is associated with impaired autophagic flux in medication-related osteonecrosis of the jaw
In this study, we aimed to explore the relationship between autophagy and apoptosis in MRONJ gingival epithelium and search for a method to prevent this disease. First, we examined clinical samples from patients diagnosed with MRONJ and healthy controls, finding that autophagy-related markers MAP1LC3/LC3 and SQSTM1/p62 synchronously increased, thus suggesting that autophagic flux was suppressed in MRONJ. Moreover, mRNA sequencing analysis and TUNEL assay showed that the process of apoptosis was upregulated in patients and animals with MRONJ, indicating autophagy and apoptosis participate in the development of MRONJ. Furthe...
Source: Autophagy - July 21, 2023 Category: Cytology Authors: Xian Dong Yang He Jingang An Linhai He Yi Zheng Xinyu Wang Jie Wang Shuo Chen Yi Zhang Source Type: research
Retracted: Efficacy Evaluation of Zoledronic Acid Combined with Chemotherapy in the Treatment of Lung Cancer Spinal Metastases on Computed Tomography Images on Intelligent Algorithms
Comput Math Methods Med. 2023 Jul 12;2023:9797160. doi: 10.1155/2023/9797160. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.1155/2022/6431852.].PMID:37475951 | PMC:PMC10356340 | DOI:10.1155/2023/9797160 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - July 21, 2023 Category: Statistics Authors: Computational And Mathematical Methods In Medicine Source Type: research
Increased apoptosis of gingival epithelium is associated with impaired autophagic flux in medication-related osteonecrosis of the jaw
In this study, we aimed to explore the relationship between autophagy and apoptosis in MRONJ gingival epithelium and search for a method to prevent this disease. First, we examined clinical samples from patients diagnosed with MRONJ and healthy controls, finding that autophagy-related markers MAP1LC3/LC3 and SQSTM1/p62 synchronously increased, thus suggesting that autophagic flux was suppressed in MRONJ. Moreover, mRNA sequencing analysis and TUNEL assay showed that the process of apoptosis was upregulated in patients and animals with MRONJ, indicating autophagy and apoptosis participate in the development of MRONJ. Furthe...
Source: Autophagy - July 21, 2023 Category: Cytology Authors: Xian Dong Yang He Jingang An Linhai He Yi Zheng Xinyu Wang Jie Wang Shuo Chen Yi Zhang Source Type: research
Retracted: Efficacy Evaluation of Zoledronic Acid Combined with Chemotherapy in the Treatment of Lung Cancer Spinal Metastases on Computed Tomography Images on Intelligent Algorithms
Comput Math Methods Med. 2023 Jul 12;2023:9797160. doi: 10.1155/2023/9797160. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.1155/2022/6431852.].PMID:37475951 | PMC:PMC10356340 | DOI:10.1155/2023/9797160 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - July 21, 2023 Category: Statistics Authors: Computational And Mathematical Methods In Medicine Source Type: research
Increased apoptosis of gingival epithelium is associated with impaired autophagic flux in medication-related osteonecrosis of the jaw
In this study, we aimed to explore the relationship between autophagy and apoptosis in MRONJ gingival epithelium and search for a method to prevent this disease. First, we examined clinical samples from patients diagnosed with MRONJ and healthy controls, finding that autophagy-related markers MAP1LC3/LC3 and SQSTM1/p62 synchronously increased, thus suggesting that autophagic flux was suppressed in MRONJ. Moreover, mRNA sequencing analysis and TUNEL assay showed that the process of apoptosis was upregulated in patients and animals with MRONJ, indicating autophagy and apoptosis participate in the development of MRONJ. Furthe...
Source: Autophagy - July 21, 2023 Category: Cytology Authors: Xian Dong Yang He Jingang An Linhai He Yi Zheng Xinyu Wang Jie Wang Shuo Chen Yi Zhang Source Type: research
Retracted: Efficacy Evaluation of Zoledronic Acid Combined with Chemotherapy in the Treatment of Lung Cancer Spinal Metastases on Computed Tomography Images on Intelligent Algorithms
Comput Math Methods Med. 2023 Jul 12;2023:9797160. doi: 10.1155/2023/9797160. eCollection 2023.ABSTRACT[This retracts the article DOI: 10.1155/2022/6431852.].PMID:37475951 | PMC:PMC10356340 | DOI:10.1155/2023/9797160 (Source: Computational and Mathematical Methods in Medicine)
Source: Computational and Mathematical Methods in Medicine - July 21, 2023 Category: Statistics Authors: Computational And Mathematical Methods In Medicine Source Type: research
