Approach to the differential diagnosis between multiple myeloma or osteonecrosis: a case report
A 67-year-old female patient, diagnosed with multiple myeloma (MM), reported intense pain in the right-side mandible and hemi-face. She was undergoing third-line chemotherapy associated with the use of zoledronic acid. Clinical exams showed drainage of purulent secretion in the gingival sulcus and gingival edema in the peri-implant region. Computed tomography showed an osteolytic lesion in the right mandible, with bone sequestration adjacent to the base of a dental implant leading to MM lesion or osteonecrosis hypothesis. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - June 15, 2023 Category: ENT & OMF Authors: Julia Lopes FERIGATTO, Iara Zapparoli Gon çalves, Maurício Eiji de Almeida Santos Yamashita, Emilze Mafra de Lima, Victor Tieghi Neto, Fábio Luiz Coracin, Renata de Freitas Varanda Source Type: research
Jaw plasmocytoma leading to a multiple myeloma relapse diagnosis: a case report
A 46-year-old female patient was diagnosed with multiple myeloma and is undergoing treatment using the chemotherapy CTD protocol, followed by autologous stem cell transplantation and zoledronic acid use. Her complaints included paresthesia in the left mental region with increased volume. Physical examination revealed a 4.5cm rubbery nodule with intact epithelium. Cone-beam computed tomography revealed an osteolytic image of the medullary bone and cortical disruption in the lower left alveolar ridge. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - June 15, 2023 Category: ENT & OMF Authors: Pedro Henrique Cossu VALLEJO, Aline Pereira de MENEZES, Daniele Moraes LOSADA, Isabela Assis de SIQUEIRA, Victor Tieghi NETO, F ábio Luiz CORACIN, Renata Freitas VARANDA Source Type: research
Osteonecrosis in the jaw associated with the use of biphosphonate after dental implant installation
Bisphosphonates are recommended to treat bone metastasis, multiple myeloma, and other diseases of bone metabolism. They inhibit the action of osteoclasts, decreasing bone resorption and turnover, and endothelial growth factor. This led to osteonecrosis, characterized by osteolytic lesions and exposure of necrotic bone, appearing spontaneously or after surgical procedures. Osteonecrosis treatment is difficult and brings morbidity to the patient. A 68-year-old diabetic man, with prostate tumor, using zoledronic acid monthly since 2008, received implants in the mandible in April 2013. (Source: Oral Surgery, Oral Medicine, Ora...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - June 15, 2023 Category: ENT & OMF Authors: Ana Maria Ip ólito BARROS, Marco Murilo BUSO, Addah Regina da Silva FREIRE, Cleomar Donizeth RODRIGUES, Ana Paula Veras SOBRAL, Márcia Maria Fonseca da SILVEIRA Source Type: research
Zoledronic acid –induced severe lymphopenia
This article describes a case of severe lymphopenia following a 5 mg zoledronic acid infusion administered to treat osteoporosis. Zoledronic acid is used to treat osteoporosis, hypercalcemia, Paget ’s disease, and solid malignancies, including multiple myeloma, breast cancer, and prostate cancer. An acute phase response can be seen in 42% of patients after zoledronic acid treatment. Acute phase response may be accompanied by short-term spontaneously recovered anemia, thrombocytopenia, and se vere lymphopenia. (Source: Osteoporosis International)
Source: Osteoporosis International - June 15, 2023 Category: Orthopaedics Source Type: research
Correction to “Durability and Delayed Treatment Effects of Zoledronic Acid on Bone Loss after Spinal Cord Injury: A Randomized, Controlled Trial”
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 12, 2023 Category: Orthopaedics Tags: Erratum Source Type: research
Zoledronic acid after spinal cord injury mitigates losses in proximal femoral strength independent of ambulation ability
ConclusionThese findings demonstrate that treatment with zoledronic acid in acute SCI attenuates losses in proximal femoral strength, which may reduce the risk of hip fractures across patients with varying degrees of ambulatory abilities. (Source: Osteoporosis International)
Source: Osteoporosis International - June 8, 2023 Category: Orthopaedics Source Type: research
GSE233745 Transcriptional alteration in the treatment of MDA-MB-231 cells using BITC and/or ZA
We report differential gene expression changes by benzyl isothiocyanate (BITC) and/or zoledronic acid (ZA) in MDA-MB-231 human breast cancer cell line (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - May 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
The impact of acute-phase reaction on mortality and re-fracture after zoledronic acid in hospitalized elderly osteoporotic fracture patients
ConclusionsOur findings suggested a potential association between the occurrence of APR and increased mortality risk. An initial dose of ZOL following orthopedic surgery was found to be protective against re-fracture in older patients with OPFs. (Source: Osteoporosis International)
Source: Osteoporosis International - May 29, 2023 Category: Orthopaedics Source Type: research
Safety of Inpatient Zoledronic Acid in the Immediate Post-Fracture Setting
CONCLUSIONS: IP-ZA along with standing multiple-doses-per-day acetaminophen, administered to patients in the immediate post-fracture period, is not associated with significant acute adverse effects.PMID:37227016 | DOI:10.1210/clinem/dgad295 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 25, 2023 Category: Endocrinology Authors: WuQiang Fan Benjamin Z Leder Michael Mannstadt Thuan V Ly Esteban Franco-Garcia Marcy B Bolster Source Type: research
Safety of Inpatient Zoledronic Acid in the Immediate Post-Fracture Setting
CONCLUSIONS: IP-ZA along with standing multiple-doses-per-day acetaminophen, administered to patients in the immediate post-fracture period, is not associated with significant acute adverse effects.PMID:37227016 | DOI:10.1210/clinem/dgad295 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 25, 2023 Category: Endocrinology Authors: WuQiang Fan Benjamin Z Leder Michael Mannstadt Thuan V Ly Esteban Franco-Garcia Marcy B Bolster Source Type: research
Granulocyte-colony stimulating factor producing cervical cancer with elevated levels of parathyroid hormone-related protein: a case report and literature review
AbstractSystemic effects associated with hormones and cytokines secreted by tumor cells can cause paraneoplastic syndrome. Leukemoid reactions and hypercalcemia are relatively common manifestations of paraneoplastic syndrome. Here, we describe the case of a 90-year-old woman who presented with leukocytosis and hypercalcemia and was diagnosed with granulocyte-colony stimulating factor (G-CSF)-producing cervical cancer with elevated levels of parathyroid hormone-related protein (PTHrP). The patient visited our hospital complaining of general fatigue and anorexia. On admission, she presented with marked leukocytosis, hypercal...
Source: CEN Case Reports - May 25, 2023 Category: Urology & Nephrology Source Type: research
