Value of stimulated pre-ablation thyroglobulin as a prognostic marker in patients with differentiated thyroid carcinoma treated with radioiodine
ConclusionsTg pre-ablation is a valuable predictor of DTC incomplete response to treatment one year after RAIT. Levels of 4.4 ng/ml or more showed higher accuracy to predict this outcome. (Source: Endocrine)
Source: Endocrine - March 2, 2022 Category: Endocrinology Source Type: research
Cancers, Vol. 14, Pages 1272: Molecular Imaging and Theragnostics of Thyroid Cancers
vcaricek
Molecular imaging plays an important role in the evaluation and management of different thyroid cancer histotypes. The existing risk stratification models can be refined, by incorporation of tumor-specific molecular markers that have theranostic power, to optimize patient-specific (individualized) treatment decisions. Molecular imaging with varying radioisotopes of iodine (i.e., 131I, 123I, 124I) is an indispensable component of dynamic and theragnostic risk stratification of differentiated carcinoma (DTC) while [18F]F-fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) help...
Source: Cancers - March 1, 2022 Category: Cancer & Oncology Authors: Luca Giovanella Desiree ’ Deandreis Alexis Vrachims Alfredo Campenni Petra Petranovic Ovcaricek Tags: Review Source Type: research
Pregnancy Outcomes in Thyroid Cancer Survivors: A Propensity Score-Matched Cohort Study
ConclusionA history of treated papillary thyroid cancer was not associated with adverse pregnancy outcomes. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - February 17, 2022 Category: Endocrinology Source Type: research
Postoperative radioiodine therapy impact on survival in poorly differentiated thyroid carcinoma: a population-based study
Purpose
The true impact of postoperative radioiodine therapy on survival has been controversial for patients with poorly differentiated thyroid carcinoma (PDTC). We aimed to determine the impact of postoperative radioiodine on survival in PDTC through a population-based study.
Methods
Data on patients with PDTC were collected from the US SEER database (2004 to 2015). Patients were divided into the radioiodine group and nonradioiodine group. Survival comparison between groups was evaluated by Kaplan–Meier curves, log-rank test and multivariate Cox regression analysis. Akaike information criterion was used to se...
Source: Nuclear Medicine Communications - January 24, 2022 Category: Nuclear Medicine Tags: Original Articles Source Type: research
Cancers, Vol. 14, Pages 501: Initial Evaluation of Therapy Response after Adjuvant Radioiodine Therapy in Patients with Early-Stage Papillary Thyroid Cancer & mdash;Does Time Matter?
Conclusion: DC at 6 months after RAI therapy and stimulation with recombinant human thyroid-stimulating hormone (rhTSH) represent the most balanced solution. Particularly regarding quality of life and mental relief of patients, early DC with rhTSH represents sufficient and convenient assessment of ablation success. (Source: Cancers)
Source: Cancers - January 20, 2022 Category: Cancer & Oncology Authors: Freba Grawe Yuri Cramm Matthias P. Fabritius Johannes Ruebenthaler Viktoria F. Koehler Harun Ilhan Peter Bartenstein Vera Wenter Andrei Todica Tags: Article Source Type: research
Retrospective study of the influence of hypothyroidism on liver function before radioiodine therapy in China: a comparison analysis based on patients with differentiated thyroid cancer
Conclusions
Patients with minor hepatic dysfunction and ortholiposis are more likely to recover to normal liver function. Patients with moderate hepatic dysfunction should be treated with hepatoprotective drugs. For men, FT4 and TG levels tended to be associated with hepatic dysfunction, and the prognosis of hepatic dysfunction was closely related to the TG level. (Source: BMJ Open)
Source: BMJ Open - January 18, 2022 Category: General Medicine Authors: Ji, Y., Zheng, W., Meng, Z., Wu, C., Tan, J., Wang, R. Tags: Open access, Diabetes and Endocrinology Source Type: research
123I Scintigraphy Mirror Image of Graves Disease Induced by Radioiodine Treatment for Toxic Adenoma
A 61-year-old woman presenting with hyperthyroidism received 131I therapy for a toxic adenoma diagnosed by 123I scintigraphy. Six months later, the patient had a relapse of hyperthyroidism, and 123I scintigraphy showed a mirror image of the first scintigraphy: a high and diffuse uptake in the thyroid gland except for the previously treated nodule. Graves disease was confirmed by elevated thyrotropin receptor antibodies. The patient was cured by a second radioiodine therapy. Radioiodine-induced Graves disease may occur within 6 months of 131I treatment of toxic adenoma and can be treated with a second line of 131I. (Source:...
Source: Clinical Nuclear Medicine - January 16, 2022 Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Recombinant human thyrotropin (rhTSH)-aided radioiodine treatment for non-toxic multinodular goitre
CONCLUSIONS: RhTSH-aided radioiodine treatment for non-toxic multinodular goitre, compared to radioiodine alone, probably increased the risk of hypothyroidism but probably led to a greater reduction in thyroid volume. Data on QoL and costs were sparse or missing.PMID:34961921 | DOI:10.1002/14651858.CD010622.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - December 28, 2021 Category: General Medicine Authors: Yanlei Huo Jiawei Xie Suyun Chen Hui Wang Chao Ma Source Type: research
Recombinant human thyrotropin (rhTSH)-aided radioiodine treatment for non-toxic multinodular goitre
CONCLUSIONS: RhTSH-aided radioiodine treatment for non-toxic multinodular goitre, compared to radioiodine alone, probably increased the risk of hypothyroidism but probably led to a greater reduction in thyroid volume. Data on QoL and costs were sparse or missing.PMID:34961921 | DOI:10.1002/14651858.CD010622.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - December 28, 2021 Category: General Medicine Authors: Yanlei Huo Jiawei Xie Suyun Chen Hui Wang Chao Ma Source Type: research
Pregnancy exacerbated lymph node metastasis of well differentiated thyroid carcinoma: A case report
Conclusion:
Pregnancy in differentiated thyroid cancer survivors should be managed and monitored with caution, especially when cancer recurrence is noticed. Further studies are recommended to investigate these previously unreported gene mutations associated with thyroid cancer. (Source: Medicine)
Source: Medicine - December 23, 2021 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Re-Modelling 99m-Technetium Pertechnetate Thyroid Uptake; Statistical, Machine Learning and Deep Learning Approaches
Conclusion: Thyroid scintigraphy is useful in identifying hyperthyroid patients suitable for radioiodine therapy when using an appropriately validated cut-off for the patient population (4.5% in this population). ML ANN algorithms can be developed to improve accuracy as second readers systems when biochemistry results are available. DL CNN algorithms can be developed to improve accuracy in the absence of biochemistry results. ML and DL do not displace the role of the physician in thyroid scintigraphy but could be used as second reader systems to minimize errors and increase confidence.PMID:34876477 | DOI:10.2967/jnmt.121.2...
Source: Journal of Nuclear Medicine Technology - December 8, 2021 Category: Nuclear Medicine Authors: Geoffrey M Currie Basit M Iqbal Source Type: research
