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Clinical challenges in applying the new lung function test interpretive strategies: navigating pitfalls and possible solutions
Extract The European Respiratory Society (ERS)/American Thoracic Society (ATS) recently released updated interpretive strategies for routine pulmonary function tests (PFTs) [1] building upon their previous standardisation document [2]. Although some authors have already discussed the advantages and drawbacks of these new strategies [3], there remain several unclear points that require to be clarified. The published document proposes two interpretative flow charts and some tables [1], which lack integration and contradict each other at times, leading to confusion. For instance, a scenario in which the forced expiratory volu...
Source: European Respiratory Journal - January 25, 2024 Category: Respiratory Medicine Authors: Ora, J., Rogliani, P. Tags: Research letters Source Type: research

Anti-IL-5 and anti-IL-5R biologics for severe asthma. Are there any differences in their effects?
CONCLUSION: The anti-IL-5 and anti-IL-5Rα biologics have shown similar effectiveness despite having different mechanisms of action. The anti-IL-5 group appeared to be better than benralizumab at improving ACT scores and FEV1/FVC and at reducing the number of inhalers. Although these differences were not statistically significant, it is not clear whether they may have clinical relevance and they might highlight the need for further head-to-head studies comparing these treatments.PMID:38266131 | DOI:10.1080/02770903.2024.2308684 (Source: Journal of Asthma)
Source: Journal of Asthma - January 24, 2024 Category: Respiratory Medicine Authors: Paula Granda Elena Villama ñán Carlos Carpio Daniel Laorden Santiago Quirce Rodolfo Álvarez-Sala NEUMO Study Group Source Type: research

Real-world outcomes from a series of patients with late onset Pompe disease who switched from alglucosidase alfa to avalglucosidase alfa
This study presents evidence that switching from alglucosidase to avalglucosidase may be associated with improved outcomes in certain patients with LOPD. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - January 19, 2024 Category: Genetics & Stem Cells Source Type: research

A formula for predicting emphysema extent in combined idiopathic pulmonary fibrosis and emphysema
No single pulmonary function test captures the functional effect of emphysema in idiopathic pulmonary fibrosis (IPF). Without experienced radiologists, other methods are needed to determine emphysema extent. H... (Source: Respiratory Research)
Source: Respiratory Research - January 18, 2024 Category: Respiratory Medicine Authors: Athol U. Wells, Joseph Jacob, Nicola Sverzellati, Gary Cross, Joseph Barnett, Angelo De Lauretis, Katerina Antoniou, Derek Weycker, Mark Atwood, Klaus-Uwe Kirchgaessler and Vincent Cottin Tags: Research Source Type: research

Prognostic Factors for Predicting Post-COVID-19 Condition in Patients With COVID-19 in an Outpatient Setting
CONCLUSION: The non-use of antivirals, lower 25(OH)D3 levels, leukocytosis, FVC < 90% predicted, and the presence of dyspnea and anxiety/depression symptoms could be useful prognostic factors for predicting post-COVID-19 condition in outpatients with COVID-19. We suggest that the use of antiviral agents during the acute phase and vitamin D supplements might help reduce COVID-19 symptom duration.PMID:38225786 | PMC:PMC10789531 | DOI:10.3346/jkms.2024.39.e23 (Source: J Korean Med Sci)
Source: J Korean Med Sci - January 16, 2024 Category: General Medicine Authors: Myeong Geun Choi Young Woong Joo Min-Ho Kim Sojung Park Yune-Young Shin Eun Mi Chun Source Type: research

Prognostic Factors for Predicting Post-COVID-19 Condition in Patients With COVID-19 in an Outpatient Setting
CONCLUSION: The non-use of antivirals, lower 25(OH)D3 levels, leukocytosis, FVC < 90% predicted, and the presence of dyspnea and anxiety/depression symptoms could be useful prognostic factors for predicting post-COVID-19 condition in outpatients with COVID-19. We suggest that the use of antiviral agents during the acute phase and vitamin D supplements might help reduce COVID-19 symptom duration.PMID:38225786 | PMC:PMC10789531 | DOI:10.3346/jkms.2024.39.e23 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - January 16, 2024 Category: Biomedical Science Authors: Myeong Geun Choi Young Woong Joo Min-Ho Kim Sojung Park Yune-Young Shin Eun Mi Chun Source Type: research

Obstructive Sleep Apnea: a risk for uncontrolled and more severe asthma in adults that we should keep an eye on
Conclusions. It is crucial to actively investigate OSA, especially in patients with uncontrolled and more severe forms of asthma.PMID:38223952 | DOI:10.23822/EurAnnACI.1764-1489.324 (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - January 15, 2024 Category: Allergy & Immunology Authors: G Martins Dos Santos P Sim ão Coelho J Gaspar Marques S Serranho S Santos A Brito P Carreiro Martins P Leiria Pinto Source Type: research

Evaluation of the effectiveness of Tadalafil on improving pulmonary function and asthma severity in severe asthmatic patients: a randomized controlled trial study
This study aims to assess the impact of Tadalafil, a selective phosphodiesterase inhibitor, on pulmonary function in patients with asthma. This study was a randomized, double-blind clinical trial conducted in 2021 at Imam Khomeini Hospital in Ahvaz, Iran. The study enrolled 44 patients with severe asthma, who were divided equally into a Tadalafil group and a placebo group. The Tadalafil group received 20 mg/day of Tadalafil, while the placebo group received a placebo at the same dose. The patients' spirometry tests, asthma quality of life questionnaire, 6-minute walk distance, and quality of life were measured at the begin...
Source: Monaldi Archives for Chest Disease - January 12, 2024 Category: Respiratory Medicine Authors: Seyed Hamid Borsi Seyed Ali Asghar Fakhr Mousavi Fakhr Mousavi Mehrdad Dargahi Mal-Amir Heshmatollah Tavakol Hanieh Raji Source Type: research

The effects of inspiratory muscle warm-up prior to inspiratory muscle training during pulmonary rehabilitation in subjects with chronic obstructive pulmonary disease: a randomized trial
CONCLUSIONS: This study demonstrated improvements in both groups, surpassing or closely approaching the established minimal clinically important difference values for the respective outcomes. Performing a warm-up for inspiratory muscles before IMT boosts benefits for pulmonary function, inspiratory muscle strength, exercise capacity, dyspnea, and HRQoL in subjects with moderate-to-severe COPD and inspiratory muscle weakness.PMID:38205730 | DOI:10.1080/09593985.2023.2301439 (Source: Physiotherapy Theory and Practice)
Source: Physiotherapy Theory and Practice - January 11, 2024 Category: Physiotherapy Authors: R ıdvan Aktan Sevgi Özalevli Hazal Yakut Aylin Özgen Alpaydin Source Type: research

The effect of respiratory muscle training on respiratory muscle strength, diaphragm thickness/mobility, and exercise capacity in patients with systemic lupus erythematosus and associated shrinking lung syndrome
The objective of the current case series was to investigate the effects of inspiratory muscle training (IMT) on diaphragm thickness/mobility, respiratory muscle strength, peripheral muscle thickness/strength, and functional exercise capacity in patients with SLE and associated SLS. Three patients with SLE were included in the case series. Respiratory muscle strength, peripheral muscle strength, peripheral muscle thickness, diaphragm muscle thickness, diaphragm muscle mobility, functional exercise capacity, and pulmonary function test were assessed. A significant improvement has been determined in respiratory muscle strengt...
Source: Lupus - January 9, 2024 Category: Rheumatology Authors: Fulden Sari Deran Oskay Abdurrahman Tufan Source Type: research

Cardiopulmonary function in paediatric post-COVID-19: a controlled clinical trial
Conclusion: This is the first study to investigate post-COVID-19 in children using the cardiopulmonary exercise test. Although there was a significantly reduced\(\dot{{\text{V}}}{{\text{O}}}_{2}{\text{peak}}\) in the post-COVID-19 group, this was not true for the percent of predicted values. No pathological findings with respect to cardiac or pulmonary functions could be discerned. Deconditioning was the most plausible cause for the experienced symptoms. Trial registration: clinicaltrials.gov, NCT054445531, Low-field Magnetic Resonance Imaging in Pediatric Post Covid-19 —Full Text View—ClinicalTrials.gov.What is K...
Source: European Journal of Pediatrics - January 9, 2024 Category: Pediatrics Source Type: research

Structural and functional features of asthma participants with fixed airway obstruction using CT imaging and 1D computational fluid dynamics: A feasibility study
In conclusion, asthma participants with FAO had worse lung functions and higher-pressure drops than those wit hout FAO. (Source: Physiological Reports)
Source: Physiological Reports - January 8, 2024 Category: Physiology Authors: Quoc Hung Nguyen, So Ri Kim, Kum Ju Chae, Gong Yong Jin, Sanghun Choi Tags: ORIGINAL ARTICLE Source Type: research

Impulse Oscillometry as an Alternative Lung Function Test for Hospitalized Adults
CONCLUSIONS: We found that the IOS performed well in diagnosing small airway and obstructive diseases among hospitalized subjects. IOS might serve as an alternative to standard PFTs in non-cooperative or dyspneic hospitalized patients.PMID:38167212 | DOI:10.4187/respcare.10963 (Source: Respiratory Care)
Source: Respiratory Care - January 3, 2024 Category: Respiratory Medicine Authors: Eyal Kleinhendler Maya Rosman Elisabeth Fireman Ophir Freund Ivgeny Gershman Irena Pumin Tal Perluk Boaz Tiran Avraham Unterman Amir Bar-Shai Source Type: research