Fight Aging! Newsletter, January 17th 2022
In conclusion, fibroblasts in monolayers cultured with soluble pentosidine and tridimensional in vitro skin constructs exposed to the combination of AGEs and UVA promote an inflammatory state and an alteration of the dermal compartment in relation to an elastosis-like environment. (Source: Fight Aging!)
Source: Fight Aging! - January 16, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
New Wearable Detects Respiratory Exacerbations: Interview with Dr. Maria Artunduaga, CEO of Respira Labs
Respira Labs, a medtech company based in California, created the Sylvee sensor, an adhesive patch that the user wears on their lower rib cage, and which monitors respiratory health. The device works through acoustic resonance, whereby it emits sound into the chest cavity and analyzes the echoed vibrations.
The measured data provide information on lung air volume and correlate with the amount of air that is trapped in the lungs, which can offer a warning sign that a respiratory exacerbation is possible. With many COVID-19 patients experiencing impaired breathing for sustained periods after their initial infection has sub...
Source: Medgadget - December 21, 2021 Category: Medical Devices Authors: Conn Hastings Tags: Cardiology Diagnostics Exclusive Medicine respiralabs Source Type: blogs
Fight Aging! Newsletter, November 16th 2020
This study conclusively demonstrates the long-speculated relationship between aging, gene regulation, and somatic damage. The results open up new avenues of research with practical implications. If the same level of coordination reduction between genes is indeed a leading cause for aging phenomena, there may be a need to change course in current efforts to develop aging treatments.
Using Oligodendrocyte Extracellular Vesicles to Induce Tolerance to Myelin as a Treatment for Multiple Sclerosis
https://www.fightaging.org/archives/2020/11/using-oligodendrocyte-extracellular-vesicles-to-induce-tolerance-to-myelin-...
Source: Fight Aging! - November 15, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, July 13th 2020
In conclusion, sitting for prolonged periods of time without interruption is unfavorably associated with DBP and HDL cholesterol.
Exercise Slows Inappropriate Growth of Blood Vessels in a Mouse Model of Macular Degeneration
https://www.fightaging.org/archives/2020/07/exercise-slows-inappropriate-growth-of-blood-vessels-in-a-mouse-model-of-macular-degeneration/
Excessive growth of blood vessels beneath the retina is a proximate cause of blindness in conditions such as macular degeneration. Researchers here provide evidence for physical activity to be influential in the pace at which this process of tissu...
Source: Fight Aging! - July 12, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Breathtaking: The Future Of Respiratory Care And Pulmonology
Smoke-measuring smart shirts, breath sound analyzing
algorithms, and smart inhalers pave the way of pulmonology and respiratory care
into the future. As the number of patients suffering from asthma, COPD, or lung
cancer due to rising air pollution and steady smoker-levels will unfortunately
not decrease any time soon, we looked around what technology can do to help
both patients and caregivers. The results are breathtaking.
Attacks of
breathlessness are too common
The diseases which pulmonologists and respiratory care
specialists attempt to fight are among the most common conditions in the modern
world – and the n...
Source: The Medical Futurist - September 25, 2019 Category: Information Technology Authors: nora Tags: Artificial Intelligence Future of Medicine Health Sensors & Trackers AI asthma cancer cancer treatment care COPD diagnostics inhaler lung lung cancer management medical specialty pulmonology respiratory respiratory care Source Type: blogs
Fight Aging! Newsletter, January 14th 2019
In conclusion, reduction of LDL-C to less than 50 mg/dl seems safe and provides greater CV benefits compared with higher levels. Data for achieved LDL-C lower than 20-25 mg/dl is limited, although findings from the above mentioned studies are encouraging. However, further evaluation is needed for future studies and post-hoc analyses.
Wary of the Beautiful Fairy Tale of Near Term Rejuvenation
https://www.fightaging.org/archives/2019/01/wary-of-the-beautiful-fairy-tale-of-near-term-rejuvenation/
One might compare this interview with researcher Leonid Peshkin to last year's discussion with Vadim Gladyshev....
Source: Fight Aging! - January 13, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Results from a Pilot Human Trial of Senolytics versus Idiopathic Pulmonary Fibrosis
Researchers here report on results from an initial pilot trial of the use of a senolytic therapy to treat idiopathic pulmonary fibrosis. The data is perhaps much as expected for a first pass at removing senescent cells associated with a specific condition, using the tools available today: a starting point, benefits observed, but definitely room for improvement. The particular senolytic combination used here is cheap and readily available and can remove as much as half of senescent cells in some tissues in mice, but the degree of clearance varies widely by tissue type, and the optimal human dose is yet to be determined. Typ...
Source: Fight Aging! - January 7, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 23rd 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - July 22, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, June 25th 2018
In this study, we investigate mitochondrial energetics and mtDNA methylation in senescent cells, and evaluate the potential of humanin and MOTS-c as novel senolytics or SASP modulators that can alleviate symptoms of frailty and extend health span by targeting mitochondrial bioenergetics.
Exercise versus the Hallmarks of Aging
https://www.fightaging.org/archives/2018/06/exercise-versus-the-hallmarks-of-aging/
The paper I'll point out today walks through the ways in which exercise is known to beneficially affect the Hallmarks of Aging. The Hallmarks are a list of the significant causes of aging that I di...
Source: Fight Aging! - June 24, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
4Dx Uses Algorithms to Better Visualize Lung Function
Chronic obstructive pulmonary disease affects millions of people in the United States. The main method of diagnosis is the pulmonary function tests (PFTs), in which a patient breathes into a machine that measures pulmonary parameters. The disadvantage, however, is that pulmonary function tests take an “average” of a patient’s lung without being able to detect specific areas of lung function and compare them over time.
4Dx is hoping to improve that. Using principles of air flow dynamics and applying them to data from a simple X-ray, the company’s algorithms can calculate the amount of air that each area of the lung ...
Source: Medgadget - April 19, 2018 Category: Medical Devices Authors: Cici Zhou Tags: Anesthesiology Cardiology Critical Care Diagnostics Exclusive Medicine Radiology Surgery Thoracic Surgery Source Type: blogs
Fight Aging! Newsletter, April 9th 2018
This studycounters that notion, and the findings may suggest that many senior citizens remain more cognitively and emotionally intact than commonly believed.
"We found that older people have similar ability to make thousands of hippocampal new neurons from progenitor cells as younger people do. We also found equivalent volumes of the hippocampus (a brain structure used for emotion and cognition) across ages. Nevertheless, older individuals had less vascularization and maybe less ability of new neurons to make connections. It is possible that ongoing hippocampal neurogenesis sustains human-specific cognitive function...
Source: Fight Aging! - April 8, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Correlation Between More AGEs in the Skin and Worse Pulmonary Function
This study demonstrated that SAF is an independent factor associated with FEV1/FVC in the elderly group. According to other studies, AGEs in the blood and AGE accumulation in skin were higher in smokers than in non-smokers. AGEs can bind to and activate RAGE, which are present on cell surfaces in tissues, especially in the lung. Activation of RAGE increases inflammation via NF-κB. Therefore, the decrease in FEV1/FVC was likely accelerated by AGE accumulation.
With respect to the younger group, SAF was not associated with decreased FEV1/FVC. There are several potential explanations for the differences observed betwe...
Source: Fight Aging! - April 3, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Thoughts on diagnostic errors in 2017
The Society to Improve Diagnosis in Medicine has on its website this quote:
Reducing Harm from Diagnostic Error
1 in 10 diagnoses are incorrect.
Diagnostic error accounts for 40,000-80,000 US deaths annually—somewhere between breast cancer and diabetes.
Chances are, we will all experience diagnostic error in our lifetime.
(US Institute of Medicine 2015, BMJ Quality & Safety 25-Year Summary of US Malpractice Claims, 2013.)
The current focus on diagnostic error raises an interesting question: Is this a larger problem in 2017 than in the 1970s and 1980s?
In this post, I postulate that the problem has increased. Se...
Source: DB's Medical Rants - August 7, 2017 Category: Internal Medicine Authors: rcentor Tags: Medical Rants Source Type: blogs
Fight Aging! Newsletter, August 7th 2017
Discussions of radical life extension, technological acceleration, and artificial general intelligence were far more fringe concerns back then than is now the case, but this growth in awareness isn't a coincidence. Visions slowly become reality because people work to make that happen. Technological progress is not accidental: it is led by our desires.
I should say that de Magalhães is here generous in not passing judgement on the value (or lack thereof) of most of the various ventures and classes of approach he surveys. But some approaches are definitely better than others, and to my eyes one the principal challeng...
Source: Fight Aging! - August 6, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
More Evidence for Senolytic Therapies as a Treatment for Lung Fibrosis
Research into cellular senescence as a cause of aging and age-related disease has expanded greatly these past few years. Several companies are developing approaches to safely remove these unwanted cells. Very compelling evidence has emerged for the role of senescent cells in aging; a number of research teams have demonstrated reversal of specific measures of aging in various tissues, with one study reporting extended life spans in normal mice in which senescent cells were cleared. The evidence to date is particular interesting in the case of lung conditions, especially those in which inflammation and fibrosis are prominent...
Source: Fight Aging! - August 4, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
