α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden
DISCUSSION: Results suggest that in ADAD LBP occurs later than AD pathology and often as amygdala- or olfactory-predominant LBP, for which CSF α-synuclein SAA has low sensitivity.HIGHLIGHTS: Cerebrospinal fluid (CSF) real-time quaking-induced conversion (RT-QuIC) detects misfolded α-synuclein in ≈ 10% of symptomatic autosomal dominant Alzheimer's disease (ADAD) patients. CSF RT-QuIC does not detect α-synuclein seeding activity in asymptomatic mutation carriers. Lewy body pathology (LBP) in ADAD mainly occurs as olfactory only or amygdala-predominant variants. LBP develops late in the disease course in ADAD. CSF α-syn...
Source: The Journal of Alzheimers Association - April 26, 2024 Category: Psychiatry Authors: Johannes Levin Simone Baiardi Corinne Quadalti Marcello Rossi Angela Mammana Jonathan V öglein Alexander Bernhardt Richard J Perrin Mathias Jucker Oliver Preische Anna Hofmann G ünter U Höglinger Nigel J Cairns Erin E Franklin Patricio Chrem Carlos Cru Source Type: research
Identification of key mRNAs and signaling pathways in obsessive compulsive disorder based on weighted gene co ‐expression network analysis and cytoHubba plugin
ConclusionThe key molecules obtained in this study lay a foundation for further research on the molecular mechanism of OCD. (Source: Brain and Behavior)
Source: Brain and Behavior - April 26, 2024 Category: Neurology Authors: Xiaoming Zhang,
Yanru Liu,
Bin Guo,
Binbin Li,
Huaqing Liu,
Zhiren Wang Tags: ORIGINAL ARTICLE Source Type: research
Where are services regarding sexual minorities and psychological therapies post-COVID in 2024? A mixed-method systematised review
Matt Broadway-Horner Mental Health and Social Inclusion, Vol. ahead-of-print, No. ahead-of-print, pp.- Since COVID-19, many services have burgeoned within the UK, but what about sexual minorities? Since the last review, there are appropriate therapies, but there is often inadequate research. The purpose of this mixed-method review synthesis looking into the efficacy of psychological therapies for sexual minorities. Seven studies were found in total.A mixed-method review synthesis, three studies looking into the efficacy of psychological therapies for sexual minorities and four studies addressing the experiences of sexual ...
Source: Mental Health and Social Inclusion - April 26, 2024 Category: Psychiatry Authors: Matt Broadway-Horner Source Type: research
IJERPH, Vol. 21, Pages 551: Consensus Panel Recommendations for the Pharmacological Management of Breastfeeding Women with Postpartum Depression
Conclusions: The ensuing recommendations were as follows: Recommendation 1: Depressive and anxiety disorders, as well as their pharmacological treatment, are not contraindications for breastfeeding. Recommendation 2: The Panel advocates for the continuation of medication that has demonstrated efficacy during pregnancy. If initiating an antidepressant during breastfeeding is necessary, drugs with a superior safety profile and substantial epidemiological data, such as SSRIs, should be favored and prescribed at the lowest effective dose. Recommendation 3: For the short-term alleviation of anxiety symptoms and sleep disturbanc...
Source: International Journal of Environmental Research and Public Health - April 26, 2024 Category: Environmental Health Authors: Georgios Eleftheriou Riccardo Zandonella Callegher Raffaella Butera Marco De Santis Anna Franca Cavaliere Sarah Vecchio Cecilia Lanzi Riccardo Davanzo Giovanna Mangili Emi Bondi Lorenzo Somaini Mariapina Gallo Matteo Balestrieri Guido Mannaioni Guglielmo Tags: Review Source Type: research
CBT More Effective Than Mindfulness for Prolonged Grief Symptoms Over Time, Study Finds
Both grief-focused cognitive-behavioral therapy (CBT) and mindfulness-based cognitive therapy improved patients ’ symptoms of prolonged grief disorder immediately after 11 weeks of treatment, according to astudy published yesterday inJAMA Psychiatry. Grief-focused CBT, however, was more effective in reducing patients ’ symptom severity six months after treatment ended.“[B]etween 15% and 25% of patients with prolonged grief disorder offered grief-focused cognitive behavior therapy decline to participate in treatment, and between 17% and 50% may not respond to treatment,” wrote Richard A. Bryant, Ph.D., of the Univer...
Source: Psychiatr News - April 25, 2024 Category: Psychiatry Tags: cognitive behavior therapy JAMA Psychiatry meditation mindfulness-based cognitive therapy Ph.D. prolonged grief disorder Randomized Clinical Trial Richard A. Bryant University of New South Wales Source Type: research
Editorial Board Page
(Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - April 25, 2024 Category: Psychiatry Source Type: research
Council Page
(Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - April 25, 2024 Category: Psychiatry Source Type: research
Table of Contents
(Source: Journal of the American Academy of Child and Adolescent Psychiatry)
Source: Journal of the American Academy of Child and Adolescent Psychiatry - April 25, 2024 Category: Psychiatry Source Type: research
A Synthesized Model for Applying Stress Management and Biofeedback Interventions in Research Utilization: A Systematic Review and Meta-analysis
CONCLUSION: The results emphasize the importance of evidence-based practice and highlight the need for ongoing evaluation and refinement of interventions. The proposed model was supported by related theories and research studies in order to ensure the robustness and reliability to guide practice and future research in the field of biofeedback interventions. By following this model, researchers and practitioners can ensure that stress management and biofeedback interventions are evidence-based and are effective in improving mental and physical health outcomes.PMID:38660573 | PMC:PMC11037511 | DOI:10.2174/0117450179276691231...
Source: Clinical Practice and Epidemiology in Mental Health - April 25, 2024 Category: Psychiatry Authors: Manyat Ruchiwit Sararud Vuthiarpa Kampol Ruchiwit Kasorn Muijeen Kanjanee Phanphairoj Source Type: research
Telemedicine, e-Health, and Digital Health Equity: A Scoping Review
CONCLUSION: In summary, the present paper has discussed Digital Health Equity in Telemedicine and e-Health. Promoting equity of access to healthcare is a significant challenge in contemporary times and in the near future. While on the one hand, the construct "equity" applied to the health context highlights the importance of creating and sustaining the conditions to allow anyone to be able to reach (and develop) their "health potential", it also raises numerous questions on "how this can happen". An overall and integrated picture of all the variables that promote DHE is needed, taking into account the interdependence among...
Source: Clinical Practice and Epidemiology in Mental Health - April 25, 2024 Category: Psychiatry Authors: Donatella Rita Petretto Gian Pietro Carrogu Luca Gaviano Roberta Berti Martina Pinna Andrea Domenico Petretto Roberto Pili Source Type: research
Understanding University Students' Perspectives towards Digital Tools for Mental Health Support: A Cross-country Study
CONCLUSION: Although considering some specific features, digital tools could be a useful instrument to support the mental health needs of students. Since personal contact remains crucial, digital tools should be integrated with face-to-face interventions through a multi-modal approach.PMID:38660572 | PMC:PMC11037510 | DOI:10.2174/0117450179271467231231060255 (Source: Clinical Practice and Epidemiology in Mental Health)
Source: Clinical Practice and Epidemiology in Mental Health - April 25, 2024 Category: Psychiatry Authors: Ilaria Riboldi Angela Calabrese Susanna Piacenti Chiara Alessandra Capogrosso Susanna Lucini Paioni Francesco Bartoli Giuseppe Carr à Jo Armes Cath Taylor Cristina Crocamo Source Type: research
Self-compassion, Positive and Negative Affect and Social Avoidance among Adolescence: Mediating Role of Mindfulness
CONCLUSION: Mindfulness is the awareness and acceptance of the feelings, thoughts and sensations attached to self and its possible reciprocity with social surroundings to mitigate fear-self-compassion and positive emotional affect augment, and negative emotional affect attenuate mindfulness. Results analysis highlights the mediation of mindfulness on social anxiety, self-compassion, positive affect, and negative affect.PMID:38660066 | PMC:PMC11041389 | DOI:10.2174/0117450179268979231114045116 (Source: Clinical Practice and Epidemiology in Mental Health)
Source: Clinical Practice and Epidemiology in Mental Health - April 25, 2024 Category: Psychiatry Authors: M S Sujamani Barani Kanth Source Type: research
Systematic Review and Meta-Analysis of Health-Related Quality of Life in Patients with β-Thalassemia that Underwent Hematopoietic Stem Cell Transplantation
CONCLUSION: HRQoL is generally good in β-TM transplanted patients and may significantly contribute in deciding whether or not to transplant a β-TM patient treated with conventional therapy.PMID:38659631 | PMC:PMC11037551 | DOI:10.2174/17450179-v17-e211208-2021-HT2-1910-4 (Source: Clinical Practice and Epidemiology in Mental Health)
Source: Clinical Practice and Epidemiology in Mental Health - April 25, 2024 Category: Psychiatry Authors: Olga Mulas Ilaria Pili Marco Sanna Giorgio La Nasa Source Type: research
The association of neighborhood socioeconomic status with executive function and processing speed in cognitively normal Mexican Americans elders from the Health and Aging Brains Study - Health Disparities cohort
CONCLUSION: Our study revealed that living in an area of higher deprivation was associated with lower cognitive function in MA but not in NHW, which is important to consider in future interventions to slow cognitive decline.PMID:38663362 | DOI:10.1159/000539035 (Source: Dementia and Geriatric Cognitive Disorders)
Source: Dementia and Geriatric Cognitive Disorders - April 25, 2024 Category: Psychiatry Authors: Raul Vintimilla Abigail Benton Roya Morakabian James R Hall Leigh A Johnson Sid E O'Bryant HABS-HD Study Team Source Type: research
Sleep Quality and Suicidal Ideation in Adolescent Depression: A Chain Mediation Effect of Perceived Social Support and Resilience
CONCLUSIONS: This study establishes that sleep quality indirectly predicts suicide ideation in major depressive adolescents, mediated independently by perceived social support and resilience.PMID:38659274 | DOI:10.1002/cpp.2990 (Source: Clinical Psychology and Psychotherapy)
Source: Clinical Psychology and Psychotherapy - April 25, 2024 Category: Psychiatry Authors: Yan Wu Zixuan Guo Dawei Zhang Yongna Wang Shufen Wang Source Type: research
