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The Role of Infection and Immune Responsiveness in a Case of Treatment-Resistant Pediatric Bipolar Disorder
Rosalie Greenberg (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - May 22, 2017 Category: Psychiatry Source Type: research

Individual Differences in Subjective Utility and Risk Preferences: The Influence of Hedonic Capacity and Trait Anxiety
Jonathon R. Howlett, Martin P. Paulus (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - May 22, 2017 Category: Psychiatry Source Type: research

Pharmacotherapy of Insomnia and Current Updates.
Authors: Misra AK, Sharma PK Abstract Insomnia is highly prevalent and is associated with a range of psychological, psychiatric, and medical conditions. Insomnia affects health by influencing cognitive, emotional and social functioning. Circadian and sleep homeostatic processes play an important role in insomnia development and its maintenance. Several efficacious treatments, both pharmacologic and non-pharmacologic, exist for the management of insomnia. Among non-pharmacologic treatments including stimulus control therapy, sleep restriction, relaxation, sleep hygiene and cognitive therapy have been shown to be eff...
Source: Journal of the Association of Physicians of India - May 22, 2017 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

Innovative Solutions for Expanding MH Care and More From APA ’s 2017 Annual Meeting Day Two
Day two of APA ’s Annual Meeting included an announcement of the results of a national poll on Americans’ views on access to mental health care, an address by the director of NIAAA, and discussion about ways to strengthen the therapeutic alliance with a patient after a suicide attempt.From now through May 24,Psychiatric News will deliver an evening digest of some of the day ’s highlights—from the lecture halls to the exhibit floor. Whether you are here in San Diego or at home, these reports will convey the excitement and outstanding scientific program being presented at this year’s meeting.Oquendo Recounts Victor...
Source: Psychiatr News - May 22, 2017 Category: Psychiatry Tags: addiction Anita Everett children's books genes George Koob James Batterson Maria Oquendo NIAAA pain physician burnout poll Steven Daviss suicide Source Type: research

Reduced amygdala reactivity and impaired working memory during dissociation in borderline personality disorder.
Authors: Krause-Utz A, Winter D, Schriner F, Chiu CD, Lis S, Spinhoven P, Bohus M, Schmahl C, Elzinga BM Abstract Affective hyper-reactivity and impaired cognitive control of emotional material are core features of borderline personality disorder (BPD). A high percentage of individuals with BPD experience stress-related dissociation, including emotional numbing and memory disruptions. So far little is known about how dissociation influences the neural processing of emotional material in the context of a working memory task in BPD. We aimed to investigate whole-brain activity and amygdala functional connectivity (FC...
Source: European Archives of Psychiatry and Clinical Neuroscience - May 22, 2017 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

Suicide attempts and self ‐injurious behaviours in adolescent and adult patients with borderline personality disorder
ConclusionsSelf‐mutilation and suicide attempts among adolescent borderline patients are prevalent and serious. Taken together, these results suggest that extreme levels of self‐mutilation distinguish adolescent BPD from adults with BPD. Copyright © 2017 John Wiley & Sons, Ltd. (Source: Personality and Mental Health)
Source: Personality and Mental Health - May 22, 2017 Category: Psychiatry Authors: Marianne Goodman, Irene Alvarez Tomas, Christina M. Temes, Garrett M. Fitzmaurice, Blaise A. Aguirre, Mary C. Zanarini Tags: Special Issue Article Source Type: research

Behavioral Effects of a Novel Benzofuranyl-Piperazine Serotonin-2C Receptor Agonist Suggest a Potential Therapeutic Application in the Treatment of Obsessive –Compulsive Disorder
Michelle M. Rodriguez, Carl Overshiner, J. David Leander, Xia Li, Denise Morrow, Richard G. Conway, David L. Nelson, Karin Briner, Jeffrey M. Witkin (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - May 22, 2017 Category: Psychiatry Source Type: research

Is a delay in the diagnosis of bipolar disorder inevitable?
ConclusionThe findings from the present study suggested that an earlier diagnosis of depression is related to experiencing a longer delay in conversion to BD. The clinical implications of this are briefly discussed, with a view to reducing the seemingly inevitable delay in the diagnosis of BD. (Source: Bipolar Disorders)
Source: Bipolar Disorders - May 22, 2017 Category: Psychiatry Authors: Kristina Fritz, Alex M T Russell, Christine Allwang, Sandy Kuiper, Lisa Lampe, Gin S Malhi Tags: BRIEF REPORT Source Type: research

Similar familial underpinnings for full and subsyndromal pediatric bipolar disorder: A familial risk analysis
ConclusionsOur results showed that youth with subthreshold BP‐I had similarly elevated risk for BP‐I and major depressive disorder in first‐degree relatives as youth with full BP‐I. These findings support the diagnostic continuity between subsyndromal and fully syndromatic states of pediatric BP‐I disorder. (Source: Bipolar Disorders)
Source: Bipolar Disorders - May 22, 2017 Category: Psychiatry Authors: Janet Wozniak, Mai Uchida, Stephen V Faraone, Maura Fitzgerald, Carrie Vaudreuil, Nicholas Carrellas, Jacqueline Davis, Rebecca Wolenski, Joseph Biederman Tags: ORIGINAL ARTICLE Source Type: research

Psychiatric and physical comorbidities and their impact on the course of bipolar disorder: A prospective, naturalistic 4 ‐year follow‐up study
ConclusionsOur data underline the negative long‐term impact of thyroid diseases, and especially hypothyroidism with high blood levels of bTSH, on bipolar disorder with more manic episodes, and the importance of its detection and treatment. (Source: Bipolar Disorders)
Source: Bipolar Disorders - May 22, 2017 Category: Psychiatry Authors: Benedikt L Amann, Joaquim Radua, Christian Wunsch, Barbara K önig, Christian Simhandl Tags: ORIGINAL ARTICLE Source Type: research

Lipid nanoparticles for administration of poorly water soluble neuroactive drugs.
This study describes the potential of solid lipid nanoparticles and nanostructured lipid carriers as nano-formulations to administer to the central nervous system poorly water soluble drugs. Different neuroactive drugs, i.e. dimethylfumarate, retinyl palmitate, progesterone and the endocannabinoid hydrolysis inhibitor URB597 have been studied. Lipid nanoparticles constituted of tristearin or tristearin in association with gliceryl monoolein were produced. The nanoencapsulation strategy allowed to obtain biocompatible and non-toxic vehicles, able to increase the solubility of the considered neuroactive drugs. To improve URB...
Source: Biomedical Microdevices - May 21, 2017 Category: Biomedical Engineering Authors: Esposito E, Drechsler M, Mariani P, Carducci F, Servadio M, Melancia F, Ratano P, Campolongo P, Trezza V, Cortesi R, Nastruzzi C Tags: Biomed Microdevices Source Type: research

Histone Posttranslational Modifications in Schizophrenia.
Authors: Thomas EA Abstract Schizophrenia is a complex neuropsychiatric disorder with high heritability; however, family and twin studies have indicated that environmental factors also play important roles in the etiology of disease. Environmental triggers exert their influence on behavior via epigenetic mechanisms. Epigenetic modifications, such as histone acetylation and methylation, as well as DNA methylation, can induce lasting changes in gene expression and have therefore been implicated in promoting the behavioral and neuronal behaviors that characterize this disorder. Importantly, because epigenetic processe...
Source: Advances in Experimental Medicine and Biology - May 21, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Anxiety and Epigenetics.
Authors: Bartlett AA, Singh R, Hunter RG Abstract Anxiety disorders are highly prevalent psychiatric disorders often comorbid with depression and substance abuse. Twin studies have shown that anxiety disorders are moderately heritable. Yet, genome-wide association studies (GWASs) have failed to identify gene(s) significantly associated with diagnosis suggesting a strong role for environmental factors and the epigenome. A number of anxiety disorder subtypes are considered "stress related." A large focus of research has been on the epigenetic and anxiety-like behavioral consequences of stress. Animal models of anxiet...
Source: Advances in Experimental Medicine and Biology - May 21, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Histone Modifications in Major Depressive Disorder and Related Rodent Models.
Authors: Deussing JM, Jakovcevski M Abstract Major depressive disorder (MDD) is a multifactorial disease, weakly linked to multiple genetic risk factors. In contrast to that, environmental factors and "gene × environment" interaction between specific risk genes and environmental factors, such as severe or early stress exposure, have been strongly linked to MDD vulnerability. Stressors can act on the interface between an organism and the environment, the epigenome. The molecular foundation for the impact of stressors on the risk to develop MDD is based on the hormonal stress response itself: the glucocorticoid rece...
Source: Advances in Experimental Medicine and Biology - May 21, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Noncoding RNAs in Depression.
Authors: Lin R, Turecki G Abstract Major depressive disorder (MDD) is a common psychiatric disorder affecting millions of people worldwide, yet its etiology remains elusive. The last decades have seen great advances in our understanding of the genome structure and functional organization. Noncoding RNAs (ncRNAs) are RNAs that do not code for proteins but have important regulatory roles. The investigation of ncRNAs as regulators of gene expression has been a topic of growing interest in health research, including in studies investigating etiological and therapeutic factors in major depression. Several different spec...
Source: Advances in Experimental Medicine and Biology - May 21, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

DNA Methylation in Schizophrenia.
Authors: Pries LK, Gülöksüz S, Kenis G Abstract Schizophrenia is a highly heritable psychiatric condition that displays a complex phenotype. A multitude of genetic susceptibility loci have now been identified, but these fail to explain the high heritability estimates of schizophrenia. In addition, epidemiologically relevant environmental risk factors for schizophrenia may lead to permanent changes in brain function. In conjunction with genetic liability, these environmental risk factors-likely through epigenetic mechanisms-may give rise to schizophrenia, a clinical syndrome characterized by florid psychotic symp...
Source: Advances in Experimental Medicine and Biology - May 21, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Epigenome Editing in the Brain.
Authors: Bashtrykov P, Jeltsch A Abstract Epigenome editing aims for an introduction or removal of chromatin marks at a defined genomic region using artificial EpiEffectors resulting in a modulation of the activity of the targeted functional DNA elements. Rationally designed EpiEffectors consist of a targeting DNA-binding module (such as a zinc finger protein, TAL effector, or CRISPR/Cas complex) and usually, but not exclusively, a catalytic domain of a chromatin-modifying enzyme. Epigenome editing opens a completely new strategy for basic research of the central nervous system and causal treatment of psychiatric a...
Source: Advances in Experimental Medicine and Biology - May 21, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Clinical/Research News From APA ’s 2017 Annual Meeting Day One
Welcome to San Diego!APA ’s 2017 Annual Meeting began in San Diego today. From now through May 24,Psychiatric Newswill deliver an evening digest of some of the day ’s highlights—from the lecture halls to the exhibit floor. Whether you are here in San Diego or at home, these reports will convey the excitement and outstanding scientific program being presented at this year’s meeting.Strengthening Sense of Identity Can Promote Mental Health of Students of ColorIdentity can be a source of both emotional adversity and strength for ethnic minority college students, said speakers at a panel today at APA ’s Annual Meetin...
Source: Psychiatr News - May 21, 2017 Category: Psychiatry Tags: APA's 2017 Annual Meeting BPD college students mental health minorities Nora Volkow NPD physician burnout psychotherapy PTSD scopolamine smartphone app telemedicine Source Type: research

Affective disorders and completed suicide by self-poisoning, trend of using antidepressants as a method of self-poisoning
The aim of this research was to study the role and trend of antidepressant use as a method of suicide in completed self-poisoning suicides in patients with affective disorders during a 23-year follow up period. The data consisted of 483 completed self-poisoning suicides from 1988 to 2011 in the province of Oulu in Northern Finland (286 men and 197 women). Of the self-poisoning victims, 26.9% (n=130) had hospital-treated unipolar depression and 3.1% (n=15) hospital-treated bipolar disorder. Further, 53.8% (n=70) of those with unipolar depression and 53.3% (n=8) of those with bipolar depression died by suicide using antidepr...
Source: Psychiatry Research - May 21, 2017 Category: Psychiatry Authors: Sanna L öfman, Helinä Hakko, Arja Mainio, Pirkko Riipinen Source Type: research

Issue Information
(Source: Early Intervention in Psychiatry)
Source: Early Intervention in Psychiatry - May 21, 2017 Category: Psychiatry Tags: Issue Information Source Type: research

Parents ’ perceptions of dental care challenges in male children with autism spectrum disorder: An initial qualitative exploration
Conclusions The qualitative findings from this study both confirmed our previous survey findings and expanded upon them. These findings can help professionals better understand the challenges experienced by children with ASD and their parents as well as help identify priorities for planning efforts to address the oral health-related needs of this population. (Source: Research in Autism Spectrum Disorders)
Source: Research in Autism Spectrum Disorders - May 21, 2017 Category: Psychiatry Source Type: research

Taking control! Structural and behavioural plasticity in response to game-based inhibition training in older adults
Publication date: 1 August 2017 Source:NeuroImage, Volume 156 Author(s): Simone Kühn, Robert C. Lorenz, Markus Weichenberger, Maxi Becker, Marten Haesner, Julie O'Sullivan, Anika Steinert, Elisabeth Steinhagen-Thiessen, Susanne Brandhorst, Thomas Bremer, Jürgen Gallinat While previous attempts to train self-control in humans have frequently failed, we set out to train response inhibition using computer-game elements. We trained older adults with a newly developed game-based inhibition training on a tablet for two months and compared them to an active and passive control group. Behavioural effects reflected in shorter st...
Source: NeuroImage - May 21, 2017 Category: Neuroscience Source Type: research

CASE REPORT: Epilepsy Surgical outcome for epileptic and non epileptic seizures with posttraumatic stress disorder and depression
Publication date: Available online 20 May 2017 Source:Epilepsy & Behavior Case Reports Author(s): Mazen Basheikh A 48year old male was diagnosed with both drug resistant epileptic and psychogenic nonepileptic seizures. Both diagnoses were confirmed by video-EEG monitoring. His epileptic seizures were a consequence of right mesial temporal sclerosis. He was diagnosed by a psychiatrist to have depression and posttraumatic stress disorder (PTSD). Following a right anterior temporal resection he became seizure free (both epileptic and nonepileptic) with a remarkable improvement in his psychiatric comorbidities leading...
Source: Epilepsy and Behavior Case Reports - May 21, 2017 Category: Neurology Source Type: research

Affect in response to stressors and coping strategies: an ecological momentary assessment study of borderline personality disorder
ConclusionsThese findings provide valuable insights into affective instability in BPD and can help inform treatment with individuals with the disorder. (Source: Borderline Personality Disorder and Emotion Dysregulation)
Source: Borderline Personality Disorder and Emotion Dysregulation - May 21, 2017 Category: Psychiatry Source Type: research

Baseline dimensional psychopathology and future mood disorder onset: findings from the Dutch Bipolar Offspring Study
ConclusionThis study extends our knowledge of prodromal manifestations of BD in a high‐risk population. Although preliminary, findings of this study provide potential targets for early identification and underscore the importance of detailed assessment of manic symptomatology in bipolar offspring. (Source: Acta Psychiatrica Scandinavica)
Source: Acta Psychiatrica Scandinavica - May 20, 2017 Category: Psychiatry Authors: E. Mesman, W. A. Nolen, L. Keijsers, M. H. J. Hillegers Tags: Original Article Source Type: research

Weighty matters.
PMID: 28521535 [PubMed - in process] (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - May 20, 2017 Category: Psychiatry Authors: Henderson S Tags: Aust N Z J Psychiatry Source Type: research

Can we raise the standard of care in treating schizophrenia: A cautionary note!
PMID: 28521536 [PubMed - in process] (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - May 20, 2017 Category: Psychiatry Authors: Jayaram M, Hopwood M, Pantelis C Tags: Aust N Z J Psychiatry Source Type: research

Fifty years of anorexia nervosa and other eating disorders in the Australian & New Zealand Journal of Psychiatry.
Fifty years of anorexia nervosa and other eating disorders in the Australian & New Zealand Journal of Psychiatry. Aust N Z J Psychiatry. 2017 Jun;51(6):555-556 Authors: Hay P PMID: 28521537 [PubMed - in process] (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - May 20, 2017 Category: Psychiatry Authors: Hay P Tags: Aust N Z J Psychiatry Source Type: research

Editorial.
PMID: 28521608 [PubMed - in process] (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - May 20, 2017 Category: Psychiatry Authors: Kasper S Tags: World J Biol Psychiatry Source Type: research

The association between systemic lupus erythematosus and bipolar disorder  - a big data analysis.
CONCLUSIONS: SLE was found to be independently associated with BD. These findings may imply that an autoimmune process affecting the central nervous system among SLE patients facilitates the expression of concomitant BD. PMID: 28525775 [PubMed - as supplied by publisher] (Source: Journal of the Association of European Psychiatrists)
Source: Journal of the Association of European Psychiatrists - May 20, 2017 Category: Psychiatry Tags: Eur Psychiatry Source Type: research

Courttney Cooper: mapping the interior.
Authors: Wiley M PMID: 28514975 [PubMed - as supplied by publisher] (Source: Epidemiology and Psychiatric Sciences)
Source: Epidemiology and Psychiatric Sciences - May 20, 2017 Category: Psychiatry Tags: Epidemiol Psychiatr Sci Source Type: research

Navigating the challenges of digital health innovation: considerations and solutions in developing online and smartphone-application-based interventions for mental health disorders.
This article presents an analysis of challenges and considerations when developing digital mental health innovations. Recommendations include collaborative working between clinicians, researchers, industry and service users in order to successfully navigate challenges and to ensure e-therapies are engaging, acceptable, evidence based, scalable and sustainable. PMID: 28522435 [PubMed - as supplied by publisher] (Source: The British Journal of Psychiatry for Mental Science)
Source: The British Journal of Psychiatry for Mental Science - May 20, 2017 Category: Psychiatry Tags: Br J Psychiatry Source Type: research

Beneficial and harmful effects of educative suicide prevention websites: randomised controlled trial exploring Papageno v. Werther effects.
ConclusionsEducative professional suicide prevention websites appeared to increase suicide-prevention-related knowledge, and among vulnerable individuals website exposure may be associated with a reduction of suicidal ideation. PMID: 28522433 [PubMed - as supplied by publisher] (Source: The British Journal of Psychiatry for Mental Science)
Source: The British Journal of Psychiatry for Mental Science - May 20, 2017 Category: Psychiatry Tags: Br J Psychiatry Source Type: research

One-year symptom trajectories in patients with stable schizophrenia maintained on antipsychotics versus placebo: meta-analysis.
ConclusionsWhen considering long-term antipsychotic treatment of schizophrenia, clinicians must balance symptomatic and functional outcomes. PMID: 28522434 [PubMed - as supplied by publisher] (Source: The British Journal of Psychiatry for Mental Science)
Source: The British Journal of Psychiatry for Mental Science - May 20, 2017 Category: Psychiatry Tags: Br J Psychiatry Source Type: research

Commentary: Is the Placebo Effect Actually Increasing Over Time?
Authors: Jeste DV, Lee EE PMID: 28522120 [PubMed - as supplied by publisher] (Source: The American Journal of Geriatric Psychiatry)
Source: The American Journal of Geriatric Psychiatry - May 20, 2017 Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research

Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and Alzheimer's disease in older adults.
DISCUSSION: This large prospective study of French older adults suggests that maintaining adequate vitamin D status in older age could contribute to slow down cognitive decline and to delay or prevent the onset of dementia, especially of AD etiology. PMID: 28522216 [PubMed - as supplied by publisher] (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - May 20, 2017 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

Editorial Board
(Source: Psychiatry Research: Neuroimaging)
Source: Psychiatry Research: Neuroimaging - May 20, 2017 Category: Psychiatry Source Type: research

Risk of eating disorders in immigrant populations
ConclusionThe decreased risk of eating disorders among immigrants is opposite to what has been observed for other psychiatric disorders, particularly schizophrenia. Possible explanations include buffering sociocultural factors and underdetection in health care. (Source: Acta Psychiatrica Scandinavica)
Source: Acta Psychiatrica Scandinavica - May 20, 2017 Category: Psychiatry Authors: L. Mustelin, A. M. Hedman, L. M. Thornton, R. Kuja ‐Halkola, A. Keski‐Rahkonen, E. Cantor‐Graae, C. Almqvist, A. Birgegård, P. Lichtenstein, P. B. Mortensen, C. B. Pedersen, C. M. Bulik Tags: Original Article Source Type: research

Electroconvulsive Therapy in Schizophrenia in China: A National Survey
This study examined the frequency of ECT use, its trend between 2006 and 2012, and its independent demographic and clinical correlates in a nationwide survey in China. Methods: A total of 5162 inpatients in 45 Chinese psychiatric hospitals/centers were interviewed (2696 in 2006 and 2466 in 2012). Patients' sociodemographic and clinical characteristics were recorded using a standardized protocol and data collection procedure. Results: Electroconvulsive therapy was used in 6.1% of the whole sample; 4.7% in 2006 and 7.7% in 2012 (P (Source: The Journal of ECT)
Source: The Journal of ECT - May 20, 2017 Category: Psychiatry Tags: Original Studies Source Type: research

Serum Oxytocin Concentration in Patients Receiving Electroconvulsive Therapy: An Exploratory Study and Review of Literature
Conclusions: Change in serum oxytocin immediately after the first ECT in a course may not be a useful biomarker of ECT action. This is the first report on the subject in a sample comprising mostly patients with nonaffective psychosis and mania rather than depression. We discuss our findings in the light of previous research and offer general conclusions about the field. (Source: The Journal of ECT)
Source: The Journal of ECT - May 20, 2017 Category: Psychiatry Tags: Original Studies Source Type: research

Alcohol Use Disorder as a Possible Predictor of Electroconvulsive Therapy Response
Conclusions: Within the limitations of a retrospective study, a history of an AUD seems to be a positive predictor for an ECT response in patients experiencing a major depressive episode, which has not been found in 2 earlier studies. Findings are in line with neurobiological hypotheses of excitatory/inhibitory neurotransmitter changes with ketamine and ECT. (Source: The Journal of ECT)
Source: The Journal of ECT - May 20, 2017 Category: Psychiatry Tags: Original Studies Source Type: research

Effect of Low Dose of Ketamine on Learning Memory Function in Patients Undergoing Electroconvulsive Therapy—A Randomized, Double-Blind, Controlled Clinical Study
Conclusions: As adjunctive medication, ketamine can attenuate learning and memory impairment, especially for short-term memory, caused by ECT performed under propofol anesthesia. Ketamine can also reduce ECT treatment times during the therapy course without inducing significant adverse effects. (Source: The Journal of ECT)
Source: The Journal of ECT - May 20, 2017 Category: Psychiatry Tags: Original Studies Source Type: research

Modulation of HPA axis response to social stress in schizophrenia by childhood trauma
(Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - May 20, 2017 Category: Psychiatry Authors: Claudia Lange, Christian G. Huber, Daniela Fr öhlich, Stefan Borgwardt, Undine E. Lang, Marc Walter Source Type: research

Social stress contagion in rats: Behavioural, autonomic and neuroendocrine correlates
(Source: Psychoneuroendocrinology)
Source: Psychoneuroendocrinology - May 20, 2017 Category: Psychiatry Authors: Luca Carnevali, Nicola Montano, Rosario Statello, Gino Coud é, Federica Vacondio, Silvia Rivara, Pier Francesco Ferrari, Andrea Sgoifo Source Type: research

Chronic and episodic stress predict physical symptom bother following breast cancer diagnosis
AbstractBreast cancer patients often experience adverse physical side effects of medical treatments. According to the biobehavioral model of cancer stress and disease, life stress during diagnosis and treatment may negatively influence the trajectory of women ’s physical health-related adjustment to breast cancer. This longitudinal study examined chronic and episodic stress as predictors of bothersome physical symptoms during the year after breast cancer diagnosis. Women diagnosed with breast cancer in the previous 4 months (N = 460) completed a life stress interview for contextual assessment of chronic and episodic s...
Source: Journal of Behavioral Medicine - May 20, 2017 Category: Psychiatry Source Type: research

Circadian Disruptions in the Myshkin Mouse Model of Mania are Independent of Deficits in Suprachiasmatic Molecular Clock Function
Alterations in environmental light and intrinsic circadian function have strong associations with mood disorders. The neural origins underpinning these changes remain unclear, although genetic deficits in the molecular clock regularly render mice with altered mood-associated phenotypes. (Source: Biological Psychiatry)
Source: Biological Psychiatry - May 20, 2017 Category: Psychiatry Authors: Joseph W.S. Timothy, Natasza Klas, Harshmeena Sanghani, Taghreed Al-Mansouri, Alun T.L. Hughes, Greer S. Kirshenbaum, Vincent Brienza, Mino D.C. Belle, Martin R. Ralph, Steven J. Clapcote, Hugh D. Piggins Tags: Archival Report Source Type: research

The relation of childhood trauma to suicide ideation in patients suffering from obsessive-compulsive disorder with lifetime suicide attempts
The aim of this study was to evaluate the relations of childhood trauma (CT) and obsessive-compulsive (OC) symptom dimensions to suicide ideation in patients with obsessive-compulsive disorder (OCD). Seventy OCD outpatients with lifetime suicide attempts and 60 controls were included. Participants completed the Scale for Suicide Ideation (SSI), the Childhood Trauma Questionnaire-Short Form (CTQ-SF), the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), the Dimensional Obsessive-Compulsive Scale (DOCS) and the Depression Anxiety Stress Scales (DASS-21). (Source: Psychiatry Research)
Source: Psychiatry Research - May 20, 2017 Category: Psychiatry Authors: Vahid Khosravani, Zoleikha Kamali, Razieh Jamaati Ardakani, Mehdi Samimi Ardestani Source Type: research

Brain neurodevelopmental markers related to the deficit subtype of schizophrenia
Deficit schizophrenia is a homogeneous subtype characterized by a trait-like feature of primary and prominent negative symptoms, but the etiologic factors related to this specific subtype remain largely unknown. This magnetic resonance imaging study aimed to examine gross brain morphology that probably reflects early neurodevelopment in 38 patients with deficit schizophrenia, 37 patients with non-deficit schizophrenia, and 59 healthy controls. Potential brain neurodevelopmental markers investigated in this study were the adhesio interthalamica (AI), cavum septi pellucidi (CSP), and surface morphology (i.e., olfactory sulcu...
Source: Psychiatry Research: Neuroimaging - May 20, 2017 Category: Psychiatry Authors: Tsutomu Takahashi, Yoichiro Takayanagi, Yumiko Nishikawa, Mihoko Nakamura, Yuko Komori, Atsushi Furuichi, Mikio Kido, Daiki Sasabayashi, Kyo Noguchi, Michio Suzuki Source Type: research

Long-term antipsychotic and benzodiazepine use and brain volume changes in schizophrenia: The Northern Finland Birth Cohort 1966 study
High doses of antipsychotics have been associated with loss in cortical and total gray matter in schizophrenia. However, previous imaging studies have not taken benzodiazepine use into account, in spite of evidence suggesting adverse effects such as cognitive impairment and increased mortality. In this Northern Finland Birth Cohort 1966 study, 69 controls and 38 individuals with schizophrenia underwent brain MRI at the ages of 34 and 43 years. At baseline, the average illness duration was over 10 years. (Source: Psychiatry Research: Neuroimaging)
Source: Psychiatry Research: Neuroimaging - May 20, 2017 Category: Psychiatry Authors: Sanna Huhtaniska, Erika J ääskeläinen, Tuomas Heikka, Jani S. Moilanen, Heli Lehtiniemi, Jussi Tohka, José V. Manjón, Pierrick Coupé, Lassi Björnholm, Hannu Koponen, Juha Veijola, Matti Isohanni, Vesa Kiviniemi, Graham K. Murray, Jouko Miettunen Source Type: research

Pragmatic approach to intersex, including genital ambiguity, in the newborn
The evaluation and management of a newborn with ambiguous genitalia must be undertaken as quickly as possible and with great sensitivity for the child ’s family. Where possible, a comprehensive team approach with a pediatric urologist, endocrinologist, geneticist, neonatologist, and child psychiatrist/psychologist should work closely with the family to establish the diagnosis and determine gender. Although the preferred gender assignment is not always clear, a thorough examination of endocrine function, karyotype, and potential for fertility should guide the determination. (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - May 20, 2017 Category: Perinatology & Neonatology Authors: Kanthi Bangalore Krishna, Christopher P. Houk, Peter A. Lee Source Type: research