Biosensors for psychiatric biomarkers in mental health monitoring
Biosens Bioelectron. 2024 Mar 29;256:116242. doi: 10.1016/j.bios.2024.116242. Online ahead of print.ABSTRACTPsychiatric disorders are associated with serve disturbances in cognition, emotional control, and/or behavior regulation, yet few routine clinical tools are available for the real-time evaluation and early-stage diagnosis of mental health. Abnormal levels of relevant biomarkers may imply biological, neurological, and developmental dysfunctions of psychiatric patients. Exploring biosensors that can provide rapid, in-situ, and real-time monitoring of psychiatric biomarkers is therefore vital for prevention, diagnosis, ...
Source: Biosensors and Bioelectronics - April 17, 2024 Category: Biotechnology Authors: Lin Wang Yubing Hu Nan Jiang Ali K Yetisen Source Type: research
A taxonomy of regulatory and policy matters relevant to psychedelic-assisted therapy in Australia
CONCLUSIONS: The taxonomy provides a roadmap for health services establishing and implementing a psychedelic-assisted therapy program, or for government and other policymakers when determining areas that may require further regulation.PMID:38628079 | DOI:10.1177/00048674241240597 (Source: The Australian and New Zealand Journal of Psychiatry)
Source: The Australian and New Zealand Journal of Psychiatry - April 17, 2024 Category: Psychiatry Authors: Samuel P Hatfield Nicollette Lr Thornton Kayla Greenstien Nick Glozier Source Type: research
The selective serotonin reuptake inhibitor sertraline alters learning from aversive reinforcements in patients with depression: evidence from a randomized controlled trial
CONCLUSIONS: The study findings indicate a relationship between aversive reinforcement learning mechanisms and aspects of depression, anxiety, and SSRI treatment, but these relationships did not align with the initial hypotheses. Poor task performance limits the interpretability and likely generalizability of the findings, and highlights the critical importance of developing acceptable and reliable tasks for use in clinical studies.FUNDING: This article presents research supported by NIHR Program Grants for Applied Research (RP-PG-0610-10048), the NIHR BRC, and UCL, with additional support from IMPRS COMP2PSYCH (JM, QH) an...
Source: Psychological Medicine - April 17, 2024 Category: Psychiatry Authors: Jolanda Malamud Gemma Lewis Michael Moutoussis Larisa Duffy Jessica Bone Ramya Srinivasan Glyn Lewis Quentin J M Huys Source Type: research
MINocyclinE to Reduce inflammation and blood-brain barrier leakage in small Vessel diseAse (MINERVA): A phase II, randomized, double-blind, placebo-controlled experimental medicine trial
DISCUSSION: 11C-PK11195 binding and increased BBB permeability are present in SVD; minocycline did not reduce either process. Whether these pathophysiological mechanisms are disease-causing remains unclear.INTERNATIONAL CLINICAL TRIALS REGISTRY PORTAL IDENTIFIER: ISRCTN15483452 HIGHLIGHTS: We found focal areas of increased microglial signal and increased blood-brain barrier permeability in patients with small vessel disease. Minocycline treatment was not associated with a change in these processes measured using advanced neuroimaging. Blood-brain barrier permeability was dynamic but MRI-derived measurements correlated well...
Source: The Journal of Alzheimers Association - April 17, 2024 Category: Psychiatry Authors: Robin B Brown Daniel J Tozer Laurence Loubi ère Eric L Harshfield Young T Hong Tim D Fryer Guy B Williams Martin J Graves Franklin I Aigbirhio John T O'Brien Hugh S Markus Source Type: research
White matter hyperintensities and the surrounding normal appearing white matter are associated with water channel disruption in the oldest old
DISCUSSION: Decreased AQP expression within WMH and proximal NAWM suggest an overwhelmed system wherein water homeostasis is no longer maintained, contributing to WM damage in older individuals.HIGHLIGHTS: Post mortem magnetic resonance imaging (MRI) was used to characterize the pathology of white matter hyperintensities (WMHs) and surrounding normal appearing white matter (NAWM). Stained immunohistochemical (IHC) slides from targeted WMH and NAWM samples were digitized and quantified. WMHs and NAWM were associated with inflammation, demyelination, and gliosis. WMHs and NAWM astrocytic changes included decreased AQP1 and A...
Source: The Journal of Alzheimers Association - April 17, 2024 Category: Psychiatry Authors: Lisa C Silbert Natalie E Roese Victoria Krajbich Justin Hurworth David Lahna Daniel L Schwartz Hiroko H Dodge Randall L Woltjer Source Type: research
Racial and ethnic differences in plasma biomarker eligibility for a preclinical Alzheimer's disease trial
We examined plasma amyloid beta 42/40 and positron emission tomography (PET) amyloid eligibility for the ongoing AHEAD Study preclinical AD program (NCT04468659).METHODS: Univariate logistic regression models were used to examine group differences in plasma and PET amyloid screening eligibility.RESULTS: Of 4905 participants screened at time of analysis, 1724 were plasma eligible to continue in screening: 13.3% Hispanic Black, 24.7% Hispanic White, 20.8% non-Hispanic (NH) Asian, 24.7% NH Black, and 38.9% NH White. Plasma eligibility differed across groups in models controlling for covariates (odds ratio from 1.9 to 4.0 comp...
Source: The Journal of Alzheimers Association - April 17, 2024 Category: Psychiatry Authors: Doris Patricia Molina-Henry Rema Raman Andy Liu Oliver Langford Keith Johnson Leona K Shum Crystal M Glover Shobha Dhadda Michael Irizarry Gustavo Jimenez-Maggiora Joel B Braunstein Kevin Yarasheski Venky Venkatesh Tim West Philip B Verghese Robert A Riss Source Type: research
Dissonance in the face of Alzheimer's disease breakthroughs: clinician and lay stakeholder acceptance, concerns and willingness to pay for emerging disease-modifying therapies
CONCLUSIONS: This study exposes complex attitudes toward emerging DMTs for Alzheimer's disease, challenging conventional wisdom in multiple dimensions. A surprising 25% of the public expressed aversion to these new treatments, despite society's deep-rooted fear of dementia in older age. Healthcare professionals displayed nuanced concerns, prioritising clinical effectiveness and potential brain complications. Intriguingly, younger, better-educated and privately insured individuals exhibited a greater WTP, foregrounding critical questions about healthcare equity. These multifaceted findings serve as a guidepost for healthcar...
Source: The British Journal of Psychiatry for Mental Science - April 17, 2024 Category: Psychiatry Authors: Irina Kinchin Sharon Walsh Rachel Dinh Margaret Kapuwa Sean P Kennelly Ann-Marie Miller Ann Nolan Sean O'Dowd Laura O'Philbin Suzanne Timmons Iracema Leroi Source Type: research
Downregulation of lncRNAs Gomafu, NONMMUT033604.2, and NONMMUT064397.2 in the hippocampus of mice with model of post-traumatic stress disorder
Conclusions. This data provides evidence that the three studied lncRNAs could be potential biomarkers of PTSD development.PMID:38629762 | DOI:10.1080/15622975.2024.2342849 (Source: The World Journal of Biological Psychiatry)
Source: The World Journal of Biological Psychiatry - April 17, 2024 Category: Psychiatry Authors: A Klymenko V Nagibin A Horlova Y Dobropolska R Bohovyk D Stroy D Isaev V Dosenko Source Type: research
Morphological heterogeneity of neurons in the human central amygdaloid nucleus
J Neurosci Res. 2024 Apr;102(4):e25319. doi: 10.1002/jnr.25319.ABSTRACTThe central amygdaloid nucleus (CeA) has an ancient phylogenetic development and functions relevant for animal survival. Local cells receive intrinsic amygdaloidal information that codes emotional stimuli of fear, integrate them, and send cortical and subcortical output projections that prompt rapid visceral and social behavior responses. We aimed to describe the morphology of the neurons that compose the human CeA (N = 8 adult men). Cells within CeA coronal borders were identified using the thionine staining and were further analyzed using the "single-...
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Carlos E V ásquez K étlyn T Knak Guerra Josu é Renner Alberto A Rasia-Filho Source Type: research
Severity of Antipsychotic-Induced Cervical Dystonia Assessed by the Algorithm-Based Rating System
Conclusion: While further validation with new cases is needed, the range of tilt angles in this study could provide a standard for future artificial intelligence devices for cervical dystonia.PMID:38629708 | DOI:10.4088/JCP.23m14929 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - April 17, 2024 Category: Psychiatry Authors: Toshiya Inada Yuta Tanabe Yuji Fukaya Kazuyoshi Ogasawara Nobutomo Yamamoto Source Type: research
The Prevalence of Hyperuricemia and the Association Between Hyperuricemia and Age in Patients with Psychiatric Disorders to a General Hospital: A Cross-Section Study
(Source: International Journal of General Medicine)
Source: International Journal of General Medicine - April 17, 2024 Category: General Medicine Tags: International Journal of General Medicine Source Type: research
GSE263711 Fibroblasts as an in vitro model of circadian genetic and genomic studies: A temporal analysis (ATAC-Seq)
In this study, we characterize the biological pathways that are activated in this in vitro circadian model, evaluating the relevance of these processes in the context of the genetic architecture of BD and other disorders, highlighting its limitations and future applications for circadian genomic studies (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE263713 Fibroblasts as an in vitro model of circadian genetic and genomic studies: A temporal analysis (RNA-Seq)
In this study, we characterize the biological pathways that are activated in this in vitro circadian model, evaluating the relevance of these processes in the context of the genetic architecture of BD and other disorders, highlighting its limitations and future applications for circadian genomic studies (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 17, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Teneurin C-terminal associated peptide (TCAP)-1 attenuates the development and expression of naloxone-precipitated morphine withdrawal in male Swiss Webster mice
ConclusionsThese findings establish TCAP-1 as a potential therapeutic candidate for the prevention and treatment of morphine withdrawal. (Source: Psychopharmacology)
Source: Psychopharmacology - April 17, 2024 Category: Psychiatry Source Type: research
Coenzyme Q10 and exercise training reinstate middle cerebral artery occlusion-induced behavioral deficits and hippocampal long-term potentiation suppression in aging rats
ConclusionCollectively, the findings of the present study imply that 12 weeks of aerobic training and Q10 supplementation alone can simultaneously reverse cerebral ischemia induced neurobehavioral deficits via amelioration of synaptic plasticity and a reduction in cerebral infarction volume in senescent rats. (Source: Psychopharmacology)
Source: Psychopharmacology - April 17, 2024 Category: Psychiatry Source Type: research
