Laryngopharyngeal Reflux Patient Changes during the COVID-19 Quarantine
Conclusions: During the lockdown, the diet habits of LPR patients were improved in one-third and unchanged in 44% of cases. The stress level was increased in one-third of patients, which was associated with an increase in symptom scores.PMID:37629765 | PMC:PMC10456535 | DOI:10.3390/medicina59081475 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - August 26, 2023 Category: Universities & Medical Training Authors: Alexandra Rodriguez Younes Steffens Christian Calvo-Henriquez Miguel Mayo-Y áñez Mihaela Horoi Jerome R Lechien Source Type: research
Laryngopharyngeal Reflux Patient Changes during the COVID-19 Quarantine
Conclusions: During the lockdown, the diet habits of LPR patients were improved in one-third and unchanged in 44% of cases. The stress level was increased in one-third of patients, which was associated with an increase in symptom scores.PMID:37629765 | PMC:PMC10456535 | DOI:10.3390/medicina59081475 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - August 26, 2023 Category: Universities & Medical Training Authors: Alexandra Rodriguez Younes Steffens Christian Calvo-Henriquez Miguel Mayo-Y áñez Mihaela Horoi Jerome R Lechien Source Type: research
Laryngopharyngeal Reflux Patient Changes during the COVID-19 Quarantine
Conclusions: During the lockdown, the diet habits of LPR patients were improved in one-third and unchanged in 44% of cases. The stress level was increased in one-third of patients, which was associated with an increase in symptom scores.PMID:37629765 | PMC:PMC10456535 | DOI:10.3390/medicina59081475 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - August 26, 2023 Category: Universities & Medical Training Authors: Alexandra Rodriguez Younes Steffens Christian Calvo-Henriquez Miguel Mayo-Y áñez Mihaela Horoi Jerome R Lechien Source Type: research
Laryngopharyngeal Reflux Patient Changes during the COVID-19 Quarantine
Conclusions: During the lockdown, the diet habits of LPR patients were improved in one-third and unchanged in 44% of cases. The stress level was increased in one-third of patients, which was associated with an increase in symptom scores.PMID:37629765 | PMC:PMC10456535 | DOI:10.3390/medicina59081475 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - August 26, 2023 Category: Universities & Medical Training Authors: Alexandra Rodriguez Younes Steffens Christian Calvo-Henriquez Miguel Mayo-Y áñez Mihaela Horoi Jerome R Lechien Source Type: research
Laryngopharyngeal Reflux Patient Changes during the COVID-19 Quarantine
Conclusions: During the lockdown, the diet habits of LPR patients were improved in one-third and unchanged in 44% of cases. The stress level was increased in one-third of patients, which was associated with an increase in symptom scores.PMID:37629765 | PMC:PMC10456535 | DOI:10.3390/medicina59081475 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - August 26, 2023 Category: Universities & Medical Training Authors: Alexandra Rodriguez Younes Steffens Christian Calvo-Henriquez Miguel Mayo-Y áñez Mihaela Horoi Jerome R Lechien Source Type: research
Laryngopharyngeal Reflux Patient Changes during the COVID-19 Quarantine
Conclusions: During the lockdown, the diet habits of LPR patients were improved in one-third and unchanged in 44% of cases. The stress level was increased in one-third of patients, which was associated with an increase in symptom scores.PMID:37629765 | PMC:PMC10456535 | DOI:10.3390/medicina59081475 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - August 26, 2023 Category: Universities & Medical Training Authors: Alexandra Rodriguez Younes Steffens Christian Calvo-Henriquez Miguel Mayo-Y áñez Mihaela Horoi Jerome R Lechien Source Type: research
Molecular Insights into the Mechanism of Modulatory Effects of Proton Pump Inhibitors on P-glycoprotein Mediated Drug Transport of Palbociclib and Ribociclib
CONCLUSION: The experimental evidence presented highlights the fact that proton pump inhibitors have potential to inhibit P-glycoprotein, giving rise to drug interactions with palbociclib and ribociclib. Hence, monitoring is required while proton pump inhibitors and cyclin-dependent kinase inhibitors are being co-administered to avoid adverse events.PMID:37581514 | DOI:10.2174/1389200224666230815122312 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 15, 2023 Category: Drugs & Pharmacology Authors: Mrunal Pradeep Desai Prajakta Harish Patil Sai Krishna Anand Vullendula Sumit Birangal G Gautham Shenoy Mahadev Rao Swapnil Jayant Dengale Krishnamurthy Bhat Jagadish Puralae Channabasavaiah Source Type: research
Molecular Insights into the Mechanism of Modulatory Effects of Proton Pump Inhibitors on P-glycoprotein Mediated Drug Transport of Palbociclib and Ribociclib
CONCLUSION: The experimental evidence presented highlights the fact that proton pump inhibitors have potential to inhibit P-glycoprotein, giving rise to drug interactions with palbociclib and ribociclib. Hence, monitoring is required while proton pump inhibitors and cyclin-dependent kinase inhibitors are being co-administered to avoid adverse events.PMID:37581514 | DOI:10.2174/1389200224666230815122312 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 15, 2023 Category: Drugs & Pharmacology Authors: Mrunal Pradeep Desai Prajakta Harish Patil Sai Krishna Anand Vullendula Sumit Birangal G Gautham Shenoy Mahadev Rao Swapnil Jayant Dengale Krishnamurthy Bhat Jagadish Puralae Channabasavaiah Source Type: research
Molecular Insights into the Mechanism of Modulatory Effects of Proton Pump Inhibitors on P-glycoprotein Mediated Drug Transport of Palbociclib and Ribociclib
CONCLUSION: The experimental evidence presented highlights the fact that proton pump inhibitors have potential to inhibit P-glycoprotein, giving rise to drug interactions with palbociclib and ribociclib. Hence, monitoring is required while proton pump inhibitors and cyclin-dependent kinase inhibitors are being co-administered to avoid adverse events.PMID:37581514 | DOI:10.2174/1389200224666230815122312 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 15, 2023 Category: Drugs & Pharmacology Authors: Mrunal Pradeep Desai Prajakta Harish Patil Sai Krishna Anand Vullendula Sumit Birangal G Gautham Shenoy Mahadev Rao Swapnil Jayant Dengale Krishnamurthy Bhat Jagadish Puralae Channabasavaiah Source Type: research
Impact of CYP2C:TG haplotype on CYP2C19 substrates clearance in vivo, protein content and in vitro activity
Clin Pharmacol Ther. 2023 Aug 1. doi: 10.1002/cpt.3012. Online ahead of print.ABSTRACTA novel haplotype composed of two non-coding variants, CYP2C18 NM_000772.3:c.*31T (rs2860840) and NM_000772.2:c.819+2182G (rs11188059), referred to as "CYP2C:TG", was recently associated with ultrarapid metabolism of various CYP2C19 substrates. As the underlying mechanism and clinical relevance of this effect remain uncertain, we analyzed existing in vivo and in vitro data to determine the magnitude of the CYP2C:TG haplotype effect. We assessed variability in pharmacokinetics of CYP2C19 substrates, including citalopram, sertraline, vorico...
Source: Clinical Pharmacology and Therapeutics - August 1, 2023 Category: Drugs & Pharmacology Authors: Pablo Zubiaur Paula Soria-Chacartegui Erin C Boone Bhagwat Prasad Jean Dinh Wendy Y Wang Santiago Zugbi Andrea Rodr íguez-Lopez Eva Gonz ález-Iglesias J Steven Leeder Francisco Abad-Santos Andrea Gaedigk Source Type: research
Impact of CYP2C:TG haplotype on CYP2C19 substrates clearance in vivo, protein content and in vitro activity
Clin Pharmacol Ther. 2023 Aug 1. doi: 10.1002/cpt.3012. Online ahead of print.ABSTRACTA novel haplotype composed of two non-coding variants, CYP2C18 NM_000772.3:c.*31T (rs2860840) and NM_000772.2:c.819+2182G (rs11188059), referred to as "CYP2C:TG", was recently associated with ultrarapid metabolism of various CYP2C19 substrates. As the underlying mechanism and clinical relevance of this effect remain uncertain, we analyzed existing in vivo and in vitro data to determine the magnitude of the CYP2C:TG haplotype effect. We assessed variability in pharmacokinetics of CYP2C19 substrates, including citalopram, sertraline, vorico...
Source: Clinical Pharmacology and Therapeutics - August 1, 2023 Category: Drugs & Pharmacology Authors: Pablo Zubiaur Paula Soria-Chacartegui Erin C Boone Bhagwat Prasad Jean Dinh Wendy Y Wang Santiago Zugbi Andrea Rodr íguez-Lopez Eva Gonz ález-Iglesias J Steven Leeder Francisco Abad-Santos Andrea Gaedigk Source Type: research
Case report: metoclopramide induced acute dystonic reaction in adolescent CYP2D6 poor metabolizers
We present two cases of acute dystonia in two non-consanguineous male adolescents: one following metoclopramide and cimetidine administration in a 14-year-old to treat gastroesophageal reflux, and another following metoclopramide and pantoprazole administration in a 17-year-old with acute gastroenteritis. A retrospective pharmacogenetic analysis revealed both patients as CYP2D6 PMs. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - July 11, 2023 Category: Drugs & Pharmacology Source Type: research
Anaphylaxis to Commonly Used Drug Oral Pantoprazole
J Assoc Physicians India. 2022 Dec;70(12):11-12.NO ABSTRACTPMID:37355982 (Source: Journal of the Association of Physicians of India)
Source: Journal of the Association of Physicians of India - June 25, 2023 Category: General Medicine Authors: Meenaxi Sharda Sachin Kumar Mittal Maneesh Gadhwal Ankit Vijay Source Type: research
