Evaluation of Hydroxychloroquine as a Perpetrator on Cytochrome P450 (CYP) 3A and CYP2D6 Activity with Microdosed Probe Drugs in Healthy Volunteers
ConclusionIn conclusion, we observed an increased midazolam exposure most likely related to pantoprazole. (Source: European Journal of Drug Metabolism and Pharmacokinetics)
Source: European Journal of Drug Metabolism and Pharmacokinetics - December 20, 2023 Category: Drugs & Pharmacology Source Type: research
REVISE: re-evaluating the inhibition of stress erosions in the ICU —statistical analysis plan for a randomized trial
The REVISE (Re-Evaluating the Inhibition of Stress Erosions in the ICU) trial will evaluate the impact of the proton pump inhibitor pantoprazole compared to placebo in invasively ventilated critically ill patient... (Source: Trials)
Source: Trials - December 6, 2023 Category: General Medicine Authors: Diane Heels-Ansdell, Laurent Billot, Lehana Thabane, Waleed Alhazzani, Adam Deane, Gordon Guyatt, Simon Finfer, Fran çois Lauzier, John Myburgh, Paul Young, Yaseen Arabi, John Marshall, Shane English, John Muscedere, Marlies Ostermann, Bala Venkatesh & h Tags: Research Source Type: research
Acid ‐suppressive drugs: A systematic review and network meta‐analysis of their nocturnal acid‐inhibitory effect
ConclusionsThis is the first study to compare the effect of ASDs on inhibiting nocturnal acid breakthrough. Overall, in terms of nocturnal acid-inhibitory effect, vonoprazan and tegoprazan had an advantage against other regimens including H2RAs, isomer PPIs, traditional PPIs, AHB, and new PPIs. Even in some subgroups, such as language classification (English), types of study design (crossover-RCT), age ( ≤40 years), BMI (18.5-24.9 kg/m2), continent (Asia and North America), disease status (health), the duration of therapy (2 weeks), and time of administration (at daytime or at night-time), the nocturnal acid-inhibit...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 5, 2023 Category: Drugs & Pharmacology Authors: Shupeng Zou,
Mengling Ouyang,
Qian Cheng,
Xuan Shi,
Minghui Sun Tags: RESEARCH ARTICLE Source Type: research
69-Year-Old Man With Inflammatory Bowel Disease and Diarrhea
A 69-year-old man presented to the emergency department with 1 week of diarrhea and abdominal pain. Stools were described as loose and nonbloody, occurring 8 to 12 times a day, associated with abdominal cramping, urgency, and nocturnal diarrhea. The patient ’s medical conditions included a 20-year history of left-sided ulcerative colitis (currently in endoscopic remission) treated with tofacitinib 5 mg twice daily and Barrett esophagus treated with pantoprazole 40 mg daily. The patient denied associated fever, weight loss, vomiting, correlation with diet, recent travel, sick contacts, hospitalization, and antibiotic or c...
Source: Mayo Clinic Proceedings - December 1, 2023 Category: Internal Medicine Authors: Christian Karime, Caroline Olson, Razvan Chirila Tags: Residents ’ Clinic Source Type: research
Investigation into the Impact of Proton Pump Inhibitors on Sertraline Transport across the Blood-Brain Barrier
In this study, PPIs were further found to inhibit the mRNA and protein expression of brain BCRP. To sum up, the findings of this study revealed that PPIs could enhance the brain distribution and antidepressant effect of sertraline, which may be attributed to the inhibition of BCRP expression at the BBB by PPIs.PMID:38006986 | DOI:10.1016/j.ejps.2023.106653 (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - November 25, 2023 Category: Drugs & Pharmacology Authors: Yumeng Xiao Wenwen Xu Dandan Niu Zhuowei Quan Ling Wang Source Type: research
REVISE: Re-Evaluating the Inhibition of Stress Erosions in the ICU: a randomised trial protocol
The objective of this report is to describe the rationale, methodology, ethics and management of REVISE.
Methods and analysis
REVISE is an international, randomised, concealed, stratified, blinded parallel-group individual patient trial being conducted in ICUs in Canada, Australia, Saudi Arabia, UK, US, Kuwait, Pakistan and Brazil. Patients≥18 years old expected to remain invasively mechanically ventilated beyond the calendar day after enrolment are being randomised to either 40 mg pantoprazole intravenously or an identical placebo daily while mechanically ventilated in the ICU. The primary efficacy outcome is clinical...
Source: BMJ Open - November 15, 2023 Category: General Medicine Authors: Deane, A. M., Alhazzani, W., Guyatt, G., Finfer, S., Marshall, J. C., Myburgh, J., Zytaruk, N., Hardie, M., Saunders, L., Knowles, S., Lauzier, F., Chapman, M. J., English, S., Muscedere, J., Arabi, Y., Ostermann, M., Venkatesh, B., Young, P., Thabane, L. Tags: Open access, Intensive care Source Type: research
pH-Sensitive Adsorption of Gastrointestinal Drugs (Famotidine and Pantoprazole) as pharmaceutical pollutants by Au-Doped@ZIF-90-Glycerol Adsorbent: Insights from Computational Modeling
J. Mater. Chem. A, 2023, Accepted Manuscript DOI: 10.1039/D3TA05221D, PaperNarjes Montazeri, Iman Salahshoori , Parivash Feyzishendi, Fatemeh Sadat Miri, Mehdi Moayed Mohseni, Hossein Ali Khonakdar Pharmaceutical pollutants, such as gastrointestinal drugs, pose a significant environmental concern due to their widespread use and potential adverse effects on ecosystems. Insights obtained from computational simulations yielded a more... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. Mater. Chem. latest articles)
Source: RSC - J. Mater. Chem. latest articles - November 9, 2023 Category: Chemistry Authors: Narjes Montazeri Source Type: research
Incidence of Small Intestinal Bacterial Overgrowth and Symptoms After 7 Days of Proton Pump Inhibitor Use: A Study on Healthy Volunteers
ConclusionsOur study showed that a short-term 7-day PPI course produced SIBO in 7.8% of healthy subjects. Although, inappropriate use of PPIs should be discouraged, but since more than 90% of subjects who received PPIs for one week did not develop SIBO, the advantages of PPI administration seem to outweigh the disadvantages. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - November 1, 2023 Category: Gastroenterology Source Type: research
A Linked Electronic Medical Record-Claims Analysis of the Clinical and Economic Outcomes of Patients Coded for Erosive Esophagitis in the United States
ConclusionsPatients with EE are commonly treated with prescription PPIs; however, 19.0% of patients cycled through multiple PPIs. Higher PPI use was associated with a higher comorbidity burden and higher healthcare costs compared to 0 PPI use. (Source: Advances in Therapy)
Source: Advances in Therapy - October 27, 2023 Category: Drugs & Pharmacology Source Type: research
A Linked Electronic Medical Record-Claims Analysis of the Clinical and Economic Outcomes of Patients Coded for Erosive Esophagitis in the United States
CONCLUSIONS: Patients with EE are commonly treated with prescription PPIs; however, 19.0% of patients cycled through multiple PPIs. Higher PPI use was associated with a higher comorbidity burden and higher healthcare costs compared to 0 PPI use.PMID:37837526 | DOI:10.1007/s12325-023-02688-7 (Source: Adv Data)
Source: Adv Data - October 14, 2023 Category: Epidemiology Authors: Rena Yadlapati Katherine Cappell Robert Sedgley Corey Pelletier Rinu Jacob Machaon Bonafede Shailja C Shah Source Type: research
Pantoprazole-Induced Bone Loss through Gastrin Secretion: A Stereological Study
CONCLUSION: Overall findings revealed that pantoprazole caused bone loss, which could be prevented by adding octreotide. Because these detrimental effects were not detected in rats given both Oct and Pan, it was suggested that the effect of Pan on bone was produced by a hypergastrinemic condition.PMID:37711876 | PMC:PMC10499535 | DOI:10.1155/2023/2594664 (Source: Biomed Res)
Source: Biomed Res - September 15, 2023 Category: Research Authors: Forough Saki Mesbah Shams Sanaz Dastghaib Farhad Koohpeyma Source Type: research
Pantoprazole-Induced Bone Loss through Gastrin Secretion: A Stereological Study
CONCLUSION: Overall findings revealed that pantoprazole caused bone loss, which could be prevented by adding octreotide. Because these detrimental effects were not detected in rats given both Oct and Pan, it was suggested that the effect of Pan on bone was produced by a hypergastrinemic condition.PMID:37711876 | PMC:PMC10499535 | DOI:10.1155/2023/2594664 (Source: Biomed Res)
Source: Biomed Res - September 15, 2023 Category: Research Authors: Forough Saki Mesbah Shams Sanaz Dastghaib Farhad Koohpeyma Source Type: research
Drug repurposing analysis for colorectal cancer through network medicine framework: Novel candidate drugs and small molecules
This study aimed to reveal the drug repurposing candidates for colorectal cancer (CRC) via drug repurposing methods and network biology approaches. A novel, differentially co-expressed, highly interconnected, and co-regulated prognostic gene module was identified for CRC. Based on the gene module, polyethylene glycol, gallic acid, pyrazole, cordycepin, phenothiazine, pantoprazole, cysteamine, indisulam, valinomycin, trametinib, BRD-K81473043, AZD8055, dovitinib, BRD-A17065207, and tyrphostin AG1478 presented as drugs and small molecule candidates previously studied in the CRC. Lornoxicam, suxamethonium, oprelvekin, sirukum...
Source: Cancer Investigation - September 8, 2023 Category: Cancer & Oncology Authors: Ulku Unal Esra Gov Source Type: research
