Liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for determination of free and total dabigatran in human plasma and its application to a pharmacokinetic study
Drug Dev Ind Pharm. 2022 Apr 22:1-23. doi: 10.1080/03639045.2022.2069257. Online ahead of print.ABSTRACTA high performance liquid chromatography tandem mass spectrometric method for the determination of free and total dabigatran in human plasma has been developed and validated using stable labeled internal standard (IS) as dabigatran D4. The extraction of analyte and IS was accomplished by solid phase extraction technique. Chromatographic separations were achieved using Peerless basic C8 (150 x 4.6) mm, 5ยต column eluted at flow rate of 1 mL/min with mobile phase Acetonitrile: 5 mM ammonium formate: Methanol and 0.2% formi...
Source: Drug Development and Industrial Pharmacy - April 22, 2022 Category: Drugs & Pharmacology Authors: Khurshid Shaikh Ashish Mungantiwar Supriya Halde Nancy Pandita Source Type: research
Method Development and Validation of Reverse Phase High Performance Liquid Chromatography Method for Estimation of Ondansetron and Pantoprazole in their Tablet Dosage Form
G. K. Rakam*, Arunabha Mallik and Ch.Sucharitha (Source: Indian Journal of Pharmaceutical Sciences)
Source: Indian Journal of Pharmaceutical Sciences - April 20, 2022 Category: Drugs & Pharmacology Source Type: research
