Comparison of the Efficacy of 12-day Concomitant Quadruple Therapy versus 14-day High dose Dual Therapy as a First-line < em > H. pylori < /em > Eradication Regimen
CONCLUSIONS: Twelve-day concomitant therapy seems to be an acceptable regimen for first-line H. pylori eradication in Iran, a country with a high rate of antibiotic resistance. Although, high dose dual therapy did not result in an ideal eradication rate, but it had fewer drug side effects than the 12-day concomitant regimen.PMID:38659251 | DOI:10.4166/kjg.2024.012 (Source: Korean J Gastroenter...)
Source: Korean J Gastroenter... - April 25, 2024 Category: Gastroenterology Authors: Seyed Mohammad Valizadeh Toosi Sahar Feyzi Arash Kazemi Source Type: research

Combined effect of pantoprazole and mesenchymal stem cells on experimentally induced gastric ulcer: implication of oxidative stress, inflammation and apoptosis pathways
This study aimed to investigate the possible alleviating effect of a combined treatment of pantoprazole (PANTO) and adipose tissue-derived mesenchymal stem cells (ADSCs) in comparison with each treatment alone on the healing process of the experimentally induced GU in rats, and to uncover the involved pathways. Rats were divided into five groups: (1) Control, (2) GU, (3) PANTO, (4) ADSCs and (5) ADSCs  + PANTO. Markers of oxidative stress, inflammation and apoptosis were assessed. The current data indicated that PANTO-, ADSCs- and ADSCs + PANTO-treated groups showed significant drop (p <  0.05) in serum adva...
Source: Inflammopharmacology - April 23, 2024 Category: Drugs & Pharmacology Source Type: research

Reflux Finding Score and Reflux Symptom Index Potential Indicators for Diagnosis and Management of Laryngopharyngeal Reflux Disease
The objective of the study is to investigate the clinical profile of LPR and its response to treatment. Three hundred consecutive patients who presented to the ENT outpatient department with a clinical profile of LPR were selected. The patients ’ symptoms were assessed using the Reflux Symptom Index (RSI), followed by an endoscopic examination of the larynx and scoring using the Reflux Finding Score (RFS). Patients were started on LPR treatment if they had an RSI score of 13 and an RFS of more than 7. The patients were then started on me dication and monitored for three months. The most common symptom in our research sam...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 20, 2024 Category: ENT & OMF Source Type: research

Pantoprazole-Induced Liver Injury in the Setting of Diabetic Ketoacidosis
Acta Med Port. 2024 Apr 1;37(4):308-309. doi: 10.20344/amp.20928. Epub 2024 Apr 1.NO ABSTRACTPMID:38631049 | DOI:10.20344/amp.20928 (Source: Acta Medica Portuguesa)
Source: Acta Medica Portuguesa - April 17, 2024 Category: General Medicine Authors: Raquel Oliveira Manuel Almeida Pedro Lavado Alexandre Baptista Source Type: research

Proton Pump Inhibitors and Cancer Risk: A Comprehensive Review of Epidemiological and Mechanistic Evidence
Conclusions: Despite the well-established cancer risk associated with PPIs, it is notable that these medications continue to be widely prescribed for periods longer than 3 months. Thus, it is of paramount importance for clinicians and patients to thoughtfully evaluate the potential risks and benefits of long-term PPI usage and explore alternative treatments before making informed decisions regarding their medical management.PMID:38610738 | DOI:10.3390/jcm13071970 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 13, 2024 Category: Cancer & Oncology Authors: Ibrahim O Sawaid Abraham O Samson Source Type: research

Proton Pump Inhibitors and Cancer Risk: A Comprehensive Review of Epidemiological and Mechanistic Evidence
Conclusions: Despite the well-established cancer risk associated with PPIs, it is notable that these medications continue to be widely prescribed for periods longer than 3 months. Thus, it is of paramount importance for clinicians and patients to thoughtfully evaluate the potential risks and benefits of long-term PPI usage and explore alternative treatments before making informed decisions regarding their medical management.PMID:38610738 | PMC:PMC11012754 | DOI:10.3390/jcm13071970 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 13, 2024 Category: Cancer & Oncology Authors: Ibrahim O Sawaid Abraham O Samson Source Type: research

Evaluation of prescriptions from tertiary care hospitals across India for deviations from treatment guidelines & amp; their potential consequences
CONCLUSIONS: The overall prevalence of deviations found was 45 per cent of which unacceptable deviations was estimated to be 9.8 per cent. To minimize the deviations, clinicians recommended online training on rational prescribing and administrative directives as potential interventions.PMID:38528817 | DOI:10.4103/ijmr.ijmr_2309_22 (Source: Indian J Med Res)
Source: Indian J Med Res - March 26, 2024 Category: Research Authors: Yashashri Shetty Sandhya Kamat Raakhi Tripathi Urwashi Parmar Ratinder Jhaj Aditya Banerjee Sadasivam Balakrishnan Niyati Trivedi Janki Chauhan Preeta Kaur Chugh C D Tripathi Dinesh Kumar Badyal Lydia Solomon Sandeep Kaushal Kanchan Gupta M Jayanthi G Jee Source Type: research

Evaluation of prescriptions from tertiary care hospitals across India for deviations from treatment guidelines & amp; their potential consequences
CONCLUSIONS: The overall prevalence of deviations found was 45 per cent of which unacceptable deviations was estimated to be 9.8 per cent. To minimize the deviations, clinicians recommended online training on rational prescribing and administrative directives as potential interventions.PMID:38528817 | DOI:10.4103/ijmr.ijmr_2309_22 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - March 26, 2024 Category: Biomedical Science Authors: Yashashri Shetty Sandhya Kamat Raakhi Tripathi Urwashi Parmar Ratinder Jhaj Aditya Banerjee Sadasivam Balakrishnan Niyati Trivedi Janki Chauhan Preeta Kaur Chugh C D Tripathi Dinesh Kumar Badyal Lydia Solomon Sandeep Kaushal Kanchan Gupta M Jayanthi G Jee Source Type: research

Evaluation of prescriptions from tertiary care hospitals across India for deviations from treatment guidelines & amp; their potential consequences
CONCLUSIONS: The overall prevalence of deviations found was 45 per cent of which unacceptable deviations was estimated to be 9.8 per cent. To minimize the deviations, clinicians recommended online training on rational prescribing and administrative directives as potential interventions.PMID:38528817 | DOI:10.4103/ijmr.ijmr_2309_22 (Source: Indian J Med Res)
Source: Indian J Med Res - March 26, 2024 Category: Research Authors: Yashashri Shetty Sandhya Kamat Raakhi Tripathi Urwashi Parmar Ratinder Jhaj Aditya Banerjee Sadasivam Balakrishnan Niyati Trivedi Janki Chauhan Preeta Kaur Chugh C D Tripathi Dinesh Kumar Badyal Lydia Solomon Sandeep Kaushal Kanchan Gupta M Jayanthi G Jee Source Type: research

Evaluation of prescriptions from tertiary care hospitals across India for deviations from treatment guidelines & amp; their potential consequences
CONCLUSIONS: The overall prevalence of deviations found was 45 per cent of which unacceptable deviations was estimated to be 9.8 per cent. To minimize the deviations, clinicians recommended online training on rational prescribing and administrative directives as potential interventions.PMID:38528817 | DOI:10.4103/ijmr.ijmr_2309_22 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - March 26, 2024 Category: Biomedical Science Authors: Yashashri Shetty Sandhya Kamat Raakhi Tripathi Urwashi Parmar Ratinder Jhaj Aditya Banerjee Sadasivam Balakrishnan Niyati Trivedi Janki Chauhan Preeta Kaur Chugh C D Tripathi Dinesh Kumar Badyal Lydia Solomon Sandeep Kaushal Kanchan Gupta M Jayanthi G Jee Source Type: research

Evaluation of prescriptions from tertiary care hospitals across India for deviations from treatment guidelines & amp; their potential consequences
CONCLUSIONS: The overall prevalence of deviations found was 45 per cent of which unacceptable deviations was estimated to be 9.8 per cent. To minimize the deviations, clinicians recommended online training on rational prescribing and administrative directives as potential interventions.PMID:38528817 | DOI:10.4103/ijmr.ijmr_2309_22 (Source: Indian J Med Res)
Source: Indian J Med Res - March 26, 2024 Category: Research Authors: Yashashri Shetty Sandhya Kamat Raakhi Tripathi Urwashi Parmar Ratinder Jhaj Aditya Banerjee Sadasivam Balakrishnan Niyati Trivedi Janki Chauhan Preeta Kaur Chugh C D Tripathi Dinesh Kumar Badyal Lydia Solomon Sandeep Kaushal Kanchan Gupta M Jayanthi G Jee Source Type: research

Evaluation of prescriptions from tertiary care hospitals across India for deviations from treatment guidelines & amp; their potential consequences
CONCLUSIONS: The overall prevalence of deviations found was 45 per cent of which unacceptable deviations was estimated to be 9.8 per cent. To minimize the deviations, clinicians recommended online training on rational prescribing and administrative directives as potential interventions.PMID:38528817 | DOI:10.4103/ijmr.ijmr_2309_22 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - March 26, 2024 Category: Biomedical Science Authors: Yashashri Shetty Sandhya Kamat Raakhi Tripathi Urwashi Parmar Ratinder Jhaj Aditya Banerjee Sadasivam Balakrishnan Niyati Trivedi Janki Chauhan Preeta Kaur Chugh C D Tripathi Dinesh Kumar Badyal Lydia Solomon Sandeep Kaushal Kanchan Gupta M Jayanthi G Jee Source Type: research

Evaluation of prescriptions from tertiary care hospitals across India for deviations from treatment guidelines & amp; their potential consequences
CONCLUSIONS: The overall prevalence of deviations found was 45 per cent of which unacceptable deviations was estimated to be 9.8 per cent. To minimize the deviations, clinicians recommended online training on rational prescribing and administrative directives as potential interventions.PMID:38528817 | DOI:10.4103/ijmr.ijmr_2309_22 (Source: Indian J Med Res)
Source: Indian J Med Res - March 26, 2024 Category: Research Authors: Yashashri Shetty Sandhya Kamat Raakhi Tripathi Urwashi Parmar Ratinder Jhaj Aditya Banerjee Sadasivam Balakrishnan Niyati Trivedi Janki Chauhan Preeta Kaur Chugh C D Tripathi Dinesh Kumar Badyal Lydia Solomon Sandeep Kaushal Kanchan Gupta M Jayanthi G Jee Source Type: research

Evaluation of prescriptions from tertiary care hospitals across India for deviations from treatment guidelines & amp; their potential consequences
CONCLUSIONS: The overall prevalence of deviations found was 45 per cent of which unacceptable deviations was estimated to be 9.8 per cent. To minimize the deviations, clinicians recommended online training on rational prescribing and administrative directives as potential interventions.PMID:38528817 | DOI:10.4103/ijmr.ijmr_2309_22 (Source: The Indian Journal of Medical Research)
Source: The Indian Journal of Medical Research - March 26, 2024 Category: Biomedical Science Authors: Yashashri Shetty Sandhya Kamat Raakhi Tripathi Urwashi Parmar Ratinder Jhaj Aditya Banerjee Sadasivam Balakrishnan Niyati Trivedi Janki Chauhan Preeta Kaur Chugh C D Tripathi Dinesh Kumar Badyal Lydia Solomon Sandeep Kaushal Kanchan Gupta M Jayanthi G Jee Source Type: research