Molecular Insights into the Mechanism of Modulatory Effects of Proton Pump Inhibitors on P-glycoprotein Mediated Drug Transport of Palbociclib and Ribociclib

CONCLUSION: The experimental evidence presented highlights the fact that proton pump inhibitors have potential to inhibit P-glycoprotein, giving rise to drug interactions with palbociclib and ribociclib. Hence, monitoring is required while proton pump inhibitors and cyclin-dependent kinase inhibitors are being co-administered to avoid adverse events.PMID:37581514 | DOI:10.2174/1389200224666230815122312

Source: Current Drug Metabolism - August 15, 2023 Category: Drugs & Pharmacology Authors: Mrunal Pradeep Desai Prajakta Harish Patil Sai Krishna Anand Vullendula Sumit Birangal G Gautham Shenoy Mahadev Rao Swapnil Jayant Dengale Krishnamurthy Bhat Jagadish Puralae Channabasavaiah Source Type: research