Molecular Insights into the Mechanism of Modulatory Effects of Proton Pump Inhibitors on P-glycoprotein Mediated Drug Transport of Palbociclib and Ribociclib
CONCLUSION: The experimental evidence presented highlights the fact that proton pump inhibitors have potential to inhibit P-glycoprotein, giving rise to drug interactions with palbociclib and ribociclib. Hence, monitoring is required while proton pump inhibitors and cyclin-dependent kinase inhibitors are being co-administered to avoid adverse events.PMID:37581514 | DOI:10.2174/1389200224666230815122312
Source: Current Drug Metabolism - Category: Drugs & Pharmacology Authors: Mrunal Pradeep Desai Prajakta Harish Patil Sai Krishna Anand Vullendula Sumit Birangal G Gautham Shenoy Mahadev Rao Swapnil Jayant Dengale Krishnamurthy Bhat Jagadish Puralae Channabasavaiah Source Type: research
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