Case report: metoclopramide induced acute dystonic reaction in adolescent CYP2D6 poor metabolizers

We present two cases of acute dystonia in two non-consanguineous male adolescents: one following metoclopramide and cimetidine administration in a 14-year-old to treat gastroesophageal reflux, and another following metoclopramide and pantoprazole administration in a 17-year-old with acute gastroenteritis. A retrospective pharmacogenetic analysis revealed both patients as CYP2D6 PMs.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research