Premature Ovarian Insufficiency After Coronavirus Disease 2019 (COVID-19): Autoimmune Follicle-Stimulating Hormone (FSH) and FSH Receptor Blockade
CONCLUSION: Auto-antibody production in response to COVID-19 before vaccination may be a rare cause of autoimmune poor ovarian response. Although vaccination is likely protective, further study will be required to evaluate the effect of vaccination and duration of autoimmune FSH or FSH receptor blockade.PMID:38574363 | DOI:10.1097/AOG.0000000000005574 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - April 4, 2024 Category: OBGYN Authors: Rachel Stern Moses Bibi Martin D Keltz Source Type: research
CD9 shapes glucocorticoid sensitivity in pediatric B-cell precursor acute lymphoblastic leukemia
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.282952. Online ahead of print.ABSTRACTResistance to glucocorticoids (GCs), the common agents for remission induction in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL), poses a significant therapeutic hurdle. Therefore, dissecting the mechanisms shaping GC resistance could lead to new treatment modalities. Here, we showed that CD9- BCP-ALL cells were preferentially resistant to prednisone and dexamethasone over other standard cytotoxic agents. Concordantly, we identified significantly more poor responders to the prednisone prephase among BCP-ALL patien...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Chi Zhang Kathy Yuen Yee Chan Wing Hei Ng John Tak Kit Cheung Qiwei Sun Han Wang Po Yee Chung Frankie Wai Tsoi Cheng Alex Wing Kwan Leung Xiao-Bing Zhang Po Yi Lee Siu Ping Fok Guanglan Lin Ellen Ngar Yun Poon Jian-Hua Feng Yan-Lai Tang Xue-Qun Luo Li-Bin Source Type: research
Premature Ovarian Insufficiency After Coronavirus Disease 2019 (COVID-19): Autoimmune Follicle-Stimulating Hormone (FSH) and FSH Receptor Blockade
CONCLUSION: Auto-antibody production in response to COVID-19 before vaccination may be a rare cause of autoimmune poor ovarian response. Although vaccination is likely protective, further study will be required to evaluate the effect of vaccination and duration of autoimmune FSH or FSH receptor blockade.PMID:38574363 | DOI:10.1097/AOG.0000000000005574 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - April 4, 2024 Category: OBGYN Authors: Rachel Stern Moses Bibi Martin D Keltz Source Type: research
CD9 shapes glucocorticoid sensitivity in pediatric B-cell precursor acute lymphoblastic leukemia
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.282952. Online ahead of print.ABSTRACTResistance to glucocorticoids (GCs), the common agents for remission induction in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL), poses a significant therapeutic hurdle. Therefore, dissecting the mechanisms shaping GC resistance could lead to new treatment modalities. Here, we showed that CD9- BCP-ALL cells were preferentially resistant to prednisone and dexamethasone over other standard cytotoxic agents. Concordantly, we identified significantly more poor responders to the prednisone prephase among BCP-ALL patien...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Chi Zhang Kathy Yuen Yee Chan Wing Hei Ng John Tak Kit Cheung Qiwei Sun Han Wang Po Yee Chung Frankie Wai Tsoi Cheng Alex Wing Kwan Leung Xiao-Bing Zhang Po Yi Lee Siu Ping Fok Guanglan Lin Ellen Ngar Yun Poon Jian-Hua Feng Yan-Lai Tang Xue-Qun Luo Li-Bin Source Type: research
CD9 shapes glucocorticoid sensitivity in pediatric B-cell precursor acute lymphoblastic leukemia
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.282952. Online ahead of print.ABSTRACTResistance to glucocorticoids (GCs), the common agents for remission induction in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL), poses a significant therapeutic hurdle. Therefore, dissecting the mechanisms shaping GC resistance could lead to new treatment modalities. Here, we showed that CD9- BCP-ALL cells were preferentially resistant to prednisone and dexamethasone over other standard cytotoxic agents. Concordantly, we identified significantly more poor responders to the prednisone prephase among BCP-ALL patien...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Chi Zhang Kathy Yuen Yee Chan Wing Hei Ng John Tak Kit Cheung Qiwei Sun Han Wang Po Yee Chung Frankie Wai Tsoi Cheng Alex Wing Kwan Leung Xiao-Bing Zhang Po Yi Lee Siu Ping Fok Guanglan Lin Ellen Ngar Yun Poon Jian-Hua Feng Yan-Lai Tang Xue-Qun Luo Li-Bin Source Type: research
An inconspicuous identification: isolation and identification of a novel Pichia species presenting as fungemia following cardiac surgery.
An 84-year-old woman with an implantable cardiac pacemaker and a history of temporal arteritis on chronic prednisone (7 mg/day) noted increasing bilateral lower extremity edema approximately 2 months prior to hospital admission. The patient, an avid traveler, was born in South Africa and moved to the United States Pacific Northwest in the early 1960s. An outpatient transthoracic echocardiogram demonstrated an ascending aortic aneurysm and moderate aortic stenosis. CT angiogram confirmed severe aneurysmal dilation of the ascending thoracic aorta (7.4 cm), aortic arch (4.7 cm), and descending thoracic aorta (3.7 cm). (Source...
Source: International Journal of Infectious Diseases - April 3, 2024 Category: Infectious Diseases Authors: Allorie T. Caldwell, Toni Gabald ón, Verónica Mixão, Nancy L. Wengenack, Benjamin P. Westley, Ryan W. Stevens Tags: Case Report Source Type: research
A novel flow cytometry panel to identify prognostic markers for steroid-sensitive forms of idiopathic nephrotic syndrome in childhood
ConclusionWe have set up a novel, reproducible, disease-specific flow cytometry panel that allows a comprehensive characterization of circulating lymphocytes. We found that, at disease onset, relapsing patients had significantly more transitional, CD19+CD27+ memory and unswitched memory B cells and those who are at higher risk of relapse had increased circulating levels of unswitched memory B cells, independently of age. This approach can allow prediction of clinical evolution, monitoring of immunosuppression and tailored treatment in different forms of INS. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - April 2, 2024 Category: Allergy & Immunology Source Type: research
Effectiveness of methotrexate and leflunomide as corticoid-sparing drugs in patients with polymyalgia rheumatica
CONCLUSIONS: This study demonstrated the clinical effectiveness of LEF and even its superiority in achieving remission when compared with MTX as GCSD in PMR patients. Further research is needed to support these findings.PMID:38560643 | PMC:PMC10978571 | DOI:10.1093/rap/rkae033 (Source: Adv Data)
Source: Adv Data - April 1, 2024 Category: Epidemiology Authors: Juan Pablo Vinicki Alejandra Cusa Daniela Domingo Jos é Luis Velasco Zamora Sebasti án Magri Alejandro Brigante Maria Marcela Schmid Paola Ávila Natalia Zamora Laura Sorrentino Anabella M Rodriguez Miguel Linarez Cecilia Pisoni Carolina Costi Gustavo R Source Type: research
Prednisone
(Source: Reactions Weekly)
Source: Reactions Weekly - April 1, 2024 Category: Drugs & Pharmacology Source Type: research
The Impact of Pre-Trauma Steroid Use on Wound Healing and Outcomes
This study presents data on pre-trauma steroid use, a topic underrepresented in the trauma literature. Long-term steroid use has been linked to impaired wound healing, compromised immune responses, and hindrance of bone healing, alongside the potential for adrenal insufficiency during traumatic events. The aim of this study was to conduct a retrospective analysis of clinical outcomes for trauma patients with chronic steroid use. Examining adult trauma cases with pre-trauma steroid use at a level 1 trauma center (January 2016-September 2023), we identified 18 patients (58.6 ± 19.4 years, 55.6% males). All were on prednison...
Source: The American Surgeon - March 30, 2024 Category: Surgery Authors: Kaleb Derouen Sarah Aleman Harrison Travis John P Hunt Alan Marr Patrick Greiffenstein Lance Stuke Jonathan Schoen Alison Smith Source Type: research
The Impact of Pre-Trauma Steroid Use on Wound Healing and Outcomes
This study presents data on pre-trauma steroid use, a topic underrepresented in the trauma literature. Long-term steroid use has been linked to impaired wound healing, compromised immune responses, and hindrance of bone healing, alongside the potential for adrenal insufficiency during traumatic events. The aim of this study was to conduct a retrospective analysis of clinical outcomes for trauma patients with chronic steroid use. Examining adult trauma cases with pre-trauma steroid use at a level 1 trauma center (January 2016-September 2023), we identified 18 patients (58.6 ± 19.4 years, 55.6% males). All were on prednison...
Source: The American Surgeon - March 30, 2024 Category: Surgery Authors: Kaleb Derouen Sarah Aleman Harrison Travis John P Hunt Alan Marr Patrick Greiffenstein Lance Stuke Jonathan Schoen Alison Smith Source Type: research
The Impact of Pre-Trauma Steroid Use on Wound Healing and Outcomes
This study presents data on pre-trauma steroid use, a topic underrepresented in the trauma literature. Long-term steroid use has been linked to impaired wound healing, compromised immune responses, and hindrance of bone healing, alongside the potential for adrenal insufficiency during traumatic events. The aim of this study was to conduct a retrospective analysis of clinical outcomes for trauma patients with chronic steroid use. Examining adult trauma cases with pre-trauma steroid use at a level 1 trauma center (January 2016-September 2023), we identified 18 patients (58.6 ± 19.4 years, 55.6% males). All were on prednison...
Source: The American Surgeon - March 30, 2024 Category: Surgery Authors: Kaleb Derouen Sarah Aleman Harrison Travis John P Hunt Alan Marr Patrick Greiffenstein Lance Stuke Jonathan Schoen Alison Smith Source Type: research
Refractory guillain-barr É syndrome in a patient with asymptomatic multiple myeloma successfully treated with low-dose rituximab
Acta Clin Croat. 2023 Aug;62(2):382-386. doi: 10.20471/acc.2023.62.02.19.ABSTRACTDespite being extremely rare, Guillain-Barré syndrome (GBS) has been recognized as a neurological complication of multiple myeloma, with variable responses to plasmapheresis (PEX), intravenous immunoglobulins (IVIG), and anti-myeloma therapies. In this paper, we report a case of a female patient with asymptomatic multiple myeloma (aMM) who initially presented as PEX- and IVIG-refractory GBS. After failure of PEX, IVIG, and anti-myeloma therapy (bortezomib, melphalan, and prednisone), the patient was eventually successfully treated with low-do...
Source: Acta Clinica Croatica - March 29, 2024 Category: General Medicine Authors: Ivan Kre čak Velka Gveri ć-Krečak Source Type: research
Inhibition of RAC attenuates Adriamycin-induced podocyte injury
In conclusion, our research suggests that EHT-1864 may be a promising new molecular drug candidate for patients with MCD and FSGS.PMID:38552554 | DOI:10.1016/j.bbrc.2024.149807 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - March 29, 2024 Category: Biochemistry Authors: Hao Wu Yujin Liu Zhanjun Jia Songming Huang Guixia Ding Aihua Zhang Jing Yu Source Type: research
