ANCA-associated vasculitis presenting with isolated neurological manifestations in a patient with cocaine abuse: a case report and literature review
We present a unique case of AAV with isolated neurological manifestations presenting with multiple cranial neuropathies, leptomeningeal enhancement on imaging and histopathologic evidence of small-vessel vasculitis in the leptomeninges and brain and extensive dural fibrosis in a patient with cocaine abuse. The patient ’s progressive neurological deficits were controlled after starting immunosuppression with rituximab and prednisone. We also reviewed the literature to provide the diagnostic overview of AAV and evaluate intervention options. To our knowledge, this is the first case of AAV with isolated neurologic al manife...
Source: Clinical Rheumatology - March 26, 2024 Category: Rheumatology Source Type: research
Cancers, Vol. 16, Pages 1285: Comparing R-Bendamustine vs. R-CHOP Plus Maintenance Therapy as First-Line Systemic Treatment in Follicular Lymphoma: A Multicenter Retrospective GELTAMO Study
In conclusion, R-B followed by rituximab maintenance therapy in patients with previously untreated FL resulted in significantly longer PFS than R-CHOP, with older patients also benefiting from this treatment without further toxicity. Adverse events during maintenance were more frequent with R-B without impacting mortality. (Source: Cancers)
Source: Cancers - March 26, 2024 Category: Cancer & Oncology Authors: Mariana Bastos-Oreiro Antonio Gutierrez Almudena Cabero Javier L ópez Paola Villafuerte Ana Jim énez-Ubieto Raquel de O ña Adolfo De la Fuente Bel én Navarro Javier Pe ñalver Pilar Mart ínez Carmen Alonso Mar ía Infante Ra úl Córdoba Blanca Perez Tags: Article Source Type: research
Precise infliximab exposure and pharmacodynamic control to achieve deep remission in paediatric Crohns disease (REMODEL-CD): study protocol for a multicentre, open-label, pragmatic clinical trial in the USA
Introduction
The only biologic therapy currently approved to treat moderate to severe Crohn’s disease in children (<18 years old) are those that antagonise tumour necrosis factor-alpha (anti-TNF). Therefore, it is critically important to develop novel strategies that maximise treatment effectiveness in this population. There is growing evidence that rates of sustained corticosteroid-free clinical remission, endoscopic healing and drug durability considerably improve when patients receive early anti-TNF dose optimisations guided by reactive or proactive therapeutic drug monitoring and pharmacodynamic monitoring. In...
Source: BMJ Open - March 25, 2024 Category: General Medicine Authors: Minar, P. P., Colman, R. J., Zhang, N., Mizuno, T., Vinks, A. A. Tags: Open access, Gastroenterology and hepatology Source Type: research
Real-World experience with efgartigimod in patients with myasthenia gravis
AbstractRecommendations for the treatment of myasthenia gravis (MG) have been difficult to develop because of limited evidence from large randomized controlled trials. New drugs and treatment approaches have recently been shown to be effective in phase 3 studies in seropositive generalized (g) MG. One such drug is efgartigimod, a human-Fc-fragment of IgG1, with a high affinity for the endosomal FcRn. We conducted a multicenter study to evaluate the real-world clinical and safety effects of efgartigimod in 22 gMG patients. We evaluated the strategies for the timing of re-treatment with it. The participants received a tota...
Source: Journal of Neurology - March 25, 2024 Category: Neurology Source Type: research
Real-World Outcomes of Dual Advanced Therapy in Children and Young Adults with Inflammatory Bowel Disease
ConclusionMost children and young adults treated with DAT achieved remission with minimal safety events; however, de-intensification had limited success. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 23, 2024 Category: Gastroenterology Source Type: research
Uveal effusion syndrome: a case report
ConclusionThis case report emphasizes the value in early detection, keen diagnostic evaluation, and cross-collaboration between multiple ophthalmology specialists to optimize healthcare outcomes for patients with uveal effusion syndrome. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 21, 2024 Category: General Medicine Source Type: research
Improvement of idiopathic pulmonary fibrosis through a combination of < em > Astragalus < /em > radix and < em > Angelica sinensis < /em > radix via mammalian target of rapamycin signaling pathway-induced autophagy in rat
CONCLUSIONS: The combination of AR and AS protects against IPF by inducing autophagy via inhibiting the mTOR signaling pathway. The synergistic action of AR and AS is superior to that of either AR or AS alone.PMID:38505077 | PMC:PMC10944740 | DOI:10.21037/jtd-24-28 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - March 20, 2024 Category: Respiratory Medicine Authors: Chao Sun Huaman Liu Baihong Chi Jia Han Yasuhiko Koga Kamyar Afshar Xue Liu Source Type: research
