< em > Jianpi Zishen < /em > granule inhibits podocyte autophagy in systemic lupus erythematosus: a network pharmacology and clinical study
CONCLUSION: The therapeutic effect of JPZS granules on SLE is mediated probably by coordinated actions of quercetin, kaempferol, β-sitosterol, and isorhamnetin on their target gene STAT1 to inhibit the JAK/STAT pathway, thus suppressing autophagy and alleviating podocyte injuries in SLE.PMID:38597437 | PMC:PMC11006693 | DOI:10.12122/j.issn.1673-4254.2024.03.07 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: J Chen C Huang M Li Source Type: research
< em > Jianpi Zishen < /em > granule inhibits podocyte autophagy in systemic lupus erythematosus: a network pharmacology and clinical study
CONCLUSION: The therapeutic effect of JPZS granules on SLE is mediated probably by coordinated actions of quercetin, kaempferol, β-sitosterol, and isorhamnetin on their target gene STAT1 to inhibit the JAK/STAT pathway, thus suppressing autophagy and alleviating podocyte injuries in SLE.PMID:38597437 | PMC:PMC11006693 | DOI:10.12122/j.issn.1673-4254.2024.03.07 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: J Chen C Huang M Li Source Type: research
< em > Jianpi Zishen < /em > granule inhibits podocyte autophagy in systemic lupus erythematosus: a network pharmacology and clinical study
CONCLUSION: The therapeutic effect of JPZS granules on SLE is mediated probably by coordinated actions of quercetin, kaempferol, β-sitosterol, and isorhamnetin on their target gene STAT1 to inhibit the JAK/STAT pathway, thus suppressing autophagy and alleviating podocyte injuries in SLE.PMID:38597437 | PMC:PMC11006693 | DOI:10.12122/j.issn.1673-4254.2024.03.07 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: J Chen C Huang M Li Source Type: research
< em > Jianpi Zishen < /em > granule inhibits podocyte autophagy in systemic lupus erythematosus: a network pharmacology and clinical study
CONCLUSION: The therapeutic effect of JPZS granules on SLE is mediated probably by coordinated actions of quercetin, kaempferol, β-sitosterol, and isorhamnetin on their target gene STAT1 to inhibit the JAK/STAT pathway, thus suppressing autophagy and alleviating podocyte injuries in SLE.PMID:38597437 | PMC:PMC11006693 | DOI:10.12122/j.issn.1673-4254.2024.03.07 (Source: Journal of Southern Medical University)
Source: Journal of Southern Medical University - April 10, 2024 Category: Universities & Medical Training Authors: J Chen C Huang M Li Source Type: research
Real ‐world patient characteristics, treatment patterns, and treatment outcomes of patients with diffuse large B‐cell lymphoma by line of therapy
ConclusionsIn this real-world analysis, 25.2% of patients experienced R/R-DLBCL after 1L with poor outcomes. Given the findings of this study, there is a high unmet need for novel, safe, and effective treatment options for patients with R/R DLBCL. (Source: Cancer Medicine)
Source: Cancer Medicine - April 10, 2024 Category: Cancer & Oncology Authors: Helmneh M. Sineshaw,
Christina M. Zettler,
Jennifer Prescott,
Mahek Garg,
Samhita Chakraborty,
Eric M. Sarpong,
Claire Bai,
Andrew J. Belli,
Laura L. Fernandes,
Ching ‐Kun Wang Tags: RESEARCH ARTICLE Source Type: research
Role of plasma EBV-DNA load and EBER status on newly diagnosed peripheral T-cell lymphoma
ConclusionEBER, DNA1, and DNA4 emerged as sensitive markers for prognosis. CHOP plus azacytidine might present a preferable option for PTCL patients with DNA methylation due to EBV infection. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 8, 2024 Category: Cancer & Oncology Source Type: research
CD9 shapes glucocorticoid sensitivity in pediatric B-cell precursor acute lymphoblastic leukemia
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.282952. Online ahead of print.ABSTRACTResistance to glucocorticoids (GCs), the common agents for remission induction in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL), poses a significant therapeutic hurdle. Therefore, dissecting the mechanisms shaping GC resistance could lead to new treatment modalities. Here, we showed that CD9- BCP-ALL cells were preferentially resistant to prednisone and dexamethasone over other standard cytotoxic agents. Concordantly, we identified significantly more poor responders to the prednisone prephase among BCP-ALL patien...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Chi Zhang Kathy Yuen Yee Chan Wing Hei Ng John Tak Kit Cheung Qiwei Sun Han Wang Po Yee Chung Frankie Wai Tsoi Cheng Alex Wing Kwan Leung Xiao-Bing Zhang Po Yi Lee Siu Ping Fok Guanglan Lin Ellen Ngar Yun Poon Jian-Hua Feng Yan-Lai Tang Xue-Qun Luo Li-Bin Source Type: research
Premature Ovarian Insufficiency After Coronavirus Disease 2019 (COVID-19): Autoimmune Follicle-Stimulating Hormone (FSH) and FSH Receptor Blockade
CONCLUSION: Auto-antibody production in response to COVID-19 before vaccination may be a rare cause of autoimmune poor ovarian response. Although vaccination is likely protective, further study will be required to evaluate the effect of vaccination and duration of autoimmune FSH or FSH receptor blockade.PMID:38574363 | DOI:10.1097/AOG.0000000000005574 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - April 4, 2024 Category: OBGYN Authors: Rachel Stern Moses Bibi Martin D Keltz Source Type: research
CD9 shapes glucocorticoid sensitivity in pediatric B-cell precursor acute lymphoblastic leukemia
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.282952. Online ahead of print.ABSTRACTResistance to glucocorticoids (GCs), the common agents for remission induction in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL), poses a significant therapeutic hurdle. Therefore, dissecting the mechanisms shaping GC resistance could lead to new treatment modalities. Here, we showed that CD9- BCP-ALL cells were preferentially resistant to prednisone and dexamethasone over other standard cytotoxic agents. Concordantly, we identified significantly more poor responders to the prednisone prephase among BCP-ALL patien...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Chi Zhang Kathy Yuen Yee Chan Wing Hei Ng John Tak Kit Cheung Qiwei Sun Han Wang Po Yee Chung Frankie Wai Tsoi Cheng Alex Wing Kwan Leung Xiao-Bing Zhang Po Yi Lee Siu Ping Fok Guanglan Lin Ellen Ngar Yun Poon Jian-Hua Feng Yan-Lai Tang Xue-Qun Luo Li-Bin Source Type: research
Premature Ovarian Insufficiency After Coronavirus Disease 2019 (COVID-19): Autoimmune Follicle-Stimulating Hormone (FSH) and FSH Receptor Blockade
CONCLUSION: Auto-antibody production in response to COVID-19 before vaccination may be a rare cause of autoimmune poor ovarian response. Although vaccination is likely protective, further study will be required to evaluate the effect of vaccination and duration of autoimmune FSH or FSH receptor blockade.PMID:38574363 | DOI:10.1097/AOG.0000000000005574 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - April 4, 2024 Category: OBGYN Authors: Rachel Stern Moses Bibi Martin D Keltz Source Type: research
CD9 shapes glucocorticoid sensitivity in pediatric B-cell precursor acute lymphoblastic leukemia
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.282952. Online ahead of print.ABSTRACTResistance to glucocorticoids (GCs), the common agents for remission induction in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL), poses a significant therapeutic hurdle. Therefore, dissecting the mechanisms shaping GC resistance could lead to new treatment modalities. Here, we showed that CD9- BCP-ALL cells were preferentially resistant to prednisone and dexamethasone over other standard cytotoxic agents. Concordantly, we identified significantly more poor responders to the prednisone prephase among BCP-ALL patien...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Chi Zhang Kathy Yuen Yee Chan Wing Hei Ng John Tak Kit Cheung Qiwei Sun Han Wang Po Yee Chung Frankie Wai Tsoi Cheng Alex Wing Kwan Leung Xiao-Bing Zhang Po Yi Lee Siu Ping Fok Guanglan Lin Ellen Ngar Yun Poon Jian-Hua Feng Yan-Lai Tang Xue-Qun Luo Li-Bin Source Type: research
Premature Ovarian Insufficiency After Coronavirus Disease 2019 (COVID-19): Autoimmune Follicle-Stimulating Hormone (FSH) and FSH Receptor Blockade
CONCLUSION: Auto-antibody production in response to COVID-19 before vaccination may be a rare cause of autoimmune poor ovarian response. Although vaccination is likely protective, further study will be required to evaluate the effect of vaccination and duration of autoimmune FSH or FSH receptor blockade.PMID:38574363 | DOI:10.1097/AOG.0000000000005574 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - April 4, 2024 Category: OBGYN Authors: Rachel Stern Moses Bibi Martin D Keltz Source Type: research
CD9 shapes glucocorticoid sensitivity in pediatric B-cell precursor acute lymphoblastic leukemia
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.282952. Online ahead of print.ABSTRACTResistance to glucocorticoids (GCs), the common agents for remission induction in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL), poses a significant therapeutic hurdle. Therefore, dissecting the mechanisms shaping GC resistance could lead to new treatment modalities. Here, we showed that CD9- BCP-ALL cells were preferentially resistant to prednisone and dexamethasone over other standard cytotoxic agents. Concordantly, we identified significantly more poor responders to the prednisone prephase among BCP-ALL patien...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Chi Zhang Kathy Yuen Yee Chan Wing Hei Ng John Tak Kit Cheung Qiwei Sun Han Wang Po Yee Chung Frankie Wai Tsoi Cheng Alex Wing Kwan Leung Xiao-Bing Zhang Po Yi Lee Siu Ping Fok Guanglan Lin Ellen Ngar Yun Poon Jian-Hua Feng Yan-Lai Tang Xue-Qun Luo Li-Bin Source Type: research
Premature Ovarian Insufficiency After Coronavirus Disease 2019 (COVID-19): Autoimmune Follicle-Stimulating Hormone (FSH) and FSH Receptor Blockade
CONCLUSION: Auto-antibody production in response to COVID-19 before vaccination may be a rare cause of autoimmune poor ovarian response. Although vaccination is likely protective, further study will be required to evaluate the effect of vaccination and duration of autoimmune FSH or FSH receptor blockade.PMID:38574363 | DOI:10.1097/AOG.0000000000005574 (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - April 4, 2024 Category: OBGYN Authors: Rachel Stern Moses Bibi Martin D Keltz Source Type: research
CD9 shapes glucocorticoid sensitivity in pediatric B-cell precursor acute lymphoblastic leukemia
Haematologica. 2024 Apr 4. doi: 10.3324/haematol.2023.282952. Online ahead of print.ABSTRACTResistance to glucocorticoids (GCs), the common agents for remission induction in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL), poses a significant therapeutic hurdle. Therefore, dissecting the mechanisms shaping GC resistance could lead to new treatment modalities. Here, we showed that CD9- BCP-ALL cells were preferentially resistant to prednisone and dexamethasone over other standard cytotoxic agents. Concordantly, we identified significantly more poor responders to the prednisone prephase among BCP-ALL patien...
Source: Haematologica - April 4, 2024 Category: Hematology Authors: Chi Zhang Kathy Yuen Yee Chan Wing Hei Ng John Tak Kit Cheung Qiwei Sun Han Wang Po Yee Chung Frankie Wai Tsoi Cheng Alex Wing Kwan Leung Xiao-Bing Zhang Po Yi Lee Siu Ping Fok Guanglan Lin Ellen Ngar Yun Poon Jian-Hua Feng Yan-Lai Tang Xue-Qun Luo Li-Bin Source Type: research
