Ferroptosis mechanisms and its novel potential therapeutic targets for DLBCL
Biomed Pharmacother. 2024 Mar 15;173:116386. doi: 10.1016/j.biopha.2024.116386. Online ahead of print.ABSTRACTDiffuse large B-cell lymphoma (DLBCL), a heterogeneous lymphoid malignancy, poses a significant threat to human health. The standard therapeutic regimen for patients with DLBCL is rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP), with a typical cure rate of 50-70%. However, some patients either relapse after complete remission (CR) or exhibit resistance to R-CHOP treatment. Therefore, novel therapeutic approaches are imperative for managing high-risk or refractory DLBCL. Ferroptosis is...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 16, 2024 Category: Drugs & Pharmacology Authors: Wenxia Bian Haoran Li Yuhan Chen Yanhua Yu Guojie Lei Xinyi Yang Sainan Li Xi Chen Huanjuan Li Jing Yang Chen Yang Yanchun Li Yi Zhou Source Type: research
Ferroptosis mechanisms and its novel potential therapeutic targets for DLBCL
Biomed Pharmacother. 2024 Mar 15;173:116386. doi: 10.1016/j.biopha.2024.116386. Online ahead of print.ABSTRACTDiffuse large B-cell lymphoma (DLBCL), a heterogeneous lymphoid malignancy, poses a significant threat to human health. The standard therapeutic regimen for patients with DLBCL is rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP), with a typical cure rate of 50-70%. However, some patients either relapse after complete remission (CR) or exhibit resistance to R-CHOP treatment. Therefore, novel therapeutic approaches are imperative for managing high-risk or refractory DLBCL. Ferroptosis is...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 16, 2024 Category: Drugs & Pharmacology Authors: Wenxia Bian Haoran Li Yuhan Chen Yanhua Yu Guojie Lei Xinyi Yang Sainan Li Xi Chen Huanjuan Li Jing Yang Chen Yang Yanchun Li Yi Zhou Source Type: research
Pushing the CART to the Finish Line: Integrating Radiation Therapy Into Chimeric Antigen Receptor T-Cell Therapy Programs to Improve Outcomes for Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma
Most patients with diffuse large B-cell lymphoma (DLBCL) experience excellent outcomes with first-line immunochemotherapy-based regimens that usually include rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) and frequently consolidation radiation therapy (RT) to sites at higher risk of local relapse.1-7 Despite these optimal efforts, however, approximately 30% to 40% of patients may experience relapse or primary refractory disease.8 For fit patients, the standard treatment approach in this scenario is usually high-dose chemotherapy and autologous stem cell rescue/transplantation. (Source: Inter...
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2024 Category: Radiology Authors: Rahul R. Parikh, Sarah A. Milgrom, Belinda A. Campbell Tags: Oncology Scan Source Type: research
Clinical outcomes of intestinal transplant recipients receiving maintenance basiliximab, sublingual tacrolimus and prednisone: A case series
CONCLUSION: The combination of monthly basiliximab, sublingual tacrolimus, and prednisone is an effective novel maintenance immunosuppression in intestinal transplantation. A larger and more extended study duration would be necessary to thoroughly assess the safety and sustained benefits of the novel maintenance immunosuppression regimen.PMID:38480040 | DOI:10.1016/j.humimm.2024.110787 (Source: Human Immunology)
Source: Human Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Pierpaolo Di Cocco Alessandro Martinino Giulia Bencini Rachel Christensen Benito Valdepenas Egor Petrochenkov Stepan Akshelyan Jorge Almario-Alvarez Mario Spaggiari Ivo Tzvetanov Enrico Benedetti Source Type: research
Linear IgA bullous dermatosis associated with immunotherapy
We present the case of a 67-year-old woman with metastatic ovarian cancer receiving anti-PD1 and anti-CTLA4 with new onset pruritic tense bullae to the trunk, hands, elbows (in annular distribution) that occurred after immunotherapy. Skin biopsy showed subepidermal blister with abundant neutrophils on H&E histology, and linear IgA staining at the basement membrane on direct immunofluorescence consistent with the diagnosis of LABD. The condition did not improve on initial prednisone taper, but blisters rapidly resolved a few days after initiation of dapsone therapy. We favor that our patient's LABD is secondary to h...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Bahar Momin Tue F Nguyen Daniel Glade Alison Messer Source Type: research
Clinical outcomes of intestinal transplant recipients receiving maintenance basiliximab, sublingual tacrolimus and prednisone: A case series
CONCLUSION: The combination of monthly basiliximab, sublingual tacrolimus, and prednisone is an effective novel maintenance immunosuppression in intestinal transplantation. A larger and more extended study duration would be necessary to thoroughly assess the safety and sustained benefits of the novel maintenance immunosuppression regimen.PMID:38480040 | DOI:10.1016/j.humimm.2024.110787 (Source: Human Immunology)
Source: Human Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Pierpaolo Di Cocco Alessandro Martinino Giulia Bencini Rachel Christensen Benito Valdepenas Egor Petrochenkov Stepan Akshelyan Jorge Almario-Alvarez Mario Spaggiari Ivo Tzvetanov Enrico Benedetti Source Type: research
Linear IgA bullous dermatosis associated with immunotherapy
We present the case of a 67-year-old woman with metastatic ovarian cancer receiving anti-PD1 and anti-CTLA4 with new onset pruritic tense bullae to the trunk, hands, elbows (in annular distribution) that occurred after immunotherapy. Skin biopsy showed subepidermal blister with abundant neutrophils on H&E histology, and linear IgA staining at the basement membrane on direct immunofluorescence consistent with the diagnosis of LABD. The condition did not improve on initial prednisone taper, but blisters rapidly resolved a few days after initiation of dapsone therapy. We favor that our patient's LABD is secondary to h...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Bahar Momin Tue F Nguyen Daniel Glade Alison Messer Source Type: research
Clinical outcomes of intestinal transplant recipients receiving maintenance basiliximab, sublingual tacrolimus and prednisone: A case series
CONCLUSION: The combination of monthly basiliximab, sublingual tacrolimus, and prednisone is an effective novel maintenance immunosuppression in intestinal transplantation. A larger and more extended study duration would be necessary to thoroughly assess the safety and sustained benefits of the novel maintenance immunosuppression regimen.PMID:38480040 | DOI:10.1016/j.humimm.2024.110787 (Source: Human Immunology)
Source: Human Immunology - March 13, 2024 Category: Allergy & Immunology Authors: Pierpaolo Di Cocco Alessandro Martinino Giulia Bencini Rachel Christensen Benito Valdepenas Egor Petrochenkov Stepan Akshelyan Jorge Almario-Alvarez Mario Spaggiari Ivo Tzvetanov Enrico Benedetti Source Type: research
Linear IgA bullous dermatosis associated with immunotherapy
We present the case of a 67-year-old woman with metastatic ovarian cancer receiving anti-PD1 and anti-CTLA4 with new onset pruritic tense bullae to the trunk, hands, elbows (in annular distribution) that occurred after immunotherapy. Skin biopsy showed subepidermal blister with abundant neutrophils on H&E histology, and linear IgA staining at the basement membrane on direct immunofluorescence consistent with the diagnosis of LABD. The condition did not improve on initial prednisone taper, but blisters rapidly resolved a few days after initiation of dapsone therapy. We favor that our patient's LABD is secondary to h...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Bahar Momin Tue F Nguyen Daniel Glade Alison Messer Source Type: research
Linear IgA bullous dermatosis associated with immunotherapy
We present the case of a 67-year-old woman with metastatic ovarian cancer receiving anti-PD1 and anti-CTLA4 with new onset pruritic tense bullae to the trunk, hands, elbows (in annular distribution) that occurred after immunotherapy. Skin biopsy showed subepidermal blister with abundant neutrophils on H&E histology, and linear IgA staining at the basement membrane on direct immunofluorescence consistent with the diagnosis of LABD. The condition did not improve on initial prednisone taper, but blisters rapidly resolved a few days after initiation of dapsone therapy. We favor that our patient's LABD is secondary to h...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Bahar Momin Tue F Nguyen Daniel Glade Alison Messer Source Type: research
Linear IgA bullous dermatosis associated with immunotherapy
We present the case of a 67-year-old woman with metastatic ovarian cancer receiving anti-PD1 and anti-CTLA4 with new onset pruritic tense bullae to the trunk, hands, elbows (in annular distribution) that occurred after immunotherapy. Skin biopsy showed subepidermal blister with abundant neutrophils on H&E histology, and linear IgA staining at the basement membrane on direct immunofluorescence consistent with the diagnosis of LABD. The condition did not improve on initial prednisone taper, but blisters rapidly resolved a few days after initiation of dapsone therapy. We favor that our patient's LABD is secondary to h...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Bahar Momin Tue F Nguyen Daniel Glade Alison Messer Source Type: research
Linear IgA bullous dermatosis associated with immunotherapy
We present the case of a 67-year-old woman with metastatic ovarian cancer receiving anti-PD1 and anti-CTLA4 with new onset pruritic tense bullae to the trunk, hands, elbows (in annular distribution) that occurred after immunotherapy. Skin biopsy showed subepidermal blister with abundant neutrophils on H&E histology, and linear IgA staining at the basement membrane on direct immunofluorescence consistent with the diagnosis of LABD. The condition did not improve on initial prednisone taper, but blisters rapidly resolved a few days after initiation of dapsone therapy. We favor that our patient's LABD is secondary to h...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Bahar Momin Tue F Nguyen Daniel Glade Alison Messer Source Type: research
Linear IgA bullous dermatosis associated with immunotherapy
We present the case of a 67-year-old woman with metastatic ovarian cancer receiving anti-PD1 and anti-CTLA4 with new onset pruritic tense bullae to the trunk, hands, elbows (in annular distribution) that occurred after immunotherapy. Skin biopsy showed subepidermal blister with abundant neutrophils on H&E histology, and linear IgA staining at the basement membrane on direct immunofluorescence consistent with the diagnosis of LABD. The condition did not improve on initial prednisone taper, but blisters rapidly resolved a few days after initiation of dapsone therapy. We favor that our patient's LABD is secondary to h...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Bahar Momin Tue F Nguyen Daniel Glade Alison Messer Source Type: research
Linear IgA bullous dermatosis associated with immunotherapy
We present the case of a 67-year-old woman with metastatic ovarian cancer receiving anti-PD1 and anti-CTLA4 with new onset pruritic tense bullae to the trunk, hands, elbows (in annular distribution) that occurred after immunotherapy. Skin biopsy showed subepidermal blister with abundant neutrophils on H&E histology, and linear IgA staining at the basement membrane on direct immunofluorescence consistent with the diagnosis of LABD. The condition did not improve on initial prednisone taper, but blisters rapidly resolved a few days after initiation of dapsone therapy. We favor that our patient's LABD is secondary to h...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Bahar Momin Tue F Nguyen Daniel Glade Alison Messer Source Type: research
