Patient-reported outcomes provide evidence for increased depressive symptoms and increased mental impairment in giant cell arteritis
CONCLUSION: PRO show a relevant impairment of mental health up to symptoms of major depression disorder. The degree of depressive symptoms is also distinctly associated with the serological inflammatory marker CRP.PMID:37324155 | PMC:PMC10262919 | DOI:10.3389/fmed.2023.1146815 (Source: Pain Physician)
Source: Pain Physician - June 16, 2023 Category: Anesthesiology Authors: Matthias Froehlich Antonia Zahner Marc Schmalzing Michael Gernert Patrick-Pascal Strunz Sebastian Hueper Jan Portegys Eva Christina Schwaneck Ottar Gadeholt Andrea K übler Johannes Hewig Philipp Ziebell Source Type: research
Biomarkers in the era of targeted therapy in giant cell arteritis and polymyalgia rheumatica: is it possible to replace acute-phase reactants?
Research into giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) has become more important in the last few decades. Physicians are facing several challenges in managing the diagnosis, treatment, and relapses of GCA and PMR patients. The search for biomarkers could provide elements to guide a physician’s decision. In this review, we aim to summarize the scientific publications about biomarkers in GCA and PMR in the past decade. The first point raised by this review is the number of clinical situations in which biomarkers could be useful: differential diagnosis of either GCA or PMR, diagnosis of underlying vasculi...
Source: Frontiers in Immunology - June 15, 2023 Category: Allergy & Immunology Source Type: research
Tolerability of immune checkpoint inhibitors in patients with cancer and pre-existing multiple sclerosis
In the last 10 years, immune checkpoint inhibitor (ICI) immunotherapies have become a pivotal treatment in many types of cancer and the management of immune-related adverse events is now well codified [1]. At the beginning of ICI utilisation, patients with a history of autoimmune diseases were initially contraindicated to receive ICI, subsequently safety data accumulated in favour of using ICI in patients with controlled and inactive autoimmune diseases [2,3]. A risk of usually mild autoimmune flare (up to 75%) is reported in patients with autoimmune diseases such as rheumatoid arthritis, polymyalgia rheumatica, psoriatic ...
Source: European Journal of Cancer - June 13, 2023 Category: Cancer & Oncology Authors: L. Chavaz, D. Guyon, A. Boespflug, C. Cauquil, J.M. Michot Tags: Letter to the Editor Source Type: research
Disease stratification in GCA and PMR: state of the art and future perspectives
Nature Reviews Rheumatology, Published online: 12 June 2023; doi:10.1038/s41584-023-00976-8Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are increasingly viewed as parts of a single disease spectrum. In this Review, the authors outline how stratification of patients with GCA–PMR spectrum disease using clinical, imaging and laboratory data can to help guide therapy. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - June 12, 2023 Category: Rheumatology Authors: Alessandro Tomelleri Kornelis S. M. van der Geest Muhammad Asim Khurshid Alwin Sebastian Fiona Coath Daniel Robbins Barbara Pierscionek Christian Dejaco Eric Matteson Yannick van Sleen Bhaskar Dasgupta Source Type: research
Polymyalgia rheumatica after pembrolizumab treatment
Med Clin (Barc). 2023 Jun 2:S0025-7753(23)00246-4. doi: 10.1016/j.medcli.2023.04.030. Online ahead of print.NO ABSTRACTPMID:37271671 | DOI:10.1016/j.medcli.2023.04.030 (Source: Medicina Clinica)
Source: Medicina Clinica - June 4, 2023 Category: General Medicine Authors: Silvia Ramirez-Poza Alfredo Jos é Pardo-Cabello Juan Salvatierra Source Type: research
Methods for assessment of disease activity of polymyalgia rheumatica
Z Rheumatol. 2023 May 15. doi: 10.1007/s00393-023-01358-x. Online ahead of print.ABSTRACTPolymyalgia rheumatica (PMR) is the second most frequent inflammatory rheumatic disease in old age. Remission and recurrence are frequently used as endpoints in clinical trials; however, there is as yet no international consensus on the definition of these states, which limits the comparability of published studies. The PMR activity score (PMR-AS) is the only composite score specifically developed for PMR, which together with remission is used to define low, middle and high disease activity. In recent studies the PMR-AS was often used ...
Source: Zeitschrift fur Rheumatologie - May 15, 2023 Category: Rheumatology Authors: Myriam Reisch Christian Dejaco Source Type: research
Methods for assessment of disease activity of polymyalgia rheumatica
Z Rheumatol. 2023 May 15. doi: 10.1007/s00393-023-01358-x. Online ahead of print.ABSTRACTPolymyalgia rheumatica (PMR) is the second most frequent inflammatory rheumatic disease in old age. Remission and recurrence are frequently used as endpoints in clinical trials; however, there is as yet no international consensus on the definition of these states, which limits the comparability of published studies. The PMR activity score (PMR-AS) is the only composite score specifically developed for PMR, which together with remission is used to define low, middle and high disease activity. In recent studies the PMR-AS was often used ...
Source: Zeitschrift fur Rheumatologie - May 15, 2023 Category: Rheumatology Authors: Myriam Reisch Christian Dejaco Source Type: research
Methods for assessment of disease activity of polymyalgia rheumatica
Z Rheumatol. 2023 May 15. doi: 10.1007/s00393-023-01358-x. Online ahead of print.ABSTRACTPolymyalgia rheumatica (PMR) is the second most frequent inflammatory rheumatic disease in old age. Remission and recurrence are frequently used as endpoints in clinical trials; however, there is as yet no international consensus on the definition of these states, which limits the comparability of published studies. The PMR activity score (PMR-AS) is the only composite score specifically developed for PMR, which together with remission is used to define low, middle and high disease activity. In recent studies the PMR-AS was often used ...
Source: Zeitschrift fur Rheumatologie - May 15, 2023 Category: Rheumatology Authors: Myriam Reisch Christian Dejaco Source Type: research
Methods for assessment of disease activity of polymyalgia rheumatica
Z Rheumatol. 2023 May 15. doi: 10.1007/s00393-023-01358-x. Online ahead of print.ABSTRACTPolymyalgia rheumatica (PMR) is the second most frequent inflammatory rheumatic disease in old age. Remission and recurrence are frequently used as endpoints in clinical trials; however, there is as yet no international consensus on the definition of these states, which limits the comparability of published studies. The PMR activity score (PMR-AS) is the only composite score specifically developed for PMR, which together with remission is used to define low, middle and high disease activity. In recent studies the PMR-AS was often used ...
Source: Zeitschrift fur Rheumatologie - May 15, 2023 Category: Rheumatology Authors: Myriam Reisch Christian Dejaco Source Type: research
Methods for assessment of disease activity of polymyalgia rheumatica
Z Rheumatol. 2023 May 15. doi: 10.1007/s00393-023-01358-x. Online ahead of print.ABSTRACTPolymyalgia rheumatica (PMR) is the second most frequent inflammatory rheumatic disease in old age. Remission and recurrence are frequently used as endpoints in clinical trials; however, there is as yet no international consensus on the definition of these states, which limits the comparability of published studies. The PMR activity score (PMR-AS) is the only composite score specifically developed for PMR, which together with remission is used to define low, middle and high disease activity. In recent studies the PMR-AS was often used ...
Source: Zeitschrift fur Rheumatologie - May 15, 2023 Category: Rheumatology Authors: Myriam Reisch Christian Dejaco Source Type: research
Methods for assessment of disease activity of polymyalgia rheumatica
Z Rheumatol. 2023 May 15. doi: 10.1007/s00393-023-01358-x. Online ahead of print.ABSTRACTPolymyalgia rheumatica (PMR) is the second most frequent inflammatory rheumatic disease in old age. Remission and recurrence are frequently used as endpoints in clinical trials; however, there is as yet no international consensus on the definition of these states, which limits the comparability of published studies. The PMR activity score (PMR-AS) is the only composite score specifically developed for PMR, which together with remission is used to define low, middle and high disease activity. In recent studies the PMR-AS was often used ...
Source: Zeitschrift fur Rheumatologie - May 15, 2023 Category: Rheumatology Authors: Myriam Reisch Christian Dejaco Source Type: research
Acute Outcomes of Cardiac Operations in Patients With Autoimmune Disorders: A National Analysis
DISCUSSION: Autoimmune connective tissue disease patients demonstrated acceptable outcomes following CABG and valve procedures. However, novel prophylactic care pathways should be developed and instituted to address greater thrombotic and blood transfusion risk. Further investigation is needed to identify factors contributing to greater non-elective readmissions among these patients.PMID:37170846 | DOI:10.1177/00031348231175484 (Source: The American Surgeon)
Source: The American Surgeon - May 12, 2023 Category: Surgery Authors: Sara Sakowitz Syed Shahyan Bakhtiyar Shineui Kim Konmal Ali Arjun Verma Nikhil Chervu Yas Sanaiha Peyman Benharash Source Type: research
Acute Outcomes of Cardiac Operations in Patients With Autoimmune Disorders: A National Analysis
DISCUSSION: Autoimmune connective tissue disease patients demonstrated acceptable outcomes following CABG and valve procedures. However, novel prophylactic care pathways should be developed and instituted to address greater thrombotic and blood transfusion risk. Further investigation is needed to identify factors contributing to greater non-elective readmissions among these patients.PMID:37170846 | DOI:10.1177/00031348231175484 (Source: Atherosclerosis)
Source: Atherosclerosis - May 12, 2023 Category: Cardiology Authors: Sara Sakowitz Syed Shahyan Bakhtiyar Shineui Kim Konmal Ali Arjun Verma Nikhil Chervu Yas Sanaiha Peyman Benharash Source Type: research
Acute Outcomes of Cardiac Operations in Patients With Autoimmune Disorders: A National Analysis
DISCUSSION: Autoimmune connective tissue disease patients demonstrated acceptable outcomes following CABG and valve procedures. However, novel prophylactic care pathways should be developed and instituted to address greater thrombotic and blood transfusion risk. Further investigation is needed to identify factors contributing to greater non-elective readmissions among these patients.PMID:37170846 | DOI:10.1177/00031348231175484 (Source: The American Surgeon)
Source: The American Surgeon - May 12, 2023 Category: Surgery Authors: Sara Sakowitz Syed Shahyan Bakhtiyar Shineui Kim Konmal Ali Arjun Verma Nikhil Chervu Yas Sanaiha Peyman Benharash Source Type: research
