Water vapor therapy and polymyalgia rheumatica: Coincidental?
J Family Med Prim Care. 2023 Nov;12(11):2976-2978. doi: 10.4103/jfmpc.jfmpc_676_23. Epub 2023 Nov 21.ABSTRACTPolymyalgia rheumatica (PMR) is an inflammatory rheumatic condition characterized by pain and stiffness around the shoulders and hip girdles, an elevated erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP) and a dramatic response to corticosteroids. It is usually seen in adults aged over 50 years; about 30% also have giant cell arteritis. Its etiology is unknown. A 72-year-old male received water vapor therapy, a novel, minimally invasive therapy for benign prostate hypertrophy (BPH). On postoperative d...
Source: Primary Care - January 8, 2024 Category: Primary Care Authors: Joshua Lee Sandy Lee Tracy U Nguyen-Oghalai Source Type: research
Advances in the treatment of polymyalgia rheumatica and giant cell arteritis
Nature Reviews Rheumatology, Published online: 08 January 2024; doi:10.1038/s41584-023-01069-2Research published in 2023 has demonstrated the efficacy of sarilumab for IL-6 blockade in polymyalgia rheumatica and of secukinumab for IL-17 blockade in giant cell arteritis (GCA). Furthermore, preliminary results with human monocyte-derived suppressive cells suggest the potential of cellular therapeutics for the treatment of GCA. (Source: Nature Reviews Rheumatology)
Source: Nature Reviews Rheumatology - January 8, 2024 Category: Rheumatology Authors: Lindsay Lally Robert Spiera Source Type: research
Review of phase 2/3 trials in Polymyalgia Rheumatica and giant cell arteritis
Expert Opin Emerg Drugs. 2024 Jan 5. doi: 10.1080/14728214.2024.2303093. Online ahead of print.ABSTRACTINTRODUCTION: GCA (Giant cell arteritis) and PMR (Polymyalgia Rheumatica) are two overlapping inflammatory rheumatic conditions that are seen exclusively in older adults, sharing some common features. GCA is a clinical syndrome characterized by inflammation of the medium and large arteries, with both cranial and extracranial symptoms. PMR is a clinical syndrome characterized by stiffness in the neck, shoulder and pelvic girdle muscles. Both are associated with constitutional symptoms.AREAS COVERED: In this review, we asse...
Source: Expert Opinion on Emerging Drugs - January 5, 2024 Category: Drugs & Pharmacology Authors: Pratheeshaa Nageswaran Saad Ahmed Hasan Tahir Source Type: research
Treat-to-target recommendations in giant cell arteritis and polymyalgia rheumatica
Conclusion
These are the first T2T recommendations for GCA and PMR. Treatment targets, as well as strategies to assess, achieve and maintain these targets have been defined. The research agenda highlights the gaps in evidence and the need for future research. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - January 2, 2024 Category: Rheumatology Authors: Dejaco, C., Kerschbaumer, A., Aletaha, D., Bond, M., Hysa, E., Camellino, D., Ehlers, L., Abril, A., Appenzeller, S., Cid, M. C., Dasgupta, B., Duftner, C., Grayson, P. C., Hellmich, B., Hocevar, A., Kermani, T. A., Matteson, E. L., Mollan, S. P., Neill, Tags: Open access, ARD Recommendation Source Type: research
Biological therapy in polymyalgia rheumatica
Volume 23, Issue 12, July - December 2023, Page 1255-1263 . (Source: Expert Opinion on Biological Therapy)
Source: Expert Opinion on Biological Therapy - December 28, 2023 Category: Drugs & Pharmacology Authors: Daniel Wendlinga Rheumatology, CHU (University Teaching Hospital), Besan çon, Franceb EA4266 EPILAB, Université de Franche-Comté, Besançon, France Source Type: research
Decoding polymyalgia rheumatica, the role of nuclear medicine imaging
Rev Esp Med Nucl Imagen Mol (Engl Ed). 2023 Dec 16:S2253-8089(23)00097-6. doi: 10.1016/j.remnie.2023.12.002. Online ahead of print.ABSTRACTPolymyalgia rheumatica (PMR) is an inflammatory joint disease that presents in patients older than 50 years with prolonged morning pain and stiffness in the shoulder and hip joints and neck. The lack of specific clinical findings, laboratory signs, biomarkers and established imaging methods makes it difficult to diagnose patients with this disease. 18 F-FDG PET/CT is a functional imaging technique that is an established tool in oncology and has also proven useful in the field of inflamm...
Source: Molecular Medicine - December 18, 2023 Category: Molecular Biology Authors: Edel Noriega- Álvarez Bego ña Rodríguez-Alfonso Carolina Merino Argum ánez Luis Dom ínguez Gadea Virginia Peir ó-Valgañón Source Type: research
[ < sup > 18 < /sup > F]FDG PET/CT for therapeutic assessment of Abatacept in early-onset polymyalgia rheumatica
CONCLUSION: [18F] FDG PET/CT uptake did not decrease significantly after ABA compared to placebo in anatomical areas usually affected in PMR patients. These results are correlated with the clinical-biological therapeutic assessment.CLINICAL TRIAL REGISTRATION: The study was approved by the appropriate ethics committee (CPP Sud-Est II Ref CPP: 2018-33), and all patients gave their written informed consent before study enrollment. The protocol was registered on Clinicaltrials.gov (NCT03632187).PMID:38095675 | DOI:10.1007/s00259-023-06557-x (Source: Molecular Medicine)
Source: Molecular Medicine - December 14, 2023 Category: Molecular Biology Authors: Bastien Allard Val érie Devauchelle-Pensec Alain Saraux Emmanuel Nowak Alice Tison Sara Boukhlal Dewi Guellec Sandrine Jousse-Joulin Divi Cornec Thierry Marhadour Romain Le Pennec Pierre-Yves Sala ün Sol ène Querellou Source Type: research
[18F]FDG PET/CT for therapeutic assessment of Abatacept in early-onset polymyalgia rheumatica
Conclusion[18F] FDG PET/CT uptake did not decrease significantly after ABA compared to placebo in anatomical areas usually affected in PMR patients. These results are correlated with the clinical-biological therapeutic assessment.Clinical trial registrationThe study was approved by the appropriate ethics committee (CPP Sud-Est II Ref CPP: 2018 –33), and all patients gave their written informed consent before study enrollment.The protocol was registered on Clinicaltrials.gov (NCT03632187). (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - December 14, 2023 Category: Nuclear Medicine Source Type: research
Senescent cells in giant cell arteritis display an inflammatory phenotype participating in tissue injury via IL-6-dependent pathways
CONCLUSIONS: Senescent cells with inflammatory phenotype are present in GCA arteries and are associated with the tissue inflammatory bulk, suggesting a potential implication in disease pathogenesis.PMID:38050005 | DOI:10.1136/ard-2023-224467 (Source: Cancer Control)
Source: Cancer Control - December 5, 2023 Category: Cancer & Oncology Authors: Dimitris Veroutis Ourania D Argyropoulou Andreas V Goules Konstantinos Kambas Dimitris Anastasios Palamidas Konstantinos Evangelou Sophia Havaki Aikaterini Polyzou Dimitrios Valakos Evangelia Xingi Elli Karatza Kyriaki A Boki Alberto Cavazza Christos Kitt Source Type: research
Clinical Year in Review: 2023
SAN DIEGO—At ACR Convergence 2023, Philip Seo, MD, MHS, presented an overview of clinical updates in rheumatology from the past year. (Source: The Rheumatologist)
Source: The Rheumatologist - December 5, 2023 Category: Rheumatology Authors: Samantha C. Shapiro, MD Tags: ACR Convergence Biologics/DMARDs Conditions Drug Updates Meeting Reports ACR Convergence 2023 ankylosing spondylosis Polymyalgia Rheumatica Source Type: research
