Did the first description of patients with polymyalgia rheumatica take place in Scotland or in Denmark?
Reumatismo. 2024 Mar 22;76(1). doi: 10.4081/reumatismo.2024.1673.ABSTRACTThe first description of polymyalgia rheumatica (PMR) is generally attributed to Dr. Bruce. In an 1888 article entitled Senile rheumatic gout, he described five male patients aged from 60 to 74 years whom he had visited at the Strathpeffer spa in Scotland. In 1945, Dr. Holst and Dr. Johansen reported on five female patients examined over several months at the Medical Department of Roskilde County Hospital in Denmark. These patients suffered from hip, upper arms, and neck pain associated with elevated ESR and constitutional manifestations such as low-g...
Source: Reumatismo - March 25, 2024 Category: Rheumatology Authors: C Manzo M Isetta A Castagna Source Type: research
Did the first description of patients with polymyalgia rheumatica take place in Scotland or in Denmark?
Reumatismo. 2024 Mar 22;76(1). doi: 10.4081/reumatismo.2024.1673.ABSTRACTThe first description of polymyalgia rheumatica (PMR) is generally attributed to Dr. Bruce. In an 1888 article entitled Senile rheumatic gout, he described five male patients aged from 60 to 74 years whom he had visited at the Strathpeffer spa in Scotland. In 1945, Dr. Holst and Dr. Johansen reported on five female patients examined over several months at the Medical Department of Roskilde County Hospital in Denmark. These patients suffered from hip, upper arms, and neck pain associated with elevated ESR and constitutional manifestations such as low-g...
Source: Reumatismo - March 25, 2024 Category: Rheumatology Authors: C Manzo M Isetta A Castagna Source Type: research
Did the first description of patients with polymyalgia rheumatica take place in Scotland or in Denmark?
Reumatismo. 2024 Mar 22;76(1). doi: 10.4081/reumatismo.2024.1673.ABSTRACTThe first description of polymyalgia rheumatica (PMR) is generally attributed to Dr. Bruce. In an 1888 article entitled Senile rheumatic gout, he described five male patients aged from 60 to 74 years whom he had visited at the Strathpeffer spa in Scotland. In 1945, Dr. Holst and Dr. Johansen reported on five female patients examined over several months at the Medical Department of Roskilde County Hospital in Denmark. These patients suffered from hip, upper arms, and neck pain associated with elevated ESR and constitutional manifestations such as low-g...
Source: Reumatismo - March 25, 2024 Category: Rheumatology Authors: C Manzo M Isetta A Castagna Source Type: research
Inflammatory Arthritis due to Immune Checkpoint Inhibitors
The introduction of immune checkpoint inhibitors (ICIs) has changed the landscape of the treatment of cancer. Several immune-related adverse events (irAEs) have now been described such as ICI-inflammatory arthritis (IA), sicca syndrome, polymyalgia rheumatica, myositis, and vasculitis as a consequence of immune activation. The onset of the ICI-IA can vary from after the first infusion of ICIs to a delayed presentation a year or more after ICI initiation. Ultimately, baseline patient and tumor characteristics, the types of immunotherapies used, pre-existing autoimmune diseases, and/or other irAEs, as well as patient prefere...
Source: Rheumatic Disease Clinics of North America - March 7, 2024 Category: Rheumatology Authors: Namrata Singh, Anupama Shahane, Jeffrey A. Sparks, Samuel Bitoun, Laura C. Cappelli Source Type: research
Immune Checkpoint Inhibitor-induced Inflammatory Arthritis
The introduction of immune checkpoint inhibitors (ICIs) has changed the landscape of the treatment of cancer. Several immune-related adverse events (irAEs) have now been described such as ICI-inflammatory arthritis (IA), sicca syndrome, polymyalgia rheumatica, myositis, and vasculitis as a consequence of immune activation. The onset of the ICI-IA can vary from after the first infusion of ICIs to a delayed presentation a year or more after ICI initiation. Ultimately, baseline patient and tumor characteristics, the types of immunotherapies used, pre-existing autoimmune diseases, and/or other irAEs, as well as patient prefere...
Source: Rheumatic Disease Clinics of North America - March 7, 2024 Category: Rheumatology Authors: Namrata Singh, Anupama Shahane, Jeffrey A. Sparks, Samuel Bitoun, Laura C. Cappelli Source Type: research
Sensors, Vol. 24, Pages 1500: A Movement Classification of Polymyalgia Rheumatica Patients Using Myoelectric Sensors
This study presents a clinical gait analysis of patients with polymyalgia rheumatica to determine impaired gait patterns using machine learning models. A clinical gait assessment was conducted at KATH hospital between August and September 2022, and the 25 recruited participants comprised 18 patients and 7 control subjects. The demographics of the participants follow: age 56 years ± 7, height 175 cm ± 8, and weight 82 kg ± 10. Electromyography data were collected from four strained hip muscles of patients, which were the rectus femoris, vastus lateralis, biceps femoris, and semit...
Source: Sensors - February 26, 2024 Category: Biotechnology Authors: Anthony Bawa Konstantinos Banitsas Maysam Abbod Tags: Article Source Type: research
Rheumatic adverse events of immune checkpoint inhibitors in cancer immunotherapy
Expert Rev Clin Immunol. 2024 Feb 24. doi: 10.1080/1744666X.2024.2323966. Online ahead of print.ABSTRACTINTRODUCTION: The advent of immune checkpoint inhibitors (ICIs) in cancer treatment has marked a transformative era, albeit tempered by immune-related adverse events (irAEs), including those impacting the musculoskeletal system. The lack of precise epidemiologic data on rheumatic irAEs is attributed to factors such as potential underrecognition, underreporting in clinical trials, and the tendency to overlook manifestations without immediate life-threatening implications, further complicating the determination of accurate...
Source: Expert Review of Clinical Immunology - February 24, 2024 Category: Allergy & Immunology Authors: Noha Abdel-Wahab Maria E Suarez-Almazor Source Type: research
Long-Term Outcomes After Transcatheter Aortic Valve Implantation in Patients With Chronic Inflammatory Disease
CONCLUSIONS: This real-world analysis found that patients with CID undergoing TAVI were associated with a higher risk of postinterventional infectious complications and rehospitalization due to infection. However, valve durability and survival seem not to differ between patients with TAVI with versus without CID.PMID:38390801 | DOI:10.1161/JAHA.123.032250 (Source: Atherosclerosis)
Source: Atherosclerosis - February 23, 2024 Category: Cardiology Authors: Stephanie Brunner Olga Covtun Federico Moccetti Lucca Loretz Matthias Bossard Adrian Attinger-Toller Florim Cuculi Mathias Wolfrum Reto Kurmann Stefan Toggweiler Source Type: research
De Novo Connective Tissue Disorders as Immune-Related Adverse Events
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment through blocking immunoregulatory pathways, resulting in augmented antitumor responses. However, ICIs can cause inflammatory autoimmune toxicities, known as immune-related adverse events (irAEs). Common rheumatic irAEs include inflammatory arthritis, polymyalgia rheumatica-like symptoms, and myositis. Fewer cases of de novo connective tissue disease as irAEs have been described and have mainly presented with cutaneous manifestations of systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). Treatments include glucocorticoids and steroid-spari...
Source: Rheumatic Disease Clinics of North America - February 23, 2024 Category: Rheumatology Authors: Lindsay Kristin Cho, Shahin Jamal Source Type: research
The Utility of Laboratory Investigations for the Assessment and Management of Rheumatic Immune-Related Adverse Events
This article summarizes the latest evidence regarding the utility of laboratory investigations in Rh-irAEs. (Source: Rheumatic Disease Clinics of North America)
Source: Rheumatic Disease Clinics of North America - February 22, 2024 Category: Rheumatology Authors: Alexandra Ladouceur, Aiarpi Ezdoglian, Jeffrey A. Sparks, Marie Hudson, Shahin Jamal, Alison Clifford, Janet Roberts, Carrie Ye Source Type: research
The Utility of Laboratory Investigations for the Assessment and Management of Rheumatic Immune Related Adverse Events
This article summarizes the latest evidence regarding the utility of laboratory investigations in Rh-irAEs. (Source: Rheumatic Disease Clinics of North America)
Source: Rheumatic Disease Clinics of North America - February 22, 2024 Category: Rheumatology Authors: Alexandra Ladouceur, Aiarpi Ezdoglian, Jeffrey A. Sparks, Marie Hudson, Shahin Jamal, Alison Clifford, Janet Roberts, Carrie Ye Source Type: research
Polymyalgia rheumatica: crafting the future of a simple (but not easy!) clinical syndrome
Since its first description in 1888,1 the concept of polymyalgia rheumatica (PMR) has significantly evolved. Initially perceived as a mild form of rheumatoid arthritis,2 its recognition as a distinct clinical entity came only in 1957 when Barber introduced the term.3 Is PMR a separate entity? Although characteristic for PMR, polymyalgic symptoms, including pain and stiffness in the shoulder and pelvic girdle, are non-specific clinical manifestation. They may serve as the initial presentation for a range of elderly-onset rheumatic (eg, rheumatoid arthritis, spondylarthritis, crystal-induced arthritis, vasculitis and connect...
Source: Annals of the Rheumatic Diseases - February 15, 2024 Category: Rheumatology Authors: Bond, M., Dejaco, C. Tags: ARD Editorials Source Type: research
Subclinical giant cell arteritis increases the risk of relapse in polymyalgia rheumatica
Conclusions
Patients with PMR and subclinical GCA had a significantly higher number of relapses during a 2-year follow-up than patients with isolated PMR. Lower starting doses and rapid glucocorticoid tapering in the first 3 months emerged as risk factors for relapse. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - February 15, 2024 Category: Rheumatology Authors: De Miguel, E., Karalilova, R., Macchioni, P., Ponte, C., Conticini, E., Cowley, S., Tomelleri, A., Monti, S., Monjo, I., Batalov, Z., Klinowski, G., Falsetti, P., Kane, D. J., Campochiaro, C., Hocevar, A. Tags: Editor's choice, ARD Lay summaries, ARD, Vasculitis Source Type: research
Senescent cells in giant cell arteritis display an inflammatory phenotype participating in tissue injury via IL-6-dependent pathways
Conclusions
Senescent cells with inflammatory phenotype are present in GCA arteries and are associated with the tissue inflammatory bulk, suggesting a potential implication in disease pathogenesis. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - February 15, 2024 Category: Rheumatology Authors: Veroutis, D., Argyropoulou, O. D., Goules, A. V., Kambas, K., Palamidas, D. A., Evangelou, K., Havaki, S., Polyzou, A., Valakos, D., Xingi, E., Karatza, E., Boki, K. A., Cavazza, A., Kittas, C., Thanos, D., Ricordi, C., Marvisi, C., Muratore, F., Galli, E Tags: ARD, Vasculitis Source Type: research
