Senescent cells in giant cell arteritis display an inflammatory phenotype participating in tissue injury via IL-6-dependent pathways

Conclusions
Senescent cells with inflammatory phenotype are present in GCA arteries and are associated with the tissue inflammatory bulk, suggesting a potential implication in disease pathogenesis.

Source: Annals of the Rheumatic Diseases - February 15, 2024 Category: Rheumatology Authors: Veroutis, D., Argyropoulou, O. D., Goules, A. V., Kambas, K., Palamidas, D. A., Evangelou, K., Havaki, S., Polyzou, A., Valakos, D., Xingi, E., Karatza, E., Boki, K. A., Cavazza, A., Kittas, C., Thanos, D., Ricordi, C., Marvisi, C., Muratore, F., Galli, E Tags: ARD, Vasculitis Source Type: research