Virtual tissue technology reveals new drug target in polycystic kidney disease
Using virtual tissue technology, researchers have identified a potential new drug target in the fight against polycystic kidney disease, an illness with no effective FDA-approved treatment that affects 200,000 people per year in the United States. The study reveals that errors in how cells stick together give rise to two forms of kidney cysts. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 27, 2016 Category: Science Source Type: news
IU study: Virtual tissue technology reveals new drug target in polycystic kidney disease
(Indiana University) Using virtual tissue technology, researchers at Indiana University have identified a potential new drug target in the fight against polycystic kidney disease, an illness with no effective FDA-approved treatment that affects 200,000 people per year in the United States. The study, which reveals that errors in how cells stick together give rise to two forms of kidney cysts, appears in the journal Molecular Biology of the Cell. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 27, 2016 Category: Global & Universal Source Type: news
Discovery's Edge: Tackling Polycystic Kidney Disease
The term “teamwork” is widely used when talking about scientific research, but when it comes to the Mayo Clinic version, it means cross-disciplinary teams with complementary members. Some teams form to pursue special problems for limited periods, while others form alliances that last for years, with prolific results. The latter is the case with a [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - May 2, 2016 Category: Databases & Libraries Source Type: news
Signed, sealed, undelivered: Mechanisms underlying polycystic kidney disease
(Medical University of South Carolina) Zebrafish help investigators at the Medical University of South Carolina shed light on the mechanisms underlying cilia dysfunction in polycystic kidney disease and other ciliopathies (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 17, 2016 Category: Global & Universal Source Type: news
Shaping lumens by force
(National University of Singapore) Scientists from Singapore and France have revealed the underlying mechanism for the formation and growth of a fundamental type of tissue -- epithelial tubes. Defects in the architecture of epithelial tubes lead to diseases such as cholestasis, atherosclerosis and polycystic kidney disease. The study suggests that the shape and size of some types of epithelial tubes are governed by the mechanical forces that arise from the interaction of cells with the supportive extracellular matrix that surrounds them (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 23, 2016 Category: Biology Source Type: news
A diet dividend: Reducing food intake in mice diminishes the growth of their polycystic kidneys
What if polycystic kidney disease (PKD) could be combatted with a strategy as simple as dieting? Such a finding would surely be welcome news to the 12 million people worldwide with the genetic disease. Now researchers say that reducing food intake in mice diminishes the growth of their polycystic kidneys. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 29, 2016 Category: Science Source Type: news
A diet dividend
(University of California - Santa Barbara) Members of the Thomas Weimbs Lab demonstrate that reducing food intake in mice diminishes the growth of their polycystic kidneys (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 28, 2016 Category: Biology Source Type: news
SMC issues positive advice for first ever treatment for ADPKD
JINARC® (tolvaptan) is accepted for use in Scotland for the treatment of autosomal dominant polycystic kidney disease (ADPKD) (Source: Pharmacy Europe)
Source: Pharmacy Europe - January 11, 2016 Category: Drugs & Pharmacology Authors: Annabel De Coster Tags: *** Editor's Pick Practical therapeutics Legislation & regulation Nephrology Patient care adpkd jinarc Latest News smc tolvaptan Source Type: news
When Ayden met Aubrey: Kidney transplant creates a powerful bond between toddlers
Photos by Katherine C. Cohen
Theirs is a friendship nurtured by coloring books, built on board games and mad dashes down corridors — but also silently strengthened by nature of a mutual struggle.
Three-year-old Ayden Mosher of New York and 2-year-old Aubrey Ferrell of Tennessee met this fall in a lab at Boston Children’s Hospital.
It was friendship at first sight.
“They were just drawn to each other, and they have been inseparable ever since,” says Aubrey’s mom Janna Ferrell.
Aubrey’s story
Aubrey was diagnosed with congenital nephrotic syndrome at 4 months old. By 18 months, both kidneys were removed and she ...
Source: Thrive, Children's Hospital Boston - January 7, 2016 Category: Pediatrics Authors: Emily Williams Tags: Diseases & Conditions Our Patients’ Stories kidney kidney transplant Pediatric Transplant Center (PTC) Source Type: news
In their own words: Six families share the impact of organ donation
This is the season for gratitude and giving, a time to celebrate friends, family, the end of one year and the beginning of a new one. But for a select group, it also is a time to celebrate one of the greatest gifts — the gift of life through organ donation.
Mickey was born with a unique combination of congenital heart defects and spent most of his early life at Boston Children’s. He was one day shy of 6 months old when he received his heart transplant, and his family is grateful for every day since. “Mickey has shown us what courage and resiliency look like, and his transplant has taught us the true meaning of givin...
Source: Thrive, Children's Hospital Boston - January 5, 2016 Category: Pediatrics Authors: Michelle Higginson Tags: Diseases & Conditions Our Patients’ Stories double lung transplant heart transplant hepatoblastoma kidney transplant Liver transplant multivisceral transplant Pediatric Transplant Center (PTC) Source Type: news
Linking Cancer and Polycystic Kidney Disease
Polycystic kidney disease (PKD) is one of the most common inherited diseases—a parent with PKD has a 50 percent chance of passing the disease on to their child.12/15/2015 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - December 15, 2015 Category: Urology & Nephrology Source Type: news
At ASCB 2015: CRISPR/Cas9 + HPSC = human PKD lab model
(American Society for Cell Biology) By linking up CRISPR/Cas9 with another cutting edge technology, human pluripotent stem cells (hPSCs), Benjamin Freedman, now at the University of Washington, and his colleagues in Joseph Bonventre's lab at Harvard Medical School, have used CRISPR/Cas9 to guide hPSCs into becoming a human cell-based lab model system for polycystic kidney disease (PKD). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 11, 2015 Category: Global & Universal Source Type: news
How A Tinder Date Led To A Lifesaving Kidney Donation
ABC Breaking News | Latest News Videos While scrolling through Tinder over the summer, this guy swiped right -- very, very right. Rich O’Dea, a man from Tampa, Florida, and his match from the dating app, Jennifer Thomas, unexpectedly helped save a life, when the pair found out Thomas was a donor match for O’Dea’s best friend’s wife who needed a kidney transplant, ABC News reported. While out on their first date after being paired on the app, O’Dea shared with Thomas that his friend's wife, Erika Bragan, had been on the kidney donor list for nearly three years, and just days after the date, T...
Source: Healthy Living - The Huffington Post - November 13, 2015 Category: Consumer Health News Source Type: news
Study: Food Restriction Prevents and Reverses Polycystic Kidney Disease in Mice
https://www.youtube.com/watch?v=PR6klhuVeyw ROCHESTER, Minn. — Researchers at Mayo Clinic have found that a mild to moderate reduction in calories effectively prevents and reverses polycystic kidney disease (PKD) in mice. The results appear online today in the Journal of the American Society of Nephrology. “Currently, there is no FDA-approved treatment, and the only thing that can be done [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - November 4, 2015 Category: Databases & Libraries Source Type: news
NICE approves new drug for chronic kidney disease
For the first time, a treatment will be available on the NHS in England and Wales that can delay the development of autosomal dominant polycystic kidney disease (ADPKD). (Source: Nursing Times Breaking News)
Source: Nursing Times Breaking News - October 28, 2015 Category: Nursing Source Type: news
