Using nanoparticles to treat polycystic kidney disease [PODCAST]
“Excited by the promise our research holds for PKD patients, we have been packaging a variety of PKD drugs into our nanoparticles, testing their ability to act as a courier service for renal drug delivery. We ’ve been testing this process on drugs that show therapeutic benefits in animal models but are shadowed by off-target sideRead more …Using nanoparticles to treat polycystic kidney disease [PODCAST] originally appeared inKevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 20, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/the-podcast-by-kevinmd" rel="tag" > The Podcast by KevinMD < /a > < /span > Tags: Podcast Nephrology Source Type: blogs
Precision Medicine and the Reinvention of Human Disease (Book Index)
In January, 2018, Academic Press published my bookPrecision Medicine and the Reinvention of Human Disease. This book has an excellent " look inside " at itsGoogle book site, which includes the Table of Contents. In addition, I thought it might be helpful to see the topics listed in the Book ' s index. Note that page numbers followed by f indicate figures, t indicate tables, and ge indicate glossary terms.AAbandonware, 270, 310geAb initio, 34, 48ge, 108geABL (abelson leukemia) gene, 28, 58ge, 95 –97Absidia corymbifera, 218Acanthameoba, 213Acanthosis nigricans, 144geAchondroplasia, 74, 143ge, 354geAcne, 54ge, 198, 220geAcq...
Source: Specified Life - January 23, 2018 Category: Information Technology Tags: index jules berman jules j berman precision medicine Source Type: blogs
Organoids of Human Kidneys Help to Study Renal Diseases
Polycystic kidney disease is a genetic condition in which the tubules of the kidneys grow to become deformed, leading to cysts to grow on the organ. Studying this disease has been a challenge because of the difficulty of modeling it in the laboratory. Now researchers led by a team at the University of Washington have been able to grow kidney organoids from human stem cells that form cysts much like those in polycystic kidney disease (PKD). The investigators then used these organoids to study how different stimuli affect cyst formation and development. It’s been known that polycystin protein plays a key role in the d...
Source: Medgadget - October 10, 2017 Category: Medical Devices Authors: Editors Tags: Genetics Medicine Pathology Urology Source Type: blogs
Autosomal dominant polycystic kidney disease
(Source: Notes from Dr. RW)
Source: Notes from Dr. RW - December 19, 2016 Category: Internal Medicine Tags: nephrology Source Type: blogs
Is It Selfish to Mourn for Ourselves When a Loved One Dies?
There is no such thing as the right way to feel grief or loss.
My cat Rumi s a 16 year old purebred white Persian that I rescued from an abusive home nine years ago. Over the years I watched him grow into his strange, curious, social self, complete with a silent meow meant, I think, to get my attention. It always works.
On The Bright Side: 7 Surprising Benefits Of Sadness
Because he’s a purebred cat, he’s got a mother lode of health issues and always has. His stomach is sensitive, so he needs prescription food. He’s going blind, he has had all but three teeth removed. He can’t always breathe well (smushed face) an...
Source: World of Psychology - September 16, 2016 Category: Psychiatry & Psychology Authors: Psych Central Staff Tags: Grief and Loss Publishers YourTango death mourn Rebecca Jane Stokes relief Sadness selfish Source Type: blogs
Sometimes the most logical thing to do is to stop being logical
An issue came up today that probably needs some discussion. A parent of a young child was worried about protecting the child's remaining kidney with a kidney guard. The doctor was not interested in supporting the request for the kidney guard, mostly based on evidence that there is no reason to believe that they are effective and also based on the fact that kidney injuries are quite rare. (Grinsell, et al, 2012).One particular recommendation regarding kidney protection by Psooy, 2009 reads as follows:Parents should try to keep things in perspective: If they are not going to restrict a child from an activi...
Source: ABC Therapeutics Occupational Therapy Weblog - June 9, 2016 Category: Occupational Health Tags: parenting Source Type: blogs
Conservative Treatment Helps You Avoid Polycystic Kidney Disease (PKD) Relapse
For patients with Polycystic Kidney Disease (hereinafter called PKD), they have
to face a annoying reality. That is, their cysts relapse frequently after taking cyst decortications or tapping. As we know, cyst decortication and tapping are the usual practice to remove cysts in western medicine. However, these treatments can only eliminate big ... (Source: All Kidney News)
Source: All Kidney News - January 9, 2016 Category: Urology & Nephrology Authors: jadhavbca Tags: Kidney News Source Type: blogs
My Journey
By: Madhu Thibaudeau
When I was 13 years old, my mom got very sick and was in the hospital. After many days in the hospital, we found out she had a genetic disease that destroys kidney tissue function over time. The disease is called Polycystic Kidney Disease (PKD). Our family took care of her as she underwent many tests, and a kidney transplant in 1984. Since then, my brother and I have watched our mom endure many hardships, including a second transplant (in 1992) that has lasted over 20 years (first one only lasted 8 years). My brother donated the second kidney to her, and it was at that point that I knew I would one d...
Source: Life in a Medical Center - January 7, 2016 Category: Universities & Medical Training Authors: Chris Lindsley Tags: Patient Stories kidney transplant patient success story PKD Source Type: blogs
Large Kidneys What Do They Mean?
Usually kidney disease is associated with small kidneys. The process that shrinks the kidney is scarring otherwise known as fibrosis which is the end point of any damage to the kidney. However from time to time a disease process will come along that causes enlargement of the kidney as it proceeds to damage the kidney. Some of the diseases that may cause this are as follows.
Infiltrative diseases such as sarcoidosis and amyloidosis both cause this. Amyloidosis is a disease of the blood which bears certain similarities with multiple myeloma and may coexist with this condition. There is deposition of large quantities of abno...
Source: All Kidney News - September 29, 2015 Category: Urology & Nephrology Authors: jadhavbca Tags: Kidney News HIV Source Type: blogs
Other problems in Polycystic Kidney Disease
Autosomal Dominant Polycystic Kidney Disease has several manifestations which are not confined to the kidney. These manifestations include the following.
It is very common for patients to have cysts on other organs of the body. The most common organ to find cysts other than in the kidney is the liver. Cysts in the liver may produce pain and patients may have bleeding into these cysts however the liver function is not usually affected. However in patients who have the recessive type of polycystic kidney disease usually seen in children there may be fibrosis of the liver. Cysts may also be found in the pancreas intestine and...
Source: All Kidney News - September 29, 2015 Category: Urology & Nephrology Authors: jadhavbca Tags: Kidney News Few Guidelines MRI Source Type: blogs
Sirolimus for Polycystic Kidney Disease
New treatment options for polycystic kidney disease do not come along very often. The nature of the disease is such that treatment is inherently difficult as the pathophysiology is incompletely understood.
Despite that various methods are currently being investigated. One such is the drug sirolimus, which has been mentioned before. More recently however a pilot study performed in adult polycystic kidney disease patients has added further hope that sirolimus may one day be used routinely in this disease.
The effect of the drug sirolimus on development and growth of cysts was investigated over 6 consecutive months in 8 pa...
Source: All Kidney News - September 29, 2015 Category: Urology & Nephrology Authors: jadhavbca Tags: Kidney News FSGS TNF Source Type: blogs
An Otsuka Kidney Drug And A Researcher's Ironic Findings
File this under ‘Life's little ironies." Last week, an FDA advisory panel voted against recommending a drug called Tolvaptan for treating ADPKD, a rare disease in which numerous cysts grow in kidneys. The reasons for rejecting the drug, which is already approved to combat low blood sodium levels, were unanswered questions about efficacy and, in particular, safety concerns over liver toxicity.
There was, however, an interesting subtext to the meeting. The lead investigator for a key clinical trial published last year, Vincent Torres, who also made a (see here and here) on behalf of Otsuka Pharmaceuticals, the company that...
Source: Pharmalot - August 12, 2013 Category: Pharma Commentators Authors: esilverman Source Type: blogs
FDA Warns That Tolvaptan Can Lead To Serious Liver Injury
The FDA has issued a drug safety communication concerning tolvaptan (Samsca, Otsuka), a selective vasopression V2-receptor antagonist used in heart failure patients to treat clinically significant hypervolemic and euvolemic hyponatremia. The FDA said tolvaptan “should not be used for longer than 30 days and should not be used in patients with underlying liver disease because it can cause liver injury, potentially leading to liver transplant or death. “ The liver injury risk was discovered in clinical trials testing tolvaptan in patients with autosomal dominant polycystic kidney disease (ADPKD). The drug label h...
Source: CardioBrief - May 1, 2013 Category: Cardiology Authors: Larry Husten Tags: Heart Failure People, Places & Events Policy & Ethics food and drug administration liver Source Type: blogs
FDA: Partnerships to Accelerate Medical Product Development
Discussion of Key Initiatives/Activities and Outcomes
Joint liaisons to key initiatives
PSTC and SAFE-T Consortium
Remove Redundancy--Proactive sharing of strategy and plans
Build Collaborative IT Platforms
Garner then discussed how FDA and stakeholders should measure success with these new collaborations. She said that FDA will measure success based on:
The number of approvals of new medical therapies
Development of new guidance
Integration of novel biomarkers into regulatory review processes
Proactive sharing of pre-competitive data
Development of data warehouses based on standardized data in ...
Source: Policy and Medicine - April 10, 2013 Category: Health Medicine and Bioethics Commentators Authors: Thomas Sullivan Source Type: blogs
Quiz- fetal kidneys in 34 weeks pregnancy
What do you opine on this 34 week old fetus? Specifically, what is your diagnosis on observing the ultrasound images of the fetal kidneys?The answer: this fetus shows bilateral enlarged echogenic kidneys which form a major part of the volume of the abdomen. Minute cystic areas are also seen within the kidneys of this fetus if one scrutinises the images carefully. These findings are consistent with a diagnosis of autosomal recessive polycystic kidneys of the fetus.For more on this visit: http://www.ultrasound-images.com/fetal-urogenital.htm#Fetal_polycystic_kidneys_%28autosomal_recessive_polycystic_kidney_disease-_ARPKD%29 ...
Source: cochinblogs - January 25, 2013 Category: Radiology Source Type: blogs
