In their own words: Six families share the impact of organ donation
This is the season for gratitude and giving, a time to celebrate friends, family, the end of one year and the beginning of a new one. But for a select group, it also is a time to celebrate one of the greatest gifts — the gift of life through organ donation. Mickey was born with a unique combination of congenital heart defects and spent most of his early life at Boston Children’s. He was one day shy of 6 months old when he received his heart transplant, and his family is grateful for every day since. “Mickey has shown us what courage and resiliency look like, and his transplant has taught us the true meaning of giving. He has touched so many lives and because of him, we have met so many amazing children and families, whose hearts and hopes far surpass their diagnoses.” Laura received her liver transplant shortly after being diagnosed with biliary atresia. Though her family doesn’t know who her donor was, they do know it was a child around that same age and are so grateful that parents could open their hearts to save a stranger’s child in a time of grieving. She is fortunate to have encountered minimal complications post transplant, and her sister has been inspired to study medicine and one day become a doctor. “We always talked about being organ donors before Laura’s transplant, but now we’re advocates. You look at things differently when your own child is sick, and you learn to appreciate every little moment, becau...
We report a new case of BCC-MD occurring in a renal-transplant recipient and review the relevant literature. A 75-year-old white man who had received a renal allograft 7 years ago developed a tumor on the left temple clinically suggestive of basal-cell carcinoma. Microscopically, the tumor associated features typical of basal-cell carcinoma (basaloid lobules with peripheral palisading and clefting) and pilomatricoma (presence of shadow/ghost cells). The 2 tumor components expressed variably beta-catenin, HEA/Ber-EP4, CD10, PHLDA-1, MIB-1/Ki67, calretinin, and bcl-2. BCC-MD has no distinctive clinical features. It affects p...
Abstract: Lyme disease is the most commonly reported vector-borne disease in the United States. After initial antibiotic treatment for patients with Lyme disease, ongoing symptoms that may persist have considerable long-term impact on healthcare costs. Posttreatment Lyme disease syndrome is characterized by a host of chronic symptoms that can leave patients physically and mentally disabled.
ConclusionOur series confirmed that CCPRCC has an indolent clinical behavior. When the diagnosis is made in a high-grade renal tumor, it should be carefully re-confirmed using cytogenetic or genomic methods.
ConclusionsThe Caregiver Support Team was positively received. The organization received budgetary support from our hospital to disseminate the program system-wide. Additional interventions are needed to overcome the root cause of workplace stressors. A formal link between Risk Management is being developed to identify cases which warrant emotional (vs. clinical only or both) debriefing/group processing.Graphical Abstract
This study investigates process quality and structural features of classrooms serving children at-risk of poverty and social exclusion and children with disabilities in Portugal. We examine (a) whether the three-domain structure of a widely used standard observational tool, the Classroom Assessment Scoring System (CLASS; Pianta, LaParo, &Hamre, 2008) describes adequately teacher–child interactions in those classrooms and (b) associations between CLASS domains and structural features, including teacher education and group size. The study was conducted in 178 preschool classrooms. Data included classroom observatio...
In conclusion, silvestrol could be identified as pangenotypic HEV replication inhibitor in vitro with additive effect to RBV and further demonstrated high potency in vivo. The compound therefore may be considered in future treatment strategies of chronic hepatitis E in immunocompromised patients.
In this study we explore the diversity of the glycolytic and fermentative pathways within the Saccharomyces genus using S. cerevisiae, S. kudriavzevii and S. eubayanus as paradigms. Sequencing data revealed a highly conserved genetic makeup of the glycolytic and fermentative pathways in the three species in terms of number of paralogous genes. Although promoter regions were less conserved between the three species as compared to coding sequences, binding sites for Rap1, Gcr1 and Abf1, main transcriptional regulators of glycolytic and fermentative genes, were highly conserved. Transcriptome profiling of these three strains ...
CONCLUSIONS: One-third of the patients are heavily affected by neurological, psychological and vegetative symptoms after surviving TBI. Some demographic factors affected this integrity. PMID: 30024773 [PubMed - as supplied by publisher]
Conclusions: These results provide the first evidence for an intrinsic propensity of the vault complex to undergo endocytic uptake cultured eukaryotic cells.General significance.The newly developed purification procedure will greatly facilitate any investigation based on the use of the vault particle as a natural nanocarrier. Its clathrin-mediated endocytic uptake observed in normal and in some tumor cell lines sheds light on its physiological role.Graphical abstract
Publication date: August 2018Source: American Journal of Kidney Diseases, Volume 72, Issue 2Author(s): Vassilios Liakopoulos, Ioannis Stefanidis, Peter R. Mertens
More News: Atresia | Blogging | Cardiology | Child Development | Children | Dialysis | Disability | Heart | Heart Transplant | Hepatoblastoma | Hospitals | Kidney Transplant | Kidney Transplantation | Learning | Liver | Liver Transplant | Lung Transplant | Nephrotic Syndrome | Pediatrics | Polycystic Kidney Disease | Study | Transplant Surgery | Transplants | Universities & Medical Training | Urology & Nephrology