Mutations in the F protein of the live-attenuated respiratory syncytial virus vaccine candidate ΔNS2/Δ1313/I1314L increase the stability of infectivity and content of prefusion F protein
by Judith Alamares-Sapuay, Michael Kishko, Charles Lai, Mark Parrington, Simon Delagrave, Richard Herbert, Ashley Castens, Joanna Swerczek, Cindy Luongo, Lijuan Yang, Peter L. Collins, Ursula J. Buchholz, Linong Zhang
Respiratory syncytial virus (RSV) is the leading viral cause of bronchiolitis and pneumonia in infants and toddlers, but there currently is no licensed pediatric vaccine. A leading vaccine candidate that has been evaluated for intranasal immunization in a recently completed phase 1/2 clinical tria l is an attenuated version of RSV strain A2 called RSV/ΔNS2/Δ1313/I1314L (hereafter called ΔNS2). ΔNS2 is at...
Source: PLoS One - April 9, 2024 Category: Biomedical Science Authors: Judith Alamares-Sapuay Source Type: research
Human immunoglobulin in combination with antimicrobial agents enhances the treatment efficacy and reduces inflammatory response in children with severe pneumonia
CONCLUSION: The combination of human immunoglobulin and antibiotics for the treatment of pediatric severe pneumonia is beneficial, because it improves efficacy, boosts the immune system, and reduces inflammation.PMID:38586114 | PMC:PMC10994785 | DOI:10.62347/KQUW5330 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Wenli Zhang Yue Jin Source Type: research
Comparative analysis of immunological biomarkers in COVID-19 and bacterial pneumonia
This study highlights the potential significant impact of COVID-19 on the immunological biomarkers investigated.PMID:38585537 | PMC:PMC10994609 | DOI:10.25122/jml-2023-0273 (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Mudathir Abdelshafea Abdelkareem Abakar Daralnaeem Hassan Ali Hamad Eman Faisal Hashim Mohamed Fad-Alla Omer Mahmoud Taha Mohamed Faki Abdellla Esmail Mohammed Idris Rouwida Omer Zeinab Osman Entesar Ahmed Gaffar Elhassan Mohamed Ahmed Abrahim-Holie Moham Source Type: research
Human immunoglobulin in combination with antimicrobial agents enhances the treatment efficacy and reduces inflammatory response in children with severe pneumonia
CONCLUSION: The combination of human immunoglobulin and antibiotics for the treatment of pediatric severe pneumonia is beneficial, because it improves efficacy, boosts the immune system, and reduces inflammation.PMID:38586114 | PMC:PMC10994785 | DOI:10.62347/KQUW5330 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Wenli Zhang Yue Jin Source Type: research
Comparative analysis of immunological biomarkers in COVID-19 and bacterial pneumonia
This study highlights the potential significant impact of COVID-19 on the immunological biomarkers investigated.PMID:38585537 | PMC:PMC10994609 | DOI:10.25122/jml-2023-0273 (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Mudathir Abdelshafea Abdelkareem Abakar Daralnaeem Hassan Ali Hamad Eman Faisal Hashim Mohamed Fad-Alla Omer Mahmoud Taha Mohamed Faki Abdellla Esmail Mohammed Idris Rouwida Omer Zeinab Osman Entesar Ahmed Gaffar Elhassan Mohamed Ahmed Abrahim-Holie Moham Source Type: research
Human immunoglobulin in combination with antimicrobial agents enhances the treatment efficacy and reduces inflammatory response in children with severe pneumonia
CONCLUSION: The combination of human immunoglobulin and antibiotics for the treatment of pediatric severe pneumonia is beneficial, because it improves efficacy, boosts the immune system, and reduces inflammation.PMID:38586114 | PMC:PMC10994785 | DOI:10.62347/KQUW5330 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Wenli Zhang Yue Jin Source Type: research
Comparative analysis of immunological biomarkers in COVID-19 and bacterial pneumonia
This study highlights the potential significant impact of COVID-19 on the immunological biomarkers investigated.PMID:38585537 | PMC:PMC10994609 | DOI:10.25122/jml-2023-0273 (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Mudathir Abdelshafea Abdelkareem Abakar Daralnaeem Hassan Ali Hamad Eman Faisal Hashim Mohamed Fad-Alla Omer Mahmoud Taha Mohamed Faki Abdellla Esmail Mohammed Idris Rouwida Omer Zeinab Osman Entesar Ahmed Gaffar Elhassan Mohamed Ahmed Abrahim-Holie Moham Source Type: research
Human immunoglobulin in combination with antimicrobial agents enhances the treatment efficacy and reduces inflammatory response in children with severe pneumonia
CONCLUSION: The combination of human immunoglobulin and antibiotics for the treatment of pediatric severe pneumonia is beneficial, because it improves efficacy, boosts the immune system, and reduces inflammation.PMID:38586114 | PMC:PMC10994785 | DOI:10.62347/KQUW5330 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Wenli Zhang Yue Jin Source Type: research
Veliparib ‑Induced Toxicity in Cancer Patients: A Systematic Review and Meta‑Analysis
In this study, we investigate the veliparib‑induced toxicity in cancer patients. Databases were searched for RCTs treated with veliparib. We found veliparib could increase the risk of hematologic and gastrointestinal toxicities. Anemia, neutropenia, thrombocytopenia, and nausea were the most common toxicities. Patients diagnosed with gastrointestinal tumors tend to have a higher risk of high-grade neutropenia; patients in the first-line setting tend to have a higher risk of high-grade anemia and neutropenia than those in the ≥ second line setting. Patients receiving higher dosage of veliparib tend to have a higher risk...
Source: Cancer Investigation - April 8, 2024 Category: Cancer & Oncology Authors: Peirong Wang Ruizhen Zhao Xiaohui Jin Xianhua Zhou Xiaolong Xie Source Type: research
Comparative analysis of immunological biomarkers in COVID-19 and bacterial pneumonia
This study highlights the potential significant impact of COVID-19 on the immunological biomarkers investigated.PMID:38585537 | PMC:PMC10994609 | DOI:10.25122/jml-2023-0273 (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Mudathir Abdelshafea Abdelkareem Abakar Daralnaeem Hassan Ali Hamad Eman Faisal Hashim Mohamed Fad-Alla Omer Mahmoud Taha Mohamed Faki Abdellla Esmail Mohammed Idris Rouwida Omer Zeinab Osman Entesar Ahmed Gaffar Elhassan Mohamed Ahmed Abrahim-Holie Moham Source Type: research
Human immunoglobulin in combination with antimicrobial agents enhances the treatment efficacy and reduces inflammatory response in children with severe pneumonia
CONCLUSION: The combination of human immunoglobulin and antibiotics for the treatment of pediatric severe pneumonia is beneficial, because it improves efficacy, boosts the immune system, and reduces inflammation.PMID:38586114 | PMC:PMC10994785 | DOI:10.62347/KQUW5330 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Wenli Zhang Yue Jin Source Type: research
Veliparib ‑Induced Toxicity in Cancer Patients: A Systematic Review and Meta‑Analysis
In this study, we investigate the veliparib‑induced toxicity in cancer patients. Databases were searched for RCTs treated with veliparib. We found veliparib could increase the risk of hematologic and gastrointestinal toxicities. Anemia, neutropenia, thrombocytopenia, and nausea were the most common toxicities. Patients diagnosed with gastrointestinal tumors tend to have a higher risk of high-grade neutropenia; patients in the first-line setting tend to have a higher risk of high-grade anemia and neutropenia than those in the ≥ second line setting. Patients receiving higher dosage of veliparib tend to have a higher risk...
Source: Cancer Investigation - April 8, 2024 Category: Cancer & Oncology Authors: Peirong Wang Ruizhen Zhao Xiaohui Jin Xianhua Zhou Xiaolong Xie Source Type: research
Comparative analysis of immunological biomarkers in COVID-19 and bacterial pneumonia
This study highlights the potential significant impact of COVID-19 on the immunological biomarkers investigated.PMID:38585537 | PMC:PMC10994609 | DOI:10.25122/jml-2023-0273 (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - April 8, 2024 Category: General Medicine Authors: Mudathir Abdelshafea Abdelkareem Abakar Daralnaeem Hassan Ali Hamad Eman Faisal Hashim Mohamed Fad-Alla Omer Mahmoud Taha Mohamed Faki Abdellla Esmail Mohammed Idris Rouwida Omer Zeinab Osman Entesar Ahmed Gaffar Elhassan Mohamed Ahmed Abrahim-Holie Moham Source Type: research
Human immunoglobulin in combination with antimicrobial agents enhances the treatment efficacy and reduces inflammatory response in children with severe pneumonia
CONCLUSION: The combination of human immunoglobulin and antibiotics for the treatment of pediatric severe pneumonia is beneficial, because it improves efficacy, boosts the immune system, and reduces inflammation.PMID:38586114 | PMC:PMC10994785 | DOI:10.62347/KQUW5330 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - April 8, 2024 Category: Research Authors: Wenli Zhang Yue Jin Source Type: research
