The current STEMI paradigm: Because STEMI criteria are not met, let's wait until the myocardium is dead!!
This was sent to me by an inpatient nurse who reads this blog but wants to remain anonymous.An inpatient rapid response was called for a patient with hypotension. The patient was originally admitted for pneumonia and had been transferred out of
the ICU a day prior. He had a history of HFrEF, HTN, and AML. " When I
arrived his blood pressure was 70s/40s and he was pale and profusely
diaphoretic. " " He spoke Spanish but we did deduce that he had 7/10 chest pain radiating to the
back. " " We couldn ’t initially get a hold of the primary physician but our
hospital allows the rapid response nur...
Source: Dr. Smith's ECG Blog - April 16, 2024 Category: Cardiology Authors: Steve Smith Source Type: blogs
Wide Complex Tachycardia -- VT, SVT, or A Fib with RVR? If SVT, is it AVNRT or AVRT?
A 69 y.o. male with pertinent past medical history including Atrial fibrillation, atrial flutter, cardiomyopathy, Pulmonary Embolism, and hypertension presented to the Emergency Department via ambulance for respiratory distress and tachycardia. Per EMS report, patient believes he has been in atrial fibrillation for 5 days, since coming down with flu-like illness with rhinorrhea, productive cough, SOB. Patient is on rivaroxaben, carvedilol, and dofetilide (to suppress atrial fib -- rhythm control). He states that he maybe missed a dose or two during recent illness. On EMS arrival, patient ' s oxygen sat...
Source: Dr. Smith's ECG Blog - March 28, 2024 Category: Cardiology Authors: Steve Smith Source Type: blogs
Notice: NIGMS Support to Utilize Data and Biospecimens Generated by the ARDS, Pneumonia, and Sepsis Phenotyping Consortium
We’ve issued a new notice: NIGMS Support to Utilize Data and Biospecimens Generated by the ARDS, Pneumonia, and Sepsis (APS) Phenotyping Consortium (NOT-GM-24-018). The purpose is to inform investigators that we’ll support studies that fall within the NIGMS mission and utilize biospecimens or data generated from the APS Consortium.
Investigators can learn about the study design and structure of the APS Consortium in our previous Feedback Loop post. The APS public website, maintained by Consortium investigators, will have information about the available data and biospecimens and a process for requesting acce...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - January 25, 2024 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Funding Opportunities Sepsis Research Source Type: blogs
Fight Aging! Newsletter, January 22nd 2024
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment.
Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Novel Proteomic Aging Clock
By now there are most likely dozens of published aging clocks constructed from various omics databases. The proliferation of new clocks isn't helping to solve the fundamental problem with this approach to assessing biological age, which is that the predicted biological age produced by a clock isn't actionable, as no-one yet understands how the clocks relate to causative processes of aging. Thus factions within the research community are arguing for standardization to a single clock, followed by focused effort on understand how those clock measurements relate to underlying processes of aging.
Using a large proteomi...
Source: Fight Aging! - January 19, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Flagellin Immunization Modestly Extends Life Span After Late-Life Administration in Mice
The immune system recognizes flagellin as foreign. Flagellin is the protein found in flagellae, the whip-like structures that bacteria use to move around. Attacking and destroying these bacteria is very much a part of the immune system's portfolio of normal activities. Thus immunization with flagellin provokes the immune system into greater activity and responsiveness in the short term, and it has been tested in humans as a vaccine adjuvant, intended to make the immune system respond more effectively to the vaccine delivered alongside flagellin. Interestingly, flagellin immunization also makes the immune system clear out h...
Source: Fight Aging! - January 15, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
This Vitamin Helps Fight COVID Pneumonia
A vitamin that makes the lung lining stronger against respiratory infection and prevents COVID-19. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - January 15, 2024 Category: Psychiatry & Psychology Authors: Mina Dean Tags: COVID19 Source Type: blogs
Very fast regular tachycardia: 2 ECGs from the same patient. What is going on?
This was written by Magnus Nossen, from Norway, with comments and additions by SmithA 50 something smoker with no previous medical hx contacted EMS due to acute onset chest pain. Upon EMS arrival the patient appeared acutely ill and complained of chest pain. An ECG was recorded immediately and is shown below. How do you interpret the ECG?ECG#1There is a regular tachycardia with a ventricular rate of about 180 bpm. Smith comment: When there is a regular wide complex tachycardia, first assess whether it is sinus or not. At a rate of 180, this is unlikely. The patient is unstable. Therefore, the first s...
Source: Dr. Smith's ECG Blog - September 27, 2023 Category: Cardiology Authors: Magnus Nossen Source Type: blogs
Fight Aging! Newsletter, September 4th 2023
In conclusion, although the contribution of CRF to GrimAgeAccel and FitAgeAccel is relatively low compared to lifestyle-related factors such as smoking, the results suggest that the maintenance of CRF is associated with delayed biological ageing in older men.
« Back to Top
Release of Acetylcholine is Necessary for the Aging Brain to Compensate for a Lack of Neurogenesis
https://www.fightaging.org/archives/2023/09/release-of-acetylcholine-is-necessary-for-the-aging-brain-to-compensate-for-a-lack-of-neurogenesis/
Neurogenesis is the process by which new neurons are created by neural stem c...
Source: Fight Aging! - September 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
More Evidence for Vaccination to Reduce Alzheimer's Disease Risk
There is good evidence for the various forms of later life vaccination, such as for herpes zoster or influenza, to reduce the risk of later suffering Alzheimer's disease. One possibility is that people who take the time to obtain a vaccine tend to take better care of their health across the board. Another possibility is that vaccination produces a trained immunity effect that dampens age-related inflammation for a sustained period of time. It may also be the case that suffering from influenza, pneumonia, or similar infectious diseases causes sufficient additional inflammation to move the odds on suffering later neurodegene...
Source: Fight Aging! - August 28, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Presence of Streptococcus Species in the Gut Microbiome Correlates with Atherosclerotic Plaque Burden
It is presently possible to cheaply and reliably determine the bacterial populations making up the gut microbiome via 16S rRNA sequencing. This capability is giving rise to great deal of new knowledge regarding the ways in which changes in the gut microbiome affect health. Populations can provoke inflammation, known to drive the onset and progression of many age-related conditions, or generate harmful or helpful metabolites, about which less is known of the interaction with specific aspects of aging. Adjusting the balance of populations in the gut microbiome, particularly to restore a more youthful gut microbiome in older ...
Source: Fight Aging! - July 19, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Pulmonary Arterial Hypertension: Unraveling Its Impact On Heart And Lungs
Conclusion
Navigating the complexities of Pulmonary Arterial Hypertension (PAH) might seem daunting. However, with the right knowledge and proactive approach, it’s possible to manage the condition and maintain a good quality of life.
PAH, a unique type of high blood pressure affecting the arteries in the lungs, can put extra strain on the heart. Over time, this can lead to heart failure. The condition’s root cause may vary, from genetic factors to other health issues like heart defects, liver disease, or autoimmune diseases. Remember, sometimes the cause remains unknown, resulting in idiopathic pulmonary ...
Source: The EMT Spot - July 19, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Fight Aging! Newsletter, May 29th 2023
In this study, we used a Drosophila model to understand the role of the dec2P384R mutation on animal health and elucidate the mechanisms driving these physiological changes. We found that the expression of the mammalian dec2P384R transgene in fly sleep neurons was sufficient to mimic the short sleep phenotype observed in mammals. Remarkably, dec2P384Rmutants lived significantly longer with improved health despite sleeping less. In particular, dec2P384R mutants were more stress resistant and displayed improved mitochondrial fitness in flight muscles. Differential gene expression analyses went on to reveal several altered tr...
Source: Fight Aging! - May 28, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Sufficient Physical Activity Correlates With a Halving of the Risk of Influenza Mortality
Analysis of a large epidemiological database here shows that sufficient exercise correlates with a halving of the risk of mortality due to influenza. Like many other studies, it also shows that too much exercise may be harmful, actually increasing the risk of mortality. While correlation does not imply causation, there is plenty of evidence for physical fitness and physical activity to reduce impacts of aging related to immune function. Alternative explanations revolve around the tendency of more robust individuals to conduct more exercise, while also tending to be more resilient independently of the effects of exercise.
...
Source: Fight Aging! - May 24, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
